Putative proteasome regulatory non-ATP-ase subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit - putative

Species:

Leishmania infantum

UniProt:

A4I8A3_LEIIN

TriTrypDb:

LINF_320035300

Length:

408

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8A3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.412
CLV_C14_Caspase3-7	367	371	PF00656	0.497
CLV_NRD_NRD_1	197	199	PF00675	0.194
CLV_NRD_NRD_1	257	259	PF00675	0.298
CLV_NRD_NRD_1	301	303	PF00675	0.276
CLV_PCSK_KEX2_1	197	199	PF00082	0.212
CLV_PCSK_KEX2_1	259	261	PF00082	0.508
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.498
CLV_PCSK_SKI1_1	123	127	PF00082	0.290
CLV_PCSK_SKI1_1	181	185	PF00082	0.236

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z9	Leptomonas seymouri	88%	100%
A0A0S4IM85	Bodo saltans	61%	100%
A0A1X0NRP1	Trypanosomatidae	69%	100%
A0A3Q8IJI2	Leishmania donovani	100%	100%
A0A3R7NSJ6	Trypanosoma rangeli	69%	100%
A4HKS3	Leishmania braziliensis	97%	100%
D0AAH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B361	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P97834	Rattus norvegicus	22%	87%
Q06103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	95%

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