Prefoldin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin

Gene product:

Prefoldin subunit - putative

Species:

Leishmania infantum

UniProt:

A4I8A5_LEIIN

TriTrypDb:

LINF_320035500

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8A5

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010563	negative regulation of phosphorus metabolic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010921	regulation of phosphatase activity	5	1
GO:0010923	negative regulation of phosphatase activity	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035305	negative regulation of dephosphorylation	8	1
GO:0043086	negative regulation of catalytic activity	4	1
GO:0044092	negative regulation of molecular function	3	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045936	negative regulation of phosphate metabolic process	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051346	negative regulation of hydrolase activity	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0003712	transcription coregulator activity	2	1
GO:0003714	transcription corepressor activity	3	1
GO:0004857	enzyme inhibitor activity	3	1
GO:0005488	binding	1	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140110	transcription regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.667
CLV_NRD_NRD_1	101	103	PF00675	0.291
CLV_NRD_NRD_1	107	109	PF00675	0.291
CLV_NRD_NRD_1	285	287	PF00675	0.469
CLV_NRD_NRD_1	293	295	PF00675	0.538
CLV_NRD_NRD_1	355	357	PF00675	0.613
CLV_NRD_NRD_1	445	447	PF00675	0.698
CLV_NRD_NRD_1	473	475	PF00675	0.608
CLV_NRD_NRD_1	55	57	PF00675	0.306
CLV_PCSK_FUR_1	52	56	PF00082	0.306
CLV_PCSK_KEX2_1	101	103	PF00082	0.291
CLV_PCSK_KEX2_1	107	109	PF00082	0.291
CLV_PCSK_KEX2_1	285	287	PF00082	0.469
CLV_PCSK_KEX2_1	293	295	PF00082	0.538
CLV_PCSK_KEX2_1	355	357	PF00082	0.632
CLV_PCSK_KEX2_1	445	447	PF00082	0.675
CLV_PCSK_KEX2_1	473	475	PF00082	0.608
CLV_PCSK_KEX2_1	54	56	PF00082	0.309
CLV_PCSK_SKI1_1	273	277	PF00082	0.501
CLV_PCSK_SKI1_1	55	59	PF00082	0.307
CLV_PCSK_SKI1_1	558	562	PF00082	0.556
DEG_APCC_DBOX_1	54	62	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SCF_FBW7_1	213	220	PF00400	0.663
DEG_SPOP_SBC_1	223	227	PF00917	0.676
DEG_SPOP_SBC_1	404	408	PF00917	0.642
DEG_SPOP_SBC_1	433	437	PF00917	0.613
DOC_CKS1_1	361	366	PF01111	0.584
DOC_MAPK_gen_1	445	453	PF00069	0.655
DOC_PP2B_LxvP_1	375	378	PF13499	0.621
DOC_PP4_MxPP_1	542	545	PF00568	0.597
DOC_USP7_MATH_1	155	159	PF00917	0.665
DOC_USP7_MATH_1	185	189	PF00917	0.696
DOC_USP7_MATH_1	211	215	PF00917	0.662
DOC_USP7_MATH_1	223	227	PF00917	0.771
DOC_USP7_MATH_1	341	345	PF00917	0.727
DOC_USP7_MATH_1	371	375	PF00917	0.667
DOC_USP7_MATH_1	390	394	PF00917	0.706
DOC_USP7_MATH_1	405	409	PF00917	0.516
DOC_USP7_MATH_1	413	417	PF00917	0.578
DOC_USP7_MATH_1	419	423	PF00917	0.582
DOC_USP7_MATH_1	428	432	PF00917	0.754
DOC_USP7_MATH_1	433	437	PF00917	0.544
DOC_USP7_MATH_1	441	445	PF00917	0.630
DOC_USP7_MATH_1	88	92	PF00917	0.466
DOC_USP7_MATH_2	481	487	PF00917	0.530
DOC_USP7_UBL2_3	554	558	PF12436	0.632
DOC_WW_Pin1_4	151	156	PF00397	0.676
DOC_WW_Pin1_4	177	182	PF00397	0.554
DOC_WW_Pin1_4	196	201	PF00397	0.646
DOC_WW_Pin1_4	213	218	PF00397	0.687
DOC_WW_Pin1_4	219	224	PF00397	0.536
DOC_WW_Pin1_4	360	365	PF00397	0.628
DOC_WW_Pin1_4	477	482	PF00397	0.545
LIG_14-3-3_CanoR_1	201	209	PF00244	0.608
LIG_14-3-3_CanoR_1	221	231	PF00244	0.537
LIG_14-3-3_CanoR_1	273	280	PF00244	0.522
LIG_14-3-3_CanoR_1	490	497	PF00244	0.701
LIG_14-3-3_CanoR_1	505	509	PF00244	0.432
LIG_14-3-3_CanoR_1	536	542	PF00244	0.543
LIG_BIR_III_2	383	387	PF00653	0.602
LIG_BRCT_BRCA1_1	198	202	PF00533	0.595
LIG_Clathr_ClatBox_1	254	258	PF01394	0.462
LIG_EH1_1	507	515	PF00400	0.469
LIG_FHA_1	108	114	PF00498	0.563
LIG_FHA_1	380	386	PF00498	0.676
LIG_FHA_1	404	410	PF00498	0.743
LIG_FHA_1	43	49	PF00498	0.506
LIG_FHA_1	465	471	PF00498	0.561
LIG_FHA_1	498	504	PF00498	0.626
LIG_FHA_1	505	511	PF00498	0.473
LIG_FHA_1	73	79	PF00498	0.463
LIG_FHA_2	11	17	PF00498	0.437
LIG_FHA_2	239	245	PF00498	0.495
LIG_FHA_2	248	254	PF00498	0.436
LIG_FHA_2	361	367	PF00498	0.584
LIG_FHA_2	39	45	PF00498	0.517
LIG_LIR_Apic_2	360	364	PF02991	0.605
LIG_LIR_Gen_1	16	22	PF02991	0.433
LIG_LIR_Gen_1	232	240	PF02991	0.529
LIG_LIR_Gen_1	38	46	PF02991	0.463
LIG_LIR_LC3C_4	374	377	PF02991	0.539
LIG_LIR_Nem_3	16	21	PF02991	0.436
LIG_LIR_Nem_3	232	236	PF02991	0.542
LIG_LIR_Nem_3	38	42	PF02991	0.463
LIG_MYND_1	545	549	PF01753	0.563
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.522
LIG_PDZ_Class_3	565	570	PF00595	0.613
LIG_SH2_CRK	361	365	PF00017	0.642
LIG_SH2_CRK	39	43	PF00017	0.463
LIG_SH2_NCK_1	233	237	PF00017	0.495
LIG_SH2_SRC	508	511	PF00017	0.371
LIG_SH2_SRC	6	9	PF00017	0.397
LIG_SH2_STAP1	68	72	PF00017	0.511
LIG_SH2_STAT5	18	21	PF00017	0.436
LIG_SH2_STAT5	508	511	PF00017	0.547
LIG_SH3_3	161	167	PF00018	0.623
LIG_SH3_3	375	381	PF00018	0.611
LIG_SH3_3	397	403	PF00018	0.580
LIG_SH3_3	475	481	PF00018	0.613
LIG_SH3_3	538	544	PF00018	0.588
LIG_SH3_3	54	60	PF00018	0.463
LIG_SH3_4	554	561	PF00018	0.584
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.506
LIG_SUMO_SIM_par_1	250	258	PF11976	0.466
LIG_SUMO_SIM_par_1	77	84	PF11976	0.465
LIG_TRAF2_1	122	125	PF00917	0.500
LIG_TRAF2_1	168	171	PF00917	0.758
LIG_TYR_ITIM	231	236	PF00017	0.523
LIG_WRC_WIRS_1	240	245	PF05994	0.532
MOD_CDK_SPK_2	196	201	PF00069	0.628
MOD_CK1_1	156	162	PF00069	0.782
MOD_CK1_1	175	181	PF00069	0.538
MOD_CK1_1	204	210	PF00069	0.733
MOD_CK1_1	224	230	PF00069	0.748
MOD_CK1_1	334	340	PF00069	0.748
MOD_CK1_1	351	357	PF00069	0.577
MOD_CK1_1	379	385	PF00069	0.586
MOD_CK1_1	407	413	PF00069	0.663
MOD_CK1_1	432	438	PF00069	0.640
MOD_CK2_1	10	16	PF00069	0.433
MOD_CK2_1	239	245	PF00069	0.490
MOD_CK2_1	247	253	PF00069	0.438
MOD_CK2_1	351	357	PF00069	0.663
MOD_CK2_1	392	398	PF00069	0.713
MOD_CK2_1	477	483	PF00069	0.594
MOD_Cter_Amidation	99	102	PF01082	0.263
MOD_GlcNHglycan	175	178	PF01048	0.679
MOD_GlcNHglycan	182	185	PF01048	0.721
MOD_GlcNHglycan	186	190	PF01048	0.669
MOD_GlcNHglycan	204	207	PF01048	0.664
MOD_GlcNHglycan	226	229	PF01048	0.679
MOD_GlcNHglycan	294	297	PF01048	0.560
MOD_GlcNHglycan	313	316	PF01048	0.677
MOD_GlcNHglycan	319	322	PF01048	0.651
MOD_GlcNHglycan	338	341	PF01048	0.569
MOD_GlcNHglycan	343	346	PF01048	0.569
MOD_GlcNHglycan	351	354	PF01048	0.608
MOD_GlcNHglycan	378	381	PF01048	0.668
MOD_GlcNHglycan	415	418	PF01048	0.709
MOD_GlcNHglycan	421	424	PF01048	0.635
MOD_GlcNHglycan	431	434	PF01048	0.492
MOD_GlcNHglycan	436	439	PF01048	0.636
MOD_GlcNHglycan	491	494	PF01048	0.667
MOD_GlcNHglycan	525	528	PF01048	0.628
MOD_GlcNHglycan	89	93	PF01048	0.263
MOD_GSK3_1	151	158	PF00069	0.574
MOD_GSK3_1	173	180	PF00069	0.754
MOD_GSK3_1	212	219	PF00069	0.686
MOD_GSK3_1	367	374	PF00069	0.641
MOD_GSK3_1	38	45	PF00069	0.517
MOD_GSK3_1	403	410	PF00069	0.614
MOD_GSK3_1	428	435	PF00069	0.620
MOD_GSK3_1	460	467	PF00069	0.563
MOD_GSK3_1	499	506	PF00069	0.626
MOD_N-GLC_1	302	307	PF02516	0.593
MOD_N-GLC_1	348	353	PF02516	0.618
MOD_N-GLC_1	72	77	PF02516	0.306
MOD_NEK2_1	202	207	PF00069	0.618
MOD_NEK2_1	231	236	PF00069	0.529
MOD_NEK2_1	42	47	PF00069	0.506
MOD_NEK2_1	464	469	PF00069	0.527
MOD_NEK2_1	503	508	PF00069	0.573
MOD_NEK2_1	72	77	PF00069	0.463
MOD_PIKK_1	153	159	PF00454	0.674
MOD_PIKK_1	166	172	PF00454	0.679
MOD_PIKK_1	497	503	PF00454	0.516
MOD_PK_1	556	562	PF00069	0.498
MOD_PKA_1	107	113	PF00069	0.474
MOD_PKA_2	107	113	PF00069	0.563
MOD_PKA_2	144	150	PF00069	0.612
MOD_PKA_2	292	298	PF00069	0.565
MOD_PKA_2	489	495	PF00069	0.615
MOD_PKA_2	504	510	PF00069	0.529
MOD_Plk_1	115	121	PF00069	0.455
MOD_Plk_1	231	237	PF00069	0.618
MOD_Plk_1	37	43	PF00069	0.422
MOD_Plk_1	88	94	PF00069	0.498
MOD_Plk_2-3	232	238	PF00069	0.530
MOD_Plk_2-3	247	253	PF00069	0.454
MOD_Plk_2-3	38	44	PF00069	0.517
MOD_Plk_4	499	505	PF00069	0.635
MOD_Plk_4	537	543	PF00069	0.608
MOD_Plk_4	556	562	PF00069	0.555
MOD_Plk_4	74	80	PF00069	0.506
MOD_ProDKin_1	151	157	PF00069	0.679
MOD_ProDKin_1	177	183	PF00069	0.555
MOD_ProDKin_1	196	202	PF00069	0.646
MOD_ProDKin_1	213	219	PF00069	0.688
MOD_ProDKin_1	360	366	PF00069	0.629
MOD_ProDKin_1	477	483	PF00069	0.548
MOD_SUMO_for_1	122	125	PF00179	0.500
MOD_SUMO_for_1	281	284	PF00179	0.468
MOD_SUMO_rev_2	454	460	PF00179	0.512
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.582
TRG_ENDOCYTIC_2	18	21	PF00928	0.436
TRG_ENDOCYTIC_2	233	236	PF00928	0.514
TRG_ENDOCYTIC_2	39	42	PF00928	0.463
TRG_ER_diArg_1	106	108	PF00400	0.496
TRG_ER_diArg_1	285	288	PF00400	0.479
TRG_ER_diArg_1	473	475	PF00400	0.584
TRG_ER_diArg_1	52	55	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M6	Leptomonas seymouri	46%	100%
A0A3R7KPD3	Trypanosoma rangeli	35%	100%
A0A3S7X5Y7	Leishmania donovani	99%	100%
A4HKS5	Leishmania braziliensis	70%	99%
E9B363	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q4Z1	Leishmania major	89%	100%