AB hydrolase-1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family - putative

Species:

Leishmania infantum

UniProt:

A4I8G4_LEIIN

TriTrypDb:

LINF_320041500

Length:

604

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I8G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.381
CLV_NRD_NRD_1	291	293	PF00675	0.529
CLV_PCSK_KEX2_1	291	293	PF00082	0.615
CLV_PCSK_SKI1_1	104	108	PF00082	0.630
CLV_PCSK_SKI1_1	267	271	PF00082	0.606
CLV_PCSK_SKI1_1	303	307	PF00082	0.483
CLV_PCSK_SKI1_1	561	565	PF00082	0.394
CLV_PCSK_SKI1_1	86	90	PF00082	0.589
DEG_APCC_DBOX_1	302	310	PF00400	0.301
DEG_APCC_DBOX_1	560	568	PF00400	0.378
DEG_MDM2_SWIB_1	552	559	PF02201	0.457
DEG_SPOP_SBC_1	154	158	PF00917	0.321
DOC_ANK_TNKS_1	180	187	PF00023	0.328
DOC_CDC14_PxL_1	312	320	PF14671	0.364
DOC_CDC14_PxL_1	325	333	PF14671	0.343
DOC_CKS1_1	480	485	PF01111	0.364
DOC_CYCLIN_RxL_1	389	401	PF00134	0.371
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.355
DOC_MAPK_DCC_7	8	18	PF00069	0.435
DOC_MAPK_gen_1	68	74	PF00069	0.342
DOC_MAPK_MEF2A_6	108	115	PF00069	0.375
DOC_MAPK_MEF2A_6	303	310	PF00069	0.346
DOC_MAPK_MEF2A_6	561	568	PF00069	0.331
DOC_MAPK_MEF2A_6	86	93	PF00069	0.377
DOC_MAPK_NFAT4_5	303	311	PF00069	0.342
DOC_MAPK_NFAT4_5	561	569	PF00069	0.363
DOC_PP1_RVXF_1	283	289	PF00149	0.329
DOC_PP1_RVXF_1	509	515	PF00149	0.316
DOC_PP1_RVXF_1	69	75	PF00149	0.358
DOC_PP2B_LxvP_1	397	400	PF13499	0.301
DOC_PP4_FxxP_1	531	534	PF00568	0.376
DOC_USP7_MATH_1	118	122	PF00917	0.343
DOC_USP7_MATH_1	131	135	PF00917	0.362
DOC_USP7_MATH_1	153	157	PF00917	0.417
DOC_USP7_MATH_1	261	265	PF00917	0.336
DOC_USP7_MATH_1	407	411	PF00917	0.411
DOC_USP7_MATH_1	41	45	PF00917	0.440
DOC_USP7_MATH_2	52	58	PF00917	0.321
DOC_WW_Pin1_4	479	484	PF00397	0.394
DOC_WW_Pin1_4	48	53	PF00397	0.396
LIG_14-3-3_CanoR_1	267	272	PF00244	0.356
LIG_14-3-3_CanoR_1	389	397	PF00244	0.385
LIG_14-3-3_CanoR_1	417	427	PF00244	0.337
LIG_14-3-3_CanoR_1	47	52	PF00244	0.366
LIG_14-3-3_CanoR_1	593	599	PF00244	0.653
LIG_14-3-3_CanoR_1	71	77	PF00244	0.330
LIG_Actin_WH2_2	458	473	PF00022	0.414
LIG_APCC_ABBA_1	489	494	PF00400	0.294
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BRCT_BRCA1_1	594	598	PF00533	0.610
LIG_CtBP_PxDLS_1	161	165	PF00389	0.310
LIG_deltaCOP1_diTrp_1	527	531	PF00928	0.325
LIG_EH1_1	73	81	PF00400	0.379
LIG_FHA_1	17	23	PF00498	0.335
LIG_FHA_1	430	436	PF00498	0.364
LIG_FHA_1	440	446	PF00498	0.366
LIG_FHA_1	480	486	PF00498	0.366
LIG_FHA_1	503	509	PF00498	0.388
LIG_FHA_1	56	62	PF00498	0.426
LIG_FHA_2	180	186	PF00498	0.326
LIG_IBAR_NPY_1	135	137	PF08397	0.323
LIG_LIR_Apic_2	219	223	PF02991	0.318
LIG_LIR_Apic_2	530	534	PF02991	0.350
LIG_LIR_Gen_1	227	237	PF02991	0.303
LIG_LIR_Gen_1	262	272	PF02991	0.308
LIG_LIR_Gen_1	401	408	PF02991	0.288
LIG_LIR_Gen_1	90	100	PF02991	0.377
LIG_LIR_Nem_3	227	232	PF02991	0.268
LIG_LIR_Nem_3	262	268	PF02991	0.306
LIG_LIR_Nem_3	596	602	PF02991	0.593
LIG_LIR_Nem_3	90	95	PF02991	0.225
LIG_LYPXL_S_1	314	318	PF13949	0.511
LIG_LYPXL_yS_3	315	318	PF13949	0.358
LIG_NRBOX	240	246	PF00104	0.298
LIG_PCNA_PIPBox_1	225	234	PF02747	0.281
LIG_PCNA_yPIPBox_3	321	334	PF02747	0.326
LIG_Pex14_2	552	556	PF04695	0.474
LIG_Pex14_3	372	377	PF04695	0.273
LIG_Rb_pABgroove_1	344	352	PF01858	0.269
LIG_SH2_CRK	350	354	PF00017	0.267
LIG_SH2_CRK	591	595	PF00017	0.625
LIG_SH2_GRB2like	599	602	PF00017	0.596
LIG_SH2_NCK_1	359	363	PF00017	0.343
LIG_SH2_NCK_1	591	595	PF00017	0.646
LIG_SH2_PTP2	220	223	PF00017	0.339
LIG_SH2_SRC	220	223	PF00017	0.354
LIG_SH2_STAT3	137	140	PF00017	0.368
LIG_SH2_STAT3	333	336	PF00017	0.250
LIG_SH2_STAT5	220	223	PF00017	0.286
LIG_SH2_STAT5	231	234	PF00017	0.265
LIG_SH2_STAT5	352	355	PF00017	0.332
LIG_SH2_STAT5	577	580	PF00017	0.305
LIG_SH2_STAT5	582	585	PF00017	0.545
LIG_SH3_3	310	316	PF00018	0.316
LIG_SH3_3	477	483	PF00018	0.400
LIG_SUMO_SIM_par_1	14	19	PF11976	0.311
LIG_SUMO_SIM_par_1	214	219	PF11976	0.301
LIG_TYR_ITIM	575	580	PF00017	0.215
LIG_UBA3_1	268	276	PF00899	0.362
LIG_WRC_WIRS_1	385	390	PF05994	0.432
LIG_WRC_WIRS_1	399	404	PF05994	0.249
MOD_CK1_1	121	127	PF00069	0.410
MOD_CK1_1	156	162	PF00069	0.410
MOD_CK1_1	165	171	PF00069	0.343
MOD_CK1_1	236	242	PF00069	0.420
MOD_CK1_1	281	287	PF00069	0.342
MOD_CK1_1	387	393	PF00069	0.378
MOD_CK1_1	4	10	PF00069	0.597
MOD_CK1_1	421	427	PF00069	0.494
MOD_CK1_1	536	542	PF00069	0.592
MOD_CK1_1	592	598	PF00069	0.637
MOD_CK2_1	48	54	PF00069	0.376
MOD_GlcNHglycan	167	170	PF01048	0.562
MOD_GlcNHglycan	27	30	PF01048	0.693
MOD_GlcNHglycan	353	356	PF01048	0.585
MOD_GlcNHglycan	390	393	PF01048	0.530
MOD_GlcNHglycan	405	408	PF01048	0.526
MOD_GlcNHglycan	409	412	PF01048	0.549
MOD_GlcNHglycan	420	423	PF01048	0.663
MOD_GlcNHglycan	477	480	PF01048	0.506
MOD_GSK3_1	126	133	PF00069	0.369
MOD_GSK3_1	25	32	PF00069	0.603
MOD_GSK3_1	384	391	PF00069	0.379
MOD_GSK3_1	403	410	PF00069	0.314
MOD_GSK3_1	41	48	PF00069	0.310
MOD_GSK3_1	475	482	PF00069	0.386
MOD_N-GLC_1	131	136	PF02516	0.628
MOD_N-GLC_1	162	167	PF02516	0.591
MOD_N-GLC_1	429	434	PF02516	0.588
MOD_NEK2_1	1	6	PF00069	0.692
MOD_NEK2_1	16	21	PF00069	0.279
MOD_NEK2_1	162	167	PF00069	0.344
MOD_NEK2_1	317	322	PF00069	0.353
MOD_NEK2_1	388	393	PF00069	0.333
MOD_NEK2_1	461	466	PF00069	0.380
MOD_NEK2_1	578	583	PF00069	0.401
MOD_NEK2_1	589	594	PF00069	0.736
MOD_PIKK_1	121	127	PF00454	0.278
MOD_PIKK_1	429	435	PF00454	0.371
MOD_PIKK_1	449	455	PF00454	0.230
MOD_PKA_2	118	124	PF00069	0.333
MOD_PKA_2	388	394	PF00069	0.370
MOD_PKA_2	416	422	PF00069	0.364
MOD_PKA_2	475	481	PF00069	0.316
MOD_PKA_2	592	598	PF00069	0.644
MOD_PKA_2	70	76	PF00069	0.333
MOD_Plk_1	162	168	PF00069	0.334
MOD_Plk_2-3	502	508	PF00069	0.378
MOD_Plk_4	123	129	PF00069	0.389
MOD_Plk_4	16	22	PF00069	0.371
MOD_Plk_4	195	201	PF00069	0.287
MOD_Plk_4	233	239	PF00069	0.330
MOD_Plk_4	267	273	PF00069	0.338
MOD_Plk_4	327	333	PF00069	0.262
MOD_Plk_4	578	584	PF00069	0.293
MOD_Plk_4	87	93	PF00069	0.291
MOD_ProDKin_1	479	485	PF00069	0.390
MOD_ProDKin_1	48	54	PF00069	0.393
MOD_SUMO_rev_2	419	427	PF00179	0.309
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.270
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.312
TRG_ENDOCYTIC_2	229	232	PF00928	0.279
TRG_ENDOCYTIC_2	315	318	PF00928	0.337
TRG_ENDOCYTIC_2	350	353	PF00928	0.292
TRG_ENDOCYTIC_2	577	580	PF00928	0.360
TRG_ENDOCYTIC_2	591	594	PF00928	0.580
TRG_ENDOCYTIC_2	599	602	PF00928	0.568
TRG_ER_diArg_1	290	292	PF00400	0.315
TRG_ER_diArg_1	5	8	PF00400	0.679
TRG_ER_FFAT_2	121	133	PF00635	0.358
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I361	Leptomonas seymouri	51%	100%
A0A0S4JGY4	Bodo saltans	25%	98%
A0A1X0NRX3	Trypanosomatidae	32%	100%
A0A3Q8IFS8	Leishmania donovani	100%	100%
A0A422P343	Trypanosoma rangeli	36%	100%
A4HKY5	Leishmania braziliensis	77%	100%
E9B3C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4T2	Leishmania major	91%	100%
V5DMC3	Trypanosoma cruzi	32%	100%