LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8A7_LEIIN
TriTrypDb:
LINF_320035700
Length:
750

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8A7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8A7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.755
CLV_NRD_NRD_1 323 325 PF00675 0.729
CLV_NRD_NRD_1 392 394 PF00675 0.605
CLV_NRD_NRD_1 721 723 PF00675 0.585
CLV_NRD_NRD_1 744 746 PF00675 0.740
CLV_PCSK_KEX2_1 323 325 PF00082 0.729
CLV_PCSK_KEX2_1 392 394 PF00082 0.605
CLV_PCSK_KEX2_1 721 723 PF00082 0.585
CLV_PCSK_KEX2_1 744 746 PF00082 0.638
CLV_PCSK_KEX2_1 91 93 PF00082 0.555
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.555
CLV_PCSK_SKI1_1 323 327 PF00082 0.720
CLV_PCSK_SKI1_1 377 381 PF00082 0.623
CLV_PCSK_SKI1_1 384 388 PF00082 0.555
CLV_PCSK_SKI1_1 468 472 PF00082 0.515
CLV_PCSK_SKI1_1 477 481 PF00082 0.476
CLV_PCSK_SKI1_1 88 92 PF00082 0.669
CLV_PCSK_SKI1_1 96 100 PF00082 0.532
DEG_SCF_FBW7_1 447 454 PF00400 0.762
DEG_SPOP_SBC_1 363 367 PF00917 0.826
DEG_SPOP_SBC_1 446 450 PF00917 0.835
DOC_CKS1_1 511 516 PF01111 0.588
DOC_MAPK_gen_1 473 481 PF00069 0.505
DOC_PP1_RVXF_1 133 140 PF00149 0.693
DOC_PP2B_LxvP_1 552 555 PF13499 0.578
DOC_PP4_FxxP_1 585 588 PF00568 0.457
DOC_USP7_MATH_1 126 130 PF00917 0.714
DOC_USP7_MATH_1 195 199 PF00917 0.714
DOC_USP7_MATH_1 230 234 PF00917 0.685
DOC_USP7_MATH_1 283 287 PF00917 0.807
DOC_USP7_MATH_1 295 299 PF00917 0.518
DOC_USP7_MATH_1 330 334 PF00917 0.538
DOC_USP7_MATH_1 362 366 PF00917 0.787
DOC_USP7_MATH_1 439 443 PF00917 0.808
DOC_USP7_MATH_1 451 455 PF00917 0.665
DOC_USP7_MATH_1 59 63 PF00917 0.620
DOC_USP7_MATH_1 734 738 PF00917 0.583
DOC_WW_Pin1_4 180 185 PF00397 0.800
DOC_WW_Pin1_4 248 253 PF00397 0.779
DOC_WW_Pin1_4 258 263 PF00397 0.619
DOC_WW_Pin1_4 401 406 PF00397 0.682
DOC_WW_Pin1_4 429 434 PF00397 0.771
DOC_WW_Pin1_4 447 452 PF00397 0.536
DOC_WW_Pin1_4 5 10 PF00397 0.804
DOC_WW_Pin1_4 510 515 PF00397 0.669
DOC_WW_Pin1_4 565 570 PF00397 0.558
DOC_WW_Pin1_4 74 79 PF00397 0.735
LIG_14-3-3_CanoR_1 218 222 PF00244 0.785
LIG_14-3-3_CanoR_1 287 293 PF00244 0.764
LIG_14-3-3_CanoR_1 377 383 PF00244 0.661
LIG_14-3-3_CanoR_1 412 417 PF00244 0.836
LIG_14-3-3_CanoR_1 438 447 PF00244 0.756
LIG_14-3-3_CanoR_1 556 560 PF00244 0.493
LIG_14-3-3_CanoR_1 606 610 PF00244 0.653
LIG_14-3-3_CanoR_1 683 692 PF00244 0.504
LIG_14-3-3_CanoR_1 744 750 PF00244 0.638
LIG_14-3-3_CanoR_1 92 98 PF00244 0.599
LIG_AP2alpha_2 70 72 PF02296 0.661
LIG_BIR_III_2 239 243 PF00653 0.751
LIG_BIR_III_4 279 283 PF00653 0.747
LIG_BRCT_BRCA1_1 231 235 PF00533 0.809
LIG_FHA_1 132 138 PF00498 0.704
LIG_FHA_1 189 195 PF00498 0.730
LIG_FHA_1 209 215 PF00498 0.467
LIG_FHA_1 249 255 PF00498 0.786
LIG_FHA_1 305 311 PF00498 0.641
LIG_FHA_1 430 436 PF00498 0.676
LIG_FHA_1 447 453 PF00498 0.700
LIG_FHA_1 488 494 PF00498 0.647
LIG_FHA_1 510 516 PF00498 0.529
LIG_FHA_1 530 536 PF00498 0.321
LIG_FHA_1 547 553 PF00498 0.574
LIG_FHA_1 730 736 PF00498 0.611
LIG_FHA_2 106 112 PF00498 0.556
LIG_FHA_2 274 280 PF00498 0.821
LIG_FHA_2 365 371 PF00498 0.751
LIG_FHA_2 413 419 PF00498 0.830
LIG_FHA_2 420 426 PF00498 0.696
LIG_FHA_2 92 98 PF00498 0.635
LIG_LIR_Gen_1 111 120 PF02991 0.656
LIG_LIR_Gen_1 378 387 PF02991 0.647
LIG_LIR_Gen_1 44 51 PF02991 0.530
LIG_LIR_Gen_1 549 559 PF02991 0.664
LIG_LIR_Gen_1 70 79 PF02991 0.746
LIG_LIR_Gen_1 704 714 PF02991 0.520
LIG_LIR_Nem_3 111 116 PF02991 0.741
LIG_LIR_Nem_3 378 382 PF02991 0.656
LIG_LIR_Nem_3 44 48 PF02991 0.532
LIG_LIR_Nem_3 549 554 PF02991 0.680
LIG_LIR_Nem_3 608 614 PF02991 0.500
LIG_LIR_Nem_3 70 75 PF02991 0.690
LIG_LIR_Nem_3 702 708 PF02991 0.571
LIG_NRBOX 518 524 PF00104 0.639
LIG_REV1ctd_RIR_1 495 504 PF16727 0.580
LIG_SH2_GRB2like 115 118 PF00017 0.689
LIG_SH2_SRC 115 118 PF00017 0.766
LIG_SH2_STAT3 693 696 PF00017 0.528
LIG_SH2_STAT5 115 118 PF00017 0.766
LIG_SH2_STAT5 27 30 PF00017 0.658
LIG_SH2_STAT5 551 554 PF00017 0.674
LIG_SH2_STAT5 678 681 PF00017 0.659
LIG_SH2_STAT5 693 696 PF00017 0.387
LIG_SH3_3 239 245 PF00018 0.821
LIG_SH3_3 542 548 PF00018 0.523
LIG_SUMO_SIM_anti_2 532 537 PF11976 0.542
LIG_SUMO_SIM_par_1 210 215 PF11976 0.698
LIG_SUMO_SIM_par_1 253 259 PF11976 0.816
LIG_SUMO_SIM_par_1 306 311 PF11976 0.603
LIG_SUMO_SIM_par_1 531 537 PF11976 0.653
LIG_SUMO_SIM_par_1 635 640 PF11976 0.614
LIG_TRAF2_1 256 259 PF00917 0.724
LIG_TRAF2_1 653 656 PF00917 0.732
LIG_TYR_ITSM 547 554 PF00017 0.677
LIG_WRC_WIRS_1 376 381 PF05994 0.661
LIG_WW_1 690 693 PF00397 0.596
MOD_CDK_SPK_2 429 434 PF00069 0.787
MOD_CK1_1 157 163 PF00069 0.715
MOD_CK1_1 198 204 PF00069 0.642
MOD_CK1_1 228 234 PF00069 0.815
MOD_CK1_1 261 267 PF00069 0.708
MOD_CK1_1 281 287 PF00069 0.622
MOD_CK1_1 378 384 PF00069 0.635
MOD_CK1_1 419 425 PF00069 0.807
MOD_CK1_1 442 448 PF00069 0.811
MOD_CK1_1 5 11 PF00069 0.797
MOD_CK1_1 63 69 PF00069 0.606
MOD_CK2_1 253 259 PF00069 0.739
MOD_CK2_1 362 368 PF00069 0.719
MOD_CK2_1 412 418 PF00069 0.787
MOD_CK2_1 419 425 PF00069 0.803
MOD_CK2_1 695 701 PF00069 0.579
MOD_CK2_1 79 85 PF00069 0.573
MOD_CK2_1 91 97 PF00069 0.592
MOD_GlcNHglycan 128 131 PF01048 0.722
MOD_GlcNHglycan 156 159 PF01048 0.615
MOD_GlcNHglycan 176 179 PF01048 0.825
MOD_GlcNHglycan 196 200 PF01048 0.584
MOD_GlcNHglycan 227 230 PF01048 0.800
MOD_GlcNHglycan 278 283 PF01048 0.803
MOD_GlcNHglycan 292 295 PF01048 0.707
MOD_GlcNHglycan 297 300 PF01048 0.600
MOD_GlcNHglycan 352 356 PF01048 0.828
MOD_GlcNHglycan 441 444 PF01048 0.834
MOD_GlcNHglycan 52 55 PF01048 0.531
MOD_GlcNHglycan 525 529 PF01048 0.490
MOD_GlcNHglycan 570 573 PF01048 0.575
MOD_GlcNHglycan 697 700 PF01048 0.702
MOD_GlcNHglycan 736 739 PF01048 0.625
MOD_GSK3_1 1 8 PF00069 0.819
MOD_GSK3_1 197 204 PF00069 0.636
MOD_GSK3_1 225 232 PF00069 0.699
MOD_GSK3_1 27 34 PF00069 0.623
MOD_GSK3_1 278 285 PF00069 0.821
MOD_GSK3_1 330 337 PF00069 0.675
MOD_GSK3_1 362 369 PF00069 0.726
MOD_GSK3_1 401 408 PF00069 0.722
MOD_GSK3_1 412 419 PF00069 0.710
MOD_GSK3_1 429 436 PF00069 0.614
MOD_GSK3_1 441 448 PF00069 0.710
MOD_GSK3_1 568 575 PF00069 0.495
MOD_GSK3_1 59 66 PF00069 0.655
MOD_GSK3_1 637 644 PF00069 0.553
MOD_GSK3_1 695 702 PF00069 0.640
MOD_GSK3_1 70 77 PF00069 0.628
MOD_GSK3_1 740 747 PF00069 0.507
MOD_N-GLC_1 154 159 PF02516 0.718
MOD_N-GLC_1 699 704 PF02516 0.613
MOD_N-GLC_2 658 660 PF02516 0.504
MOD_NEK2_1 105 110 PF00069 0.667
MOD_NEK2_1 197 202 PF00069 0.742
MOD_NEK2_1 217 222 PF00069 0.524
MOD_NEK2_1 288 293 PF00069 0.766
MOD_NEK2_1 351 356 PF00069 0.755
MOD_NEK2_1 41 46 PF00069 0.541
MOD_NEK2_1 488 493 PF00069 0.676
MOD_NEK2_1 523 528 PF00069 0.626
MOD_NEK2_1 570 575 PF00069 0.515
MOD_NEK2_1 637 642 PF00069 0.691
MOD_NEK2_1 713 718 PF00069 0.634
MOD_NEK2_2 133 138 PF00069 0.802
MOD_NEK2_2 665 670 PF00069 0.692
MOD_PIKK_1 451 457 PF00454 0.848
MOD_PIKK_1 546 552 PF00454 0.675
MOD_PIKK_1 622 628 PF00454 0.499
MOD_PIKK_1 713 719 PF00454 0.537
MOD_PIKK_1 729 735 PF00454 0.583
MOD_PKA_1 744 750 PF00069 0.545
MOD_PKA_1 91 97 PF00069 0.534
MOD_PKA_2 173 179 PF00069 0.631
MOD_PKA_2 201 207 PF00069 0.633
MOD_PKA_2 217 223 PF00069 0.766
MOD_PKA_2 433 439 PF00069 0.731
MOD_PKA_2 555 561 PF00069 0.486
MOD_PKA_2 605 611 PF00069 0.650
MOD_PKA_2 622 628 PF00069 0.347
MOD_PKA_2 744 750 PF00069 0.545
MOD_PKA_2 91 97 PF00069 0.605
MOD_PKB_1 47 55 PF00069 0.654
MOD_Plk_1 105 111 PF00069 0.555
MOD_Plk_1 21 27 PF00069 0.665
MOD_Plk_1 488 494 PF00069 0.676
MOD_Plk_1 524 530 PF00069 0.600
MOD_Plk_1 665 671 PF00069 0.689
MOD_Plk_1 699 705 PF00069 0.613
MOD_Plk_2-3 701 707 PF00069 0.596
MOD_Plk_4 488 494 PF00069 0.676
MOD_Plk_4 701 707 PF00069 0.596
MOD_ProDKin_1 180 186 PF00069 0.798
MOD_ProDKin_1 248 254 PF00069 0.778
MOD_ProDKin_1 258 264 PF00069 0.612
MOD_ProDKin_1 401 407 PF00069 0.682
MOD_ProDKin_1 429 435 PF00069 0.772
MOD_ProDKin_1 447 453 PF00069 0.536
MOD_ProDKin_1 5 11 PF00069 0.797
MOD_ProDKin_1 510 516 PF00069 0.670
MOD_ProDKin_1 565 571 PF00069 0.559
MOD_ProDKin_1 74 80 PF00069 0.732
MOD_SUMO_for_1 600 603 PF00179 0.592
TRG_DiLeu_BaEn_1 525 530 PF01217 0.519
TRG_DiLeu_BaEn_2 466 472 PF01217 0.648
TRG_ENDOCYTIC_2 551 554 PF00928 0.674
TRG_ER_diArg_1 392 394 PF00400 0.605
TRG_ER_diArg_1 472 475 PF00400 0.497
TRG_ER_diArg_1 720 722 PF00400 0.588
TRG_NES_CRM1_1 97 111 PF08389 0.659
TRG_Pf-PMV_PEXEL_1 324 329 PF00026 0.633
TRG_Pf-PMV_PEXEL_1 683 687 PF00026 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8B7 Leptomonas seymouri 45% 100%
A0A3Q8ITJ0 Leishmania donovani 100% 100%
A4HKS7 Leishmania braziliensis 75% 99%
E9B365 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q4Y9 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS