SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc-finger of the MIZ type in Nse subunit/MIZ/SP-RING zinc finger containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I8D2_LEIIN

TriTrypDb:

LINF_320038300

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8D2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0019789	SUMO transferase activity	4	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0061665	SUMO ligase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.539
CLV_C14_Caspase3-7	158	162	PF00656	0.601
CLV_C14_Caspase3-7	174	178	PF00656	0.474
CLV_C14_Caspase3-7	404	408	PF00656	0.418
CLV_NRD_NRD_1	13	15	PF00675	0.637
CLV_NRD_NRD_1	135	137	PF00675	0.558
CLV_NRD_NRD_1	192	194	PF00675	0.524
CLV_NRD_NRD_1	316	318	PF00675	0.429
CLV_NRD_NRD_1	424	426	PF00675	0.553
CLV_NRD_NRD_1	91	93	PF00675	0.513
CLV_PCSK_FUR_1	133	137	PF00082	0.607
CLV_PCSK_FUR_1	422	426	PF00082	0.613
CLV_PCSK_KEX2_1	13	15	PF00082	0.637
CLV_PCSK_KEX2_1	135	137	PF00082	0.499
CLV_PCSK_KEX2_1	192	194	PF00082	0.524
CLV_PCSK_KEX2_1	316	318	PF00082	0.426
CLV_PCSK_KEX2_1	422	424	PF00082	0.515
CLV_PCSK_KEX2_1	91	93	PF00082	0.417
CLV_PCSK_PC7_1	419	425	PF00082	0.505
CLV_PCSK_SKI1_1	353	357	PF00082	0.440
CLV_PCSK_SKI1_1	91	95	PF00082	0.490
DEG_COP1_1	407	417	PF00400	0.368
DEG_SPOP_SBC_1	172	176	PF00917	0.532
DEG_SPOP_SBC_1	378	382	PF00917	0.449
DEG_SPOP_SBC_1	93	97	PF00917	0.396
DOC_CKS1_1	18	23	PF01111	0.607
DOC_CYCLIN_RxL_1	348	360	PF00134	0.524
DOC_MAPK_gen_1	135	144	PF00069	0.555
DOC_PP4_FxxP_1	418	421	PF00568	0.426
DOC_SPAK_OSR1_1	387	391	PF12202	0.470
DOC_USP7_MATH_1	12	16	PF00917	0.800
DOC_USP7_MATH_1	125	129	PF00917	0.372
DOC_USP7_MATH_1	188	192	PF00917	0.630
DOC_USP7_MATH_1	271	275	PF00917	0.511
DOC_USP7_MATH_1	320	324	PF00917	0.444
DOC_USP7_MATH_1	426	430	PF00917	0.639
DOC_USP7_MATH_1	450	454	PF00917	0.698
DOC_USP7_MATH_1	52	56	PF00917	0.436
DOC_WW_Pin1_4	17	22	PF00397	0.658
DOC_WW_Pin1_4	195	200	PF00397	0.669
DOC_WW_Pin1_4	216	221	PF00397	0.761
DOC_WW_Pin1_4	241	246	PF00397	0.620
DOC_WW_Pin1_4	5	10	PF00397	0.776
LIG_14-3-3_CanoR_1	13	21	PF00244	0.798
LIG_14-3-3_CanoR_1	170	179	PF00244	0.455
LIG_14-3-3_CanoR_1	91	100	PF00244	0.374
LIG_BIR_III_4	307	311	PF00653	0.426
LIG_BRCT_BRCA1_1	34	38	PF00533	0.512
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.356
LIG_deltaCOP1_diTrp_1	377	383	PF00928	0.393
LIG_FHA_1	113	119	PF00498	0.418
LIG_FHA_1	331	337	PF00498	0.372
LIG_FHA_2	129	135	PF00498	0.651
LIG_FHA_2	146	152	PF00498	0.456
LIG_FHA_2	172	178	PF00498	0.645
LIG_FHA_2	247	253	PF00498	0.531
LIG_Integrin_RGDW_4	309	312	PF00362	0.416
LIG_LIR_Apic_2	416	421	PF02991	0.502
LIG_LIR_Gen_1	311	320	PF02991	0.350
LIG_LIR_Gen_1	35	44	PF02991	0.329
LIG_LIR_Gen_1	354	364	PF02991	0.570
LIG_LIR_Gen_1	67	73	PF02991	0.427
LIG_LIR_Nem_3	150	155	PF02991	0.655
LIG_LIR_Nem_3	311	315	PF02991	0.331
LIG_LIR_Nem_3	35	41	PF02991	0.392
LIG_LIR_Nem_3	360	364	PF02991	0.570
LIG_Pex14_1	379	383	PF04695	0.419
LIG_Pex14_2	314	318	PF04695	0.440
LIG_Pex14_2	388	392	PF04695	0.453
LIG_SH2_CRK	352	356	PF00017	0.567
LIG_SH2_CRK	361	365	PF00017	0.520
LIG_SH2_CRK	372	376	PF00017	0.352
LIG_SH2_CRK	44	48	PF00017	0.474
LIG_SH2_GRB2like	152	155	PF00017	0.638
LIG_SH2_NCK_1	361	365	PF00017	0.563
LIG_SH2_STAP1	152	156	PF00017	0.666
LIG_SH2_STAP1	361	365	PF00017	0.478
LIG_SH2_STAT5	155	158	PF00017	0.660
LIG_SH2_STAT5	345	348	PF00017	0.380
LIG_SH3_3	196	202	PF00018	0.736
LIG_SH3_3	242	248	PF00018	0.733
LIG_SH3_3	79	85	PF00018	0.436
LIG_SUMO_SIM_par_1	115	121	PF11976	0.403
LIG_TRAF2_1	249	252	PF00917	0.509
MOD_CK1_1	128	134	PF00069	0.400
MOD_CK1_1	17	23	PF00069	0.607
MOD_CK1_1	246	252	PF00069	0.568
MOD_CK1_1	322	328	PF00069	0.377
MOD_CK1_1	408	414	PF00069	0.418
MOD_CK1_1	429	435	PF00069	0.594
MOD_CK2_1	128	134	PF00069	0.570
MOD_CK2_1	246	252	PF00069	0.650
MOD_CK2_1	351	357	PF00069	0.482
MOD_CK2_1	360	366	PF00069	0.533
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.589
MOD_GlcNHglycan	127	130	PF01048	0.346
MOD_GlcNHglycan	182	185	PF01048	0.606
MOD_GlcNHglycan	205	208	PF01048	0.738
MOD_GlcNHglycan	209	212	PF01048	0.663
MOD_GlcNHglycan	428	431	PF01048	0.666
MOD_GlcNHglycan	440	443	PF01048	0.452
MOD_GSK3_1	125	132	PF00069	0.363
MOD_GSK3_1	173	180	PF00069	0.624
MOD_GSK3_1	203	210	PF00069	0.736
MOD_GSK3_1	243	250	PF00069	0.612
MOD_GSK3_1	318	325	PF00069	0.457
MOD_GSK3_1	32	39	PF00069	0.398
MOD_GSK3_1	426	433	PF00069	0.653
MOD_N-GLC_2	56	58	PF02516	0.231
MOD_N-GLC_2	74	76	PF02516	0.153
MOD_NEK2_1	179	184	PF00069	0.678
MOD_NEK2_1	281	286	PF00069	0.407
MOD_NEK2_1	318	323	PF00069	0.529
MOD_NEK2_1	351	356	PF00069	0.515
MOD_PIKK_1	14	20	PF00454	0.638
MOD_PIKK_1	145	151	PF00454	0.454
MOD_PIKK_1	247	253	PF00454	0.685
MOD_PIKK_1	271	277	PF00454	0.380
MOD_PIKK_1	432	438	PF00454	0.630
MOD_PIKK_1	450	456	PF00454	0.590
MOD_PKA_1	91	97	PF00069	0.365
MOD_PKA_2	12	18	PF00069	0.799
MOD_PKA_2	91	97	PF00069	0.365
MOD_Plk_1	36	42	PF00069	0.292
MOD_Plk_2-3	360	366	PF00069	0.487
MOD_Plk_4	330	336	PF00069	0.339
MOD_Plk_4	408	414	PF00069	0.509
MOD_Plk_4	65	71	PF00069	0.426
MOD_ProDKin_1	17	23	PF00069	0.655
MOD_ProDKin_1	195	201	PF00069	0.674
MOD_ProDKin_1	216	222	PF00069	0.762
MOD_ProDKin_1	241	247	PF00069	0.621
MOD_ProDKin_1	5	11	PF00069	0.778
MOD_SUMO_for_1	225	228	PF00179	0.566
MOD_SUMO_for_1	291	294	PF00179	0.517
TRG_DiLeu_BaEn_1	27	32	PF01217	0.558
TRG_ENDOCYTIC_2	352	355	PF00928	0.547
TRG_ENDOCYTIC_2	361	364	PF00928	0.510
TRG_ENDOCYTIC_2	44	47	PF00928	0.429
TRG_ER_diArg_1	192	195	PF00400	0.525
TRG_ER_diArg_1	315	317	PF00400	0.445
TRG_ER_diArg_1	421	424	PF00400	0.520
TRG_ER_diArg_1	91	93	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P907	Leptomonas seymouri	65%	73%
A0A0S4IQ84	Bodo saltans	31%	77%
A0A1X0NSE9	Trypanosomatidae	41%	99%
A0A3R7NRN3	Trypanosoma rangeli	41%	100%
A0A3S7X626	Leishmania donovani	99%	100%
A4HKV3	Leishmania braziliensis	84%	100%
D0AAU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B391	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4W4	Leishmania major	94%	100%
V5B5L3	Trypanosoma cruzi	42%	100%