LeishMANIAdb
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RWD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RWD domain-containing protein
Gene product:
Serine hydrolase (FSH1)/50S ribosome-binding GTPase/GTPase of unknown function C-terminal - putative
Species:
Leishmania infantum
UniProt:
A4I8D6_LEIIN
TriTrypDb:
LINF_320038700
Length:
959

Annotations

Annotations by Jardim et al.

Hydrolase, Serine hydrolase (FSH1)/50S ribosome-binding GTPase/GTPase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I8D6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8D6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0017076 purine nucleotide binding 4 11
GO:0019001 guanyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032561 guanyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003824 catalytic activity 1 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 145 149 PF00656 0.383
CLV_C14_Caspase3-7 311 315 PF00656 0.494
CLV_C14_Caspase3-7 618 622 PF00656 0.425
CLV_C14_Caspase3-7 68 72 PF00656 0.357
CLV_MEL_PAP_1 682 688 PF00089 0.429
CLV_NRD_NRD_1 131 133 PF00675 0.357
CLV_NRD_NRD_1 422 424 PF00675 0.620
CLV_NRD_NRD_1 428 430 PF00675 0.776
CLV_NRD_NRD_1 572 574 PF00675 0.242
CLV_NRD_NRD_1 684 686 PF00675 0.433
CLV_NRD_NRD_1 936 938 PF00675 0.496
CLV_PCSK_KEX2_1 131 133 PF00082 0.357
CLV_PCSK_KEX2_1 422 424 PF00082 0.621
CLV_PCSK_KEX2_1 428 430 PF00082 0.738
CLV_PCSK_KEX2_1 572 574 PF00082 0.242
CLV_PCSK_KEX2_1 684 686 PF00082 0.433
CLV_PCSK_KEX2_1 791 793 PF00082 0.391
CLV_PCSK_KEX2_1 895 897 PF00082 0.459
CLV_PCSK_KEX2_1 955 957 PF00082 0.448
CLV_PCSK_PC1ET2_1 791 793 PF00082 0.391
CLV_PCSK_PC1ET2_1 895 897 PF00082 0.459
CLV_PCSK_PC1ET2_1 955 957 PF00082 0.448
CLV_PCSK_SKI1_1 131 135 PF00082 0.292
CLV_PCSK_SKI1_1 666 670 PF00082 0.426
CLV_PCSK_SKI1_1 805 809 PF00082 0.315
CLV_Separin_Metazoa 239 243 PF03568 0.465
CLV_Separin_Metazoa 399 403 PF03568 0.455
DEG_SPOP_SBC_1 272 276 PF00917 0.442
DEG_SPOP_SBC_1 820 824 PF00917 0.298
DEG_SPOP_SBC_1 941 945 PF00917 0.379
DOC_ANK_TNKS_1 377 384 PF00023 0.567
DOC_CDC14_PxL_1 160 168 PF14671 0.297
DOC_CYCLIN_RxL_1 101 112 PF00134 0.404
DOC_CYCLIN_yCln2_LP_2 349 355 PF00134 0.386
DOC_CYCLIN_yCln2_LP_2 390 396 PF00134 0.507
DOC_CYCLIN_yCln2_LP_2 716 722 PF00134 0.396
DOC_CYCLIN_yCln2_LP_2 841 847 PF00134 0.334
DOC_MAPK_gen_1 322 332 PF00069 0.471
DOC_MAPK_gen_1 572 578 PF00069 0.439
DOC_MAPK_gen_1 715 724 PF00069 0.389
DOC_MAPK_gen_1 882 891 PF00069 0.426
DOC_MAPK_HePTP_8 712 724 PF00069 0.354
DOC_MAPK_MEF2A_6 363 370 PF00069 0.420
DOC_MAPK_MEF2A_6 715 724 PF00069 0.337
DOC_MAPK_MEF2A_6 754 762 PF00069 0.386
DOC_PP1_RVXF_1 292 298 PF00149 0.407
DOC_PP1_RVXF_1 713 719 PF00149 0.449
DOC_PP1_RVXF_1 752 758 PF00149 0.410
DOC_PP1_RVXF_1 880 887 PF00149 0.351
DOC_PP2B_LxvP_1 38 41 PF13499 0.357
DOC_PP4_FxxP_1 297 300 PF00568 0.411
DOC_USP7_MATH_1 150 154 PF00917 0.334
DOC_USP7_MATH_1 178 182 PF00917 0.342
DOC_USP7_MATH_1 272 276 PF00917 0.500
DOC_USP7_MATH_1 278 282 PF00917 0.510
DOC_USP7_MATH_1 385 389 PF00917 0.747
DOC_USP7_MATH_1 471 475 PF00917 0.455
DOC_USP7_MATH_1 484 488 PF00917 0.442
DOC_USP7_MATH_1 54 58 PF00917 0.334
DOC_USP7_MATH_1 565 569 PF00917 0.422
DOC_USP7_MATH_1 850 854 PF00917 0.420
DOC_WW_Pin1_4 146 151 PF00397 0.402
DOC_WW_Pin1_4 273 278 PF00397 0.479
DOC_WW_Pin1_4 672 677 PF00397 0.397
DOC_WW_Pin1_4 768 773 PF00397 0.306
DOC_WW_Pin1_4 805 810 PF00397 0.411
LIG_14-3-3_CanoR_1 298 304 PF00244 0.418
LIG_14-3-3_CanoR_1 541 547 PF00244 0.519
LIG_14-3-3_CanoR_1 652 662 PF00244 0.503
LIG_14-3-3_CanoR_1 813 819 PF00244 0.410
LIG_Actin_WH2_2 709 727 PF00022 0.329
LIG_APCC_ABBA_1 22 27 PF00400 0.355
LIG_APCC_ABBA_1 261 266 PF00400 0.484
LIG_APCC_ABBA_1 368 373 PF00400 0.389
LIG_APCC_ABBAyCdc20_2 260 266 PF00400 0.427
LIG_BRCT_BRCA1_1 180 184 PF00533 0.297
LIG_BRCT_BRCA1_1 473 477 PF00533 0.452
LIG_BRCT_BRCA1_1 567 571 PF00533 0.496
LIG_Clathr_ClatBox_1 35 39 PF01394 0.355
LIG_Clathr_ClatBox_1 883 887 PF01394 0.337
LIG_FHA_1 12 18 PF00498 0.308
LIG_FHA_1 217 223 PF00498 0.369
LIG_FHA_1 344 350 PF00498 0.488
LIG_FHA_1 429 435 PF00498 0.708
LIG_FHA_1 456 462 PF00498 0.433
LIG_FHA_1 654 660 PF00498 0.503
LIG_FHA_1 693 699 PF00498 0.472
LIG_FHA_1 750 756 PF00498 0.421
LIG_FHA_1 821 827 PF00498 0.311
LIG_FHA_1 857 863 PF00498 0.497
LIG_FHA_1 88 94 PF00498 0.306
LIG_FHA_1 937 943 PF00498 0.470
LIG_FHA_2 263 269 PF00498 0.495
LIG_FHA_2 46 52 PF00498 0.386
LIG_FHA_2 496 502 PF00498 0.517
LIG_FHA_2 616 622 PF00498 0.389
LIG_FHA_2 630 636 PF00498 0.379
LIG_FHA_2 675 681 PF00498 0.538
LIG_FHA_2 729 735 PF00498 0.425
LIG_GBD_Chelix_1 854 862 PF00786 0.407
LIG_Integrin_isoDGR_2 426 428 PF01839 0.537
LIG_LIR_Gen_1 181 191 PF02991 0.391
LIG_LIR_Gen_1 317 323 PF02991 0.523
LIG_LIR_Gen_1 474 485 PF02991 0.444
LIG_LIR_Gen_1 645 653 PF02991 0.347
LIG_LIR_Gen_1 756 762 PF02991 0.392
LIG_LIR_Gen_1 86 95 PF02991 0.421
LIG_LIR_Gen_1 867 878 PF02991 0.356
LIG_LIR_Nem_3 158 163 PF02991 0.391
LIG_LIR_Nem_3 181 187 PF02991 0.410
LIG_LIR_Nem_3 317 321 PF02991 0.588
LIG_LIR_Nem_3 474 480 PF02991 0.444
LIG_LIR_Nem_3 557 563 PF02991 0.444
LIG_LIR_Nem_3 645 651 PF02991 0.334
LIG_LIR_Nem_3 667 672 PF02991 0.415
LIG_LIR_Nem_3 756 760 PF02991 0.398
LIG_LIR_Nem_3 867 873 PF02991 0.315
LIG_MLH1_MIPbox_1 473 477 PF16413 0.455
LIG_Pex14_2 297 301 PF04695 0.416
LIG_REV1ctd_RIR_1 801 808 PF16727 0.355
LIG_RPA_C_Fungi 945 957 PF08784 0.398
LIG_SH2_CRK 648 652 PF00017 0.352
LIG_SH2_GRB2like 648 651 PF00017 0.347
LIG_SH2_PTP2 713 716 PF00017 0.449
LIG_SH2_SRC 353 356 PF00017 0.452
LIG_SH2_STAP1 323 327 PF00017 0.421
LIG_SH2_STAT5 105 108 PF00017 0.322
LIG_SH2_STAT5 337 340 PF00017 0.459
LIG_SH2_STAT5 353 356 PF00017 0.370
LIG_SH2_STAT5 405 408 PF00017 0.449
LIG_SH2_STAT5 512 515 PF00017 0.355
LIG_SH2_STAT5 713 716 PF00017 0.361
LIG_SH2_STAT5 767 770 PF00017 0.327
LIG_SH3_3 172 178 PF00018 0.375
LIG_SH3_3 256 262 PF00018 0.350
LIG_SH3_3 477 483 PF00018 0.279
LIG_SH3_3 656 662 PF00018 0.505
LIG_SH3_3 744 750 PF00018 0.385
LIG_SH3_3 77 83 PF00018 0.410
LIG_SH3_3 924 930 PF00018 0.625
LIG_Sin3_3 414 421 PF02671 0.444
LIG_SUMO_SIM_anti_2 362 369 PF11976 0.440
LIG_TRAF2_1 177 180 PF00917 0.355
LIG_UBA3_1 720 726 PF00899 0.457
LIG_UBA3_1 888 895 PF00899 0.372
LIG_WRC_WIRS_1 800 805 PF05994 0.355
MOD_CDC14_SPxK_1 810 813 PF00782 0.306
MOD_CDK_SPxK_1 807 813 PF00069 0.306
MOD_CK1_1 149 155 PF00069 0.430
MOD_CK1_1 189 195 PF00069 0.386
MOD_CK1_1 273 279 PF00069 0.506
MOD_CK1_1 302 308 PF00069 0.579
MOD_CK1_1 57 63 PF00069 0.369
MOD_CK1_1 674 680 PF00069 0.358
MOD_CK1_1 905 911 PF00069 0.657
MOD_CK1_1 912 918 PF00069 0.704
MOD_CK1_1 932 938 PF00069 0.428
MOD_CK2_1 240 246 PF00069 0.526
MOD_CK2_1 262 268 PF00069 0.488
MOD_CK2_1 495 501 PF00069 0.318
MOD_CK2_1 628 634 PF00069 0.515
MOD_CK2_1 861 867 PF00069 0.407
MOD_Cter_Amidation 169 172 PF01082 0.322
MOD_Cter_Amidation 426 429 PF01082 0.565
MOD_GlcNHglycan 144 147 PF01048 0.422
MOD_GlcNHglycan 152 155 PF01048 0.458
MOD_GlcNHglycan 179 183 PF01048 0.360
MOD_GlcNHglycan 189 192 PF01048 0.352
MOD_GlcNHglycan 223 226 PF01048 0.543
MOD_GlcNHglycan 284 287 PF01048 0.432
MOD_GlcNHglycan 334 337 PF01048 0.457
MOD_GlcNHglycan 448 451 PF01048 0.615
MOD_GlcNHglycan 469 472 PF01048 0.288
MOD_GlcNHglycan 538 541 PF01048 0.355
MOD_GlcNHglycan 543 546 PF01048 0.410
MOD_GlcNHglycan 548 551 PF01048 0.410
MOD_GlcNHglycan 59 62 PF01048 0.311
MOD_GlcNHglycan 65 70 PF01048 0.353
MOD_GlcNHglycan 669 672 PF01048 0.457
MOD_GlcNHglycan 864 867 PF01048 0.411
MOD_GlcNHglycan 931 934 PF01048 0.478
MOD_GlcNHglycan 944 947 PF01048 0.453
MOD_GSK3_1 138 145 PF00069 0.341
MOD_GSK3_1 146 153 PF00069 0.376
MOD_GSK3_1 216 223 PF00069 0.411
MOD_GSK3_1 262 269 PF00069 0.475
MOD_GSK3_1 278 285 PF00069 0.501
MOD_GSK3_1 299 306 PF00069 0.519
MOD_GSK3_1 455 462 PF00069 0.472
MOD_GSK3_1 467 474 PF00069 0.286
MOD_GSK3_1 536 543 PF00069 0.442
MOD_GSK3_1 634 641 PF00069 0.446
MOD_GSK3_1 660 667 PF00069 0.435
MOD_GSK3_1 693 700 PF00069 0.302
MOD_GSK3_1 799 806 PF00069 0.373
MOD_GSK3_1 905 912 PF00069 0.586
MOD_GSK3_1 928 935 PF00069 0.521
MOD_GSK3_1 936 943 PF00069 0.448
MOD_N-GLC_1 254 259 PF02516 0.432
MOD_NEK2_1 142 147 PF00069 0.295
MOD_NEK2_1 221 226 PF00069 0.486
MOD_NEK2_1 240 245 PF00069 0.408
MOD_NEK2_1 270 275 PF00069 0.482
MOD_NEK2_1 282 287 PF00069 0.371
MOD_NEK2_1 697 702 PF00069 0.453
MOD_NEK2_1 73 78 PF00069 0.467
MOD_NEK2_1 760 765 PF00069 0.417
MOD_NEK2_1 803 808 PF00069 0.486
MOD_NEK2_1 814 819 PF00069 0.384
MOD_NEK2_1 821 826 PF00069 0.196
MOD_NEK2_1 87 92 PF00069 0.215
MOD_NEK2_1 902 907 PF00069 0.568
MOD_NEK2_1 93 98 PF00069 0.150
MOD_NEK2_2 138 143 PF00069 0.492
MOD_NEK2_2 155 160 PF00069 0.185
MOD_NEK2_2 278 283 PF00069 0.341
MOD_NEK2_2 472 477 PF00069 0.279
MOD_NEK2_2 514 519 PF00069 0.330
MOD_NEK2_2 775 780 PF00069 0.343
MOD_PIKK_1 11 17 PF00454 0.222
MOD_PIKK_1 385 391 PF00454 0.756
MOD_PIKK_1 93 99 PF00454 0.289
MOD_PKA_1 428 434 PF00069 0.685
MOD_PKA_2 332 338 PF00069 0.477
MOD_PKA_2 428 434 PF00069 0.668
MOD_PKA_2 540 546 PF00069 0.282
MOD_PKA_2 812 818 PF00069 0.301
MOD_PKA_2 936 942 PF00069 0.466
MOD_Plk_1 138 144 PF00069 0.403
MOD_Plk_1 254 260 PF00069 0.502
MOD_Plk_1 634 640 PF00069 0.360
MOD_Plk_1 912 918 PF00069 0.516
MOD_Plk_2-3 441 447 PF00069 0.628
MOD_Plk_4 138 144 PF00069 0.339
MOD_Plk_4 155 161 PF00069 0.187
MOD_Plk_4 20 26 PF00069 0.355
MOD_Plk_4 254 260 PF00069 0.467
MOD_Plk_4 266 272 PF00069 0.516
MOD_Plk_4 472 478 PF00069 0.279
MOD_Plk_4 642 648 PF00069 0.319
MOD_Plk_4 654 660 PF00069 0.390
MOD_Plk_4 674 680 PF00069 0.230
MOD_Plk_4 693 699 PF00069 0.281
MOD_Plk_4 799 805 PF00069 0.432
MOD_Plk_4 814 820 PF00069 0.317
MOD_ProDKin_1 146 152 PF00069 0.402
MOD_ProDKin_1 273 279 PF00069 0.474
MOD_ProDKin_1 672 678 PF00069 0.393
MOD_ProDKin_1 768 774 PF00069 0.306
MOD_ProDKin_1 805 811 PF00069 0.411
MOD_SUMO_for_1 321 324 PF00179 0.508
TRG_DiLeu_BaEn_1 345 350 PF01217 0.436
TRG_DiLeu_BaEn_1 705 710 PF01217 0.251
TRG_DiLeu_BaEn_4 246 252 PF01217 0.477
TRG_DiLeu_BaLyEn_6 42 47 PF01217 0.391
TRG_ENDOCYTIC_2 103 106 PF00928 0.381
TRG_ENDOCYTIC_2 560 563 PF00928 0.327
TRG_ENDOCYTIC_2 648 651 PF00928 0.345
TRG_ENDOCYTIC_2 713 716 PF00928 0.361
TRG_ER_diArg_1 130 132 PF00400 0.357
TRG_ER_diArg_1 422 425 PF00400 0.647
TRG_ER_diArg_1 428 430 PF00400 0.754
TRG_ER_diArg_1 571 573 PF00400 0.321
TRG_ER_diArg_1 683 685 PF00400 0.418
TRG_ER_diArg_1 714 717 PF00400 0.366
TRG_NES_CRM1_1 27 39 PF08389 0.355
TRG_NES_CRM1_1 877 890 PF08389 0.360
TRG_Pf-PMV_PEXEL_1 896 900 PF00026 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDP4 Leptomonas seymouri 64% 100%
A0A0S4IRQ8 Bodo saltans 35% 96%
A0A1X0NRU1 Trypanosomatidae 39% 100%
A0A3Q8IJK7 Leishmania donovani 99% 100%
A4HKV6 Leishmania braziliensis 79% 100%
D0AAT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B395 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q4W0 Leishmania major 93% 100%
V5BL49 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS