Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0564 - putative

Species:

Leishmania infantum

UniProt:

A4I8G7_LEIIN

TriTrypDb:

LINF_320041800

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8G7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.546
CLV_C14_Caspase3-7	472	476	PF00656	0.552
CLV_C14_Caspase3-7	673	677	PF00656	0.670
CLV_C14_Caspase3-7	690	694	PF00656	0.488
CLV_C14_Caspase3-7	738	742	PF00656	0.619
CLV_C14_Caspase3-7	800	804	PF00656	0.631
CLV_NRD_NRD_1	144	146	PF00675	0.627
CLV_NRD_NRD_1	17	19	PF00675	0.502
CLV_NRD_NRD_1	185	187	PF00675	0.546
CLV_NRD_NRD_1	195	197	PF00675	0.546
CLV_NRD_NRD_1	422	424	PF00675	0.363
CLV_NRD_NRD_1	481	483	PF00675	0.352
CLV_NRD_NRD_1	494	496	PF00675	0.243
CLV_NRD_NRD_1	504	506	PF00675	0.296
CLV_NRD_NRD_1	574	576	PF00675	0.303
CLV_NRD_NRD_1	765	767	PF00675	0.630
CLV_NRD_NRD_1	88	90	PF00675	0.472
CLV_PCSK_FUR_1	183	187	PF00082	0.548
CLV_PCSK_KEX2_1	143	145	PF00082	0.617
CLV_PCSK_KEX2_1	17	19	PF00082	0.502
CLV_PCSK_KEX2_1	185	187	PF00082	0.546
CLV_PCSK_KEX2_1	23	25	PF00082	0.501
CLV_PCSK_KEX2_1	259	261	PF00082	0.556
CLV_PCSK_KEX2_1	422	424	PF00082	0.363
CLV_PCSK_KEX2_1	481	483	PF00082	0.352
CLV_PCSK_KEX2_1	494	496	PF00082	0.243
CLV_PCSK_KEX2_1	503	505	PF00082	0.301
CLV_PCSK_KEX2_1	576	578	PF00082	0.312
CLV_PCSK_KEX2_1	664	666	PF00082	0.569
CLV_PCSK_KEX2_1	765	767	PF00082	0.669
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.454
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.556
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.349
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.352
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.569
CLV_PCSK_PC7_1	139	145	PF00082	0.610
CLV_PCSK_PC7_1	572	578	PF00082	0.315
CLV_PCSK_SKI1_1	102	106	PF00082	0.507
CLV_PCSK_SKI1_1	135	139	PF00082	0.578
CLV_PCSK_SKI1_1	20	24	PF00082	0.599
CLV_PCSK_SKI1_1	407	411	PF00082	0.418
CLV_PCSK_SKI1_1	417	421	PF00082	0.288
CLV_PCSK_SKI1_1	591	595	PF00082	0.324
CLV_PCSK_SKI1_1	609	613	PF00082	0.368
CLV_PCSK_SKI1_1	647	651	PF00082	0.539
CLV_PCSK_SKI1_1	664	668	PF00082	0.546
DEG_APCC_DBOX_1	121	129	PF00400	0.592
DEG_Nend_UBRbox_3	1	3	PF02207	0.515
DEG_SPOP_SBC_1	484	488	PF00917	0.487
DOC_ANK_TNKS_1	690	697	PF00023	0.627
DOC_CKS1_1	304	309	PF01111	0.693
DOC_CYCLIN_yCln2_LP_2	775	781	PF00134	0.558
DOC_MAPK_gen_1	119	128	PF00069	0.494
DOC_MAPK_gen_1	183	191	PF00069	0.554
DOC_MAPK_gen_1	422	430	PF00069	0.570
DOC_MAPK_MEF2A_6	164	172	PF00069	0.509
DOC_MAPK_MEF2A_6	422	430	PF00069	0.607
DOC_MAPK_RevD_3	467	482	PF00069	0.505
DOC_PP1_RVXF_1	186	192	PF00149	0.556
DOC_PP2B_LxvP_1	775	778	PF13499	0.605
DOC_PP4_FxxP_1	629	632	PF00568	0.562
DOC_USP7_MATH_1	285	289	PF00917	0.680
DOC_USP7_MATH_1	29	33	PF00917	0.581
DOC_USP7_MATH_1	292	296	PF00917	0.588
DOC_USP7_MATH_1	320	324	PF00917	0.647
DOC_USP7_MATH_1	357	361	PF00917	0.676
DOC_USP7_MATH_1	378	382	PF00917	0.710
DOC_USP7_MATH_1	393	397	PF00917	0.649
DOC_USP7_MATH_1	403	407	PF00917	0.263
DOC_USP7_MATH_1	409	413	PF00917	0.391
DOC_USP7_MATH_1	483	487	PF00917	0.501
DOC_USP7_MATH_1	687	691	PF00917	0.622
DOC_USP7_MATH_1	726	730	PF00917	0.571
DOC_USP7_MATH_1	744	748	PF00917	0.498
DOC_USP7_MATH_1	759	763	PF00917	0.669
DOC_USP7_MATH_1	770	774	PF00917	0.569
DOC_WW_Pin1_4	210	215	PF00397	0.666
DOC_WW_Pin1_4	221	226	PF00397	0.564
DOC_WW_Pin1_4	258	263	PF00397	0.667
DOC_WW_Pin1_4	273	278	PF00397	0.511
DOC_WW_Pin1_4	288	293	PF00397	0.582
DOC_WW_Pin1_4	303	308	PF00397	0.649
DOC_WW_Pin1_4	381	386	PF00397	0.659
DOC_WW_Pin1_4	467	472	PF00397	0.524
DOC_WW_Pin1_4	495	500	PF00397	0.528
DOC_WW_Pin1_4	507	512	PF00397	0.467
DOC_WW_Pin1_4	520	525	PF00397	0.443
DOC_WW_Pin1_4	65	70	PF00397	0.569
DOC_WW_Pin1_4	666	671	PF00397	0.532
DOC_WW_Pin1_4	695	700	PF00397	0.646
DOC_WW_Pin1_4	717	722	PF00397	0.669
DOC_WW_Pin1_4	754	759	PF00397	0.677
LIG_14-3-3_CanoR_1	112	118	PF00244	0.470
LIG_14-3-3_CanoR_1	144	152	PF00244	0.459
LIG_14-3-3_CanoR_1	155	163	PF00244	0.460
LIG_14-3-3_CanoR_1	196	204	PF00244	0.615
LIG_14-3-3_CanoR_1	293	297	PF00244	0.552
LIG_14-3-3_CanoR_1	482	492	PF00244	0.552
LIG_14-3-3_CanoR_1	575	583	PF00244	0.534
LIG_14-3-3_CanoR_1	591	600	PF00244	0.423
LIG_14-3-3_CanoR_1	665	670	PF00244	0.559
LIG_14-3-3_CanoR_1	748	754	PF00244	0.635
LIG_14-3-3_CanoR_1	765	770	PF00244	0.499
LIG_14-3-3_CanoR_1	788	792	PF00244	0.633
LIG_Actin_WH2_2	106	121	PF00022	0.557
LIG_BIR_III_4	680	684	PF00653	0.620
LIG_EVH1_1	338	342	PF00568	0.619
LIG_EVH1_2	352	356	PF00568	0.614
LIG_EVH1_2	71	75	PF00568	0.648
LIG_FHA_1	537	543	PF00498	0.485
LIG_FHA_1	592	598	PF00498	0.491
LIG_FHA_1	666	672	PF00498	0.513
LIG_FHA_1	677	683	PF00498	0.623
LIG_FHA_1	687	693	PF00498	0.549
LIG_FHA_1	772	778	PF00498	0.630
LIG_FHA_2	136	142	PF00498	0.692
LIG_FHA_2	411	417	PF00498	0.515
LIG_LIR_Gen_1	107	118	PF02991	0.575
LIG_LIR_Nem_3	107	113	PF02991	0.574
LIG_LIR_Nem_3	418	424	PF02991	0.552
LIG_LIR_Nem_3	561	567	PF02991	0.524
LIG_LIR_Nem_3	59	65	PF02991	0.498
LIG_Pex14_2	441	445	PF04695	0.485
LIG_PTAP_UEV_1	341	346	PF05743	0.571
LIG_PTAP_UEV_1	348	353	PF05743	0.556
LIG_RPA_C_Plants	40	51	PF08784	0.560
LIG_SH2_NCK_1	220	224	PF00017	0.699
LIG_SH2_STAP1	543	547	PF00017	0.552
LIG_SH2_STAP1	79	83	PF00017	0.512
LIG_SH2_STAT3	424	427	PF00017	0.552
LIG_SH2_STAT3	546	549	PF00017	0.505
LIG_SH2_STAT5	4	7	PF00017	0.517
LIG_SH2_STAT5	546	549	PF00017	0.466
LIG_SH2_STAT5	581	584	PF00017	0.485
LIG_SH3_1	66	72	PF00018	0.562
LIG_SH3_2	490	495	PF14604	0.441
LIG_SH3_3	126	132	PF00018	0.562
LIG_SH3_3	277	283	PF00018	0.692
LIG_SH3_3	293	299	PF00018	0.582
LIG_SH3_3	301	307	PF00018	0.694
LIG_SH3_3	314	320	PF00018	0.567
LIG_SH3_3	325	331	PF00018	0.566
LIG_SH3_3	33	39	PF00018	0.598
LIG_SH3_3	333	339	PF00018	0.580
LIG_SH3_3	346	352	PF00018	0.627
LIG_SH3_3	359	365	PF00018	0.756
LIG_SH3_3	367	373	PF00018	0.584
LIG_SH3_3	433	439	PF00018	0.552
LIG_SH3_3	460	466	PF00018	0.552
LIG_SH3_3	487	493	PF00018	0.441
LIG_SH3_3	508	514	PF00018	0.524
LIG_SH3_3	66	72	PF00018	0.562
LIG_SH3_3	774	780	PF00018	0.665
LIG_TRAF2_1	702	705	PF00917	0.682
LIG_TRFH_1	467	471	PF08558	0.524
LIG_WW_2	339	342	PF00397	0.658
LIG_WW_3	37	41	PF00397	0.578
LIG_WW_3	491	495	PF00397	0.487
MOD_CDC14_SPxK_1	215	218	PF00782	0.690
MOD_CDK_SPK_2	288	293	PF00069	0.572
MOD_CDK_SPK_2	520	525	PF00069	0.478
MOD_CDK_SPxK_1	212	218	PF00069	0.677
MOD_CDK_SPxxK_3	467	474	PF00069	0.505
MOD_CDK_SPxxK_3	717	724	PF00069	0.637
MOD_CK1_1	114	120	PF00069	0.520
MOD_CK1_1	258	264	PF00069	0.663
MOD_CK1_1	276	282	PF00069	0.473
MOD_CK1_1	288	294	PF00069	0.612
MOD_CK1_1	381	387	PF00069	0.658
MOD_CK1_1	396	402	PF00069	0.585
MOD_CK1_1	523	529	PF00069	0.514
MOD_CK1_1	720	726	PF00069	0.694
MOD_CK1_1	733	739	PF00069	0.543
MOD_CK1_1	742	748	PF00069	0.620
MOD_CK1_1	750	756	PF00069	0.633
MOD_CK1_1	761	767	PF00069	0.753
MOD_CK1_1	768	774	PF00069	0.749
MOD_CK1_1	795	801	PF00069	0.661
MOD_CK2_1	117	123	PF00069	0.565
MOD_CK2_1	135	141	PF00069	0.418
MOD_CK2_1	176	182	PF00069	0.591
MOD_CK2_1	649	655	PF00069	0.494
MOD_CK2_1	787	793	PF00069	0.633
MOD_Cter_Amidation	479	482	PF01082	0.352
MOD_Cter_Amidation	501	504	PF01082	0.315
MOD_GlcNHglycan	113	116	PF01048	0.554
MOD_GlcNHglycan	147	150	PF01048	0.505
MOD_GlcNHglycan	287	290	PF01048	0.713
MOD_GlcNHglycan	359	362	PF01048	0.775
MOD_GlcNHglycan	366	369	PF01048	0.686
MOD_GlcNHglycan	380	383	PF01048	0.604
MOD_GlcNHglycan	396	399	PF01048	0.606
MOD_GlcNHglycan	471	474	PF01048	0.328
MOD_GlcNHglycan	487	490	PF01048	0.225
MOD_GlcNHglycan	499	502	PF01048	0.362
MOD_GlcNHglycan	525	528	PF01048	0.335
MOD_GlcNHglycan	578	581	PF01048	0.352
MOD_GlcNHglycan	714	717	PF01048	0.641
MOD_GlcNHglycan	732	736	PF01048	0.508
MOD_GlcNHglycan	770	773	PF01048	0.629
MOD_GlcNHglycan	789	792	PF01048	0.494
MOD_GSK3_1	114	121	PF00069	0.452
MOD_GSK3_1	151	158	PF00069	0.545
MOD_GSK3_1	191	198	PF00069	0.589
MOD_GSK3_1	254	261	PF00069	0.676
MOD_GSK3_1	288	295	PF00069	0.661
MOD_GSK3_1	340	347	PF00069	0.605
MOD_GSK3_1	381	388	PF00069	0.648
MOD_GSK3_1	547	554	PF00069	0.491
MOD_GSK3_1	672	679	PF00069	0.601
MOD_GSK3_1	726	733	PF00069	0.611
MOD_GSK3_1	735	742	PF00069	0.620
MOD_GSK3_1	743	750	PF00069	0.618
MOD_GSK3_1	754	761	PF00069	0.740
MOD_GSK3_1	764	771	PF00069	0.550
MOD_GSK3_1	795	802	PF00069	0.612
MOD_LATS_1	589	595	PF00433	0.524
MOD_NEK2_1	191	196	PF00069	0.549
MOD_NEK2_2	426	431	PF00069	0.552
MOD_PIKK_1	410	416	PF00454	0.507
MOD_PIKK_1	536	542	PF00454	0.485
MOD_PKA_1	576	582	PF00069	0.552
MOD_PKA_1	765	771	PF00069	0.652
MOD_PKA_2	111	117	PF00069	0.502
MOD_PKA_2	118	124	PF00069	0.442
MOD_PKA_2	195	201	PF00069	0.605
MOD_PKA_2	292	298	PF00069	0.549
MOD_PKA_2	484	490	PF00069	0.499
MOD_PKA_2	529	535	PF00069	0.552
MOD_PKA_2	576	582	PF00069	0.552
MOD_PKA_2	604	610	PF00069	0.495
MOD_PKA_2	747	753	PF00069	0.610
MOD_PKA_2	764	770	PF00069	0.543
MOD_PKA_2	787	793	PF00069	0.633
MOD_PKB_1	143	151	PF00069	0.612
MOD_PKB_1	153	161	PF00069	0.529
MOD_Plk_1	551	557	PF00069	0.515
MOD_Plk_1	687	693	PF00069	0.712
MOD_Plk_1	795	801	PF00069	0.661
MOD_Plk_4	71	77	PF00069	0.567
MOD_ProDKin_1	210	216	PF00069	0.667
MOD_ProDKin_1	221	227	PF00069	0.563
MOD_ProDKin_1	258	264	PF00069	0.663
MOD_ProDKin_1	273	279	PF00069	0.510
MOD_ProDKin_1	288	294	PF00069	0.583
MOD_ProDKin_1	303	309	PF00069	0.643
MOD_ProDKin_1	381	387	PF00069	0.659
MOD_ProDKin_1	467	473	PF00069	0.524
MOD_ProDKin_1	495	501	PF00069	0.528
MOD_ProDKin_1	507	513	PF00069	0.467
MOD_ProDKin_1	520	526	PF00069	0.443
MOD_ProDKin_1	65	71	PF00069	0.566
MOD_ProDKin_1	666	672	PF00069	0.538
MOD_ProDKin_1	695	701	PF00069	0.645
MOD_ProDKin_1	717	723	PF00069	0.667
MOD_ProDKin_1	754	760	PF00069	0.677
MOD_SUMO_rev_2	472	479	PF00179	0.533
MOD_SUMO_rev_2	704	709	PF00179	0.644
TRG_DiLeu_BaEn_1	31	36	PF01217	0.643
TRG_DiLeu_BaEn_2	186	192	PF01217	0.556
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.643
TRG_ENDOCYTIC_2	79	82	PF00928	0.515
TRG_ER_diArg_1	100	103	PF00400	0.609
TRG_ER_diArg_1	142	145	PF00400	0.617
TRG_ER_diArg_1	152	155	PF00400	0.518
TRG_ER_diArg_1	183	186	PF00400	0.550
TRG_ER_diArg_1	39	42	PF00400	0.611
TRG_ER_diArg_1	421	423	PF00400	0.563
TRG_ER_diArg_1	481	483	PF00400	0.495
TRG_ER_diArg_1	493	495	PF00400	0.514
TRG_ER_diArg_1	574	577	PF00400	0.507
TRG_NLS_MonoExtC_3	22	27	PF00514	0.457
TRG_NLS_MonoExtN_4	20	27	PF00514	0.451
TRG_NLS_MonoExtN_4	572	579	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTK5	Trypanosomatidae	34%	98%
A0A3Q8IJN1	Leishmania donovani	99%	100%
A4HKY6	Leishmania braziliensis	73%	100%
E9B3C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9B3C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4S9	Leishmania major	91%	100%