Cytoplasmic dynein 2 light intermediate chain 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light intermediate chain - putative

Species:

Leishmania infantum

UniProt:

A4I8E8_LEIIN

TriTrypDb:

LINF_320039800

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005868	cytoplasmic dynein complex	4	11
GO:0005875	microtubule associated complex	2	11
GO:0005929	cilium	4	10
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:1902494	catalytic complex	2	11
GO:0005815	microtubule organizing center	2	4
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4I8E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8E8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035721	intraciliary retrograde transport	4	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.434
CLV_MEL_PAP_1	202	208	PF00089	0.469
CLV_NRD_NRD_1	138	140	PF00675	0.464
CLV_NRD_NRD_1	200	202	PF00675	0.361
CLV_NRD_NRD_1	29	31	PF00675	0.624
CLV_NRD_NRD_1	381	383	PF00675	0.636
CLV_NRD_NRD_1	399	401	PF00675	0.434
CLV_NRD_NRD_1	410	412	PF00675	0.477
CLV_NRD_NRD_1	7	9	PF00675	0.664
CLV_PCSK_KEX2_1	124	126	PF00082	0.560
CLV_PCSK_KEX2_1	138	140	PF00082	0.439
CLV_PCSK_KEX2_1	200	202	PF00082	0.324
CLV_PCSK_KEX2_1	240	242	PF00082	0.438
CLV_PCSK_KEX2_1	29	31	PF00082	0.624
CLV_PCSK_KEX2_1	381	383	PF00082	0.517
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.560
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.438
CLV_PCSK_SKI1_1	124	128	PF00082	0.611
CLV_PCSK_SKI1_1	223	227	PF00082	0.464
CLV_PCSK_SKI1_1	79	83	PF00082	0.592
DEG_APCC_DBOX_1	240	248	PF00400	0.362
DEG_SCF_FBW7_2	31	38	PF00400	0.657
DOC_CKS1_1	166	171	PF01111	0.333
DOC_MAPK_DCC_7	243	252	PF00069	0.317
DOC_MAPK_gen_1	294	301	PF00069	0.458
DOC_MAPK_MEF2A_6	243	252	PF00069	0.315
DOC_MAPK_MEF2A_6	319	326	PF00069	0.457
DOC_PP2B_LxvP_1	25	28	PF13499	0.526
DOC_PP4_FxxP_1	304	307	PF00568	0.395
DOC_PP4_FxxP_1	391	394	PF00568	0.442
DOC_USP7_MATH_1	10	14	PF00917	0.777
DOC_USP7_MATH_1	137	141	PF00917	0.539
DOC_USP7_MATH_1	215	219	PF00917	0.427
DOC_USP7_MATH_1	317	321	PF00917	0.404
DOC_USP7_MATH_1	337	341	PF00917	0.427
DOC_USP7_MATH_1	418	422	PF00917	0.540
DOC_USP7_MATH_1	98	102	PF00917	0.457
DOC_WW_Pin1_4	1	6	PF00397	0.661
DOC_WW_Pin1_4	165	170	PF00397	0.343
DOC_WW_Pin1_4	217	222	PF00397	0.424
DOC_WW_Pin1_4	31	36	PF00397	0.647
DOC_WW_Pin1_4	39	44	PF00397	0.699
DOC_WW_Pin1_4	50	55	PF00397	0.583
LIG_14-3-3_CanoR_1	109	115	PF00244	0.529
LIG_14-3-3_CanoR_1	125	134	PF00244	0.303
LIG_14-3-3_CanoR_1	138	146	PF00244	0.450
LIG_14-3-3_CanoR_1	205	213	PF00244	0.490
LIG_AP2alpha_2	377	379	PF02296	0.493
LIG_Clathr_ClatBox_1	323	327	PF01394	0.434
LIG_deltaCOP1_diTrp_1	354	360	PF00928	0.437
LIG_FHA_1	102	108	PF00498	0.294
LIG_FHA_1	127	133	PF00498	0.409
LIG_FHA_1	194	200	PF00498	0.386
LIG_FHA_1	247	253	PF00498	0.328
LIG_FHA_1	68	74	PF00498	0.452
LIG_FHA_1	76	82	PF00498	0.543
LIG_FHA_1	89	95	PF00498	0.446
LIG_FHA_2	128	134	PF00498	0.402
LIG_FHA_2	313	319	PF00498	0.507
LIG_FHA_2	32	38	PF00498	0.646
LIG_Integrin_RGD_1	260	262	PF01839	0.465
LIG_LIR_Apic_2	302	307	PF02991	0.420
LIG_LIR_Apic_2	354	359	PF02991	0.406
LIG_LIR_Apic_2	388	394	PF02991	0.446
LIG_LIR_Gen_1	157	167	PF02991	0.462
LIG_LIR_Gen_1	329	339	PF02991	0.395
LIG_LIR_Gen_1	72	81	PF02991	0.426
LIG_LIR_LC3C_4	249	253	PF02991	0.279
LIG_LIR_Nem_3	157	162	PF02991	0.440
LIG_LIR_Nem_3	292	298	PF02991	0.462
LIG_LIR_Nem_3	329	334	PF02991	0.347
LIG_LIR_Nem_3	72	77	PF02991	0.417
LIG_Pex14_1	356	360	PF04695	0.427
LIG_Pex14_2	304	308	PF04695	0.370
LIG_Pex14_2	360	364	PF04695	0.442
LIG_Rb_pABgroove_1	378	386	PF01858	0.449
LIG_SH2_NCK_1	384	388	PF00017	0.525
LIG_SH2_STAT5	111	114	PF00017	0.466
LIG_SH2_STAT5	275	278	PF00017	0.388
LIG_SH2_STAT5	312	315	PF00017	0.477
LIG_SH3_2	28	33	PF14604	0.608
LIG_SH3_3	163	169	PF00018	0.335
LIG_SH3_3	25	31	PF00018	0.624
LIG_SH3_3	304	310	PF00018	0.454
LIG_SH3_3	63	69	PF00018	0.511
LIG_Sin3_3	176	183	PF02671	0.257
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.432
LIG_SUMO_SIM_par_1	322	327	PF11976	0.366
LIG_SxIP_EBH_1	240	253	PF03271	0.319
LIG_TRAF2_1	183	186	PF00917	0.490
LIG_TRAF2_1	288	291	PF00917	0.433
LIG_TRAF2_1	35	38	PF00917	0.648
LIG_WRC_WIRS_1	111	116	PF05994	0.562
LIG_WW_3	26	30	PF00397	0.694
MOD_CDC14_SPxK_1	42	45	PF00782	0.815
MOD_CDK_SPxK_1	217	223	PF00069	0.395
MOD_CDK_SPxK_1	39	45	PF00069	0.812
MOD_CDK_SPxxK_3	1	8	PF00069	0.694
MOD_CK1_1	101	107	PF00069	0.408
MOD_CK1_1	113	119	PF00069	0.491
MOD_CK1_1	191	197	PF00069	0.300
MOD_CK1_1	207	213	PF00069	0.417
MOD_CK1_1	345	351	PF00069	0.558
MOD_CK2_1	285	291	PF00069	0.436
MOD_CK2_1	31	37	PF00069	0.787
MOD_CK2_1	312	318	PF00069	0.434
MOD_GlcNHglycan	118	121	PF01048	0.628
MOD_GlcNHglycan	244	247	PF01048	0.340
MOD_GlcNHglycan	318	322	PF01048	0.559
MOD_GlcNHglycan	61	64	PF01048	0.722
MOD_GlcNHglycan	98	101	PF01048	0.412
MOD_GSK3_1	109	116	PF00069	0.471
MOD_GSK3_1	242	249	PF00069	0.363
MOD_GSK3_1	285	292	PF00069	0.359
MOD_GSK3_1	29	36	PF00069	0.737
MOD_GSK3_1	44	51	PF00069	0.605
MOD_GSK3_1	52	59	PF00069	0.801
MOD_GSK3_1	98	105	PF00069	0.441
MOD_N-GLC_1	299	304	PF02516	0.392
MOD_N-GLC_1	418	423	PF02516	0.540
MOD_N-GLC_1	75	80	PF02516	0.551
MOD_NEK2_1	114	119	PF00069	0.578
MOD_NEK2_1	132	137	PF00069	0.399
MOD_NEK2_1	242	247	PF00069	0.382
MOD_NEK2_1	269	274	PF00069	0.328
MOD_NEK2_1	299	304	PF00069	0.392
MOD_NEK2_1	342	347	PF00069	0.487
MOD_PIKK_1	154	160	PF00454	0.389
MOD_PIKK_1	207	213	PF00454	0.534
MOD_PIKK_1	44	50	PF00454	0.618
MOD_PKA_1	29	35	PF00069	0.618
MOD_PKA_1	411	417	PF00069	0.510
MOD_PKA_2	137	143	PF00069	0.520
MOD_PKA_2	204	210	PF00069	0.475
MOD_PKA_2	242	248	PF00069	0.347
MOD_PKA_2	29	35	PF00069	0.584
MOD_PKA_2	327	333	PF00069	0.434
MOD_PKA_2	44	50	PF00069	0.491
MOD_Plk_1	132	138	PF00069	0.406
MOD_Plk_1	299	305	PF00069	0.402
MOD_Plk_1	317	323	PF00069	0.364
MOD_Plk_1	337	343	PF00069	0.466
MOD_Plk_1	89	95	PF00069	0.492
MOD_Plk_2-3	327	333	PF00069	0.378
MOD_Plk_4	102	108	PF00069	0.281
MOD_Plk_4	193	199	PF00069	0.399
MOD_Plk_4	246	252	PF00069	0.331
MOD_Plk_4	327	333	PF00069	0.434
MOD_Plk_4	61	67	PF00069	0.580
MOD_Plk_4	89	95	PF00069	0.497
MOD_ProDKin_1	1	7	PF00069	0.662
MOD_ProDKin_1	165	171	PF00069	0.342
MOD_ProDKin_1	217	223	PF00069	0.427
MOD_ProDKin_1	31	37	PF00069	0.647
MOD_ProDKin_1	39	45	PF00069	0.701
MOD_ProDKin_1	50	56	PF00069	0.582
MOD_SUMO_rev_2	235	242	PF00179	0.451
MOD_SUMO_rev_2	4	10	PF00179	0.699
TRG_ENDOCYTIC_2	111	114	PF00928	0.534
TRG_ER_diArg_1	199	201	PF00400	0.426
TRG_ER_diArg_1	241	244	PF00400	0.342
TRG_ER_diArg_1	28	30	PF00400	0.621
TRG_ER_diArg_1	380	382	PF00400	0.511
TRG_NLS_Bipartite_1	400	415	PF00514	0.450
TRG_NLS_MonoExtN_4	123	128	PF00514	0.602
TRG_NLS_MonoExtN_4	237	244	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN3	Leptomonas seymouri	81%	99%
A0A0S4JG99	Bodo saltans	54%	100%
A0A1X0NS84	Trypanosomatidae	52%	100%
A0A3R7P067	Trypanosoma rangeli	50%	100%
A0A3S5H7T0	Leishmania donovani	99%	100%
A4HKW8	Leishmania braziliensis	84%	100%
D0AAS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q32KV4	Bos taurus	28%	100%
Q4Q4U9	Leishmania major	95%	100%
Q6AY43	Rattus norvegicus	28%	100%
Q7SXY4	Danio rerio	28%	100%
Q7XA07	Chlamydomonas reinhardtii	24%	99%
Q8K0T2	Mus musculus	29%	100%
Q8TCX1	Homo sapiens	25%	100%