LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative proteasome regulatory non-ATP-ase subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative proteasome regulatory non-ATP-ase subunit
Gene product:
proteasome regulatory non-ATP-ase subunit - putative
Species:
Leishmania infantum
UniProt:
A4I8A3_LEIIN
TriTrypDb:
LINF_320035300
Length:
408

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000502 proteasome complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:1905368 peptidase complex 3 12
GO:1905369 endopeptidase complex 4 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8A3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8A3

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0030234 enzyme regulator activity 2 12
GO:0098772 molecular function regulator activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.412
CLV_C14_Caspase3-7 367 371 PF00656 0.497
CLV_NRD_NRD_1 197 199 PF00675 0.194
CLV_NRD_NRD_1 257 259 PF00675 0.298
CLV_NRD_NRD_1 301 303 PF00675 0.276
CLV_PCSK_KEX2_1 197 199 PF00082 0.212
CLV_PCSK_KEX2_1 259 261 PF00082 0.508
CLV_PCSK_PC1ET2_1 259 261 PF00082 0.498
CLV_PCSK_SKI1_1 123 127 PF00082 0.290
CLV_PCSK_SKI1_1 181 185 PF00082 0.236
CLV_PCSK_SKI1_1 188 192 PF00082 0.164
CLV_PCSK_SKI1_1 387 391 PF00082 0.332
DEG_SPOP_SBC_1 49 53 PF00917 0.579
DOC_MAPK_gen_1 166 173 PF00069 0.497
DOC_MAPK_gen_1 197 203 PF00069 0.394
DOC_MAPK_gen_1 387 396 PF00069 0.354
DOC_MAPK_MEF2A_6 166 173 PF00069 0.405
DOC_MAPK_MEF2A_6 289 296 PF00069 0.535
DOC_MAPK_MEF2A_6 69 78 PF00069 0.548
DOC_PP1_RVXF_1 317 324 PF00149 0.394
DOC_PP2B_LxvP_1 83 86 PF13499 0.550
DOC_PP4_FxxP_1 342 345 PF00568 0.394
DOC_USP7_MATH_1 309 313 PF00917 0.497
DOC_USP7_MATH_1 348 352 PF00917 0.491
DOC_USP7_MATH_1 49 53 PF00917 0.579
DOC_WW_Pin1_4 261 266 PF00397 0.347
DOC_WW_Pin1_4 305 310 PF00397 0.497
DOC_WW_Pin1_4 45 50 PF00397 0.568
LIG_14-3-3_CanoR_1 43 49 PF00244 0.395
LIG_BIR_II_1 1 5 PF00653 0.669
LIG_BRCT_BRCA1_1 311 315 PF00533 0.517
LIG_FAT_LD_1 349 357 PF03623 0.405
LIG_FHA_1 322 328 PF00498 0.418
LIG_FHA_2 143 149 PF00498 0.497
LIG_FHA_2 234 240 PF00498 0.491
LIG_FHA_2 268 274 PF00498 0.425
LIG_FHA_2 379 385 PF00498 0.358
LIG_Integrin_RGD_1 377 379 PF01839 0.398
LIG_LIR_Gen_1 131 141 PF02991 0.405
LIG_LIR_Gen_1 161 172 PF02991 0.394
LIG_LIR_Gen_1 205 215 PF02991 0.438
LIG_LIR_Gen_1 236 245 PF02991 0.423
LIG_LIR_Gen_1 284 294 PF02991 0.448
LIG_LIR_Gen_1 328 338 PF02991 0.394
LIG_LIR_Gen_1 384 389 PF02991 0.333
LIG_LIR_Nem_3 131 136 PF02991 0.405
LIG_LIR_Nem_3 161 167 PF02991 0.394
LIG_LIR_Nem_3 205 211 PF02991 0.395
LIG_LIR_Nem_3 236 240 PF02991 0.415
LIG_LIR_Nem_3 284 290 PF02991 0.427
LIG_LIR_Nem_3 328 333 PF02991 0.394
LIG_LIR_Nem_3 384 388 PF02991 0.336
LIG_MLH1_MIPbox_1 311 315 PF16413 0.517
LIG_Pex14_2 211 215 PF04695 0.405
LIG_PTB_Apo_2 277 284 PF02174 0.412
LIG_PTB_Phospho_1 277 283 PF10480 0.412
LIG_REV1ctd_RIR_1 312 320 PF16727 0.400
LIG_SH2_CRK 133 137 PF00017 0.461
LIG_SH2_CRK 287 291 PF00017 0.497
LIG_SH2_CRK 330 334 PF00017 0.394
LIG_SH2_CRK 385 389 PF00017 0.335
LIG_SH2_NCK_1 133 137 PF00017 0.461
LIG_SH2_NCK_1 287 291 PF00017 0.497
LIG_SH2_NCK_1 330 334 PF00017 0.394
LIG_SH2_PTP2 75 78 PF00017 0.439
LIG_SH2_STAP1 283 287 PF00017 0.461
LIG_SH2_STAT3 283 286 PF00017 0.518
LIG_SH2_STAT5 163 166 PF00017 0.497
LIG_SH2_STAT5 306 309 PF00017 0.411
LIG_SH2_STAT5 313 316 PF00017 0.389
LIG_SH2_STAT5 41 44 PF00017 0.384
LIG_SH2_STAT5 75 78 PF00017 0.432
LIG_SH3_3 1 7 PF00018 0.590
LIG_SH3_3 259 265 PF00018 0.413
LIG_SH3_3 29 35 PF00018 0.474
LIG_TRAF2_1 145 148 PF00917 0.497
LIG_TRAF2_1 52 55 PF00917 0.559
LIG_UBA3_1 395 401 PF00899 0.315
LIG_UBA3_1 63 69 PF00899 0.471
LIG_WRC_WIRS_1 226 231 PF05994 0.394
LIG_WRC_WIRS_1 234 239 PF05994 0.394
LIG_WW_3 5 9 PF00397 0.587
MOD_CK1_1 225 231 PF00069 0.394
MOD_CK1_1 329 335 PF00069 0.394
MOD_CK1_1 372 378 PF00069 0.471
MOD_CK1_1 48 54 PF00069 0.509
MOD_CK2_1 142 148 PF00069 0.461
MOD_CK2_1 250 256 PF00069 0.405
MOD_CK2_1 48 54 PF00069 0.499
MOD_GlcNHglycan 218 221 PF01048 0.280
MOD_GlcNHglycan 390 393 PF01048 0.482
MOD_GSK3_1 241 248 PF00069 0.494
MOD_GSK3_1 305 312 PF00069 0.497
MOD_GSK3_1 348 355 PF00069 0.461
MOD_GSK3_1 44 51 PF00069 0.464
MOD_N-GLC_1 267 272 PF02516 0.421
MOD_NEK2_1 222 227 PF00069 0.408
MOD_NEK2_1 278 283 PF00069 0.461
MOD_NEK2_1 321 326 PF00069 0.412
MOD_NEK2_1 352 357 PF00069 0.424
MOD_NEK2_1 87 92 PF00069 0.341
MOD_PIKK_1 321 327 PF00454 0.445
MOD_PKA_2 216 222 PF00069 0.450
MOD_PKA_2 42 48 PF00069 0.403
MOD_PKA_2 55 61 PF00069 0.463
MOD_Plk_2-3 233 239 PF00069 0.497
MOD_Plk_4 278 284 PF00069 0.461
MOD_Plk_4 309 315 PF00069 0.497
MOD_Plk_4 348 354 PF00069 0.400
MOD_Plk_4 35 41 PF00069 0.498
MOD_ProDKin_1 261 267 PF00069 0.344
MOD_ProDKin_1 305 311 PF00069 0.497
MOD_ProDKin_1 45 51 PF00069 0.566
MOD_SUMO_rev_2 13 23 PF00179 0.498
MOD_SUMO_rev_2 88 93 PF00179 0.436
TRG_DiLeu_BaEn_1 317 322 PF01217 0.405
TRG_DiLeu_BaLyEn_6 32 37 PF01217 0.389
TRG_ENDOCYTIC_2 133 136 PF00928 0.461
TRG_ENDOCYTIC_2 204 207 PF00928 0.394
TRG_ENDOCYTIC_2 208 211 PF00928 0.394
TRG_ENDOCYTIC_2 287 290 PF00928 0.411
TRG_ENDOCYTIC_2 330 333 PF00928 0.394
TRG_ENDOCYTIC_2 385 388 PF00928 0.339
TRG_ENDOCYTIC_2 75 78 PF00928 0.371
TRG_ER_diArg_1 166 169 PF00400 0.461
TRG_ER_diArg_1 197 200 PF00400 0.394
TRG_ER_diArg_1 257 260 PF00400 0.497
TRG_NLS_MonoExtN_4 255 262 PF00514 0.454
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Z9 Leptomonas seymouri 88% 100%
A0A0S4IM85 Bodo saltans 61% 100%
A0A1X0NRP1 Trypanosomatidae 69% 100%
A0A3Q8IJI2 Leishmania donovani 100% 100%
A0A3R7NSJ6 Trypanosoma rangeli 69% 100%
A4HKS3 Leishmania braziliensis 97% 100%
D0AAH5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9B361 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
P97834 Rattus norvegicus 22% 87%
Q06103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 95%
Q10335 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
Q15008 Homo sapiens 38% 100%
Q20585 Caenorhabditis elegans 35% 100%
Q3T0B2 Bos taurus 38% 100%
Q4Q4Z3 Leishmania major 99% 100%
Q54QX3 Dictyostelium discoideum 21% 89%
Q55C75 Dictyostelium discoideum 36% 100%
Q8W425 Oryza sativa subsp. japonica 36% 100%
Q93Y35 Arabidopsis thaliana 37% 100%
Q99JI4 Mus musculus 38% 100%
Q99LD4 Mus musculus 22% 87%
Q9V3G7 Drosophila melanogaster 38% 100%
V5AXY2 Trypanosoma cruzi 69% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS