LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF778) - putative
Species:
Leishmania infantum
UniProt:
A4I8A8_LEIIN
TriTrypDb:
LINF_320035900
Length:
593

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I8A8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8A8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 400 404 PF00656 0.567
CLV_C14_Caspase3-7 423 427 PF00656 0.489
CLV_NRD_NRD_1 132 134 PF00675 0.509
CLV_NRD_NRD_1 290 292 PF00675 0.289
CLV_NRD_NRD_1 327 329 PF00675 0.289
CLV_NRD_NRD_1 330 332 PF00675 0.289
CLV_NRD_NRD_1 391 393 PF00675 0.349
CLV_NRD_NRD_1 559 561 PF00675 0.453
CLV_PCSK_FUR_1 325 329 PF00082 0.289
CLV_PCSK_KEX2_1 132 134 PF00082 0.509
CLV_PCSK_KEX2_1 290 292 PF00082 0.302
CLV_PCSK_KEX2_1 327 329 PF00082 0.289
CLV_PCSK_KEX2_1 330 332 PF00082 0.289
CLV_PCSK_KEX2_1 390 392 PF00082 0.351
CLV_PCSK_KEX2_1 559 561 PF00082 0.452
CLV_PCSK_PC1ET2_1 390 392 PF00082 0.314
CLV_PCSK_SKI1_1 318 322 PF00082 0.297
CLV_PCSK_SKI1_1 543 547 PF00082 0.289
DEG_APCC_DBOX_1 222 230 PF00400 0.541
DEG_APCC_DBOX_1 239 247 PF00400 0.488
DEG_SCF_FBW7_1 381 387 PF00400 0.462
DEG_SPOP_SBC_1 230 234 PF00917 0.541
DEG_SPOP_SBC_1 384 388 PF00917 0.488
DEG_SPOP_SBC_1 46 50 PF00917 0.756
DEG_SPOP_SBC_1 504 508 PF00917 0.462
DOC_ANK_TNKS_1 444 451 PF00023 0.489
DOC_CDC14_PxL_1 114 122 PF14671 0.738
DOC_CDC14_PxL_1 214 222 PF14671 0.462
DOC_CKS1_1 381 386 PF01111 0.462
DOC_CYCLIN_RxL_1 129 140 PF00134 0.718
DOC_CYCLIN_RxL_1 538 549 PF00134 0.567
DOC_MAPK_DCC_7 313 322 PF00069 0.489
DOC_MAPK_FxFP_2 152 155 PF00069 0.606
DOC_PP1_RVXF_1 541 547 PF00149 0.489
DOC_PP2B_LxvP_1 134 137 PF13499 0.724
DOC_PP4_FxxP_1 152 155 PF00568 0.606
DOC_USP7_MATH_1 157 161 PF00917 0.586
DOC_USP7_MATH_1 174 178 PF00917 0.424
DOC_USP7_MATH_1 247 251 PF00917 0.504
DOC_USP7_MATH_1 252 256 PF00917 0.490
DOC_USP7_MATH_1 282 286 PF00917 0.486
DOC_USP7_MATH_1 385 389 PF00917 0.480
DOC_USP7_MATH_1 409 413 PF00917 0.567
DOC_USP7_MATH_1 448 452 PF00917 0.495
DOC_USP7_MATH_1 46 50 PF00917 0.855
DOC_USP7_MATH_1 483 487 PF00917 0.462
DOC_USP7_MATH_1 497 501 PF00917 0.464
DOC_USP7_MATH_1 503 507 PF00917 0.472
DOC_USP7_MATH_1 527 531 PF00917 0.508
DOC_USP7_MATH_1 65 69 PF00917 0.661
DOC_USP7_MATH_1 7 11 PF00917 0.802
DOC_USP7_MATH_1 80 84 PF00917 0.720
DOC_USP7_UBL2_3 491 495 PF12436 0.567
DOC_WW_Pin1_4 122 127 PF00397 0.705
DOC_WW_Pin1_4 258 263 PF00397 0.495
DOC_WW_Pin1_4 274 279 PF00397 0.489
DOC_WW_Pin1_4 3 8 PF00397 0.827
DOC_WW_Pin1_4 329 334 PF00397 0.567
DOC_WW_Pin1_4 380 385 PF00397 0.495
DOC_WW_Pin1_4 451 456 PF00397 0.489
DOC_WW_Pin1_4 489 494 PF00397 0.494
DOC_WW_Pin1_4 50 55 PF00397 0.754
DOC_WW_Pin1_4 505 510 PF00397 0.454
DOC_WW_Pin1_4 95 100 PF00397 0.728
LIG_14-3-3_CanoR_1 178 183 PF00244 0.480
LIG_14-3-3_CanoR_1 272 278 PF00244 0.471
LIG_14-3-3_CanoR_1 294 302 PF00244 0.528
LIG_14-3-3_CanoR_1 515 520 PF00244 0.462
LIG_BIR_III_2 524 528 PF00653 0.567
LIG_BIR_III_4 401 405 PF00653 0.567
LIG_BRCT_BRCA1_1 159 163 PF00533 0.489
LIG_BRCT_BRCA1_1 276 280 PF00533 0.567
LIG_BRCT_BRCA1_1 463 467 PF00533 0.489
LIG_deltaCOP1_diTrp_1 536 546 PF00928 0.559
LIG_EVH1_1 381 385 PF00568 0.462
LIG_FHA_1 208 214 PF00498 0.514
LIG_FHA_1 230 236 PF00498 0.514
LIG_FHA_1 274 280 PF00498 0.567
LIG_FHA_1 307 313 PF00498 0.489
LIG_FHA_1 384 390 PF00498 0.599
LIG_FHA_1 438 444 PF00498 0.489
LIG_FHA_1 70 76 PF00498 0.764
LIG_FHA_2 138 144 PF00498 0.740
LIG_LIR_Apic_2 160 164 PF02991 0.489
LIG_LIR_Gen_1 420 430 PF02991 0.491
LIG_LIR_Gen_1 463 472 PF02991 0.489
LIG_LIR_Gen_1 574 585 PF02991 0.440
LIG_LIR_Nem_3 160 166 PF02991 0.469
LIG_LIR_Nem_3 420 425 PF02991 0.491
LIG_LIR_Nem_3 463 468 PF02991 0.504
LIG_LIR_Nem_3 574 580 PF02991 0.510
LIG_MYND_1 100 104 PF01753 0.712
LIG_NRBOX 351 357 PF00104 0.504
LIG_PDZ_Class_2 588 593 PF00595 0.480
LIG_Pex14_2 154 158 PF04695 0.567
LIG_Pex14_2 588 592 PF04695 0.408
LIG_SH2_STAP1 393 397 PF00017 0.514
LIG_SH2_STAT5 180 183 PF00017 0.509
LIG_SH2_STAT5 187 190 PF00017 0.472
LIG_SH2_STAT5 393 396 PF00017 0.499
LIG_SH2_STAT5 587 590 PF00017 0.382
LIG_SH3_2 490 495 PF14604 0.567
LIG_SH3_3 123 129 PF00018 0.819
LIG_SH3_3 241 247 PF00018 0.526
LIG_SH3_3 256 262 PF00018 0.601
LIG_SH3_3 275 281 PF00018 0.389
LIG_SH3_3 379 385 PF00018 0.562
LIG_SH3_3 484 490 PF00018 0.567
LIG_SUMO_SIM_par_1 190 198 PF11976 0.567
LIG_TRAF2_1 414 417 PF00917 0.567
LIG_WRC_WIRS_1 179 184 PF05994 0.331
LIG_WW_3 287 291 PF00397 0.303
MOD_CDC14_SPxK_1 492 495 PF00782 0.367
MOD_CDK_SPxK_1 489 495 PF00069 0.393
MOD_CDK_SPxxK_3 125 132 PF00069 0.651
MOD_CK1_1 105 111 PF00069 0.674
MOD_CK1_1 16 22 PF00069 0.604
MOD_CK1_1 234 240 PF00069 0.511
MOD_CK1_1 25 31 PF00069 0.652
MOD_CK1_1 250 256 PF00069 0.313
MOD_CK1_1 263 269 PF00069 0.355
MOD_CK1_1 297 303 PF00069 0.360
MOD_CK1_1 362 368 PF00069 0.430
MOD_CK1_1 377 383 PF00069 0.236
MOD_CK1_1 451 457 PF00069 0.331
MOD_CK1_1 463 469 PF00069 0.331
MOD_CK1_1 48 54 PF00069 0.810
MOD_CK1_1 485 491 PF00069 0.335
MOD_CK1_1 530 536 PF00069 0.400
MOD_CK1_1 569 575 PF00069 0.331
MOD_CK1_1 6 12 PF00069 0.770
MOD_CK1_1 68 74 PF00069 0.594
MOD_CK1_1 94 100 PF00069 0.793
MOD_CK2_1 137 143 PF00069 0.689
MOD_CK2_1 169 175 PF00069 0.331
MOD_CK2_1 25 31 PF00069 0.566
MOD_CK2_1 410 416 PF00069 0.339
MOD_CK2_1 530 536 PF00069 0.381
MOD_CK2_1 7 13 PF00069 0.626
MOD_Cter_Amidation 325 328 PF01082 0.331
MOD_GlcNHglycan 122 125 PF01048 0.663
MOD_GlcNHglycan 225 229 PF01048 0.404
MOD_GlcNHglycan 251 255 PF01048 0.361
MOD_GlcNHglycan 264 268 PF01048 0.385
MOD_GlcNHglycan 284 287 PF01048 0.183
MOD_GlcNHglycan 296 299 PF01048 0.275
MOD_GlcNHglycan 303 306 PF01048 0.229
MOD_GlcNHglycan 35 38 PF01048 0.624
MOD_GlcNHglycan 406 409 PF01048 0.315
MOD_GlcNHglycan 413 416 PF01048 0.306
MOD_GlcNHglycan 42 45 PF01048 0.644
MOD_GlcNHglycan 446 449 PF01048 0.344
MOD_GlcNHglycan 487 490 PF01048 0.347
MOD_GlcNHglycan 499 502 PF01048 0.382
MOD_GlcNHglycan 571 574 PF01048 0.349
MOD_GlcNHglycan 67 70 PF01048 0.605
MOD_GlcNHglycan 93 96 PF01048 0.807
MOD_GSK3_1 174 181 PF00069 0.349
MOD_GSK3_1 21 28 PF00069 0.637
MOD_GSK3_1 230 237 PF00069 0.308
MOD_GSK3_1 250 257 PF00069 0.350
MOD_GSK3_1 297 304 PF00069 0.345
MOD_GSK3_1 3 10 PF00069 0.799
MOD_GSK3_1 356 363 PF00069 0.331
MOD_GSK3_1 380 387 PF00069 0.331
MOD_GSK3_1 392 399 PF00069 0.480
MOD_GSK3_1 40 47 PF00069 0.822
MOD_GSK3_1 444 451 PF00069 0.331
MOD_GSK3_1 481 488 PF00069 0.367
MOD_GSK3_1 499 506 PF00069 0.382
MOD_GSK3_1 510 517 PF00069 0.346
MOD_GSK3_1 65 72 PF00069 0.669
MOD_GSK3_1 80 87 PF00069 0.692
MOD_GSK3_1 91 98 PF00069 0.629
MOD_N-GLC_1 437 442 PF02516 0.331
MOD_N-GLC_1 7 12 PF02516 0.690
MOD_N-GLC_1 91 96 PF02516 0.778
MOD_NEK2_1 120 125 PF00069 0.711
MOD_NEK2_1 182 187 PF00069 0.331
MOD_NEK2_1 231 236 PF00069 0.354
MOD_NEK2_1 321 326 PF00069 0.345
MOD_NEK2_1 33 38 PF00069 0.686
MOD_NEK2_1 437 442 PF00069 0.331
MOD_NEK2_1 546 551 PF00069 0.440
MOD_NEK2_2 385 390 PF00069 0.330
MOD_PIKK_1 238 244 PF00454 0.440
MOD_PIKK_1 306 312 PF00454 0.440
MOD_PIKK_1 335 341 PF00454 0.440
MOD_PIKK_1 476 482 PF00454 0.352
MOD_PK_1 192 198 PF00069 0.440
MOD_PKA_1 391 397 PF00069 0.268
MOD_PKA_2 273 279 PF00069 0.385
MOD_PKA_2 289 295 PF00069 0.278
MOD_PKA_2 326 332 PF00069 0.440
MOD_PKA_2 367 373 PF00069 0.338
MOD_PKA_2 391 397 PF00069 0.378
MOD_PKA_2 444 450 PF00069 0.334
MOD_PKA_2 514 520 PF00069 0.293
MOD_PKB_1 133 141 PF00069 0.606
MOD_PKB_1 270 278 PF00069 0.293
MOD_Plk_1 182 188 PF00069 0.331
MOD_Plk_1 224 230 PF00069 0.404
MOD_Plk_1 437 443 PF00069 0.331
MOD_Plk_1 7 13 PF00069 0.626
MOD_Plk_2-3 396 402 PF00069 0.367
MOD_Plk_4 157 163 PF00069 0.440
MOD_Plk_4 182 188 PF00069 0.331
MOD_Plk_4 209 215 PF00069 0.341
MOD_Plk_4 546 552 PF00069 0.440
MOD_Plk_4 571 577 PF00069 0.440
MOD_Plk_4 71 77 PF00069 0.713
MOD_ProDKin_1 122 128 PF00069 0.630
MOD_ProDKin_1 258 264 PF00069 0.340
MOD_ProDKin_1 274 280 PF00069 0.331
MOD_ProDKin_1 3 9 PF00069 0.805
MOD_ProDKin_1 329 335 PF00069 0.440
MOD_ProDKin_1 380 386 PF00069 0.339
MOD_ProDKin_1 451 457 PF00069 0.331
MOD_ProDKin_1 489 495 PF00069 0.338
MOD_ProDKin_1 50 56 PF00069 0.701
MOD_ProDKin_1 505 511 PF00069 0.282
MOD_ProDKin_1 95 101 PF00069 0.669
MOD_SUMO_rev_2 184 194 PF00179 0.331
TRG_DiLeu_BaEn_1 420 425 PF01217 0.367
TRG_DiLeu_BaEn_4 420 426 PF01217 0.367
TRG_DiLeu_BaLyEn_6 316 321 PF01217 0.331
TRG_ENDOCYTIC_2 422 425 PF00928 0.331
TRG_ENDOCYTIC_2 585 588 PF00928 0.469
TRG_ER_diArg_1 132 135 PF00400 0.642
TRG_ER_diArg_1 271 274 PF00400 0.479
TRG_ER_diArg_1 289 291 PF00400 0.256
TRG_ER_diArg_1 325 328 PF00400 0.339
TRG_ER_diArg_1 391 393 PF00400 0.411
TRG_ER_diArg_1 559 561 PF00400 0.552
TRG_Pf-PMV_PEXEL_1 199 203 PF00026 0.286

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M3 Leptomonas seymouri 51% 77%
A0A3S7X5W7 Leishmania donovani 100% 100%
A4HKS9 Leishmania braziliensis 73% 100%
E9B367 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q4Q4Y7 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS