LeishMANIAdb
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Leucine rich repeat-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine rich repeat-containing protein
Gene product:
Leucine Rich repeat/Leucine Rich Repeat/Leucine Rich repeats (2 copies) - putative
Species:
Leishmania infantum
UniProt:
A4I8E1_LEIIN
TriTrypDb:
LINF_320039100
Length:
817

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 10
GO:0005930 axoneme 2 1

Expansion

Sequence features

A4I8E1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8E1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 234 238 PF00656 0.657
CLV_C14_Caspase3-7 275 279 PF00656 0.731
CLV_NRD_NRD_1 503 505 PF00675 0.435
CLV_NRD_NRD_1 509 511 PF00675 0.450
CLV_NRD_NRD_1 516 518 PF00675 0.459
CLV_NRD_NRD_1 63 65 PF00675 0.668
CLV_NRD_NRD_1 693 695 PF00675 0.589
CLV_NRD_NRD_1 788 790 PF00675 0.615
CLV_PCSK_KEX2_1 373 375 PF00082 0.593
CLV_PCSK_KEX2_1 503 505 PF00082 0.435
CLV_PCSK_KEX2_1 509 511 PF00082 0.441
CLV_PCSK_KEX2_1 602 604 PF00082 0.763
CLV_PCSK_KEX2_1 63 65 PF00082 0.668
CLV_PCSK_KEX2_1 693 695 PF00082 0.586
CLV_PCSK_KEX2_1 739 741 PF00082 0.746
CLV_PCSK_KEX2_1 788 790 PF00082 0.615
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.589
CLV_PCSK_PC1ET2_1 602 604 PF00082 0.763
CLV_PCSK_PC1ET2_1 739 741 PF00082 0.746
CLV_PCSK_PC7_1 689 695 PF00082 0.535
CLV_PCSK_PC7_1 784 790 PF00082 0.611
CLV_PCSK_SKI1_1 139 143 PF00082 0.414
CLV_PCSK_SKI1_1 510 514 PF00082 0.526
CLV_PCSK_SKI1_1 681 685 PF00082 0.417
CLV_PCSK_SKI1_1 694 698 PF00082 0.460
CLV_PCSK_SKI1_1 739 743 PF00082 0.667
CLV_PCSK_SKI1_1 96 100 PF00082 0.730
DEG_APCC_DBOX_1 434 442 PF00400 0.325
DEG_Nend_Nbox_1 1 3 PF02207 0.460
DEG_SCF_FBW7_1 118 125 PF00400 0.536
DEG_SCF_FBW7_1 715 722 PF00400 0.673
DEG_SPOP_SBC_1 596 600 PF00917 0.659
DEG_SPOP_SBC_1 729 733 PF00917 0.672
DOC_CKS1_1 119 124 PF01111 0.541
DOC_CKS1_1 756 761 PF01111 0.647
DOC_CYCLIN_RxL_1 689 699 PF00134 0.437
DOC_CYCLIN_RxL_1 93 102 PF00134 0.678
DOC_MAPK_gen_1 178 187 PF00069 0.393
DOC_MAPK_gen_1 461 471 PF00069 0.311
DOC_MAPK_MEF2A_6 178 187 PF00069 0.399
DOC_MAPK_MEF2A_6 638 647 PF00069 0.505
DOC_PP4_MxPP_1 581 584 PF00568 0.589
DOC_USP7_MATH_1 231 235 PF00917 0.743
DOC_USP7_MATH_1 279 283 PF00917 0.670
DOC_USP7_MATH_1 311 315 PF00917 0.736
DOC_USP7_MATH_1 596 600 PF00917 0.809
DOC_USP7_MATH_1 624 628 PF00917 0.575
DOC_USP7_MATH_1 72 76 PF00917 0.676
DOC_USP7_MATH_1 729 733 PF00917 0.752
DOC_USP7_MATH_1 750 754 PF00917 0.728
DOC_USP7_UBL2_3 369 373 PF12436 0.485
DOC_USP7_UBL2_3 80 84 PF12436 0.767
DOC_USP7_UBL2_3 96 100 PF12436 0.575
DOC_WW_Pin1_4 111 116 PF00397 0.706
DOC_WW_Pin1_4 118 123 PF00397 0.615
DOC_WW_Pin1_4 139 144 PF00397 0.496
DOC_WW_Pin1_4 176 181 PF00397 0.526
DOC_WW_Pin1_4 267 272 PF00397 0.725
DOC_WW_Pin1_4 563 568 PF00397 0.785
DOC_WW_Pin1_4 592 597 PF00397 0.816
DOC_WW_Pin1_4 715 720 PF00397 0.773
DOC_WW_Pin1_4 755 760 PF00397 0.692
LIG_14-3-3_CanoR_1 181 186 PF00244 0.398
LIG_14-3-3_CanoR_1 259 264 PF00244 0.663
LIG_14-3-3_CanoR_1 409 414 PF00244 0.518
LIG_14-3-3_CanoR_1 475 482 PF00244 0.263
LIG_14-3-3_CanoR_1 603 611 PF00244 0.754
LIG_14-3-3_CanoR_1 747 755 PF00244 0.778
LIG_14-3-3_CanoR_1 788 792 PF00244 0.562
LIG_BIR_III_2 564 568 PF00653 0.549
LIG_Clathr_ClatBox_1 154 158 PF01394 0.361
LIG_FHA_1 119 125 PF00498 0.559
LIG_FHA_1 285 291 PF00498 0.654
LIG_FHA_1 32 38 PF00498 0.628
LIG_FHA_1 382 388 PF00498 0.481
LIG_FHA_1 422 428 PF00498 0.508
LIG_FHA_1 477 483 PF00498 0.454
LIG_FHA_1 564 570 PF00498 0.730
LIG_FHA_1 716 722 PF00498 0.750
LIG_FHA_1 740 746 PF00498 0.612
LIG_FHA_2 21 27 PF00498 0.409
LIG_FHA_2 352 358 PF00498 0.577
LIG_FHA_2 511 517 PF00498 0.462
LIG_FHA_2 668 674 PF00498 0.528
LIG_FHA_2 700 706 PF00498 0.625
LIG_FHA_2 788 794 PF00498 0.597
LIG_LIR_Apic_2 174 180 PF02991 0.514
LIG_LIR_Apic_2 338 343 PF02991 0.576
LIG_LIR_Apic_2 577 583 PF02991 0.615
LIG_LIR_Gen_1 12 20 PF02991 0.466
LIG_LIR_Gen_1 123 134 PF02991 0.422
LIG_LIR_Gen_1 168 177 PF02991 0.408
LIG_LIR_Gen_1 26 37 PF02991 0.382
LIG_LIR_Gen_1 531 538 PF02991 0.414
LIG_LIR_Gen_1 679 688 PF02991 0.519
LIG_LIR_Nem_3 12 16 PF02991 0.355
LIG_LIR_Nem_3 123 129 PF02991 0.507
LIG_LIR_Nem_3 168 172 PF02991 0.407
LIG_LIR_Nem_3 26 32 PF02991 0.429
LIG_LIR_Nem_3 344 349 PF02991 0.447
LIG_LIR_Nem_3 399 403 PF02991 0.545
LIG_LIR_Nem_3 531 535 PF02991 0.425
LIG_LIR_Nem_3 679 685 PF02991 0.518
LIG_MAD2 35 43 PF02301 0.619
LIG_MYND_1 719 723 PF01753 0.654
LIG_NRBOX 455 461 PF00104 0.442
LIG_PCNA_PIPBox_1 794 803 PF02747 0.378
LIG_PTAP_UEV_1 722 727 PF05743 0.659
LIG_SH2_CRK 169 173 PF00017 0.493
LIG_SH2_CRK 177 181 PF00017 0.533
LIG_SH2_CRK 29 33 PF00017 0.399
LIG_SH2_CRK 580 584 PF00017 0.596
LIG_SH2_PTP2 126 129 PF00017 0.494
LIG_SH2_PTP2 682 685 PF00017 0.525
LIG_SH2_STAP1 29 33 PF00017 0.437
LIG_SH2_STAP1 532 536 PF00017 0.501
LIG_SH2_STAT3 342 345 PF00017 0.549
LIG_SH2_STAT3 541 544 PF00017 0.571
LIG_SH2_STAT5 126 129 PF00017 0.491
LIG_SH2_STAT5 198 201 PF00017 0.630
LIG_SH2_STAT5 340 343 PF00017 0.555
LIG_SH2_STAT5 506 509 PF00017 0.483
LIG_SH2_STAT5 541 544 PF00017 0.505
LIG_SH2_STAT5 682 685 PF00017 0.525
LIG_SH3_1 146 152 PF00018 0.521
LIG_SH3_1 580 586 PF00018 0.623
LIG_SH3_2 585 590 PF14604 0.690
LIG_SH3_3 113 119 PF00018 0.753
LIG_SH3_3 146 152 PF00018 0.529
LIG_SH3_3 219 225 PF00018 0.595
LIG_SH3_3 34 40 PF00018 0.611
LIG_SH3_3 548 554 PF00018 0.652
LIG_SH3_3 580 586 PF00018 0.687
LIG_SH3_3 720 726 PF00018 0.768
LIG_SH3_3 759 765 PF00018 0.596
LIG_SUMO_SIM_anti_2 156 161 PF11976 0.489
LIG_SUMO_SIM_anti_2 670 676 PF11976 0.515
LIG_SUMO_SIM_anti_2 758 764 PF11976 0.590
LIG_SUMO_SIM_par_1 153 158 PF11976 0.364
LIG_SUMO_SIM_par_1 477 487 PF11976 0.364
LIG_SUMO_SIM_par_1 708 714 PF11976 0.667
LIG_TRAF2_1 101 104 PF00917 0.711
LIG_TRAF2_1 109 112 PF00917 0.688
LIG_TRAF2_1 495 498 PF00917 0.477
LIG_TRAF2_1 513 516 PF00917 0.479
LIG_TYR_ITIM 124 129 PF00017 0.399
LIG_WRC_WIRS_1 485 490 PF05994 0.378
LIG_WW_2 40 43 PF00397 0.657
LIG_WW_2 551 554 PF00397 0.685
MOD_CDK_SPK_2 176 181 PF00069 0.524
MOD_CDK_SPxxK_3 139 146 PF00069 0.507
MOD_CK1_1 153 159 PF00069 0.373
MOD_CK1_1 165 171 PF00069 0.412
MOD_CK1_1 194 200 PF00069 0.763
MOD_CK1_1 207 213 PF00069 0.528
MOD_CK1_1 250 256 PF00069 0.687
MOD_CK1_1 262 268 PF00069 0.714
MOD_CK1_1 272 278 PF00069 0.652
MOD_CK1_1 303 309 PF00069 0.691
MOD_CK1_1 333 339 PF00069 0.715
MOD_CK1_1 574 580 PF00069 0.717
MOD_CK1_1 595 601 PF00069 0.747
MOD_CK1_1 605 611 PF00069 0.685
MOD_CK1_1 717 723 PF00069 0.729
MOD_CK1_1 728 734 PF00069 0.749
MOD_CK1_1 75 81 PF00069 0.739
MOD_CK2_1 18 24 PF00069 0.411
MOD_CK2_1 351 357 PF00069 0.508
MOD_CK2_1 433 439 PF00069 0.544
MOD_CK2_1 491 497 PF00069 0.527
MOD_CK2_1 510 516 PF00069 0.318
MOD_CK2_1 667 673 PF00069 0.531
MOD_CK2_1 699 705 PF00069 0.558
MOD_CK2_1 729 735 PF00069 0.801
MOD_CK2_1 787 793 PF00069 0.631
MOD_CK2_1 98 104 PF00069 0.766
MOD_GlcNHglycan 12 16 PF01048 0.461
MOD_GlcNHglycan 164 167 PF01048 0.519
MOD_GlcNHglycan 192 196 PF01048 0.590
MOD_GlcNHglycan 252 255 PF01048 0.740
MOD_GlcNHglycan 271 274 PF01048 0.543
MOD_GlcNHglycan 281 284 PF01048 0.730
MOD_GlcNHglycan 29 32 PF01048 0.358
MOD_GlcNHglycan 307 310 PF01048 0.739
MOD_GlcNHglycan 312 316 PF01048 0.654
MOD_GlcNHglycan 329 335 PF01048 0.511
MOD_GlcNHglycan 576 579 PF01048 0.555
MOD_GlcNHglycan 599 602 PF01048 0.751
MOD_GlcNHglycan 626 629 PF01048 0.685
MOD_GlcNHglycan 634 637 PF01048 0.663
MOD_GlcNHglycan 66 69 PF01048 0.739
MOD_GlcNHglycan 723 726 PF01048 0.745
MOD_GlcNHglycan 727 730 PF01048 0.768
MOD_GlcNHglycan 742 745 PF01048 0.695
MOD_GlcNHglycan 89 92 PF01048 0.693
MOD_GSK3_1 118 125 PF00069 0.667
MOD_GSK3_1 16 23 PF00069 0.470
MOD_GSK3_1 262 269 PF00069 0.709
MOD_GSK3_1 27 34 PF00069 0.425
MOD_GSK3_1 433 440 PF00069 0.411
MOD_GSK3_1 524 531 PF00069 0.505
MOD_GSK3_1 590 597 PF00069 0.808
MOD_GSK3_1 603 610 PF00069 0.771
MOD_GSK3_1 624 631 PF00069 0.676
MOD_GSK3_1 715 722 PF00069 0.717
MOD_GSK3_1 72 79 PF00069 0.709
MOD_GSK3_1 725 732 PF00069 0.757
MOD_GSK3_1 735 742 PF00069 0.694
MOD_GSK3_1 746 753 PF00069 0.691
MOD_GSK3_1 783 790 PF00069 0.596
MOD_GSK3_1 808 815 PF00069 0.630
MOD_GSK3_1 94 101 PF00069 0.703
MOD_N-GLC_1 285 290 PF02516 0.705
MOD_N-GLC_1 446 451 PF02516 0.380
MOD_N-GLC_1 571 576 PF02516 0.706
MOD_N-GLC_1 801 806 PF02516 0.558
MOD_NEK2_1 16 21 PF00069 0.480
MOD_NEK2_1 239 244 PF00069 0.702
MOD_NEK2_1 300 305 PF00069 0.763
MOD_NEK2_1 451 456 PF00069 0.366
MOD_NEK2_1 476 481 PF00069 0.433
MOD_NEK2_1 484 489 PF00069 0.375
MOD_NEK2_1 573 578 PF00069 0.599
MOD_NEK2_1 632 637 PF00069 0.616
MOD_NEK2_1 801 806 PF00069 0.476
MOD_NEK2_1 98 103 PF00069 0.706
MOD_PIKK_1 253 259 PF00454 0.715
MOD_PIKK_1 303 309 PF00454 0.728
MOD_PIKK_1 341 347 PF00454 0.561
MOD_PIKK_1 351 357 PF00454 0.579
MOD_PIKK_1 433 439 PF00454 0.544
MOD_PIKK_1 539 545 PF00454 0.568
MOD_PIKK_1 750 756 PF00454 0.673
MOD_PIKK_1 99 105 PF00454 0.689
MOD_PK_1 181 187 PF00069 0.403
MOD_PKA_1 602 608 PF00069 0.756
MOD_PKA_1 739 745 PF00069 0.739
MOD_PKA_2 284 290 PF00069 0.793
MOD_PKA_2 300 306 PF00069 0.729
MOD_PKA_2 381 387 PF00069 0.539
MOD_PKA_2 474 480 PF00069 0.263
MOD_PKA_2 602 608 PF00069 0.756
MOD_PKA_2 641 647 PF00069 0.487
MOD_PKA_2 739 745 PF00069 0.785
MOD_PKA_2 746 752 PF00069 0.561
MOD_PKA_2 75 81 PF00069 0.791
MOD_PKA_2 783 789 PF00069 0.609
MOD_Plk_1 11 17 PF00069 0.491
MOD_Plk_1 239 245 PF00069 0.717
MOD_Plk_1 285 291 PF00069 0.768
MOD_Plk_1 571 577 PF00069 0.708
MOD_Plk_1 590 596 PF00069 0.472
MOD_Plk_1 801 807 PF00069 0.567
MOD_Plk_2-3 18 24 PF00069 0.362
MOD_Plk_2-3 528 534 PF00069 0.526
MOD_Plk_2-3 705 711 PF00069 0.639
MOD_Plk_2-3 787 793 PF00069 0.613
MOD_Plk_4 150 156 PF00069 0.383
MOD_Plk_4 165 171 PF00069 0.393
MOD_Plk_4 207 213 PF00069 0.636
MOD_Plk_4 313 319 PF00069 0.630
MOD_Plk_4 667 673 PF00069 0.424
MOD_Plk_4 681 687 PF00069 0.532
MOD_Plk_4 705 711 PF00069 0.639
MOD_Plk_4 758 764 PF00069 0.667
MOD_Plk_4 94 100 PF00069 0.690
MOD_ProDKin_1 111 117 PF00069 0.705
MOD_ProDKin_1 118 124 PF00069 0.597
MOD_ProDKin_1 139 145 PF00069 0.497
MOD_ProDKin_1 176 182 PF00069 0.521
MOD_ProDKin_1 267 273 PF00069 0.725
MOD_ProDKin_1 563 569 PF00069 0.783
MOD_ProDKin_1 592 598 PF00069 0.816
MOD_ProDKin_1 715 721 PF00069 0.777
MOD_ProDKin_1 755 761 PF00069 0.687
MOD_SUMO_rev_2 288 298 PF00179 0.695
MOD_SUMO_rev_2 365 375 PF00179 0.612
MOD_SUMO_rev_2 514 520 PF00179 0.587
TRG_DiLeu_BaEn_2 216 222 PF01217 0.620
TRG_DiLeu_BaEn_4 497 503 PF01217 0.433
TRG_DiLeu_BaLyEn_6 520 525 PF01217 0.600
TRG_DiLeu_BaLyEn_6 61 66 PF01217 0.660
TRG_ENDOCYTIC_2 126 129 PF00928 0.455
TRG_ENDOCYTIC_2 13 16 PF00928 0.443
TRG_ENDOCYTIC_2 131 134 PF00928 0.499
TRG_ENDOCYTIC_2 169 172 PF00928 0.369
TRG_ENDOCYTIC_2 29 32 PF00928 0.298
TRG_ENDOCYTIC_2 532 535 PF00928 0.422
TRG_ENDOCYTIC_2 682 685 PF00928 0.525
TRG_ER_diArg_1 502 504 PF00400 0.436
TRG_ER_diArg_1 63 65 PF00400 0.668
TRG_ER_diArg_1 693 695 PF00400 0.594
TRG_ER_diArg_1 773 776 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 233 237 PF00026 0.546

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4C3 Leptomonas seymouri 47% 97%
A0A1X0NTH1 Trypanosomatidae 31% 100%
A0A3Q8IHB8 Leishmania donovani 100% 100%
A0A422NYL4 Trypanosoma rangeli 34% 100%
A4HKW1 Leishmania braziliensis 74% 100%
D0AAT2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9B399 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q4V6 Leishmania major 91% 100%
V5BVG4 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS