Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8D5_LEIIN

TriTrypDb:

LINF_320038600

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8D5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.566
CLV_NRD_NRD_1	262	264	PF00675	0.597
CLV_NRD_NRD_1	40	42	PF00675	0.515
CLV_PCSK_KEX2_1	117	119	PF00082	0.637
CLV_PCSK_SKI1_1	118	122	PF00082	0.493
CLV_PCSK_SKI1_1	298	302	PF00082	0.520
CLV_PCSK_SKI1_1	57	61	PF00082	0.579
DEG_APCC_DBOX_1	117	125	PF00400	0.492
DEG_SPOP_SBC_1	193	197	PF00917	0.499
DEG_SPOP_SBC_1	3	7	PF00917	0.590
DOC_USP7_MATH_1	140	144	PF00917	0.527
DOC_USP7_MATH_1	155	159	PF00917	0.547
DOC_USP7_MATH_1	189	193	PF00917	0.716
DOC_USP7_MATH_1	194	198	PF00917	0.649
DOC_USP7_MATH_1	2	6	PF00917	0.612
DOC_USP7_MATH_1	257	261	PF00917	0.602
DOC_USP7_MATH_1	77	81	PF00917	0.585
DOC_WW_Pin1_4	67	72	PF00397	0.510
DOC_WW_Pin1_4	88	93	PF00397	0.621
LIG_deltaCOP1_diTrp_1	291	300	PF00928	0.507
LIG_FHA_1	164	170	PF00498	0.664
LIG_FHA_2	144	150	PF00498	0.539
LIG_FHA_2	6	12	PF00498	0.726
LIG_FHA_2	82	88	PF00498	0.576
LIG_FHA_2	89	95	PF00498	0.593
LIG_GBD_Chelix_1	17	25	PF00786	0.434
LIG_LIR_Gen_1	291	300	PF02991	0.479
LIG_LIR_Nem_3	291	296	PF02991	0.473
LIG_NRBOX	226	232	PF00104	0.490
LIG_SH2_CRK	210	214	PF00017	0.391
LIG_SH2_NCK_1	186	190	PF00017	0.527
LIG_SH2_STAP1	186	190	PF00017	0.527
LIG_SH2_STAT3	35	38	PF00017	0.413
LIG_SH2_STAT5	226	229	PF00017	0.484
LIG_SH3_1	244	250	PF00018	0.582
LIG_SH3_3	144	150	PF00018	0.539
LIG_SH3_3	244	250	PF00018	0.582
LIG_SH3_3	7	13	PF00018	0.574
LIG_TRAF2_1	106	109	PF00917	0.479
LIG_TRAF2_1	70	73	PF00917	0.574
LIG_UBA3_1	134	141	PF00899	0.434
MOD_CK1_1	143	149	PF00069	0.646
MOD_CK1_1	160	166	PF00069	0.594
MOD_CK1_1	188	194	PF00069	0.613
MOD_CK1_1	266	272	PF00069	0.635
MOD_CK1_1	5	11	PF00069	0.653
MOD_CK1_1	81	87	PF00069	0.609
MOD_CK2_1	143	149	PF00069	0.557
MOD_CK2_1	253	259	PF00069	0.614
MOD_CK2_1	5	11	PF00069	0.645
MOD_CK2_1	67	73	PF00069	0.681
MOD_CK2_1	81	87	PF00069	0.478
MOD_GlcNHglycan	109	113	PF01048	0.415
MOD_GlcNHglycan	157	160	PF01048	0.675
MOD_GlcNHglycan	187	190	PF01048	0.632
MOD_GlcNHglycan	191	194	PF01048	0.660
MOD_GlcNHglycan	196	199	PF01048	0.532
MOD_GlcNHglycan	255	258	PF01048	0.658
MOD_GlcNHglycan	259	262	PF01048	0.601
MOD_GlcNHglycan	266	269	PF01048	0.592
MOD_GlcNHglycan	286	289	PF01048	0.495
MOD_GSK3_1	108	115	PF00069	0.549
MOD_GSK3_1	153	160	PF00069	0.660
MOD_GSK3_1	185	192	PF00069	0.616
MOD_GSK3_1	253	260	PF00069	0.667
MOD_GSK3_1	262	269	PF00069	0.546
MOD_GSK3_1	298	305	PF00069	0.553
MOD_GSK3_1	33	40	PF00069	0.591
MOD_GSK3_1	77	84	PF00069	0.630
MOD_LATS_1	123	129	PF00433	0.466
MOD_NEK2_1	277	282	PF00069	0.520
MOD_NEK2_1	78	83	PF00069	0.598
MOD_PIKK_1	125	131	PF00454	0.397
MOD_PIKK_1	153	159	PF00454	0.666
MOD_PIKK_1	34	40	PF00454	0.592
MOD_PKA_1	263	269	PF00069	0.577
MOD_PKA_2	253	259	PF00069	0.675
MOD_PKA_2	262	268	PF00069	0.618
MOD_PKA_2	33	39	PF00069	0.516
MOD_PKA_2	40	46	PF00069	0.454
MOD_PKB_1	32	40	PF00069	0.509
MOD_PKB_1	63	71	PF00069	0.570
MOD_Plk_1	57	63	PF00069	0.570
MOD_ProDKin_1	67	73	PF00069	0.511
MOD_ProDKin_1	88	94	PF00069	0.620
TRG_DiLeu_BaEn_1	116	121	PF01217	0.433
TRG_DiLeu_BaEn_1	223	228	PF01217	0.473
TRG_ENDOCYTIC_2	210	213	PF00928	0.420
TRG_ER_diArg_1	244	247	PF00400	0.709
TRG_ER_diArg_1	32	35	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D0	Leptomonas seymouri	31%	84%
A0A3Q8IG66	Leishmania donovani	99%	100%
E9B394	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q4W1	Leishmania major	85%	100%