ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8C2_LEIIN

TriTrypDb:

LINF_320037100

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.485
CLV_C14_Caspase3-7	177	181	PF00656	0.388
CLV_C14_Caspase3-7	286	290	PF00656	0.454
CLV_C14_Caspase3-7	431	435	PF00656	0.433
CLV_C14_Caspase3-7	463	467	PF00656	0.399
CLV_C14_Caspase3-7	73	77	PF00656	0.406
CLV_NRD_NRD_1	350	352	PF00675	0.346
CLV_NRD_NRD_1	375	377	PF00675	0.555
CLV_NRD_NRD_1	487	489	PF00675	0.487
CLV_NRD_NRD_1	682	684	PF00675	0.538
CLV_PCSK_KEX2_1	350	352	PF00082	0.346
CLV_PCSK_KEX2_1	375	377	PF00082	0.453
CLV_PCSK_KEX2_1	684	686	PF00082	0.553
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.548
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	214	218	PF00082	0.543
CLV_PCSK_SKI1_1	219	223	PF00082	0.572
CLV_PCSK_SKI1_1	350	354	PF00082	0.470
CLV_PCSK_SKI1_1	369	373	PF00082	0.238
CLV_PCSK_SKI1_1	436	440	PF00082	0.311
CLV_PCSK_SKI1_1	488	492	PF00082	0.451
CLV_PCSK_SKI1_1	678	682	PF00082	0.576
CLV_Separin_Metazoa	294	298	PF03568	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DEG_ODPH_VHL_1	206	217	PF01847	0.451
DEG_ODPH_VHL_1	394	407	PF01847	0.511
DEG_SPOP_SBC_1	653	657	PF00917	0.645
DOC_CKS1_1	352	357	PF01111	0.464
DOC_CKS1_1	615	620	PF01111	0.490
DOC_CYCLIN_RxL_1	132	142	PF00134	0.447
DOC_CYCLIN_RxL_1	675	682	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.402
DOC_MAPK_gen_1	687	695	PF00069	0.593
DOC_MAPK_MEF2A_6	245	252	PF00069	0.367
DOC_MAPK_MEF2A_6	273	280	PF00069	0.446
DOC_MAPK_MEF2A_6	44	53	PF00069	0.518
DOC_MAPK_MEF2A_6	445	454	PF00069	0.373
DOC_PP1_RVXF_1	434	441	PF00149	0.310
DOC_PP1_RVXF_1	475	481	PF00149	0.474
DOC_PP1_RVXF_1	572	579	PF00149	0.355
DOC_PP1_SILK_1	91	96	PF00149	0.441
DOC_PP2B_LxvP_1	205	208	PF13499	0.341
DOC_PP2B_LxvP_1	448	451	PF13499	0.375
DOC_PP4_FxxP_1	198	201	PF00568	0.493
DOC_PP4_FxxP_1	352	355	PF00568	0.466
DOC_PP4_FxxP_1	444	447	PF00568	0.419
DOC_PP4_FxxP_1	558	561	PF00568	0.550
DOC_PP4_FxxP_1	742	745	PF00568	0.452
DOC_SPAK_OSR1_1	417	421	PF12202	0.507
DOC_SPAK_OSR1_1	62	66	PF12202	0.418
DOC_USP7_MATH_1	192	196	PF00917	0.565
DOC_USP7_MATH_1	209	213	PF00917	0.373
DOC_USP7_MATH_1	301	305	PF00917	0.433
DOC_USP7_MATH_1	363	367	PF00917	0.433
DOC_USP7_MATH_1	460	464	PF00917	0.411
DOC_USP7_MATH_1	482	486	PF00917	0.604
DOC_USP7_MATH_1	611	615	PF00917	0.496
DOC_USP7_MATH_1	710	714	PF00917	0.521
DOC_USP7_UBL2_3	4	8	PF12436	0.489
DOC_WW_Pin1_4	197	202	PF00397	0.477
DOC_WW_Pin1_4	351	356	PF00397	0.482
DOC_WW_Pin1_4	483	488	PF00397	0.523
DOC_WW_Pin1_4	512	517	PF00397	0.462
DOC_WW_Pin1_4	614	619	PF00397	0.502
LIG_14-3-3_CanoR_1	138	142	PF00244	0.568
LIG_14-3-3_CanoR_1	231	238	PF00244	0.591
LIG_14-3-3_CanoR_1	25	32	PF00244	0.584
LIG_14-3-3_CanoR_1	383	389	PF00244	0.468
LIG_14-3-3_CanoR_1	412	417	PF00244	0.345
LIG_Actin_WH2_2	122	140	PF00022	0.561
LIG_Actin_WH2_2	198	216	PF00022	0.442
LIG_APCC_ABBA_1	604	609	PF00400	0.471
LIG_BIR_III_4	191	195	PF00653	0.488
LIG_BRCT_BRCA1_1	110	114	PF00533	0.370
LIG_BRCT_BRCA1_1	127	131	PF00533	0.286
LIG_BRCT_BRCA1_1	194	198	PF00533	0.511
LIG_BRCT_BRCA1_1	414	418	PF00533	0.333
LIG_BRCT_BRCA1_1	697	701	PF00533	0.552
LIG_BRCT_BRCA1_1	77	81	PF00533	0.421
LIG_CtBP_PxDLS_1	583	587	PF00389	0.445
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.531
LIG_DLG_GKlike_1	318	325	PF00625	0.385
LIG_Dynein_DLC8_1	381	387	PF01221	0.355
LIG_EH1_1	80	88	PF00400	0.400
LIG_eIF4E_1	675	681	PF01652	0.584
LIG_FHA_1	29	35	PF00498	0.491
LIG_FHA_1	383	389	PF00498	0.417
LIG_FHA_1	402	408	PF00498	0.216
LIG_FHA_1	427	433	PF00498	0.446
LIG_FHA_1	45	51	PF00498	0.327
LIG_FHA_1	473	479	PF00498	0.495
LIG_FHA_2	429	435	PF00498	0.361
LIG_FHA_2	706	712	PF00498	0.501
LIG_HP1_1	201	205	PF01393	0.411
LIG_Integrin_RGD_1	266	268	PF01839	0.344
LIG_LIR_Apic_2	195	201	PF02991	0.467
LIG_LIR_Apic_2	741	745	PF02991	0.488
LIG_LIR_Gen_1	111	121	PF02991	0.543
LIG_LIR_Gen_1	379	388	PF02991	0.383
LIG_LIR_Gen_1	564	572	PF02991	0.437
LIG_LIR_Gen_1	9	16	PF02991	0.405
LIG_LIR_Nem_3	111	117	PF02991	0.442
LIG_LIR_Nem_3	254	259	PF02991	0.529
LIG_LIR_Nem_3	319	325	PF02991	0.613
LIG_LIR_Nem_3	354	359	PF02991	0.425
LIG_LIR_Nem_3	379	384	PF02991	0.366
LIG_LIR_Nem_3	564	569	PF02991	0.496
LIG_LIR_Nem_3	585	591	PF02991	0.380
LIG_LIR_Nem_3	748	753	PF02991	0.457
LIG_LIR_Nem_3	9	13	PF02991	0.408
LIG_LYPXL_yS_3	588	591	PF13949	0.379
LIG_NRBOX	81	87	PF00104	0.421
LIG_PDZ_Class_2	754	759	PF00595	0.431
LIG_Pex14_1	440	444	PF04695	0.429
LIG_REV1ctd_RIR_1	129	139	PF16727	0.414
LIG_SH2_CRK	364	368	PF00017	0.391
LIG_SH2_CRK	381	385	PF00017	0.287
LIG_SH2_NCK_1	539	543	PF00017	0.549
LIG_SH2_NCK_1	97	101	PF00017	0.391
LIG_SH2_PTP2	10	13	PF00017	0.445
LIG_SH2_STAP1	153	157	PF00017	0.428
LIG_SH2_STAP1	225	229	PF00017	0.505
LIG_SH2_STAT5	10	13	PF00017	0.445
LIG_SH2_STAT5	364	367	PF00017	0.382
LIG_SH2_STAT5	511	514	PF00017	0.466
LIG_SH2_STAT5	566	569	PF00017	0.396
LIG_SH2_STAT5	672	675	PF00017	0.585
LIG_SH2_STAT5	753	756	PF00017	0.357
LIG_SH3_3	205	211	PF00018	0.433
LIG_SH3_3	352	358	PF00018	0.530
LIG_SH3_3	390	396	PF00018	0.442
LIG_SH3_3	516	522	PF00018	0.511
LIG_SH3_3	612	618	PF00018	0.463
LIG_SH3_3	658	664	PF00018	0.586
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.351
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.442
LIG_SUMO_SIM_par_1	27	36	PF11976	0.520
LIG_SUMO_SIM_par_1	298	304	PF11976	0.426
LIG_SUMO_SIM_par_1	403	408	PF11976	0.436
LIG_SUMO_SIM_par_1	428	434	PF11976	0.455
LIG_TRAF2_1	290	293	PF00917	0.476
LIG_TRAF2_1	714	717	PF00917	0.515
LIG_TRFH_1	558	562	PF08558	0.496
LIG_TYR_ITIM	586	591	PF00017	0.383
LIG_UBA3_1	721	729	PF00899	0.527
MOD_CDK_SPK_2	483	488	PF00069	0.523
MOD_CDK_SPxK_1	483	489	PF00069	0.517
MOD_CDK_SPxxK_3	354	361	PF00069	0.495
MOD_CK1_1	197	203	PF00069	0.383
MOD_CK1_1	224	230	PF00069	0.412
MOD_CK1_1	357	363	PF00069	0.460
MOD_CK1_1	514	520	PF00069	0.425
MOD_CK1_1	614	620	PF00069	0.501
MOD_CK1_1	656	662	PF00069	0.545
MOD_CK1_1	75	81	PF00069	0.438
MOD_CK2_1	231	237	PF00069	0.467
MOD_CK2_1	287	293	PF00069	0.477
MOD_CK2_1	705	711	PF00069	0.450
MOD_CK2_1	738	744	PF00069	0.545
MOD_CK2_1	9	15	PF00069	0.484
MOD_Cter_Amidation	735	738	PF01082	0.536
MOD_GlcNHglycan	194	197	PF01048	0.580
MOD_GlcNHglycan	289	292	PF01048	0.387
MOD_GlcNHglycan	334	337	PF01048	0.531
MOD_GlcNHglycan	5	8	PF01048	0.548
MOD_GlcNHglycan	516	519	PF01048	0.424
MOD_GlcNHglycan	56	59	PF01048	0.489
MOD_GlcNHglycan	563	566	PF01048	0.609
MOD_GlcNHglycan	625	628	PF01048	0.527
MOD_GlcNHglycan	656	659	PF01048	0.601
MOD_GlcNHglycan	711	715	PF01048	0.533
MOD_GSK3_1	108	115	PF00069	0.453
MOD_GSK3_1	11	18	PF00069	0.379
MOD_GSK3_1	116	123	PF00069	0.383
MOD_GSK3_1	133	140	PF00069	0.421
MOD_GSK3_1	20	27	PF00069	0.551
MOD_GSK3_1	401	408	PF00069	0.473
MOD_GSK3_1	426	433	PF00069	0.405
MOD_GSK3_1	52	59	PF00069	0.572
MOD_GSK3_1	526	533	PF00069	0.562
MOD_GSK3_1	607	614	PF00069	0.511
MOD_GSK3_1	623	630	PF00069	0.337
MOD_GSK3_1	652	659	PF00069	0.550
MOD_GSK3_1	701	708	PF00069	0.566
MOD_N-GLC_2	471	473	PF02516	0.457
MOD_N-GLC_2	54	56	PF02516	0.469
MOD_N-GLC_2	603	605	PF02516	0.461
MOD_NEK2_1	106	111	PF00069	0.447
MOD_NEK2_1	137	142	PF00069	0.431
MOD_NEK2_1	156	161	PF00069	0.536
MOD_NEK2_1	20	25	PF00069	0.499
MOD_NEK2_1	251	256	PF00069	0.431
MOD_NEK2_1	3	8	PF00069	0.560
MOD_NEK2_1	384	389	PF00069	0.362
MOD_NEK2_1	472	477	PF00069	0.365
MOD_NEK2_1	52	57	PF00069	0.433
MOD_NEK2_1	584	589	PF00069	0.435
MOD_NEK2_1	597	602	PF00069	0.404
MOD_NEK2_1	623	628	PF00069	0.516
MOD_NEK2_1	654	659	PF00069	0.569
MOD_NEK2_1	701	706	PF00069	0.537
MOD_NEK2_1	721	726	PF00069	0.289
MOD_NEK2_1	81	86	PF00069	0.326
MOD_OFUCOSY	298	305	PF10250	0.426
MOD_OFUCOSY	72	79	PF10250	0.391
MOD_PIKK_1	382	388	PF00454	0.488
MOD_PKA_2	137	143	PF00069	0.567
MOD_PKA_2	24	30	PF00069	0.593
MOD_PKA_2	382	388	PF00069	0.527
MOD_Plk_1	112	118	PF00069	0.470
MOD_Plk_1	133	139	PF00069	0.383
MOD_Plk_1	405	411	PF00069	0.392
MOD_Plk_1	584	590	PF00069	0.446
MOD_Plk_1	710	716	PF00069	0.495
MOD_Plk_2-3	28	34	PF00069	0.473
MOD_Plk_2-3	428	434	PF00069	0.456
MOD_Plk_2-3	9	15	PF00069	0.432
MOD_Plk_4	15	21	PF00069	0.546
MOD_Plk_4	194	200	PF00069	0.507
MOD_Plk_4	252	258	PF00069	0.371
MOD_Plk_4	318	324	PF00069	0.544
MOD_Plk_4	405	411	PF00069	0.374
MOD_Plk_4	460	466	PF00069	0.367
MOD_Plk_4	592	598	PF00069	0.421
MOD_Plk_4	611	617	PF00069	0.339
MOD_Plk_4	628	634	PF00069	0.249
MOD_Plk_4	657	663	PF00069	0.511
MOD_Plk_4	81	87	PF00069	0.320
MOD_Plk_4	89	95	PF00069	0.326
MOD_ProDKin_1	197	203	PF00069	0.471
MOD_ProDKin_1	351	357	PF00069	0.477
MOD_ProDKin_1	483	489	PF00069	0.517
MOD_ProDKin_1	512	518	PF00069	0.463
MOD_ProDKin_1	614	620	PF00069	0.500
MOD_SUMO_rev_2	428	438	PF00179	0.333
MOD_SUMO_rev_2	698	704	PF00179	0.459
TRG_DiLeu_BaEn_1	717	722	PF01217	0.506
TRG_DiLeu_BaEn_2	47	53	PF01217	0.372
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.396
TRG_ENDOCYTIC_2	10	13	PF00928	0.390
TRG_ENDOCYTIC_2	153	156	PF00928	0.516
TRG_ENDOCYTIC_2	256	259	PF00928	0.511
TRG_ENDOCYTIC_2	322	325	PF00928	0.569
TRG_ENDOCYTIC_2	356	359	PF00928	0.470
TRG_ENDOCYTIC_2	364	367	PF00928	0.379
TRG_ENDOCYTIC_2	381	384	PF00928	0.292
TRG_ENDOCYTIC_2	566	569	PF00928	0.432
TRG_ENDOCYTIC_2	588	591	PF00928	0.394
TRG_ENDOCYTIC_2	97	100	PF00928	0.564
TRG_ER_diArg_1	349	351	PF00400	0.337
TRG_ER_diArg_1	683	686	PF00400	0.557
TRG_NES_CRM1_1	104	120	PF08389	0.445
TRG_NLS_MonoExtC_3	682	687	PF00514	0.571
TRG_NLS_MonoExtN_4	683	688	PF00514	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N0	Leptomonas seymouri	54%	89%
A0A1X0NTF1	Trypanosomatidae	30%	88%
A0A3Q8ILH1	Leishmania donovani	100%	100%
A0A422NYN9	Trypanosoma rangeli	30%	88%
A4HKU3	Leishmania braziliensis	84%	100%
D0AAV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
E9B381	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4X4	Leishmania major	95%	100%