Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8F9_LEIIN

TriTrypDb:

LINF_320040900

Length:

1111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1103	1107	PF00656	0.647
CLV_C14_Caspase3-7	317	321	PF00656	0.699
CLV_C14_Caspase3-7	357	361	PF00656	0.474
CLV_C14_Caspase3-7	447	451	PF00656	0.575
CLV_C14_Caspase3-7	544	548	PF00656	0.548
CLV_NRD_NRD_1	1086	1088	PF00675	0.754
CLV_NRD_NRD_1	1098	1100	PF00675	0.601
CLV_NRD_NRD_1	13	15	PF00675	0.544
CLV_NRD_NRD_1	374	376	PF00675	0.543
CLV_NRD_NRD_1	528	530	PF00675	0.580
CLV_NRD_NRD_1	685	687	PF00675	0.577
CLV_NRD_NRD_1	900	902	PF00675	0.782
CLV_NRD_NRD_1	989	991	PF00675	0.580
CLV_PCSK_KEX2_1	1086	1088	PF00082	0.768
CLV_PCSK_KEX2_1	13	15	PF00082	0.440
CLV_PCSK_KEX2_1	374	376	PF00082	0.545
CLV_PCSK_KEX2_1	528	530	PF00082	0.556
CLV_PCSK_KEX2_1	609	611	PF00082	0.543
CLV_PCSK_KEX2_1	685	687	PF00082	0.577
CLV_PCSK_KEX2_1	900	902	PF00082	0.782
CLV_PCSK_KEX2_1	989	991	PF00082	0.580
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.543
CLV_PCSK_SKI1_1	1048	1052	PF00082	0.565
CLV_PCSK_SKI1_1	1102	1106	PF00082	0.769
CLV_PCSK_SKI1_1	151	155	PF00082	0.558
CLV_PCSK_SKI1_1	254	258	PF00082	0.533
CLV_PCSK_SKI1_1	337	341	PF00082	0.681
CLV_PCSK_SKI1_1	375	379	PF00082	0.530
CLV_PCSK_SKI1_1	504	508	PF00082	0.514
CLV_PCSK_SKI1_1	613	617	PF00082	0.476
CLV_PCSK_SKI1_1	956	960	PF00082	0.567
DEG_APCC_DBOX_1	1058	1066	PF00400	0.583
DEG_APCC_DBOX_1	503	511	PF00400	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DEG_SCF_FBW7_1	572	579	PF00400	0.590
DEG_SPOP_SBC_1	312	316	PF00917	0.588
DEG_SPOP_SBC_1	708	712	PF00917	0.680
DEG_SPOP_SBC_1	861	865	PF00917	0.680
DOC_CKS1_1	573	578	PF01111	0.603
DOC_CYCLIN_RxL_1	28	36	PF00134	0.552
DOC_CYCLIN_RxL_1	385	396	PF00134	0.574
DOC_CYCLIN_RxL_1	819	833	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	869	872	PF00134	0.734
DOC_CYCLIN_yCln2_LP_2	947	953	PF00134	0.524
DOC_MAPK_DCC_7	992	1001	PF00069	0.404
DOC_MAPK_gen_1	1102	1110	PF00069	0.739
DOC_MAPK_gen_1	29	37	PF00069	0.520
DOC_MAPK_gen_1	821	829	PF00069	0.593
DOC_MAPK_MEF2A_6	1059	1067	PF00069	0.533
DOC_MAPK_MEF2A_6	277	286	PF00069	0.431
DOC_MAPK_MEF2A_6	29	37	PF00069	0.523
DOC_PP1_RVXF_1	669	676	PF00149	0.546
DOC_PP2B_LxvP_1	116	119	PF13499	0.570
DOC_PP2B_LxvP_1	510	513	PF13499	0.566
DOC_PP2B_LxvP_1	869	872	PF13499	0.734
DOC_PP2B_LxvP_1	947	950	PF13499	0.517
DOC_PP2B_PxIxI_1	565	571	PF00149	0.544
DOC_USP7_MATH_1	1024	1028	PF00917	0.664
DOC_USP7_MATH_1	1089	1093	PF00917	0.729
DOC_USP7_MATH_1	119	123	PF00917	0.602
DOC_USP7_MATH_1	153	157	PF00917	0.485
DOC_USP7_MATH_1	169	173	PF00917	0.589
DOC_USP7_MATH_1	174	178	PF00917	0.726
DOC_USP7_MATH_1	282	286	PF00917	0.446
DOC_USP7_MATH_1	312	316	PF00917	0.632
DOC_USP7_MATH_1	355	359	PF00917	0.570
DOC_USP7_MATH_1	51	55	PF00917	0.661
DOC_USP7_MATH_1	511	515	PF00917	0.618
DOC_USP7_MATH_1	65	69	PF00917	0.715
DOC_USP7_MATH_1	687	691	PF00917	0.593
DOC_USP7_MATH_1	708	712	PF00917	0.762
DOC_USP7_MATH_1	893	897	PF00917	0.759
DOC_WW_Pin1_4	1072	1077	PF00397	0.643
DOC_WW_Pin1_4	262	267	PF00397	0.622
DOC_WW_Pin1_4	290	295	PF00397	0.624
DOC_WW_Pin1_4	410	415	PF00397	0.775
DOC_WW_Pin1_4	428	433	PF00397	0.434
DOC_WW_Pin1_4	572	577	PF00397	0.592
DOC_WW_Pin1_4	77	82	PF00397	0.658
LIG_14-3-3_CanoR_1	1038	1044	PF00244	0.599
LIG_14-3-3_CanoR_1	1099	1105	PF00244	0.739
LIG_14-3-3_CanoR_1	254	260	PF00244	0.515
LIG_14-3-3_CanoR_1	302	311	PF00244	0.583
LIG_14-3-3_CanoR_1	337	342	PF00244	0.724
LIG_14-3-3_CanoR_1	34	38	PF00244	0.567
LIG_14-3-3_CanoR_1	374	382	PF00244	0.563
LIG_14-3-3_CanoR_1	577	583	PF00244	0.542
LIG_14-3-3_CanoR_1	613	622	PF00244	0.460
LIG_14-3-3_CanoR_1	746	752	PF00244	0.473
LIG_14-3-3_CanoR_1	792	798	PF00244	0.501
LIG_14-3-3_CanoR_1	823	828	PF00244	0.581
LIG_14-3-3_CanoR_1	842	849	PF00244	0.431
LIG_Actin_WH2_2	21	36	PF00022	0.463
LIG_Actin_WH2_2	382	400	PF00022	0.574
LIG_Actin_WH2_2	620	636	PF00022	0.572
LIG_Actin_WH2_2	726	744	PF00022	0.411
LIG_Actin_WH2_2	764	780	PF00022	0.487
LIG_BIR_III_4	360	364	PF00653	0.570
LIG_Clathr_ClatBox_1	194	198	PF01394	0.542
LIG_EH1_1	496	504	PF00400	0.482
LIG_FHA_1	1001	1007	PF00498	0.646
LIG_FHA_1	333	339	PF00498	0.703
LIG_FHA_1	479	485	PF00498	0.527
LIG_FHA_1	567	573	PF00498	0.559
LIG_FHA_1	582	588	PF00498	0.496
LIG_FHA_1	736	742	PF00498	0.410
LIG_FHA_1	746	752	PF00498	0.411
LIG_FHA_1	784	790	PF00498	0.521
LIG_FHA_1	824	830	PF00498	0.508
LIG_FHA_1	832	838	PF00498	0.579
LIG_FHA_1	968	974	PF00498	0.622
LIG_FHA_1	977	983	PF00498	0.544
LIG_FHA_2	429	435	PF00498	0.662
LIG_FHA_2	577	583	PF00498	0.585
LIG_FHA_2	612	618	PF00498	0.483
LIG_FHA_2	724	730	PF00498	0.423
LIG_FHA_2	794	800	PF00498	0.537
LIG_FHA_2	957	963	PF00498	0.579
LIG_FHA_2	970	976	PF00498	0.620
LIG_GBD_Chelix_1	192	200	PF00786	0.458
LIG_HP1_1	282	286	PF01393	0.462
LIG_LIR_Apic_2	1027	1033	PF02991	0.623
LIG_LIR_Apic_2	156	160	PF02991	0.658
LIG_LIR_Apic_2	261	266	PF02991	0.628
LIG_LIR_Gen_1	736	745	PF02991	0.551
LIG_LIR_Gen_1	773	780	PF02991	0.508
LIG_LIR_Gen_1	807	815	PF02991	0.525
LIG_LIR_Gen_1	914	925	PF02991	0.513
LIG_LIR_Nem_3	243	248	PF02991	0.473
LIG_LIR_Nem_3	518	523	PF02991	0.431
LIG_LIR_Nem_3	736	740	PF02991	0.514
LIG_LIR_Nem_3	76	82	PF02991	0.712
LIG_LIR_Nem_3	773	777	PF02991	0.482
LIG_LIR_Nem_3	807	812	PF02991	0.516
LIG_LIR_Nem_3	914	920	PF02991	0.515
LIG_LIR_Nem_3	95	101	PF02991	0.301
LIG_LYPXL_yS_3	394	397	PF13949	0.586
LIG_NRBOX	385	391	PF00104	0.561
LIG_NRBOX	582	588	PF00104	0.546
LIG_NRBOX	729	735	PF00104	0.451
LIG_NRBOX	88	94	PF00104	0.416
LIG_PCNA_yPIPBox_3	577	587	PF02747	0.432
LIG_Pex14_1	1030	1034	PF04695	0.640
LIG_Pex14_2	735	739	PF04695	0.535
LIG_Pex14_2	913	917	PF04695	0.528
LIG_PTAP_UEV_1	894	899	PF05743	0.665
LIG_SH2_CRK	1034	1038	PF00017	0.593
LIG_SH2_CRK	157	161	PF00017	0.677
LIG_SH2_CRK	520	524	PF00017	0.470
LIG_SH2_CRK	772	776	PF00017	0.401
LIG_SH2_SRC	221	224	PF00017	0.547
LIG_SH2_STAP1	505	509	PF00017	0.502
LIG_SH2_STAT3	661	664	PF00017	0.477
LIG_SH2_STAT5	1034	1037	PF00017	0.586
LIG_SH2_STAT5	157	160	PF00017	0.634
LIG_SH2_STAT5	221	224	PF00017	0.529
LIG_SH2_STAT5	263	266	PF00017	0.504
LIG_SH2_STAT5	645	648	PF00017	0.463
LIG_SH2_STAT5	661	664	PF00017	0.326
LIG_SH2_STAT5	82	85	PF00017	0.576
LIG_SH2_STAT5	934	937	PF00017	0.490
LIG_SH2_STAT5	98	101	PF00017	0.302
LIG_SH3_2	1033	1038	PF14604	0.621
LIG_SH3_2	471	476	PF14604	0.603
LIG_SH3_2	895	900	PF14604	0.664
LIG_SH3_3	1030	1036	PF00018	0.582
LIG_SH3_3	422	428	PF00018	0.643
LIG_SH3_3	468	474	PF00018	0.812
LIG_SH3_3	510	516	PF00018	0.585
LIG_SH3_3	865	871	PF00018	0.785
LIG_SH3_3	887	893	PF00018	0.733
LIG_SH3_3	904	910	PF00018	0.574
LIG_SH3_3	992	998	PF00018	0.614
LIG_SH3_CIN85_PxpxPR_1	424	429	PF14604	0.556
LIG_SUMO_SIM_anti_2	1061	1068	PF11976	0.397
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.592
LIG_SUMO_SIM_anti_2	826	834	PF11976	0.587
LIG_SUMO_SIM_par_1	192	198	PF11976	0.512
LIG_SUMO_SIM_par_1	948	955	PF11976	0.525
LIG_SUMO_SIM_par_1	997	1003	PF11976	0.560
LIG_TRAF2_1	40	43	PF00917	0.593
LIG_TRAF2_1	593	596	PF00917	0.585
LIG_TRAF2_1	616	619	PF00917	0.550
LIG_TYR_ITIM	392	397	PF00017	0.574
LIG_TYR_ITIM	96	101	PF00017	0.418
LIG_TYR_ITSM	516	523	PF00017	0.508
LIG_UBA3_1	586	594	PF00899	0.452
LIG_UBA3_1	751	756	PF00899	0.528
LIG_WRC_WIRS_1	222	227	PF05994	0.450
LIG_WRC_WIRS_1	734	739	PF05994	0.424
LIG_WRC_WIRS_1	771	776	PF05994	0.480
LIG_WW_3	1035	1039	PF00397	0.608
MOD_CDK_SPK_2	572	577	PF00069	0.592
MOD_CK1_1	1012	1018	PF00069	0.726
MOD_CK1_1	117	123	PF00069	0.529
MOD_CK1_1	177	183	PF00069	0.734
MOD_CK1_1	258	264	PF00069	0.525
MOD_CK1_1	314	320	PF00069	0.672
MOD_CK1_1	330	336	PF00069	0.594
MOD_CK1_1	63	69	PF00069	0.733
MOD_CK1_1	690	696	PF00069	0.662
MOD_CK1_1	707	713	PF00069	0.764
MOD_CK1_1	80	86	PF00069	0.599
MOD_CK1_1	807	813	PF00069	0.453
MOD_CK1_1	850	856	PF00069	0.443
MOD_CK1_1	967	973	PF00069	0.587
MOD_CK2_1	37	43	PF00069	0.582
MOD_CK2_1	428	434	PF00069	0.665
MOD_CK2_1	51	57	PF00069	0.463
MOD_CK2_1	531	537	PF00069	0.651
MOD_CK2_1	576	582	PF00069	0.595
MOD_CK2_1	611	617	PF00069	0.474
MOD_CK2_1	793	799	PF00069	0.539
MOD_CK2_1	960	966	PF00069	0.557
MOD_CK2_1	969	975	PF00069	0.608
MOD_Cter_Amidation	1084	1087	PF01082	0.809
MOD_GlcNHglycan	1014	1017	PF01048	0.777
MOD_GlcNHglycan	1026	1029	PF01048	0.622
MOD_GlcNHglycan	103	106	PF01048	0.355
MOD_GlcNHglycan	1052	1055	PF01048	0.623
MOD_GlcNHglycan	1087	1090	PF01048	0.765
MOD_GlcNHglycan	1091	1094	PF01048	0.753
MOD_GlcNHglycan	116	119	PF01048	0.475
MOD_GlcNHglycan	172	175	PF01048	0.739
MOD_GlcNHglycan	304	307	PF01048	0.510
MOD_GlcNHglycan	316	319	PF01048	0.639
MOD_GlcNHglycan	327	330	PF01048	0.761
MOD_GlcNHglycan	357	360	PF01048	0.572
MOD_GlcNHglycan	398	401	PF01048	0.640
MOD_GlcNHglycan	410	413	PF01048	0.778
MOD_GlcNHglycan	53	56	PF01048	0.665
MOD_GlcNHglycan	629	632	PF01048	0.588
MOD_GlcNHglycan	689	692	PF01048	0.620
MOD_GlcNHglycan	706	709	PF01048	0.781
MOD_GlcNHglycan	760	763	PF01048	0.454
MOD_GlcNHglycan	852	855	PF01048	0.463
MOD_GlcNHglycan	86	89	PF01048	0.493
MOD_GlcNHglycan	895	898	PF01048	0.780
MOD_GlcNHglycan	940	943	PF01048	0.514
MOD_GSK3_1	1085	1092	PF00069	0.725
MOD_GSK3_1	149	156	PF00069	0.537
MOD_GSK3_1	170	177	PF00069	0.748
MOD_GSK3_1	254	261	PF00069	0.476
MOD_GSK3_1	323	330	PF00069	0.704
MOD_GSK3_1	33	40	PF00069	0.474
MOD_GSK3_1	337	344	PF00069	0.621
MOD_GSK3_1	406	413	PF00069	0.747
MOD_GSK3_1	457	464	PF00069	0.686
MOD_GSK3_1	511	518	PF00069	0.533
MOD_GSK3_1	527	534	PF00069	0.498
MOD_GSK3_1	572	579	PF00069	0.592
MOD_GSK3_1	704	711	PF00069	0.712
MOD_GSK3_1	73	80	PF00069	0.719
MOD_GSK3_1	741	748	PF00069	0.524
MOD_GSK3_1	804	811	PF00069	0.402
MOD_GSK3_1	938	945	PF00069	0.506
MOD_GSK3_1	956	963	PF00069	0.546
MOD_N-GLC_1	290	295	PF02516	0.635
MOD_N-GLC_2	846	848	PF02516	0.562
MOD_NEK2_1	101	106	PF00069	0.536
MOD_NEK2_1	1039	1044	PF00069	0.481
MOD_NEK2_1	1050	1055	PF00069	0.472
MOD_NEK2_1	126	131	PF00069	0.404
MOD_NEK2_1	149	154	PF00069	0.510
MOD_NEK2_1	185	190	PF00069	0.486
MOD_NEK2_1	24	29	PF00069	0.519
MOD_NEK2_1	313	318	PF00069	0.686
MOD_NEK2_1	33	38	PF00069	0.514
MOD_NEK2_1	581	586	PF00069	0.520
MOD_NEK2_1	627	632	PF00069	0.458
MOD_NEK2_1	633	638	PF00069	0.456
MOD_NEK2_1	733	738	PF00069	0.466
MOD_NEK2_1	741	746	PF00069	0.491
MOD_NEK2_1	757	762	PF00069	0.337
MOD_NEK2_1	808	813	PF00069	0.547
MOD_NEK2_1	829	834	PF00069	0.604
MOD_NEK2_1	92	97	PF00069	0.534
MOD_NEK2_1	976	981	PF00069	0.549
MOD_PIKK_1	185	191	PF00454	0.561
MOD_PIKK_1	255	261	PF00454	0.533
MOD_PIKK_1	436	442	PF00454	0.585
MOD_PIKK_1	511	517	PF00454	0.540
MOD_PIKK_1	576	582	PF00454	0.552
MOD_PIKK_1	604	610	PF00454	0.476
MOD_PIKK_1	633	639	PF00454	0.549
MOD_PIKK_1	674	680	PF00454	0.521
MOD_PIKK_1	710	716	PF00454	0.747
MOD_PIKK_1	745	751	PF00454	0.545
MOD_PK_1	1100	1106	PF00069	0.690
MOD_PKA_1	1094	1100	PF00069	0.718
MOD_PKA_2	1012	1018	PF00069	0.752
MOD_PKA_2	1085	1091	PF00069	0.761
MOD_PKA_2	33	39	PF00069	0.570
MOD_PKA_2	527	533	PF00069	0.617
MOD_PKA_2	576	582	PF00069	0.552
MOD_PKA_2	633	639	PF00069	0.542
MOD_PKA_2	741	747	PF00069	0.541
MOD_PKA_2	841	847	PF00069	0.438
MOD_Plk_1	300	306	PF00069	0.571
MOD_Plk_1	382	388	PF00069	0.316
MOD_Plk_1	489	495	PF00069	0.606
MOD_Plk_1	581	587	PF00069	0.520
MOD_Plk_1	954	960	PF00069	0.563
MOD_Plk_4	282	288	PF00069	0.457
MOD_Plk_4	515	521	PF00069	0.550
MOD_Plk_4	770	776	PF00069	0.467
MOD_Plk_4	804	810	PF00069	0.473
MOD_ProDKin_1	1072	1078	PF00069	0.649
MOD_ProDKin_1	262	268	PF00069	0.613
MOD_ProDKin_1	290	296	PF00069	0.628
MOD_ProDKin_1	410	416	PF00069	0.780
MOD_ProDKin_1	428	434	PF00069	0.427
MOD_ProDKin_1	572	578	PF00069	0.594
MOD_ProDKin_1	77	83	PF00069	0.646
MOD_SUMO_for_1	593	596	PF00179	0.585
MOD_SUMO_rev_2	1075	1084	PF00179	0.778
TRG_DiLeu_BaEn_1	109	114	PF01217	0.532
TRG_DiLeu_BaEn_1	582	587	PF01217	0.547
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.468
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.635
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.558
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.542
TRG_DiLeu_BaLyEn_6	920	925	PF01217	0.531
TRG_ENDOCYTIC_2	245	248	PF00928	0.482
TRG_ENDOCYTIC_2	276	279	PF00928	0.500
TRG_ENDOCYTIC_2	394	397	PF00928	0.586
TRG_ENDOCYTIC_2	520	523	PF00928	0.468
TRG_ENDOCYTIC_2	772	775	PF00928	0.390
TRG_ENDOCYTIC_2	934	937	PF00928	0.490
TRG_ENDOCYTIC_2	98	101	PF00928	0.428
TRG_ER_diArg_1	12	14	PF00400	0.532
TRG_ER_diArg_1	374	376	PF00400	0.533
TRG_ER_diArg_1	527	529	PF00400	0.568
TRG_ER_diArg_1	684	686	PF00400	0.567
TRG_ER_diArg_1	822	825	PF00400	0.573
TRG_ER_diArg_1	899	901	PF00400	0.765
TRG_ER_diArg_1	988	990	PF00400	0.578
TRG_NES_CRM1_1	26	38	PF08389	0.502
TRG_NES_CRM1_1	660	674	PF08389	0.563
TRG_NLS_Bipartite_1	1086	1103	PF00514	0.783
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB94	Leptomonas seymouri	56%	100%
A0A0S4JFQ5	Bodo saltans	24%	100%
A0A1X0NTJ4	Trypanosomatidae	31%	100%
A0A3S7X650	Leishmania donovani	99%	100%
A0A422P2Y6	Trypanosoma rangeli	32%	100%
A4HKX9	Leishmania braziliensis	84%	99%
D0AAR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B3B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4T8	Leishmania major	95%	100%
V5B5Q4	Trypanosoma cruzi	32%	100%