Outer dynein arm docking complex protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

outer dynein arm docking complex - putative

Species:

Leishmania infantum

UniProt:

A4I8B1_LEIIN

TriTrypDb:

LINF_320036200

Length:

618

Annotations

Annotations by Jardim et al.

Structural Proteins, Outer dynein arm docking complex DC2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I8B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.465
CLV_C14_Caspase3-7	567	571	PF00656	0.751
CLV_NRD_NRD_1	107	109	PF00675	0.272
CLV_NRD_NRD_1	163	165	PF00675	0.410
CLV_NRD_NRD_1	274	276	PF00675	0.747
CLV_NRD_NRD_1	588	590	PF00675	0.508
CLV_NRD_NRD_1	607	609	PF00675	0.382
CLV_NRD_NRD_1	81	83	PF00675	0.452
CLV_NRD_NRD_1	88	90	PF00675	0.452
CLV_PCSK_KEX2_1	163	165	PF00082	0.425
CLV_PCSK_KEX2_1	171	173	PF00082	0.441
CLV_PCSK_KEX2_1	181	183	PF00082	0.464
CLV_PCSK_KEX2_1	274	276	PF00082	0.719
CLV_PCSK_KEX2_1	81	83	PF00082	0.471
CLV_PCSK_KEX2_1	95	97	PF00082	0.457
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.483
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.505
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.543
CLV_PCSK_SKI1_1	108	112	PF00082	0.490
CLV_PCSK_SKI1_1	163	167	PF00082	0.407
CLV_PCSK_SKI1_1	209	213	PF00082	0.486
CLV_PCSK_SKI1_1	358	362	PF00082	0.489
CLV_PCSK_SKI1_1	450	454	PF00082	0.554
CLV_PCSK_SKI1_1	595	599	PF00082	0.567
DEG_APCC_DBOX_1	95	103	PF00400	0.540
DEG_SPOP_SBC_1	288	292	PF00917	0.787
DEG_SPOP_SBC_1	481	485	PF00917	0.728
DOC_MAPK_gen_1	108	116	PF00069	0.559
DOC_MAPK_gen_1	150	158	PF00069	0.423
DOC_MAPK_gen_1	160	169	PF00069	0.424
DOC_MAPK_MEF2A_6	160	169	PF00069	0.558
DOC_MAPK_MEF2A_6	459	467	PF00069	0.550
DOC_USP7_MATH_1	482	486	PF00917	0.713
DOC_USP7_MATH_1	558	562	PF00917	0.716
DOC_USP7_UBL2_3	358	362	PF12436	0.539
DOC_WW_Pin1_4	490	495	PF00397	0.708
DOC_WW_Pin1_4	512	517	PF00397	0.697
DOC_WW_Pin1_4	529	534	PF00397	0.690
LIG_14-3-3_CanoR_1	17	25	PF00244	0.496
LIG_14-3-3_CanoR_1	416	425	PF00244	0.505
LIG_14-3-3_CanoR_1	443	449	PF00244	0.525
LIG_14-3-3_CanoR_1	459	467	PF00244	0.349
LIG_14-3-3_CanoR_1	478	482	PF00244	0.520
LIG_14-3-3_CanoR_1	595	600	PF00244	0.616
LIG_Actin_WH2_2	347	364	PF00022	0.565
LIG_Actin_WH2_2	396	413	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_Clathr_ClatBox_1	304	308	PF01394	0.586
LIG_FHA_1	218	224	PF00498	0.581
LIG_FHA_1	299	305	PF00498	0.676
LIG_FHA_1	313	319	PF00498	0.594
LIG_FHA_1	325	331	PF00498	0.576
LIG_FHA_1	338	344	PF00498	0.489
LIG_FHA_1	405	411	PF00498	0.485
LIG_FHA_1	459	465	PF00498	0.459
LIG_FHA_1	486	492	PF00498	0.656
LIG_FHA_2	290	296	PF00498	0.721
LIG_FHA_2	418	424	PF00498	0.525
LIG_FHA_2	453	459	PF00498	0.492
LIG_FHA_2	565	571	PF00498	0.738
LIG_FHA_2	57	63	PF00498	0.560
LIG_FHA_2	596	602	PF00498	0.627
LIG_LIR_Gen_1	402	413	PF02991	0.443
LIG_LIR_Gen_1	422	433	PF02991	0.528
LIG_LIR_Gen_1	59	69	PF02991	0.463
LIG_LIR_Nem_3	342	348	PF02991	0.434
LIG_LIR_Nem_3	402	408	PF02991	0.444
LIG_LIR_Nem_3	422	428	PF02991	0.369
LIG_LIR_Nem_3	59	64	PF02991	0.473
LIG_NRBOX	367	373	PF00104	0.562
LIG_PCNA_yPIPBox_3	344	358	PF02747	0.459
LIG_Rb_LxCxE_1	299	316	PF01857	0.577
LIG_SH2_CRK	348	352	PF00017	0.447
LIG_SH2_CRK	405	409	PF00017	0.442
LIG_SH2_CRK	61	65	PF00017	0.463
LIG_SH2_GRB2like	219	222	PF00017	0.503
LIG_SH2_GRB2like	350	353	PF00017	0.473
LIG_SH2_NCK_1	405	409	PF00017	0.364
LIG_SH2_NCK_1	425	429	PF00017	0.539
LIG_SH2_SRC	425	428	PF00017	0.565
LIG_SH2_SRC	61	64	PF00017	0.462
LIG_SH2_STAP1	219	223	PF00017	0.493
LIG_SH2_STAT3	219	222	PF00017	0.534
LIG_SH2_STAT3	574	577	PF00017	0.717
LIG_SH2_STAT5	219	222	PF00017	0.580
LIG_SH2_STAT5	337	340	PF00017	0.530
LIG_SH2_STAT5	350	353	PF00017	0.406
LIG_SH2_STAT5	63	66	PF00017	0.437
LIG_SH3_3	530	536	PF00018	0.674
LIG_SUMO_SIM_anti_2	154	162	PF11976	0.442
LIG_TRAF2_1	266	269	PF00917	0.766
LIG_TRAF2_1	455	458	PF00917	0.488
LIG_TYR_ITSM	57	64	PF00017	0.569
LIG_UBA3_1	230	234	PF00899	0.575
LIG_UBA3_1	317	322	PF00899	0.587
MOD_CDK_SPK_2	490	495	PF00069	0.728
MOD_CK1_1	474	480	PF00069	0.669
MOD_CK1_1	485	491	PF00069	0.723
MOD_CK1_1	54	60	PF00069	0.585
MOD_CK1_1	544	550	PF00069	0.729
MOD_CK1_1	71	77	PF00069	0.563
MOD_CK2_1	289	295	PF00069	0.766
MOD_CK2_1	452	458	PF00069	0.490
MOD_CK2_1	490	496	PF00069	0.707
MOD_CK2_1	595	601	PF00069	0.587
MOD_CK2_1	71	77	PF00069	0.350
MOD_GlcNHglycan	310	313	PF01048	0.530
MOD_GlcNHglycan	353	357	PF01048	0.562
MOD_GlcNHglycan	473	476	PF01048	0.580
MOD_GlcNHglycan	52	56	PF01048	0.489
MOD_GlcNHglycan	543	546	PF01048	0.643
MOD_GlcNHglycan	558	561	PF01048	0.498
MOD_GSK3_1	12	19	PF00069	0.580
MOD_GSK3_1	308	315	PF00069	0.531
MOD_GSK3_1	476	483	PF00069	0.660
MOD_GSK3_1	490	497	PF00069	0.608
MOD_GSK3_1	506	513	PF00069	0.686
MOD_GSK3_1	564	571	PF00069	0.707
MOD_N-GLC_1	343	348	PF02516	0.420
MOD_N-GLC_1	510	515	PF02516	0.780
MOD_NEK2_1	104	109	PF00069	0.458
MOD_NEK2_1	135	140	PF00069	0.561
MOD_NEK2_1	16	21	PF00069	0.557
MOD_NEK2_1	258	263	PF00069	0.627
MOD_NEK2_1	343	348	PF00069	0.468
MOD_NEK2_1	361	366	PF00069	0.555
MOD_NEK2_1	56	61	PF00069	0.518
MOD_PIKK_1	16	22	PF00454	0.499
MOD_PKA_2	16	22	PF00069	0.502
MOD_PKA_2	308	314	PF00069	0.585
MOD_PKA_2	442	448	PF00069	0.534
MOD_PKA_2	458	464	PF00069	0.324
MOD_PKA_2	477	483	PF00069	0.553
MOD_PKA_2	485	491	PF00069	0.622
MOD_PKA_2	568	574	PF00069	0.767
MOD_Plk_1	135	141	PF00069	0.562
MOD_Plk_1	343	349	PF00069	0.420
MOD_Plk_1	51	57	PF00069	0.546
MOD_Plk_2-3	324	330	PF00069	0.626
MOD_Plk_4	300	306	PF00069	0.694
MOD_Plk_4	313	319	PF00069	0.511
MOD_ProDKin_1	490	496	PF00069	0.711
MOD_ProDKin_1	512	518	PF00069	0.695
MOD_ProDKin_1	529	535	PF00069	0.690
MOD_SUMO_for_1	356	359	PF00179	0.541
MOD_SUMO_for_1	49	52	PF00179	0.460
MOD_SUMO_rev_2	174	179	PF00179	0.532
MOD_SUMO_rev_2	227	236	PF00179	0.511
MOD_SUMO_rev_2	255	264	PF00179	0.616
MOD_SUMO_rev_2	391	400	PF00179	0.583
TRG_DiLeu_BaEn_3	161	167	PF01217	0.557
TRG_DiLeu_BaEn_4	503	509	PF01217	0.696
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.529
TRG_ENDOCYTIC_2	348	351	PF00928	0.462
TRG_ENDOCYTIC_2	405	408	PF00928	0.443
TRG_ENDOCYTIC_2	425	428	PF00928	0.517
TRG_ENDOCYTIC_2	61	64	PF00928	0.462
TRG_ER_diArg_1	163	165	PF00400	0.425
TRG_ER_diArg_1	81	83	PF00400	0.471
TRG_NLS_Bipartite_1	163	184	PF00514	0.440
TRG_NLS_Bipartite_1	95	112	PF00514	0.536
TRG_NLS_MonoExtN_4	178	184	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M7	Leptomonas seymouri	69%	97%
A0A0S4IU95	Bodo saltans	35%	100%
A0A1X0NRP3	Trypanosomatidae	45%	90%
A0A3Q8IH93	Leishmania donovani	100%	100%
A0A3R7MTI3	Trypanosoma rangeli	42%	96%
A4HKT2	Leishmania braziliensis	84%	100%
A8JF70	Chlamydomonas reinhardtii	27%	100%
D0AAI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9B370	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9U1E6	Leishmania major	96%	100%
V5BMI0	Trypanosoma cruzi	42%	95%