LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
leucine-rich repeat protein - putative
Species:
Leishmania infantum
UniProt:
A4I8C5_LEIIN
TriTrypDb:
LINF_320037600
Length:
875

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12

Phosphorylation

Amastigote: 690

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8C5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8C5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 570 574 PF00656 0.366
CLV_NRD_NRD_1 24 26 PF00675 0.453
CLV_NRD_NRD_1 579 581 PF00675 0.403
CLV_NRD_NRD_1 677 679 PF00675 0.400
CLV_NRD_NRD_1 7 9 PF00675 0.650
CLV_PCSK_KEX2_1 677 679 PF00082 0.419
CLV_PCSK_KEX2_1 681 683 PF00082 0.523
CLV_PCSK_KEX2_1 7 9 PF00082 0.649
CLV_PCSK_KEX2_1 727 729 PF00082 0.603
CLV_PCSK_KEX2_1 81 83 PF00082 0.556
CLV_PCSK_PC1ET2_1 681 683 PF00082 0.579
CLV_PCSK_PC1ET2_1 727 729 PF00082 0.607
CLV_PCSK_PC1ET2_1 81 83 PF00082 0.482
CLV_PCSK_PC7_1 677 683 PF00082 0.514
CLV_PCSK_SKI1_1 32 36 PF00082 0.443
CLV_PCSK_SKI1_1 531 535 PF00082 0.493
CLV_PCSK_SKI1_1 546 550 PF00082 0.400
CLV_PCSK_SKI1_1 628 632 PF00082 0.429
CLV_PCSK_SKI1_1 722 726 PF00082 0.453
CLV_PCSK_SKI1_1 801 805 PF00082 0.511
DEG_APCC_DBOX_1 24 32 PF00400 0.571
DEG_SCF_FBW7_1 805 812 PF00400 0.565
DOC_ANK_TNKS_1 340 347 PF00023 0.313
DOC_CDC14_PxL_1 124 132 PF14671 0.313
DOC_CDC14_PxL_1 143 151 PF14671 0.331
DOC_CKS1_1 438 443 PF01111 0.388
DOC_CYCLIN_RxL_1 749 759 PF00134 0.456
DOC_CYCLIN_yCln2_LP_2 631 637 PF00134 0.414
DOC_MAPK_gen_1 25 36 PF00069 0.474
DOC_MAPK_MEF2A_6 59 68 PF00069 0.426
DOC_MAPK_RevD_3 714 728 PF00069 0.371
DOC_PP2B_LxvP_1 331 334 PF13499 0.301
DOC_USP7_MATH_1 117 121 PF00917 0.358
DOC_USP7_MATH_1 393 397 PF00917 0.569
DOC_USP7_MATH_1 555 559 PF00917 0.550
DOC_USP7_MATH_1 638 642 PF00917 0.446
DOC_USP7_MATH_1 809 813 PF00917 0.593
DOC_USP7_UBL2_3 198 202 PF12436 0.497
DOC_USP7_UBL2_3 581 585 PF12436 0.562
DOC_USP7_UBL2_3 598 602 PF12436 0.524
DOC_WW_Pin1_4 389 394 PF00397 0.474
DOC_WW_Pin1_4 406 411 PF00397 0.340
DOC_WW_Pin1_4 437 442 PF00397 0.347
DOC_WW_Pin1_4 483 488 PF00397 0.436
DOC_WW_Pin1_4 516 521 PF00397 0.376
DOC_WW_Pin1_4 539 544 PF00397 0.533
DOC_WW_Pin1_4 586 591 PF00397 0.518
DOC_WW_Pin1_4 612 617 PF00397 0.353
DOC_WW_Pin1_4 687 692 PF00397 0.574
DOC_WW_Pin1_4 709 714 PF00397 0.370
DOC_WW_Pin1_4 80 85 PF00397 0.426
DOC_WW_Pin1_4 805 810 PF00397 0.404
LIG_14-3-3_CanoR_1 131 136 PF00244 0.313
LIG_14-3-3_CanoR_1 387 393 PF00244 0.391
LIG_Actin_WH2_2 66 83 PF00022 0.447
LIG_AP2alpha_2 498 500 PF02296 0.418
LIG_BIR_II_1 1 5 PF00653 0.679
LIG_BRCT_BRCA1_1 133 137 PF00533 0.313
LIG_BRCT_BRCA1_1 298 302 PF00533 0.380
LIG_Clathr_ClatBox_1 180 184 PF01394 0.372
LIG_Clathr_ClatBox_1 51 55 PF01394 0.479
LIG_Clathr_ClatBox_1 63 67 PF01394 0.451
LIG_FHA_1 108 114 PF00498 0.322
LIG_FHA_1 152 158 PF00498 0.303
LIG_FHA_1 276 282 PF00498 0.471
LIG_FHA_1 309 315 PF00498 0.338
LIG_FHA_1 328 334 PF00498 0.165
LIG_FHA_1 410 416 PF00498 0.378
LIG_FHA_1 533 539 PF00498 0.433
LIG_FHA_1 545 551 PF00498 0.414
LIG_FHA_1 595 601 PF00498 0.439
LIG_FHA_1 654 660 PF00498 0.508
LIG_FHA_1 718 724 PF00498 0.507
LIG_FHA_1 72 78 PF00498 0.464
LIG_FHA_1 81 87 PF00498 0.361
LIG_FHA_1 819 825 PF00498 0.534
LIG_FHA_2 139 145 PF00498 0.433
LIG_FHA_2 409 415 PF00498 0.402
LIG_FHA_2 504 510 PF00498 0.433
LIG_FHA_2 697 703 PF00498 0.420
LIG_FHA_2 762 768 PF00498 0.501
LIG_FHA_2 795 801 PF00498 0.578
LIG_FHA_2 857 863 PF00498 0.750
LIG_Integrin_isoDGR_2 5 7 PF01839 0.680
LIG_LIR_Apic_2 284 289 PF02991 0.399
LIG_LIR_Gen_1 103 113 PF02991 0.392
LIG_LIR_Gen_1 134 143 PF02991 0.313
LIG_LIR_Gen_1 235 246 PF02991 0.503
LIG_LIR_Gen_1 394 403 PF02991 0.481
LIG_LIR_Gen_1 40 51 PF02991 0.351
LIG_LIR_Gen_1 430 441 PF02991 0.375
LIG_LIR_Gen_1 573 582 PF02991 0.414
LIG_LIR_Gen_1 779 789 PF02991 0.442
LIG_LIR_Nem_3 103 108 PF02991 0.408
LIG_LIR_Nem_3 119 124 PF02991 0.368
LIG_LIR_Nem_3 134 140 PF02991 0.287
LIG_LIR_Nem_3 141 146 PF02991 0.313
LIG_LIR_Nem_3 235 241 PF02991 0.518
LIG_LIR_Nem_3 285 291 PF02991 0.379
LIG_LIR_Nem_3 337 343 PF02991 0.329
LIG_LIR_Nem_3 394 400 PF02991 0.474
LIG_LIR_Nem_3 40 46 PF02991 0.359
LIG_LIR_Nem_3 430 436 PF02991 0.380
LIG_LIR_Nem_3 469 474 PF02991 0.476
LIG_LIR_Nem_3 479 485 PF02991 0.353
LIG_LIR_Nem_3 498 503 PF02991 0.259
LIG_LIR_Nem_3 517 521 PF02991 0.362
LIG_LIR_Nem_3 573 579 PF02991 0.398
LIG_LIR_Nem_3 587 591 PF02991 0.438
LIG_LIR_Nem_3 779 785 PF02991 0.445
LIG_LIR_Nem_3 806 810 PF02991 0.408
LIG_LYPXL_S_1 287 291 PF13949 0.433
LIG_LYPXL_yS_3 146 149 PF13949 0.348
LIG_LYPXL_yS_3 288 291 PF13949 0.433
LIG_PDZ_Class_2 870 875 PF00595 0.579
LIG_PTB_Apo_2 425 432 PF02174 0.480
LIG_RPA_C_Fungi 228 240 PF08784 0.460
LIG_SH2_CRK 340 344 PF00017 0.313
LIG_SH2_CRK 43 47 PF00017 0.477
LIG_SH2_CRK 588 592 PF00017 0.544
LIG_SH2_CRK 807 811 PF00017 0.411
LIG_SH2_GRB2like 426 429 PF00017 0.486
LIG_SH2_NCK_1 397 401 PF00017 0.444
LIG_SH2_NCK_1 588 592 PF00017 0.503
LIG_SH2_NCK_1 614 618 PF00017 0.392
LIG_SH2_SRC 286 289 PF00017 0.432
LIG_SH2_SRC 332 335 PF00017 0.318
LIG_SH2_SRC 426 429 PF00017 0.417
LIG_SH2_STAP1 338 342 PF00017 0.329
LIG_SH2_STAP1 39 43 PF00017 0.423
LIG_SH2_STAT5 238 241 PF00017 0.461
LIG_SH2_STAT5 286 289 PF00017 0.392
LIG_SH2_STAT5 326 329 PF00017 0.309
LIG_SH2_STAT5 332 335 PF00017 0.301
LIG_SH2_STAT5 342 345 PF00017 0.257
LIG_SH2_STAT5 408 411 PF00017 0.406
LIG_SH2_STAT5 426 429 PF00017 0.311
LIG_SH2_STAT5 435 438 PF00017 0.331
LIG_SH2_STAT5 45 48 PF00017 0.366
LIG_SH2_STAT5 470 473 PF00017 0.405
LIG_SH2_STAT5 588 591 PF00017 0.425
LIG_SH2_STAT5 599 602 PF00017 0.407
LIG_SH2_STAT5 609 612 PF00017 0.394
LIG_SH2_STAT5 614 617 PF00017 0.389
LIG_SH2_STAT5 663 666 PF00017 0.410
LIG_SH2_STAT5 760 763 PF00017 0.407
LIG_SH2_STAT5 792 795 PF00017 0.413
LIG_SH2_STAT5 807 810 PF00017 0.393
LIG_SH3_3 144 150 PF00018 0.328
LIG_SH3_3 155 161 PF00018 0.203
LIG_SH3_3 438 444 PF00018 0.398
LIG_SH3_3 493 499 PF00018 0.537
LIG_SH3_3 597 603 PF00018 0.573
LIG_SH3_3 731 737 PF00018 0.468
LIG_SH3_3 742 748 PF00018 0.363
LIG_SH3_3 771 777 PF00018 0.492
LIG_SH3_5 334 338 PF00018 0.348
LIG_SUMO_SIM_anti_2 61 67 PF11976 0.428
LIG_SUMO_SIM_anti_2 643 650 PF11976 0.533
LIG_SUMO_SIM_par_1 179 184 PF11976 0.414
LIG_SUMO_SIM_par_1 260 265 PF11976 0.509
LIG_SUMO_SIM_par_1 311 317 PF11976 0.329
LIG_SUMO_SIM_par_1 61 67 PF11976 0.365
LIG_SUMO_SIM_par_1 655 660 PF11976 0.387
LIG_TRAF2_1 375 378 PF00917 0.637
LIG_TRAF2_1 860 863 PF00917 0.723
LIG_TYR_ITAM 573 591 PF00017 0.378
LIG_TYR_ITIM 805 810 PF00017 0.404
LIG_WRC_WIRS_1 118 123 PF05994 0.365
LIG_WRC_WIRS_1 140 145 PF05994 0.289
LIG_WRC_WIRS_1 51 56 PF05994 0.434
MOD_CDK_SPxK_1 437 443 PF00069 0.480
MOD_CDK_SPxK_1 516 522 PF00069 0.378
MOD_CDK_SPxK_1 709 715 PF00069 0.374
MOD_CDK_SPxK_1 805 811 PF00069 0.407
MOD_CDK_SPxxK_3 539 546 PF00069 0.485
MOD_CK1_1 142 148 PF00069 0.370
MOD_CK1_1 355 361 PF00069 0.433
MOD_CK1_1 391 397 PF00069 0.527
MOD_CK1_1 439 445 PF00069 0.529
MOD_CK1_1 532 538 PF00069 0.431
MOD_CK1_1 643 649 PF00069 0.444
MOD_CK1_1 683 689 PF00069 0.584
MOD_CK1_1 849 855 PF00069 0.747
MOD_CK1_1 857 863 PF00069 0.606
MOD_CK1_1 864 870 PF00069 0.708
MOD_CK2_1 138 144 PF00069 0.348
MOD_CK2_1 27 33 PF00069 0.437
MOD_CK2_1 485 491 PF00069 0.559
MOD_CK2_1 66 72 PF00069 0.360
MOD_CK2_1 761 767 PF00069 0.574
MOD_CK2_1 856 862 PF00069 0.720
MOD_CK2_1 866 872 PF00069 0.650
MOD_Cter_Amidation 5 8 PF01082 0.679
MOD_GlcNHglycan 18 21 PF01048 0.501
MOD_GlcNHglycan 294 297 PF01048 0.348
MOD_GlcNHglycan 393 396 PF01048 0.574
MOD_GlcNHglycan 487 490 PF01048 0.537
MOD_GlcNHglycan 591 594 PF01048 0.570
MOD_GlcNHglycan 667 670 PF01048 0.514
MOD_GlcNHglycan 830 835 PF01048 0.725
MOD_GSK3_1 107 114 PF00069 0.361
MOD_GSK3_1 138 145 PF00069 0.421
MOD_GSK3_1 292 299 PF00069 0.375
MOD_GSK3_1 308 315 PF00069 0.299
MOD_GSK3_1 348 355 PF00069 0.433
MOD_GSK3_1 389 396 PF00069 0.439
MOD_GSK3_1 402 409 PF00069 0.405
MOD_GSK3_1 661 668 PF00069 0.588
MOD_GSK3_1 683 690 PF00069 0.497
MOD_GSK3_1 703 710 PF00069 0.198
MOD_GSK3_1 761 768 PF00069 0.498
MOD_GSK3_1 790 797 PF00069 0.501
MOD_GSK3_1 805 812 PF00069 0.449
MOD_GSK3_1 842 849 PF00069 0.688
MOD_GSK3_1 850 857 PF00069 0.662
MOD_GSK3_1 858 865 PF00069 0.550
MOD_N-GLC_1 138 143 PF02516 0.348
MOD_N-GLC_1 308 313 PF02516 0.316
MOD_N-GLC_1 476 481 PF02516 0.503
MOD_N-GLC_1 594 599 PF02516 0.439
MOD_N-GLC_2 416 418 PF02516 0.447
MOD_NEK2_1 282 287 PF00069 0.483
MOD_NEK2_1 327 332 PF00069 0.329
MOD_NEK2_1 436 441 PF00069 0.363
MOD_NEK2_1 452 457 PF00069 0.416
MOD_NEK2_1 66 71 PF00069 0.334
MOD_NEK2_1 803 808 PF00069 0.468
MOD_NEK2_1 848 853 PF00069 0.683
MOD_NEK2_1 866 871 PF00069 0.605
MOD_NEK2_1 89 94 PF00069 0.363
MOD_PIKK_1 555 561 PF00454 0.526
MOD_PIKK_1 851 857 PF00454 0.734
MOD_PKA_1 680 686 PF00069 0.514
MOD_PKA_2 276 282 PF00069 0.475
MOD_Plk_1 138 144 PF00069 0.348
MOD_Plk_1 32 38 PF00069 0.438
MOD_Plk_1 402 408 PF00069 0.429
MOD_Plk_1 429 435 PF00069 0.492
MOD_Plk_1 476 482 PF00069 0.462
MOD_Plk_1 66 72 PF00069 0.350
MOD_Plk_1 707 713 PF00069 0.429
MOD_Plk_1 861 867 PF00069 0.697
MOD_Plk_2-3 209 215 PF00069 0.481
MOD_Plk_2-3 312 318 PF00069 0.433
MOD_Plk_2-3 50 56 PF00069 0.477
MOD_Plk_4 282 288 PF00069 0.473
MOD_Plk_4 327 333 PF00069 0.317
MOD_Plk_4 379 385 PF00069 0.466
MOD_Plk_4 476 482 PF00069 0.467
MOD_Plk_4 571 577 PF00069 0.398
MOD_Plk_4 643 649 PF00069 0.529
MOD_Plk_4 765 771 PF00069 0.580
MOD_ProDKin_1 389 395 PF00069 0.481
MOD_ProDKin_1 406 412 PF00069 0.342
MOD_ProDKin_1 437 443 PF00069 0.355
MOD_ProDKin_1 483 489 PF00069 0.439
MOD_ProDKin_1 516 522 PF00069 0.378
MOD_ProDKin_1 539 545 PF00069 0.527
MOD_ProDKin_1 586 592 PF00069 0.523
MOD_ProDKin_1 612 618 PF00069 0.355
MOD_ProDKin_1 687 693 PF00069 0.571
MOD_ProDKin_1 709 715 PF00069 0.374
MOD_ProDKin_1 80 86 PF00069 0.417
MOD_ProDKin_1 805 811 PF00069 0.407
MOD_SUMO_for_1 58 61 PF00179 0.521
MOD_SUMO_for_1 601 604 PF00179 0.460
MOD_SUMO_for_1 770 773 PF00179 0.476
MOD_SUMO_rev_2 524 533 PF00179 0.451
MOD_SUMO_rev_2 53 60 PF00179 0.510
MOD_SUMO_rev_2 733 742 PF00179 0.496
TRG_DiLeu_BaEn_3 251 257 PF01217 0.533
TRG_ENDOCYTIC_2 146 149 PF00928 0.329
TRG_ENDOCYTIC_2 168 171 PF00928 0.368
TRG_ENDOCYTIC_2 238 241 PF00928 0.461
TRG_ENDOCYTIC_2 288 291 PF00928 0.398
TRG_ENDOCYTIC_2 340 343 PF00928 0.319
TRG_ENDOCYTIC_2 397 400 PF00928 0.443
TRG_ENDOCYTIC_2 43 46 PF00928 0.350
TRG_ENDOCYTIC_2 435 438 PF00928 0.349
TRG_ENDOCYTIC_2 576 579 PF00928 0.387
TRG_ENDOCYTIC_2 588 591 PF00928 0.405
TRG_ENDOCYTIC_2 609 612 PF00928 0.424
TRG_ENDOCYTIC_2 807 810 PF00928 0.407
TRG_ER_diArg_1 676 678 PF00400 0.390
TRG_NES_CRM1_1 50 61 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.313

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IME5 Leptomonas seymouri 79% 90%
A0A0S4II95 Bodo saltans 53% 100%
A0A1X0NRQ9 Trypanosomatidae 61% 90%
A0A3Q8IDD1 Leishmania donovani 100% 100%
A0A422NYS0 Trypanosoma rangeli 61% 95%
A4HKU6 Leishmania braziliensis 83% 100%
D0AAU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 90%
E9B384 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q4X1 Leishmania major 96% 100%
V5BQQ6 Trypanosoma cruzi 62% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS