Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I8E3_LEIIN

TriTrypDb:

LINF_320039300

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8E3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.463
CLV_NRD_NRD_1	269	271	PF00675	0.542
CLV_NRD_NRD_1	292	294	PF00675	0.542
CLV_NRD_NRD_1	396	398	PF00675	0.376
CLV_PCSK_KEX2_1	12	14	PF00082	0.539
CLV_PCSK_KEX2_1	222	224	PF00082	0.463
CLV_PCSK_KEX2_1	269	271	PF00082	0.542
CLV_PCSK_KEX2_1	291	293	PF00082	0.552
CLV_PCSK_KEX2_1	395	397	PF00082	0.475
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.539
CLV_PCSK_PC7_1	265	271	PF00082	0.513
CLV_PCSK_PC7_1	288	294	PF00082	0.516
CLV_PCSK_SKI1_1	12	16	PF00082	0.484
CLV_PCSK_SKI1_1	169	173	PF00082	0.410
CLV_PCSK_SKI1_1	222	226	PF00082	0.365
CLV_PCSK_SKI1_1	237	241	PF00082	0.384
CLV_PCSK_SKI1_1	265	269	PF00082	0.556
CLV_PCSK_SKI1_1	299	303	PF00082	0.450
CLV_PCSK_SKI1_1	318	322	PF00082	0.307
CLV_PCSK_SKI1_1	328	332	PF00082	0.358
CLV_PCSK_SKI1_1	336	340	PF00082	0.325
CLV_PCSK_SKI1_1	428	432	PF00082	0.479
CLV_PCSK_SKI1_1	499	503	PF00082	0.404
CLV_PCSK_SKI1_1	51	55	PF00082	0.372
CLV_PCSK_SKI1_1	522	526	PF00082	0.595
CLV_PCSK_SKI1_1	536	540	PF00082	0.317
CLV_PCSK_SKI1_1	571	575	PF00082	0.586
CLV_PCSK_SKI1_1	615	619	PF00082	0.439
CLV_Separin_Metazoa	333	337	PF03568	0.343
CLV_Separin_Metazoa	612	616	PF03568	0.360
DEG_APCC_DBOX_1	327	335	PF00400	0.361
DEG_APCC_DBOX_1	38	46	PF00400	0.507
DEG_APCC_DBOX_1	498	506	PF00400	0.401
DEG_APCC_DBOX_1	614	622	PF00400	0.444
DOC_ANK_TNKS_1	268	275	PF00023	0.548
DOC_CDC14_PxL_1	411	419	PF14671	0.444
DOC_CKS1_1	282	287	PF01111	0.591
DOC_CKS1_1	658	663	PF01111	0.556
DOC_CYCLIN_RxL_1	325	333	PF00134	0.440
DOC_CYCLIN_RxL_1	401	410	PF00134	0.378
DOC_CYCLIN_RxL_1	499	509	PF00134	0.396
DOC_CYCLIN_RxL_1	643	653	PF00134	0.368
DOC_CYCLIN_RxL_1	68	78	PF00134	0.452
DOC_CYCLIN_yClb5_NLxxxL_5	71	79	PF00134	0.446
DOC_MAPK_MEF2A_6	169	176	PF00069	0.410
DOC_MAPK_MEF2A_6	412	419	PF00069	0.532
DOC_MAPK_MEF2A_6	495	504	PF00069	0.406
DOC_MAPK_MEF2A_6	552	561	PF00069	0.451
DOC_MAPK_NFAT4_5	169	177	PF00069	0.374
DOC_MAPK_NFAT4_5	552	560	PF00069	0.389
DOC_PP1_RVXF_1	316	323	PF00149	0.455
DOC_PP1_RVXF_1	402	409	PF00149	0.359
DOC_PP4_FxxP_1	341	344	PF00568	0.395
DOC_USP7_MATH_1	258	262	PF00917	0.543
DOC_USP7_MATH_1	364	368	PF00917	0.597
DOC_USP7_MATH_1	594	598	PF00917	0.406
DOC_WW_Pin1_4	105	110	PF00397	0.469
DOC_WW_Pin1_4	2	7	PF00397	0.591
DOC_WW_Pin1_4	226	231	PF00397	0.456
DOC_WW_Pin1_4	281	286	PF00397	0.645
DOC_WW_Pin1_4	432	437	PF00397	0.490
DOC_WW_Pin1_4	476	481	PF00397	0.391
DOC_WW_Pin1_4	545	550	PF00397	0.335
DOC_WW_Pin1_4	657	662	PF00397	0.523
LIG_14-3-3_CanoR_1	120	124	PF00244	0.382
LIG_14-3-3_CanoR_1	141	151	PF00244	0.396
LIG_14-3-3_CanoR_1	395	400	PF00244	0.432
LIG_14-3-3_CanoR_1	503	512	PF00244	0.337
LIG_Actin_WH2_2	69	84	PF00022	0.386
LIG_APCC_ABBA_1	310	315	PF00400	0.413
LIG_BIR_III_4	271	275	PF00653	0.639
LIG_BRCT_BRCA1_1	220	224	PF00533	0.402
LIG_eIF4E_1	175	181	PF01652	0.437
LIG_FHA_1	109	115	PF00498	0.343
LIG_FHA_1	120	126	PF00498	0.423
LIG_FHA_1	143	149	PF00498	0.394
LIG_FHA_1	180	186	PF00498	0.427
LIG_FHA_1	192	198	PF00498	0.342
LIG_FHA_1	227	233	PF00498	0.500
LIG_FHA_1	238	244	PF00498	0.338
LIG_FHA_1	26	32	PF00498	0.541
LIG_FHA_1	3	9	PF00498	0.562
LIG_FHA_1	425	431	PF00498	0.471
LIG_FHA_1	461	467	PF00498	0.383
LIG_FHA_1	489	495	PF00498	0.385
LIG_FHA_1	507	513	PF00498	0.257
LIG_FHA_1	580	586	PF00498	0.373
LIG_FHA_1	587	593	PF00498	0.302
LIG_FHA_1	76	82	PF00498	0.403
LIG_FHA_1	89	95	PF00498	0.460
LIG_FHA_2	162	168	PF00498	0.473
LIG_FHA_2	247	253	PF00498	0.413
LIG_FHA_2	282	288	PF00498	0.604
LIG_FHA_2	33	39	PF00498	0.529
LIG_FHA_2	602	608	PF00498	0.483
LIG_FHA_2	664	670	PF00498	0.642
LIG_LIR_Gen_1	111	118	PF02991	0.367
LIG_LIR_Gen_1	129	137	PF02991	0.336
LIG_LIR_Gen_1	551	562	PF02991	0.437
LIG_LIR_Nem_3	111	115	PF02991	0.545
LIG_LIR_Nem_3	126	131	PF02991	0.354
LIG_LIR_Nem_3	295	301	PF02991	0.486
LIG_LIR_Nem_3	3	7	PF02991	0.529
LIG_LIR_Nem_3	304	310	PF02991	0.353
LIG_LIR_Nem_3	409	414	PF02991	0.454
LIG_LIR_Nem_3	551	557	PF02991	0.376
LIG_LIR_Nem_3	63	67	PF02991	0.457
LIG_NRBOX	501	507	PF00104	0.391
LIG_PCNA_TLS_4	169	176	PF02747	0.410
LIG_Pex14_2	130	134	PF04695	0.353
LIG_Pex14_2	64	68	PF04695	0.405
LIG_PTAP_UEV_1	602	607	PF05743	0.467
LIG_PTB_Apo_2	211	218	PF02174	0.375
LIG_SH2_SRC	250	253	PF00017	0.424
LIG_SH2_STAP1	387	391	PF00017	0.459
LIG_SH2_STAT5	102	105	PF00017	0.315
LIG_SH2_STAT5	175	178	PF00017	0.435
LIG_SH2_STAT5	250	253	PF00017	0.425
LIG_SH2_STAT5	4	7	PF00017	0.581
LIG_SH2_STAT5	554	557	PF00017	0.357
LIG_SH2_STAT5	587	590	PF00017	0.297
LIG_SH2_STAT5	92	95	PF00017	0.397
LIG_SH3_3	274	280	PF00018	0.675
LIG_SH3_3	600	606	PF00018	0.477
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.435
LIG_SUMO_SIM_par_1	589	597	PF11976	0.419
LIG_TRAF2_1	136	139	PF00917	0.496
LIG_TRAF2_1	490	493	PF00917	0.389
LIG_TRAF2_1	529	532	PF00917	0.509
LIG_TRAF2_2	276	281	PF00917	0.573
LIG_UBA3_1	170	177	PF00899	0.335
LIG_UBA3_1	75	82	PF00899	0.380
MOD_CDK_SPK_2	226	231	PF00069	0.446
MOD_CDK_SPxxK_3	281	288	PF00069	0.635
MOD_CDK_SPxxK_3	545	552	PF00069	0.405
MOD_CK1_1	108	114	PF00069	0.442
MOD_CK1_1	207	213	PF00069	0.394
MOD_CK1_1	365	371	PF00069	0.702
MOD_CK1_1	548	554	PF00069	0.406
MOD_CK2_1	161	167	PF00069	0.426
MOD_CK2_1	246	252	PF00069	0.393
MOD_CK2_1	281	287	PF00069	0.613
MOD_CK2_1	32	38	PF00069	0.479
MOD_CK2_1	487	493	PF00069	0.393
MOD_CK2_1	663	669	PF00069	0.657
MOD_CMANNOS	322	325	PF00535	0.469
MOD_GlcNHglycan	103	106	PF01048	0.432
MOD_GlcNHglycan	199	203	PF01048	0.450
MOD_GlcNHglycan	206	209	PF01048	0.381
MOD_GlcNHglycan	364	367	PF01048	0.537
MOD_GlcNHglycan	371	374	PF01048	0.482
MOD_GlcNHglycan	420	423	PF01048	0.354
MOD_GSK3_1	101	108	PF00069	0.437
MOD_GSK3_1	179	186	PF00069	0.435
MOD_GSK3_1	365	372	PF00069	0.553
MOD_GSK3_1	506	513	PF00069	0.537
MOD_GSK3_1	8	15	PF00069	0.532
MOD_LATS_1	10	16	PF00433	0.509
MOD_NEK2_1	103	108	PF00069	0.379
MOD_NEK2_1	316	321	PF00069	0.382
MOD_NEK2_1	32	37	PF00069	0.558
MOD_NEK2_1	406	411	PF00069	0.442
MOD_NEK2_1	506	511	PF00069	0.388
MOD_NEK2_1	561	566	PF00069	0.488
MOD_NEK2_1	579	584	PF00069	0.304
MOD_NEK2_1	586	591	PF00069	0.329
MOD_NEK2_1	593	598	PF00069	0.316
MOD_NEK2_1	75	80	PF00069	0.497
MOD_NEK2_1	90	95	PF00069	0.271
MOD_PIKK_1	103	109	PF00454	0.383
MOD_PIKK_1	32	38	PF00454	0.557
MOD_PIKK_1	441	447	PF00454	0.401
MOD_PIKK_1	594	600	PF00454	0.364
MOD_PIKK_1	663	669	PF00454	0.646
MOD_PKA_1	12	18	PF00069	0.552
MOD_PKA_1	395	401	PF00069	0.432
MOD_PKA_2	119	125	PF00069	0.369
MOD_PKA_2	12	18	PF00069	0.552
MOD_PKA_2	395	401	PF00069	0.432
MOD_PKA_2	514	520	PF00069	0.494
MOD_PKB_1	49	57	PF00069	0.361
MOD_Plk_1	286	292	PF00069	0.576
MOD_Plk_1	40	46	PF00069	0.440
MOD_Plk_1	51	57	PF00069	0.351
MOD_Plk_4	119	125	PF00069	0.369
MOD_Plk_4	147	153	PF00069	0.435
MOD_Plk_4	246	252	PF00069	0.404
MOD_Plk_4	587	593	PF00069	0.397
MOD_ProDKin_1	105	111	PF00069	0.464
MOD_ProDKin_1	2	8	PF00069	0.581
MOD_ProDKin_1	226	232	PF00069	0.451
MOD_ProDKin_1	281	287	PF00069	0.639
MOD_ProDKin_1	432	438	PF00069	0.486
MOD_ProDKin_1	476	482	PF00069	0.387
MOD_ProDKin_1	545	551	PF00069	0.334
MOD_ProDKin_1	657	663	PF00069	0.536
MOD_SUMO_rev_2	490	497	PF00179	0.406
TRG_DiLeu_BaEn_1	167	172	PF01217	0.359
TRG_DiLeu_BaEn_1	297	302	PF01217	0.350
TRG_DiLeu_BaEn_1	492	497	PF01217	0.377
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.347
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.439
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.309
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.339
TRG_ENDOCYTIC_2	131	134	PF00928	0.348
TRG_ENDOCYTIC_2	307	310	PF00928	0.354
TRG_ENDOCYTIC_2	411	414	PF00928	0.452
TRG_ENDOCYTIC_2	554	557	PF00928	0.422
TRG_ER_diArg_1	18	21	PF00400	0.575
TRG_ER_diArg_1	222	224	PF00400	0.463
TRG_ER_diArg_1	268	270	PF00400	0.524
TRG_ER_diArg_1	290	293	PF00400	0.556
TRG_ER_diArg_1	394	397	PF00400	0.387
TRG_NES_CRM1_1	300	315	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY7	Leptomonas seymouri	36%	100%
A0A3S7X637	Leishmania donovani	100%	100%
A4HKW3	Leishmania braziliensis	76%	100%
E9B3A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4V4	Leishmania major	92%	100%