Secreted protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania infantum

UniProt:

A4I8C1_LEIIN

TriTrypDb:

LINF_320037050

Length:

198

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	57	59	PF00675	0.409
CLV_NRD_NRD_1	79	81	PF00675	0.410
CLV_PCSK_KEX2_1	57	59	PF00082	0.534
CLV_PCSK_PC7_1	53	59	PF00082	0.289
CLV_PCSK_SKI1_1	38	42	PF00082	0.434
CLV_PCSK_SKI1_1	69	73	PF00082	0.531
DEG_Nend_UBRbox_3	1	3	PF02207	0.490
DOC_CDC14_PxL_1	156	164	PF14671	0.369
DOC_MAPK_MEF2A_6	104	112	PF00069	0.406
DOC_USP7_MATH_1	40	44	PF00917	0.405
DOC_USP7_UBL2_3	38	42	PF12436	0.355
LIG_14-3-3_CanoR_1	152	156	PF00244	0.347
LIG_14-3-3_CanoR_1	58	64	PF00244	0.402
LIG_14-3-3_CanoR_1	80	88	PF00244	0.429
LIG_APCC_ABBA_1	72	77	PF00400	0.331
LIG_BRCT_BRCA1_1	168	172	PF00533	0.312
LIG_FHA_1	145	151	PF00498	0.389
LIG_FHA_1	180	186	PF00498	0.454
LIG_FHA_1	4	10	PF00498	0.498
LIG_FHA_1	54	60	PF00498	0.366
LIG_LIR_Apic_2	100	106	PF02991	0.393
LIG_LIR_Gen_1	169	176	PF02991	0.324
LIG_LIR_Nem_3	154	158	PF02991	0.447
LIG_LIR_Nem_3	169	175	PF02991	0.288
LIG_SH2_CRK	103	107	PF00017	0.426
LIG_SH2_CRK	170	174	PF00017	0.339
LIG_SH2_CRK	60	64	PF00017	0.335
LIG_SH2_SRC	118	121	PF00017	0.343
LIG_SH2_SRC	124	127	PF00017	0.338
LIG_SH2_STAP1	135	139	PF00017	0.345
LIG_SH2_STAT5	118	121	PF00017	0.408
LIG_SH2_STAT5	124	127	PF00017	0.338
LIG_SH2_STAT5	156	159	PF00017	0.528
LIG_SH2_STAT5	83	86	PF00017	0.512
LIG_SUMO_SIM_par_1	16	25	PF11976	0.355
LIG_SUMO_SIM_par_1	5	10	PF11976	0.401
LIG_TRFH_1	156	160	PF08558	0.342
LIG_TYR_ITIM	122	127	PF00017	0.359
MOD_CK1_1	62	68	PF00069	0.429
MOD_CK2_1	160	166	PF00069	0.526
MOD_CK2_1	177	183	PF00069	0.401
MOD_GlcNHglycan	162	165	PF01048	0.447
MOD_GSK3_1	140	147	PF00069	0.391
MOD_GSK3_1	184	191	PF00069	0.454
MOD_GSK3_1	3	10	PF00069	0.408
MOD_GSK3_1	47	54	PF00069	0.408
MOD_GSK3_1	83	90	PF00069	0.469
MOD_GSK3_1	95	102	PF00069	0.296
MOD_N-GLC_1	51	56	PF02516	0.496
MOD_NEK2_1	133	138	PF00069	0.517
MOD_NEK2_1	144	149	PF00069	0.378
MOD_NEK2_1	3	8	PF00069	0.490
MOD_PIKK_1	87	93	PF00454	0.369
MOD_PKA_2	140	146	PF00069	0.464
MOD_PKA_2	151	157	PF00069	0.346
MOD_PKB_1	97	105	PF00069	0.381
MOD_Plk_1	131	137	PF00069	0.372
MOD_Plk_1	22	28	PF00069	0.546
MOD_Plk_2-3	22	28	PF00069	0.546
MOD_Plk_4	140	146	PF00069	0.522
MOD_Plk_4	151	157	PF00069	0.464
MOD_Plk_4	59	65	PF00069	0.340
MOD_SUMO_rev_2	76	82	PF00179	0.360
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.384
TRG_ENDOCYTIC_2	124	127	PF00928	0.465
TRG_ENDOCYTIC_2	155	158	PF00928	0.490
TRG_ENDOCYTIC_2	170	173	PF00928	0.282
TRG_ENDOCYTIC_2	60	63	PF00928	0.341
TRG_ER_diArg_1	57	59	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRP9	Trypanosomatidae	37%	99%
A0A3Q8IFP0	Leishmania donovani	99%	100%
A0A422NZW7	Trypanosoma rangeli	38%	99%
A4HKU2	Leishmania braziliensis	77%	100%
D0AAJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9B380	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9U1D7	Leishmania major	91%	100%