Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase - putative

Species:

Leishmania infantum

UniProt:

A4I8C6_LEIIN

TriTrypDb:

LINF_320037700

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8C6

PDB structure(s): 7am2_BV

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	502	506	PF00656	0.788
CLV_C14_Caspase3-7	598	602	PF00656	0.554
CLV_C14_Caspase3-7	657	661	PF00656	0.585
CLV_NRD_NRD_1	244	246	PF00675	0.764
CLV_NRD_NRD_1	381	383	PF00675	0.599
CLV_NRD_NRD_1	488	490	PF00675	0.593
CLV_NRD_NRD_1	684	686	PF00675	0.469
CLV_NRD_NRD_1	697	699	PF00675	0.500
CLV_PCSK_FUR_1	242	246	PF00082	0.743
CLV_PCSK_KEX2_1	175	177	PF00082	0.294
CLV_PCSK_KEX2_1	244	246	PF00082	0.749
CLV_PCSK_KEX2_1	381	383	PF00082	0.596
CLV_PCSK_KEX2_1	488	490	PF00082	0.593
CLV_PCSK_KEX2_1	699	701	PF00082	0.531
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.294
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.524
CLV_PCSK_SKI1_1	17	21	PF00082	0.573
CLV_PCSK_SKI1_1	493	497	PF00082	0.730
CLV_PCSK_SKI1_1	66	70	PF00082	0.538
CLV_PCSK_SKI1_1	743	747	PF00082	0.477
CLV_PCSK_SKI1_1	758	762	PF00082	0.595
DEG_Nend_Nbox_1	1	3	PF02207	0.671
DOC_CKS1_1	135	140	PF01111	0.490
DOC_CYCLIN_RxL_1	161	172	PF00134	0.563
DOC_CYCLIN_RxL_1	293	304	PF00134	0.503
DOC_CYCLIN_RxL_1	488	499	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	584	590	PF00134	0.695
DOC_MAPK_gen_1	204	213	PF00069	0.561
DOC_MAPK_MEF2A_6	607	614	PF00069	0.533
DOC_PP1_RVXF_1	119	126	PF00149	0.490
DOC_PP1_RVXF_1	173	180	PF00149	0.490
DOC_PP2B_LxvP_1	436	439	PF13499	0.700
DOC_PP2B_LxvP_1	584	587	PF13499	0.715
DOC_PP4_FxxP_1	238	241	PF00568	0.617
DOC_PP4_FxxP_1	349	352	PF00568	0.431
DOC_SPAK_OSR1_1	489	493	PF12202	0.574
DOC_USP7_MATH_1	18	22	PF00917	0.709
DOC_USP7_MATH_1	292	296	PF00917	0.557
DOC_USP7_MATH_1	33	37	PF00917	0.680
DOC_USP7_MATH_1	345	349	PF00917	0.419
DOC_USP7_MATH_1	432	436	PF00917	0.751
DOC_USP7_MATH_1	457	461	PF00917	0.680
DOC_USP7_MATH_1	629	633	PF00917	0.530
DOC_WW_Pin1_4	134	139	PF00397	0.490
DOC_WW_Pin1_4	184	189	PF00397	0.561
DOC_WW_Pin1_4	22	27	PF00397	0.588
DOC_WW_Pin1_4	537	542	PF00397	0.747
DOC_WW_Pin1_4	554	559	PF00397	0.555
LIG_14-3-3_CanoR_1	13	17	PF00244	0.652
LIG_14-3-3_CanoR_1	186	192	PF00244	0.516
LIG_14-3-3_CanoR_1	206	212	PF00244	0.561
LIG_14-3-3_CanoR_1	381	390	PF00244	0.585
LIG_14-3-3_CanoR_1	447	455	PF00244	0.689
LIG_14-3-3_CanoR_1	500	507	PF00244	0.695
LIG_14-3-3_CanoR_1	607	613	PF00244	0.504
LIG_Actin_WH2_2	155	171	PF00022	0.545
LIG_Actin_WH2_2	386	402	PF00022	0.468
LIG_Actin_WH2_2	53	71	PF00022	0.435
LIG_BRCT_BRCA1_1	159	163	PF00533	0.561
LIG_Clathr_ClatBox_1	132	136	PF01394	0.561
LIG_DCNL_PONY_1	1	4	PF03556	0.629
LIG_eIF4E_1	308	314	PF01652	0.467
LIG_FHA_1	117	123	PF00498	0.490
LIG_FHA_1	26	32	PF00498	0.561
LIG_FHA_1	275	281	PF00498	0.520
LIG_FHA_1	308	314	PF00498	0.435
LIG_FHA_1	418	424	PF00498	0.669
LIG_FHA_1	454	460	PF00498	0.805
LIG_FHA_2	212	218	PF00498	0.561
LIG_FHA_2	500	506	PF00498	0.797
LIG_FHA_2	596	602	PF00498	0.508
LIG_LIR_Apic_2	236	241	PF02991	0.610
LIG_LIR_Apic_2	328	332	PF02991	0.441
LIG_LIR_Apic_2	347	352	PF02991	0.263
LIG_LIR_Apic_2	710	715	PF02991	0.466
LIG_LIR_Nem_3	160	166	PF02991	0.528
LIG_LIR_Nem_3	217	223	PF02991	0.546
LIG_LIR_Nem_3	83	87	PF02991	0.364
LIG_NRBOX	3	9	PF00104	0.721
LIG_PCNA_PIPBox_1	268	277	PF02747	0.488
LIG_PCNA_yPIPBox_3	356	370	PF02747	0.501
LIG_Pex14_2	159	163	PF04695	0.490
LIG_PTB_Apo_2	55	62	PF02174	0.534
LIG_REV1ctd_RIR_1	251	259	PF16727	0.620
LIG_SH2_CRK	329	333	PF00017	0.465
LIG_SH2_NCK_1	329	333	PF00017	0.446
LIG_SH2_SRC	329	332	PF00017	0.464
LIG_SH2_STAP1	637	641	PF00017	0.541
LIG_SH2_STAT3	223	226	PF00017	0.576
LIG_SH2_STAT3	308	311	PF00017	0.422
LIG_SH2_STAT5	165	168	PF00017	0.485
LIG_SH2_STAT5	308	311	PF00017	0.379
LIG_SH2_STAT5	422	425	PF00017	0.701
LIG_SH2_STAT5	596	599	PF00017	0.548
LIG_SH2_STAT5	695	698	PF00017	0.470
LIG_SH3_3	132	138	PF00018	0.490
LIG_SH3_3	240	246	PF00018	0.520
LIG_SH3_3	561	567	PF00018	0.707
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.531
LIG_SUMO_SIM_par_1	130	137	PF11976	0.490
LIG_SUMO_SIM_par_1	608	613	PF11976	0.537
LIG_TRAF2_1	448	451	PF00917	0.609
LIG_TRAF2_1	636	639	PF00917	0.602
LIG_TRAF2_1	643	646	PF00917	0.610
LIG_WRC_WIRS_1	198	203	PF05994	0.591
LIG_WRC_WIRS_1	346	351	PF05994	0.425
LIG_WW_1	566	569	PF00397	0.565
MOD_CDK_SPxxK_3	537	544	PF00069	0.698
MOD_CK1_1	184	190	PF00069	0.591
MOD_CK1_1	426	432	PF00069	0.733
MOD_CK1_1	503	509	PF00069	0.753
MOD_CK1_1	552	558	PF00069	0.699
MOD_CK1_1	608	614	PF00069	0.435
MOD_CK1_1	732	738	PF00069	0.623
MOD_CK1_1	756	762	PF00069	0.488
MOD_CK1_1	99	105	PF00069	0.487
MOD_CK2_1	80	86	PF00069	0.382
MOD_Cter_Amidation	486	489	PF01082	0.562
MOD_GlcNHglycan	182	186	PF01048	0.391
MOD_GlcNHglycan	20	23	PF01048	0.653
MOD_GlcNHglycan	285	288	PF01048	0.543
MOD_GlcNHglycan	378	381	PF01048	0.527
MOD_GlcNHglycan	383	386	PF01048	0.511
MOD_GlcNHglycan	631	634	PF01048	0.475
MOD_GlcNHglycan	681	684	PF01048	0.499
MOD_GlcNHglycan	755	758	PF01048	0.531
MOD_GSK3_1	113	120	PF00069	0.490
MOD_GSK3_1	18	25	PF00069	0.580
MOD_GSK3_1	180	187	PF00069	0.591
MOD_GSK3_1	207	214	PF00069	0.561
MOD_GSK3_1	313	320	PF00069	0.520
MOD_GSK3_1	451	458	PF00069	0.744
MOD_GSK3_1	499	506	PF00069	0.643
MOD_GSK3_1	550	557	PF00069	0.774
MOD_GSK3_1	717	724	PF00069	0.643
MOD_GSK3_1	95	102	PF00069	0.490
MOD_N-GLC_1	169	174	PF02516	0.363
MOD_N-GLC_1	292	297	PF02516	0.583
MOD_N-GLC_1	355	360	PF02516	0.490
MOD_N-GLC_1	376	381	PF02516	0.445
MOD_N-GLC_1	54	59	PF02516	0.502
MOD_NEK2_1	180	185	PF00069	0.591
MOD_NEK2_1	2	7	PF00069	0.680
MOD_NEK2_1	283	288	PF00069	0.498
MOD_NEK2_1	423	428	PF00069	0.773
MOD_NEK2_1	679	684	PF00069	0.527
MOD_NEK2_1	729	734	PF00069	0.622
MOD_PIKK_1	307	313	PF00454	0.462
MOD_PIKK_1	500	506	PF00454	0.709
MOD_PK_1	701	707	PF00069	0.579
MOD_PKA_1	381	387	PF00069	0.595
MOD_PKA_2	12	18	PF00069	0.561
MOD_PKA_2	381	387	PF00069	0.595
MOD_PKA_2	446	452	PF00069	0.789
MOD_PKA_2	499	505	PF00069	0.698
MOD_PKA_2	677	683	PF00069	0.576
MOD_PKA_2	764	770	PF00069	0.489
MOD_Plk_1	317	323	PF00069	0.509
MOD_Plk_1	355	361	PF00069	0.570
MOD_Plk_1	701	707	PF00069	0.579
MOD_Plk_4	197	203	PF00069	0.591
MOD_Plk_4	2	8	PF00069	0.720
MOD_Plk_4	345	351	PF00069	0.426
MOD_Plk_4	418	424	PF00069	0.741
MOD_Plk_4	600	606	PF00069	0.396
MOD_Plk_4	96	102	PF00069	0.490
MOD_ProDKin_1	134	140	PF00069	0.490
MOD_ProDKin_1	184	190	PF00069	0.561
MOD_ProDKin_1	22	28	PF00069	0.586
MOD_ProDKin_1	537	543	PF00069	0.747
MOD_ProDKin_1	554	560	PF00069	0.554
MOD_SUMO_rev_2	364	371	PF00179	0.511
TRG_DiLeu_BaEn_2	269	275	PF01217	0.546
TRG_DiLeu_BaEn_3	196	202	PF01217	0.490
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.531
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.659
TRG_ENDOCYTIC_2	16	19	PF00928	0.667
TRG_ENDOCYTIC_2	165	168	PF00928	0.490
TRG_ENDOCYTIC_2	178	181	PF00928	0.490
TRG_ENDOCYTIC_2	637	640	PF00928	0.511
TRG_ER_diArg_1	143	146	PF00400	0.531
TRG_ER_diArg_1	241	244	PF00400	0.730
TRG_ER_diArg_1	381	383	PF00400	0.599
TRG_ER_diArg_1	488	490	PF00400	0.583
TRG_ER_diArg_1	491	494	PF00400	0.579
TRG_ER_diArg_1	676	679	PF00400	0.636
TRG_NES_CRM1_1	341	353	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF47	Leptomonas seymouri	60%	99%
A0A1X0NRQ7	Trypanosomatidae	41%	100%
A0A3R7LAS2	Trypanosoma rangeli	41%	100%
A0A3S7X600	Leishmania donovani	100%	100%
A4HKU7	Leishmania braziliensis	79%	98%
E9B385	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4X0	Leishmania major	91%	100%
V5BVC8	Trypanosoma cruzi	42%	100%