Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAj - putative

Species:

Leishmania infantum

UniProt:

A4I8C7_LEIIN

TriTrypDb:

LINF_320037800

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8C7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051087	protein-folding chaperone binding	3	1
GO:0051787	misfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.530
CLV_NRD_NRD_1	134	136	PF00675	0.409
CLV_NRD_NRD_1	155	157	PF00675	0.570
CLV_NRD_NRD_1	263	265	PF00675	0.567
CLV_PCSK_FUR_1	153	157	PF00082	0.395
CLV_PCSK_KEX2_1	127	129	PF00082	0.502
CLV_PCSK_KEX2_1	133	135	PF00082	0.418
CLV_PCSK_KEX2_1	153	155	PF00082	0.666
CLV_PCSK_KEX2_1	262	264	PF00082	0.627
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.491
CLV_PCSK_SKI1_1	23	27	PF00082	0.384
DEG_SPOP_SBC_1	212	216	PF00917	0.581
DOC_PP1_RVXF_1	52	59	PF00149	0.274
DOC_USP7_MATH_1	144	148	PF00917	0.367
DOC_USP7_MATH_1	169	173	PF00917	0.690
DOC_USP7_MATH_1	211	215	PF00917	0.600
DOC_USP7_MATH_1	237	241	PF00917	0.569
DOC_USP7_MATH_1	47	51	PF00917	0.350
DOC_WW_Pin1_4	96	101	PF00397	0.550
LIG_14-3-3_CanoR_1	10	19	PF00244	0.556
LIG_14-3-3_CanoR_1	118	126	PF00244	0.511
LIG_14-3-3_CanoR_1	186	192	PF00244	0.423
LIG_14-3-3_CanoR_1	23	30	PF00244	0.368
LIG_14-3-3_CanoR_1	264	274	PF00244	0.525
LIG_APCC_ABBA_1	103	108	PF00400	0.524
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_4	320	324	PF00653	0.428
LIG_BRCT_BRCA1_1	269	273	PF00533	0.460
LIG_BRCT_BRCA1_1	49	53	PF00533	0.350
LIG_CtBP_PxDLS_1	100	104	PF00389	0.464
LIG_FHA_1	10	16	PF00498	0.497
LIG_FHA_1	121	127	PF00498	0.511
LIG_FHA_1	172	178	PF00498	0.617
LIG_FHA_1	266	272	PF00498	0.635
LIG_FHA_2	185	191	PF00498	0.414
LIG_FHA_2	24	30	PF00498	0.295
LIG_FHA_2	299	305	PF00498	0.592
LIG_LIR_Apic_2	201	207	PF02991	0.577
LIG_LIR_Gen_1	13	21	PF02991	0.320
LIG_LIR_Gen_1	298	303	PF02991	0.475
LIG_LIR_Nem_3	13	19	PF02991	0.340
LIG_LIR_Nem_3	298	302	PF02991	0.433
LIG_LIR_Nem_3	50	56	PF02991	0.315
LIG_PTB_Apo_2	139	146	PF02174	0.423
LIG_PTB_Apo_2	293	300	PF02174	0.442
LIG_PTB_Phospho_1	293	299	PF10480	0.437
LIG_SH2_CRK	204	208	PF00017	0.679
LIG_SH2_CRK	297	301	PF00017	0.427
LIG_SH2_GRB2like	294	297	PF00017	0.438
LIG_SH2_STAP1	283	287	PF00017	0.452
LIG_SH2_STAT5	299	302	PF00017	0.431
LIG_SUMO_SIM_par_1	172	178	PF11976	0.465
LIG_WRC_WIRS_1	248	253	PF05994	0.501
LIG_WRC_WIRS_1	299	304	PF05994	0.519
MOD_CK1_1	2	8	PF00069	0.644
MOD_CK1_1	240	246	PF00069	0.631
MOD_CK1_1	247	253	PF00069	0.624
MOD_CK2_1	119	125	PF00069	0.458
MOD_CK2_1	144	150	PF00069	0.497
MOD_CK2_1	184	190	PF00069	0.443
MOD_CK2_1	23	29	PF00069	0.315
MOD_CK2_1	240	246	PF00069	0.679
MOD_CK2_1	298	304	PF00069	0.462
MOD_CK2_1	61	67	PF00069	0.364
MOD_GlcNHglycan	12	15	PF01048	0.508
MOD_GlcNHglycan	164	167	PF01048	0.653
MOD_GlcNHglycan	171	174	PF01048	0.632
MOD_GlcNHglycan	187	190	PF01048	0.468
MOD_GlcNHglycan	215	218	PF01048	0.633
MOD_GlcNHglycan	241	245	PF01048	0.750
MOD_GlcNHglycan	252	255	PF01048	0.690
MOD_GlcNHglycan	257	260	PF01048	0.617
MOD_GlcNHglycan	287	290	PF01048	0.608
MOD_GlcNHglycan	73	76	PF01048	0.496
MOD_GSK3_1	171	178	PF00069	0.661
MOD_GSK3_1	19	26	PF00069	0.424
MOD_GSK3_1	219	226	PF00069	0.514
MOD_GSK3_1	240	247	PF00069	0.596
MOD_GSK3_1	253	260	PF00069	0.600
MOD_GSK3_1	281	288	PF00069	0.559
MOD_N-GLC_1	212	217	PF02516	0.569
MOD_N-GLC_1	23	28	PF02516	0.423
MOD_NEK2_1	177	182	PF00069	0.702
MOD_NEK2_1	19	24	PF00069	0.368
MOD_NEK2_1	266	271	PF00069	0.434
MOD_NEK2_1	71	76	PF00069	0.524
MOD_NEK2_1	9	14	PF00069	0.577
MOD_NEK2_2	257	262	PF00069	0.485
MOD_PIKK_1	110	116	PF00454	0.488
MOD_PIKK_1	23	29	PF00454	0.417
MOD_PKA_2	110	116	PF00069	0.547
MOD_PKA_2	185	191	PF00069	0.466
MOD_PKA_2	9	15	PF00069	0.541
MOD_Plk_1	2	8	PF00069	0.558
MOD_Plk_2-3	298	304	PF00069	0.481
MOD_Plk_4	2	8	PF00069	0.606
MOD_Plk_4	247	253	PF00069	0.502
MOD_Plk_4	298	304	PF00069	0.485
MOD_ProDKin_1	96	102	PF00069	0.551
MOD_SUMO_for_1	145	148	PF00179	0.459
MOD_SUMO_rev_2	137	143	PF00179	0.490
TRG_DiLeu_BaEn_4	198	204	PF01217	0.533
TRG_ENDOCYTIC_2	16	19	PF00928	0.314
TRG_ENDOCYTIC_2	297	300	PF00928	0.439
TRG_ENDOCYTIC_2	34	37	PF00928	0.274
TRG_ER_diArg_1	126	128	PF00400	0.512
TRG_ER_diArg_1	153	156	PF00400	0.564
TRG_ER_diArg_1	261	264	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML6	Leptomonas seymouri	54%	100%
A0A0S4ILI1	Bodo saltans	35%	100%
A0A1X0NRT2	Trypanosomatidae	45%	100%
A0A3Q8IHA8	Leishmania donovani	100%	100%
A0A422NYS2	Trypanosoma rangeli	42%	100%
A4HKU8	Leishmania braziliensis	80%	100%
D0AAU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B386	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4W9	Leishmania major	91%	100%
V5BL40	Trypanosoma cruzi	44%	100%