LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8B3_LEIIN
TriTrypDb:
LINF_320036400
Length:
727

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 6
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4I8B3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8B3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.551
CLV_NRD_NRD_1 202 204 PF00675 0.534
CLV_NRD_NRD_1 256 258 PF00675 0.648
CLV_NRD_NRD_1 297 299 PF00675 0.652
CLV_NRD_NRD_1 309 311 PF00675 0.583
CLV_NRD_NRD_1 358 360 PF00675 0.590
CLV_NRD_NRD_1 538 540 PF00675 0.528
CLV_NRD_NRD_1 561 563 PF00675 0.769
CLV_NRD_NRD_1 603 605 PF00675 0.646
CLV_NRD_NRD_1 717 719 PF00675 0.465
CLV_NRD_NRD_1 81 83 PF00675 0.615
CLV_PCSK_FUR_1 355 359 PF00082 0.700
CLV_PCSK_KEX2_1 202 204 PF00082 0.534
CLV_PCSK_KEX2_1 297 299 PF00082 0.687
CLV_PCSK_KEX2_1 309 311 PF00082 0.660
CLV_PCSK_KEX2_1 355 357 PF00082 0.660
CLV_PCSK_KEX2_1 358 360 PF00082 0.605
CLV_PCSK_KEX2_1 421 423 PF00082 0.685
CLV_PCSK_KEX2_1 537 539 PF00082 0.531
CLV_PCSK_KEX2_1 603 605 PF00082 0.624
CLV_PCSK_KEX2_1 723 725 PF00082 0.442
CLV_PCSK_KEX2_1 80 82 PF00082 0.605
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.684
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.548
CLV_PCSK_PC1ET2_1 723 725 PF00082 0.482
CLV_PCSK_PC7_1 293 299 PF00082 0.729
CLV_PCSK_SKI1_1 309 313 PF00082 0.700
CLV_PCSK_SKI1_1 351 355 PF00082 0.659
CLV_PCSK_SKI1_1 48 52 PF00082 0.569
CLV_PCSK_SKI1_1 538 542 PF00082 0.614
CLV_PCSK_SKI1_1 570 574 PF00082 0.582
CLV_PCSK_SKI1_1 60 64 PF00082 0.425
CLV_PCSK_SKI1_1 720 724 PF00082 0.456
DEG_Nend_UBRbox_1 1 4 PF02207 0.415
DEG_SCF_FBW7_1 133 139 PF00400 0.312
DOC_CKS1_1 133 138 PF01111 0.416
DOC_CKS1_1 98 103 PF01111 0.397
DOC_MAPK_gen_1 2 11 PF00069 0.380
DOC_MAPK_gen_1 355 365 PF00069 0.359
DOC_MAPK_gen_1 586 594 PF00069 0.457
DOC_MAPK_gen_1 623 633 PF00069 0.327
DOC_MAPK_MEF2A_6 2 11 PF00069 0.382
DOC_MAPK_MEF2A_6 333 341 PF00069 0.412
DOC_MAPK_MEF2A_6 497 506 PF00069 0.312
DOC_MAPK_RevD_3 681 697 PF00069 0.331
DOC_PP1_RVXF_1 536 543 PF00149 0.312
DOC_PP2B_LxvP_1 146 149 PF13499 0.257
DOC_PP4_FxxP_1 32 35 PF00568 0.267
DOC_USP7_MATH_1 136 140 PF00917 0.276
DOC_USP7_MATH_1 300 304 PF00917 0.579
DOC_USP7_MATH_1 54 58 PF00917 0.405
DOC_USP7_MATH_1 552 556 PF00917 0.425
DOC_USP7_UBL2_3 295 299 PF12436 0.432
DOC_USP7_UBL2_3 715 719 PF12436 0.657
DOC_WW_Pin1_4 132 137 PF00397 0.356
DOC_WW_Pin1_4 496 501 PF00397 0.307
DOC_WW_Pin1_4 550 555 PF00397 0.402
DOC_WW_Pin1_4 97 102 PF00397 0.371
LIG_14-3-3_CanoR_1 309 314 PF00244 0.470
LIG_14-3-3_CanoR_1 342 349 PF00244 0.458
LIG_14-3-3_CanoR_1 478 484 PF00244 0.471
LIG_14-3-3_CanoR_1 60 70 PF00244 0.306
LIG_14-3-3_CanoR_1 629 634 PF00244 0.439
LIG_14-3-3_CanoR_1 670 679 PF00244 0.384
LIG_14-3-3_CanoR_1 718 723 PF00244 0.740
LIG_14-3-3_CterR_2 724 727 PF00244 0.636
LIG_Actin_WH2_2 327 344 PF00022 0.389
LIG_BIR_III_4 183 187 PF00653 0.288
LIG_BRCT_BRCA1_1 24 28 PF00533 0.379
LIG_BRCT_BRCA1_1 360 364 PF00533 0.380
LIG_deltaCOP1_diTrp_1 260 266 PF00928 0.319
LIG_FHA_1 40 46 PF00498 0.389
LIG_FHA_1 451 457 PF00498 0.402
LIG_FHA_1 480 486 PF00498 0.386
LIG_FHA_1 497 503 PF00498 0.201
LIG_FHA_1 525 531 PF00498 0.321
LIG_FHA_1 605 611 PF00498 0.374
LIG_FHA_1 626 632 PF00498 0.353
LIG_FHA_1 649 655 PF00498 0.383
LIG_FHA_1 705 711 PF00498 0.668
LIG_FHA_1 98 104 PF00498 0.406
LIG_FHA_2 224 230 PF00498 0.525
LIG_FHA_2 263 269 PF00498 0.355
LIG_FHA_2 392 398 PF00498 0.317
LIG_FHA_2 529 535 PF00498 0.288
LIG_LIR_Apic_2 704 709 PF02991 0.726
LIG_LIR_Gen_1 123 133 PF02991 0.364
LIG_LIR_Gen_1 260 271 PF02991 0.372
LIG_LIR_Gen_1 394 404 PF02991 0.336
LIG_LIR_Gen_1 425 436 PF02991 0.399
LIG_LIR_Gen_1 518 525 PF02991 0.363
LIG_LIR_Gen_1 658 666 PF02991 0.305
LIG_LIR_Gen_1 67 78 PF02991 0.398
LIG_LIR_Gen_1 84 94 PF02991 0.237
LIG_LIR_Nem_3 123 129 PF02991 0.312
LIG_LIR_Nem_3 260 266 PF02991 0.323
LIG_LIR_Nem_3 394 399 PF02991 0.317
LIG_LIR_Nem_3 425 431 PF02991 0.416
LIG_LIR_Nem_3 518 523 PF02991 0.364
LIG_LIR_Nem_3 600 605 PF02991 0.409
LIG_LIR_Nem_3 614 620 PF02991 0.238
LIG_LIR_Nem_3 658 663 PF02991 0.297
LIG_LIR_Nem_3 67 73 PF02991 0.283
LIG_LIR_Nem_3 84 90 PF02991 0.253
LIG_LYPXL_S_1 286 290 PF13949 0.521
LIG_LYPXL_yS_3 287 290 PF13949 0.324
LIG_NRBOX 678 684 PF00104 0.411
LIG_Pex14_2 28 32 PF04695 0.367
LIG_PTB_Apo_2 72 79 PF02174 0.317
LIG_PTB_Phospho_1 72 78 PF10480 0.316
LIG_RPA_C_Fungi 299 311 PF08784 0.548
LIG_RPA_C_Fungi 665 677 PF08784 0.331
LIG_SH2_CRK 126 130 PF00017 0.430
LIG_SH2_CRK 428 432 PF00017 0.518
LIG_SH2_CRK 706 710 PF00017 0.676
LIG_SH2_CRK 99 103 PF00017 0.362
LIG_SH2_GRB2like 70 73 PF00017 0.305
LIG_SH2_NCK_1 396 400 PF00017 0.400
LIG_SH2_SRC 278 281 PF00017 0.424
LIG_SH2_SRC 396 399 PF00017 0.386
LIG_SH2_SRC 70 73 PF00017 0.305
LIG_SH2_STAP1 278 282 PF00017 0.470
LIG_SH2_STAP1 520 524 PF00017 0.442
LIG_SH2_STAT5 109 112 PF00017 0.460
LIG_SH2_STAT5 206 209 PF00017 0.370
LIG_SH2_STAT5 253 256 PF00017 0.511
LIG_SH2_STAT5 378 381 PF00017 0.372
LIG_SH2_STAT5 601 604 PF00017 0.426
LIG_SH2_STAT5 608 611 PF00017 0.318
LIG_SH2_STAT5 665 668 PF00017 0.390
LIG_SH2_STAT5 70 73 PF00017 0.440
LIG_SH2_STAT5 706 709 PF00017 0.682
LIG_SH2_STAT5 99 102 PF00017 0.507
LIG_SH3_3 41 47 PF00018 0.481
LIG_SH3_3 634 640 PF00018 0.349
LIG_SH3_3 95 101 PF00018 0.393
LIG_SH3_4 573 580 PF00018 0.370
LIG_SUMO_SIM_anti_2 159 165 PF11976 0.335
LIG_SUMO_SIM_anti_2 482 488 PF11976 0.468
LIG_SUMO_SIM_anti_2 5 10 PF11976 0.386
LIG_SUMO_SIM_anti_2 653 658 PF11976 0.322
LIG_SUMO_SIM_par_1 127 132 PF11976 0.377
LIG_SUMO_SIM_par_1 48 53 PF11976 0.333
LIG_SUMO_SIM_par_1 606 614 PF11976 0.289
LIG_SUMO_SIM_par_1 639 645 PF11976 0.372
LIG_SUMO_SIM_par_1 653 658 PF11976 0.302
LIG_TYR_ITIM 426 431 PF00017 0.542
LIG_TYR_ITIM 68 73 PF00017 0.362
LIG_TYR_ITSM 392 399 PF00017 0.406
MOD_CK1_1 132 138 PF00069 0.419
MOD_CK1_1 153 159 PF00069 0.463
MOD_CK1_1 381 387 PF00069 0.360
MOD_CK1_1 407 413 PF00069 0.508
MOD_CK1_1 493 499 PF00069 0.427
MOD_CK1_1 64 70 PF00069 0.460
MOD_CK1_1 669 675 PF00069 0.433
MOD_CK2_1 182 188 PF00069 0.433
MOD_CK2_1 262 268 PF00069 0.595
MOD_CK2_1 438 444 PF00069 0.547
MOD_CK2_1 629 635 PF00069 0.442
MOD_Cter_Amidation 255 258 PF01082 0.487
MOD_Cter_Amidation 295 298 PF01082 0.467
MOD_GlcNHglycan 183 187 PF01048 0.541
MOD_GlcNHglycan 192 195 PF01048 0.362
MOD_GlcNHglycan 334 337 PF01048 0.675
MOD_GlcNHglycan 440 443 PF01048 0.609
MOD_GlcNHglycan 55 59 PF01048 0.531
MOD_GlcNHglycan 92 95 PF01048 0.400
MOD_GSK3_1 107 114 PF00069 0.452
MOD_GSK3_1 132 139 PF00069 0.435
MOD_GSK3_1 18 25 PF00069 0.505
MOD_GSK3_1 262 269 PF00069 0.471
MOD_GSK3_1 337 344 PF00069 0.579
MOD_GSK3_1 378 385 PF00069 0.362
MOD_GSK3_1 446 453 PF00069 0.385
MOD_GSK3_1 524 531 PF00069 0.313
MOD_GSK3_1 615 622 PF00069 0.380
MOD_GSK3_1 625 632 PF00069 0.442
MOD_GSK3_1 665 672 PF00069 0.374
MOD_GSK3_1 718 725 PF00069 0.610
MOD_N-GLC_1 112 117 PF02516 0.468
MOD_N-GLC_1 223 228 PF02516 0.612
MOD_N-GLC_1 351 356 PF02516 0.653
MOD_N-GLC_1 446 451 PF02516 0.367
MOD_N-GLC_1 704 709 PF02516 0.657
MOD_NEK2_1 112 117 PF00069 0.437
MOD_NEK2_1 13 18 PF00069 0.594
MOD_NEK2_1 141 146 PF00069 0.392
MOD_NEK2_1 190 195 PF00069 0.496
MOD_NEK2_1 266 271 PF00069 0.470
MOD_NEK2_1 337 342 PF00069 0.530
MOD_NEK2_1 446 451 PF00069 0.365
MOD_NEK2_1 485 490 PF00069 0.499
MOD_NEK2_1 524 529 PF00069 0.347
MOD_NEK2_1 62 67 PF00069 0.330
MOD_NEK2_2 262 267 PF00069 0.563
MOD_NEK2_2 391 396 PF00069 0.325
MOD_PIKK_1 141 147 PF00454 0.528
MOD_PIKK_1 18 24 PF00454 0.505
MOD_PIKK_1 223 229 PF00454 0.598
MOD_PIKK_1 407 413 PF00454 0.387
MOD_PIKK_1 450 456 PF00454 0.537
MOD_PKA_1 309 315 PF00069 0.647
MOD_PKA_1 358 364 PF00069 0.537
MOD_PKA_1 718 724 PF00069 0.691
MOD_PKA_2 266 272 PF00069 0.497
MOD_PKA_2 300 306 PF00069 0.771
MOD_PKA_2 309 315 PF00069 0.623
MOD_PKA_2 341 347 PF00069 0.685
MOD_PKA_2 358 364 PF00069 0.463
MOD_PKA_2 561 567 PF00069 0.727
MOD_PKA_2 587 593 PF00069 0.580
MOD_PKA_2 669 675 PF00069 0.537
MOD_PKB_1 356 364 PF00069 0.426
MOD_Plk_1 112 118 PF00069 0.507
MOD_Plk_1 424 430 PF00069 0.439
MOD_Plk_1 446 452 PF00069 0.366
MOD_Plk_1 590 596 PF00069 0.489
MOD_Plk_1 615 621 PF00069 0.466
MOD_Plk_1 704 710 PF00069 0.643
MOD_Plk_1 83 89 PF00069 0.489
MOD_Plk_4 112 118 PF00069 0.481
MOD_Plk_4 13 19 PF00069 0.506
MOD_Plk_4 136 142 PF00069 0.434
MOD_Plk_4 266 272 PF00069 0.528
MOD_Plk_4 382 388 PF00069 0.396
MOD_Plk_4 579 585 PF00069 0.472
MOD_Plk_4 590 596 PF00069 0.533
MOD_Plk_4 604 610 PF00069 0.331
MOD_Plk_4 73 79 PF00069 0.473
MOD_Plk_4 83 89 PF00069 0.405
MOD_ProDKin_1 132 138 PF00069 0.433
MOD_ProDKin_1 496 502 PF00069 0.369
MOD_ProDKin_1 550 556 PF00069 0.512
MOD_ProDKin_1 97 103 PF00069 0.458
MOD_SUMO_rev_2 193 199 PF00179 0.382
TRG_DiLeu_BaEn_1 124 129 PF01217 0.447
TRG_DiLeu_BaLyEn_6 233 238 PF01217 0.629
TRG_DiLeu_BaLyEn_6 498 503 PF01217 0.405
TRG_ENDOCYTIC_2 109 112 PF00928 0.408
TRG_ENDOCYTIC_2 126 129 PF00928 0.407
TRG_ENDOCYTIC_2 192 195 PF00928 0.437
TRG_ENDOCYTIC_2 278 281 PF00928 0.395
TRG_ENDOCYTIC_2 287 290 PF00928 0.312
TRG_ENDOCYTIC_2 396 399 PF00928 0.322
TRG_ENDOCYTIC_2 428 431 PF00928 0.466
TRG_ENDOCYTIC_2 520 523 PF00928 0.443
TRG_ENDOCYTIC_2 581 584 PF00928 0.573
TRG_ENDOCYTIC_2 660 663 PF00928 0.362
TRG_ENDOCYTIC_2 70 73 PF00928 0.338
TRG_ENDOCYTIC_2 99 102 PF00928 0.390
TRG_ER_diArg_1 1 4 PF00400 0.415
TRG_ER_diArg_1 202 204 PF00400 0.410
TRG_ER_diArg_1 355 358 PF00400 0.614
TRG_ER_diArg_1 537 539 PF00400 0.420
TRG_ER_diArg_1 602 604 PF00400 0.467
TRG_ER_diArg_1 80 82 PF00400 0.480
TRG_NLS_MonoExtC_3 296 301 PF00514 0.668
TRG_NLS_MonoExtN_4 295 302 PF00514 0.577
TRG_NLS_MonoExtN_4 715 722 PF00514 0.679
TRG_Pf-PMV_PEXEL_1 236 241 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 81 85 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IML4 Leptomonas seymouri 63% 100%
A0A0S4JLI3 Bodo saltans 34% 93%
A0A1X0NRQ2 Trypanosomatidae 42% 100%
A0A3R7KWB9 Trypanosoma rangeli 43% 100%
A0A3S7X607 Leishmania donovani 100% 100%
A4HKT4 Leishmania braziliensis 86% 100%
D0AAI4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9B372 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q9U1E4 Leishmania major 96% 100%
V5AXZ0 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS