Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8G6_LEIIN

TriTrypDb:

LINF_320041700

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I8G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.529
CLV_NRD_NRD_1	378	380	PF00675	0.452
CLV_NRD_NRD_1	89	91	PF00675	0.400
CLV_PCSK_FUR_1	376	380	PF00082	0.440
CLV_PCSK_KEX2_1	378	380	PF00082	0.452
CLV_PCSK_KEX2_1	88	90	PF00082	0.419
CLV_PCSK_SKI1_1	384	388	PF00082	0.488
DEG_APCC_DBOX_1	87	95	PF00400	0.593
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DOC_MAPK_FxFP_2	392	395	PF00069	0.705
DOC_MAPK_gen_1	376	385	PF00069	0.660
DOC_MAPK_gen_1	42	50	PF00069	0.363
DOC_MAPK_MEF2A_6	281	290	PF00069	0.295
DOC_MAPK_MEF2A_6	376	385	PF00069	0.600
DOC_PP1_RVXF_1	335	341	PF00149	0.523
DOC_PP4_FxxP_1	392	395	PF00568	0.705
DOC_USP7_MATH_1	241	245	PF00917	0.392
DOC_WW_Pin1_4	43	48	PF00397	0.260
LIG_14-3-3_CanoR_1	213	220	PF00244	0.583
LIG_14-3-3_CanoR_1	391	395	PF00244	0.703
LIG_Actin_WH2_2	321	339	PF00022	0.413
LIG_BIR_III_4	149	153	PF00653	0.366
LIG_BRCT_BRCA1_1	20	24	PF00533	0.305
LIG_BRCT_BRCA1_1	214	218	PF00533	0.516
LIG_BRCT_BRCA1_1	97	101	PF00533	0.344
LIG_eIF4E_1	12	18	PF01652	0.413
LIG_FHA_1	116	122	PF00498	0.344
LIG_FHA_1	153	159	PF00498	0.366
LIG_FHA_1	202	208	PF00498	0.615
LIG_FHA_1	220	226	PF00498	0.202
LIG_FHA_1	62	68	PF00498	0.394
LIG_FHA_2	144	150	PF00498	0.550
LIG_FHA_2	241	247	PF00498	0.471
LIG_GBD_Chelix_1	127	135	PF00786	0.319
LIG_GBD_Chelix_1	286	294	PF00786	0.366
LIG_Integrin_RGD_1	138	140	PF01839	0.468
LIG_LIR_Apic_2	390	395	PF02991	0.667
LIG_LIR_Gen_1	112	122	PF02991	0.273
LIG_LIR_Gen_1	27	34	PF02991	0.417
LIG_LIR_Gen_1	96	104	PF02991	0.366
LIG_LIR_Nem_3	112	117	PF02991	0.273
LIG_LIR_Nem_3	21	26	PF02991	0.330
LIG_LIR_Nem_3	27	31	PF02991	0.321
LIG_LIR_Nem_3	96	100	PF02991	0.337
LIG_MLH1_MIPbox_1	20	24	PF16413	0.366
LIG_NRBOX	182	188	PF00104	0.413
LIG_NRBOX	293	299	PF00104	0.366
LIG_Pex14_2	20	24	PF04695	0.319
LIG_SH2_CRK	14	18	PF00017	0.328
LIG_SH2_CRK	28	32	PF00017	0.355
LIG_SH2_CRK	303	307	PF00017	0.607
LIG_SH2_CRK	97	101	PF00017	0.413
LIG_SH2_SRC	12	15	PF00017	0.342
LIG_SH2_SRC	301	304	PF00017	0.458
LIG_SH2_SRC	309	312	PF00017	0.519
LIG_SH2_STAP1	12	16	PF00017	0.319
LIG_SH2_STAP1	28	32	PF00017	0.319
LIG_SH2_STAP1	301	305	PF00017	0.468
LIG_SH2_STAP1	97	101	PF00017	0.413
LIG_SH2_STAT5	236	239	PF00017	0.466
LIG_SH2_STAT5	309	312	PF00017	0.522
LIG_SH2_STAT5	33	36	PF00017	0.423
LIG_SH3_3	272	278	PF00018	0.439
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.413
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.430
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.329
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.366
LIG_SUMO_SIM_par_1	120	126	PF11976	0.474
LIG_SUMO_SIM_par_1	15	21	PF11976	0.411
LIG_SUMO_SIM_par_1	359	364	PF11976	0.319
LIG_TRAF2_1	75	78	PF00917	0.597
LIG_TYR_ITIM	26	31	PF00017	0.366
MOD_CK1_1	27	33	PF00069	0.413
MOD_CK1_1	390	396	PF00069	0.671
MOD_CK2_1	175	181	PF00069	0.369
MOD_CK2_1	240	246	PF00069	0.428
MOD_CK2_1	72	78	PF00069	0.634
MOD_GlcNHglycan	102	105	PF01048	0.441
MOD_GlcNHglycan	195	198	PF01048	0.413
MOD_GlcNHglycan	248	251	PF01048	0.723
MOD_GlcNHglycan	266	269	PF01048	0.551
MOD_GlcNHglycan	314	317	PF01048	0.345
MOD_GlcNHglycan	325	328	PF01048	0.287
MOD_GlcNHglycan	345	348	PF01048	0.453
MOD_GlcNHglycan	366	369	PF01048	0.339
MOD_GlcNHglycan	372	375	PF01048	0.305
MOD_GSK3_1	109	116	PF00069	0.341
MOD_GSK3_1	171	178	PF00069	0.393
MOD_GSK3_1	189	196	PF00069	0.301
MOD_GSK3_1	208	215	PF00069	0.441
MOD_GSK3_1	220	227	PF00069	0.434
MOD_GSK3_1	241	248	PF00069	0.422
MOD_NEK2_1	100	105	PF00069	0.338
MOD_NEK2_1	123	128	PF00069	0.322
MOD_NEK2_1	218	223	PF00069	0.319
MOD_NEK2_1	224	229	PF00069	0.319
MOD_NEK2_1	24	29	PF00069	0.351
MOD_NEK2_1	349	354	PF00069	0.416
MOD_NEK2_1	387	392	PF00069	0.666
MOD_PIKK_1	208	214	PF00454	0.550
MOD_PKA_2	212	218	PF00069	0.594
MOD_PKA_2	390	396	PF00069	0.704
MOD_Plk_1	387	393	PF00069	0.666
MOD_Plk_2-3	77	83	PF00069	0.635
MOD_Plk_4	182	188	PF00069	0.364
MOD_Plk_4	189	195	PF00069	0.289
MOD_Plk_4	220	226	PF00069	0.319
MOD_Plk_4	232	238	PF00069	0.319
MOD_Plk_4	27	33	PF00069	0.399
MOD_Plk_4	293	299	PF00069	0.484
MOD_Plk_4	304	310	PF00069	0.443
MOD_Plk_4	77	83	PF00069	0.642
MOD_Plk_4	95	101	PF00069	0.339
MOD_ProDKin_1	43	49	PF00069	0.257
TRG_DiLeu_BaEn_3	76	82	PF01217	0.634
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.413
TRG_ENDOCYTIC_2	14	17	PF00928	0.350
TRG_ENDOCYTIC_2	28	31	PF00928	0.404
TRG_ENDOCYTIC_2	303	306	PF00928	0.607
TRG_ENDOCYTIC_2	97	100	PF00928	0.371
TRG_ER_diArg_1	377	379	PF00400	0.632
TRG_ER_diArg_1	88	90	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDQ8	Bodo saltans	25%	73%
A0A3Q8IG89	Leishmania donovani	99%	100%
E9B3C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4T0	Leishmania major	90%	100%