LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I897_LEIIN
TriTrypDb:
LINF_320034600 *
Length:
881

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I897
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I897

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 351 355 PF00656 0.455
CLV_C14_Caspase3-7 412 416 PF00656 0.612
CLV_C14_Caspase3-7 452 456 PF00656 0.545
CLV_C14_Caspase3-7 51 55 PF00656 0.617
CLV_C14_Caspase3-7 659 663 PF00656 0.683
CLV_C14_Caspase3-7 780 784 PF00656 0.608
CLV_C14_Caspase3-7 85 89 PF00656 0.657
CLV_NRD_NRD_1 147 149 PF00675 0.621
CLV_NRD_NRD_1 16 18 PF00675 0.611
CLV_NRD_NRD_1 225 227 PF00675 0.535
CLV_NRD_NRD_1 297 299 PF00675 0.747
CLV_NRD_NRD_1 37 39 PF00675 0.666
CLV_NRD_NRD_1 441 443 PF00675 0.488
CLV_NRD_NRD_1 510 512 PF00675 0.475
CLV_NRD_NRD_1 57 59 PF00675 0.571
CLV_NRD_NRD_1 633 635 PF00675 0.690
CLV_NRD_NRD_1 865 867 PF00675 0.556
CLV_PCSK_KEX2_1 146 148 PF00082 0.633
CLV_PCSK_KEX2_1 225 227 PF00082 0.535
CLV_PCSK_KEX2_1 297 299 PF00082 0.747
CLV_PCSK_KEX2_1 36 38 PF00082 0.678
CLV_PCSK_KEX2_1 441 443 PF00082 0.488
CLV_PCSK_KEX2_1 510 512 PF00082 0.492
CLV_PCSK_KEX2_1 517 519 PF00082 0.490
CLV_PCSK_KEX2_1 57 59 PF00082 0.644
CLV_PCSK_KEX2_1 633 635 PF00082 0.705
CLV_PCSK_KEX2_1 865 867 PF00082 0.480
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.596
CLV_PCSK_SKI1_1 18 22 PF00082 0.612
CLV_PCSK_SKI1_1 225 229 PF00082 0.532
CLV_PCSK_SKI1_1 526 530 PF00082 0.534
CLV_Separin_Metazoa 120 124 PF03568 0.620
CLV_Separin_Metazoa 422 426 PF03568 0.557
DEG_COP1_1 351 361 PF00400 0.464
DEG_SCF_FBW7_1 20 27 PF00400 0.697
DEG_SCF_FBW7_2 338 343 PF00400 0.388
DEG_SCF_TRCP1_1 448 453 PF00400 0.538
DEG_SPOP_SBC_1 154 158 PF00917 0.599
DEG_SPOP_SBC_1 24 28 PF00917 0.656
DEG_SPOP_SBC_1 708 712 PF00917 0.508
DOC_CKS1_1 111 116 PF01111 0.649
DOC_CKS1_1 185 190 PF01111 0.665
DOC_CKS1_1 21 26 PF01111 0.699
DOC_CKS1_1 469 474 PF01111 0.575
DOC_CYCLIN_RxL_1 12 23 PF00134 0.629
DOC_CYCLIN_yCln2_LP_2 16 22 PF00134 0.611
DOC_CYCLIN_yCln2_LP_2 185 191 PF00134 0.580
DOC_MAPK_gen_1 773 781 PF00069 0.618
DOC_MAPK_gen_1 865 874 PF00069 0.439
DOC_PP4_FxxP_1 118 121 PF00568 0.697
DOC_USP7_MATH_1 121 125 PF00917 0.668
DOC_USP7_MATH_1 155 159 PF00917 0.674
DOC_USP7_MATH_1 170 174 PF00917 0.661
DOC_USP7_MATH_1 24 28 PF00917 0.707
DOC_USP7_MATH_1 242 246 PF00917 0.459
DOC_USP7_MATH_1 536 540 PF00917 0.639
DOC_USP7_MATH_1 547 551 PF00917 0.676
DOC_USP7_MATH_1 616 620 PF00917 0.840
DOC_USP7_MATH_1 643 647 PF00917 0.679
DOC_USP7_MATH_1 758 762 PF00917 0.673
DOC_USP7_MATH_1 835 839 PF00917 0.695
DOC_USP7_MATH_1 84 88 PF00917 0.789
DOC_WW_Pin1_4 110 115 PF00397 0.672
DOC_WW_Pin1_4 122 127 PF00397 0.591
DOC_WW_Pin1_4 138 143 PF00397 0.651
DOC_WW_Pin1_4 184 189 PF00397 0.719
DOC_WW_Pin1_4 20 25 PF00397 0.632
DOC_WW_Pin1_4 206 211 PF00397 0.632
DOC_WW_Pin1_4 307 312 PF00397 0.655
DOC_WW_Pin1_4 31 36 PF00397 0.643
DOC_WW_Pin1_4 336 341 PF00397 0.421
DOC_WW_Pin1_4 468 473 PF00397 0.598
DOC_WW_Pin1_4 52 57 PF00397 0.538
DOC_WW_Pin1_4 582 587 PF00397 0.671
DOC_WW_Pin1_4 593 598 PF00397 0.610
DOC_WW_Pin1_4 604 609 PF00397 0.720
DOC_WW_Pin1_4 633 638 PF00397 0.657
DOC_WW_Pin1_4 674 679 PF00397 0.805
DOC_WW_Pin1_4 800 805 PF00397 0.610
LIG_14-3-3_CanoR_1 147 155 PF00244 0.777
LIG_14-3-3_CanoR_1 30 35 PF00244 0.718
LIG_14-3-3_CanoR_1 306 311 PF00244 0.634
LIG_14-3-3_CanoR_1 441 445 PF00244 0.578
LIG_14-3-3_CanoR_1 46 56 PF00244 0.490
LIG_14-3-3_CanoR_1 490 499 PF00244 0.439
LIG_14-3-3_CanoR_1 510 514 PF00244 0.415
LIG_14-3-3_CanoR_1 57 63 PF00244 0.443
LIG_14-3-3_CanoR_1 595 601 PF00244 0.570
LIG_14-3-3_CanoR_1 617 624 PF00244 0.691
LIG_14-3-3_CanoR_1 693 699 PF00244 0.695
LIG_14-3-3_CanoR_1 740 747 PF00244 0.553
LIG_14-3-3_CanoR_1 815 822 PF00244 0.656
LIG_Actin_WH2_2 426 443 PF00022 0.539
LIG_APCC_ABBA_1 217 222 PF00400 0.545
LIG_BIR_II_1 1 5 PF00653 0.581
LIG_BIR_III_4 603 607 PF00653 0.678
LIG_BRCT_BRCA1_1 123 127 PF00533 0.612
LIG_BRCT_BRCA1_1 777 781 PF00533 0.640
LIG_BRCT_BRCA1_1 784 788 PF00533 0.569
LIG_EVH1_1 189 193 PF00568 0.601
LIG_EVH1_2 114 118 PF00568 0.622
LIG_FHA_1 148 154 PF00498 0.662
LIG_FHA_1 192 198 PF00498 0.661
LIG_FHA_1 209 215 PF00498 0.727
LIG_FHA_1 340 346 PF00498 0.441
LIG_FHA_1 457 463 PF00498 0.654
LIG_FHA_1 464 470 PF00498 0.592
LIG_FHA_1 529 535 PF00498 0.679
LIG_FHA_1 596 602 PF00498 0.583
LIG_FHA_1 817 823 PF00498 0.713
LIG_FHA_1 829 835 PF00498 0.582
LIG_FHA_1 869 875 PF00498 0.438
LIG_FHA_2 179 185 PF00498 0.608
LIG_FHA_2 255 261 PF00498 0.483
LIG_FHA_2 410 416 PF00498 0.593
LIG_FHA_2 450 456 PF00498 0.536
LIG_FHA_2 49 55 PF00498 0.629
LIG_FHA_2 69 75 PF00498 0.461
LIG_FHA_2 716 722 PF00498 0.661
LIG_FHA_2 83 89 PF00498 0.570
LIG_GBD_Chelix_1 483 491 PF00786 0.536
LIG_Integrin_RGD_1 77 79 PF01839 0.644
LIG_LIR_Apic_2 116 121 PF02991 0.703
LIG_LIR_Gen_1 367 378 PF02991 0.426
LIG_LIR_Gen_1 465 474 PF02991 0.579
LIG_LIR_Gen_1 5 13 PF02991 0.528
LIG_LIR_Nem_3 367 373 PF02991 0.425
LIG_LIR_Nem_3 5 9 PF02991 0.509
LIG_PCNA_PIPBox_1 363 372 PF02747 0.481
LIG_PCNA_yPIPBox_3 363 375 PF02747 0.481
LIG_PDZ_Class_1 876 881 PF00595 0.577
LIG_SH2_NCK_1 22 26 PF00017 0.624
LIG_SH2_SRC 6 9 PF00017 0.511
LIG_SH2_STAP1 6 10 PF00017 0.522
LIG_SH2_STAP1 863 867 PF00017 0.566
LIG_SH2_STAT3 485 488 PF00017 0.536
LIG_SH2_STAT5 117 120 PF00017 0.625
LIG_SH2_STAT5 22 25 PF00017 0.816
LIG_SH2_STAT5 220 223 PF00017 0.590
LIG_SH2_STAT5 565 568 PF00017 0.556
LIG_SH2_STAT5 63 66 PF00017 0.482
LIG_SH3_1 207 213 PF00018 0.561
LIG_SH3_2 142 147 PF14604 0.616
LIG_SH3_2 533 538 PF14604 0.689
LIG_SH3_3 139 145 PF00018 0.674
LIG_SH3_3 185 191 PF00018 0.710
LIG_SH3_3 207 213 PF00018 0.674
LIG_SH3_3 527 533 PF00018 0.726
LIG_SH3_3 569 575 PF00018 0.561
LIG_SH3_3 580 586 PF00018 0.590
LIG_SH3_3 635 641 PF00018 0.706
LIG_SH3_3 666 672 PF00018 0.659
LIG_SH3_3 719 725 PF00018 0.633
LIG_SH3_3 831 837 PF00018 0.543
LIG_SH3_3 853 859 PF00018 0.667
LIG_SUMO_SIM_anti_2 871 876 PF11976 0.530
LIG_SUMO_SIM_par_1 181 187 PF11976 0.584
LIG_SUMO_SIM_par_1 870 876 PF11976 0.432
LIG_TRAF2_1 432 435 PF00917 0.530
LIG_TRAF2_1 512 515 PF00917 0.507
LIG_Vh1_VBS_1 319 337 PF01044 0.473
LIG_WW_1 114 117 PF00397 0.669
LIG_WW_3 770 774 PF00397 0.686
MOD_CDC14_SPxK_1 144 147 PF00782 0.646
MOD_CDC14_SPxK_1 34 37 PF00782 0.724
MOD_CDC14_SPxK_1 55 58 PF00782 0.515
MOD_CDK_SPK_2 141 146 PF00069 0.661
MOD_CDK_SPK_2 31 36 PF00069 0.719
MOD_CDK_SPK_2 312 317 PF00069 0.571
MOD_CDK_SPK_2 52 57 PF00069 0.538
MOD_CDK_SPxK_1 141 147 PF00069 0.640
MOD_CDK_SPxK_1 31 37 PF00069 0.703
MOD_CDK_SPxK_1 52 58 PF00069 0.533
MOD_CDK_SPxxK_3 141 148 PF00069 0.665
MOD_CDK_SPxxK_3 31 38 PF00069 0.719
MOD_CK1_1 11 17 PF00069 0.635
MOD_CK1_1 116 122 PF00069 0.623
MOD_CK1_1 129 135 PF00069 0.677
MOD_CK1_1 141 147 PF00069 0.787
MOD_CK1_1 2 8 PF00069 0.590
MOD_CK1_1 212 218 PF00069 0.695
MOD_CK1_1 315 321 PF00069 0.548
MOD_CK1_1 449 455 PF00069 0.639
MOD_CK1_1 465 471 PF00069 0.508
MOD_CK1_1 48 54 PF00069 0.597
MOD_CK1_1 582 588 PF00069 0.804
MOD_CK1_1 591 597 PF00069 0.590
MOD_CK1_1 607 613 PF00069 0.633
MOD_CK1_1 677 683 PF00069 0.847
MOD_CK1_1 697 703 PF00069 0.599
MOD_CK1_1 784 790 PF00069 0.595
MOD_CK1_1 798 804 PF00069 0.549
MOD_CK1_1 814 820 PF00069 0.593
MOD_CK1_1 827 833 PF00069 0.559
MOD_CK2_1 178 184 PF00069 0.607
MOD_CK2_1 2 8 PF00069 0.530
MOD_CK2_1 254 260 PF00069 0.541
MOD_CK2_1 306 312 PF00069 0.565
MOD_CK2_1 476 482 PF00069 0.502
MOD_CK2_1 499 505 PF00069 0.446
MOD_CK2_1 509 515 PF00069 0.480
MOD_CK2_1 68 74 PF00069 0.651
MOD_CK2_1 715 721 PF00069 0.621
MOD_CK2_1 784 790 PF00069 0.565
MOD_Cter_Amidation 295 298 PF01082 0.594
MOD_GlcNHglycan 1 4 PF01048 0.576
MOD_GlcNHglycan 13 16 PF01048 0.605
MOD_GlcNHglycan 157 160 PF01048 0.621
MOD_GlcNHglycan 199 202 PF01048 0.606
MOD_GlcNHglycan 283 286 PF01048 0.631
MOD_GlcNHglycan 293 297 PF01048 0.617
MOD_GlcNHglycan 302 305 PF01048 0.636
MOD_GlcNHglycan 398 401 PF01048 0.595
MOD_GlcNHglycan 448 451 PF01048 0.727
MOD_GlcNHglycan 47 50 PF01048 0.594
MOD_GlcNHglycan 547 550 PF01048 0.667
MOD_GlcNHglycan 568 571 PF01048 0.655
MOD_GlcNHglycan 579 582 PF01048 0.629
MOD_GlcNHglycan 591 594 PF01048 0.745
MOD_GlcNHglycan 618 621 PF01048 0.715
MOD_GlcNHglycan 624 627 PF01048 0.761
MOD_GlcNHglycan 647 650 PF01048 0.673
MOD_GlcNHglycan 743 746 PF01048 0.738
MOD_GlcNHglycan 82 85 PF01048 0.705
MOD_GSK3_1 122 129 PF00069 0.688
MOD_GSK3_1 134 141 PF00069 0.651
MOD_GSK3_1 153 160 PF00069 0.657
MOD_GSK3_1 170 177 PF00069 0.718
MOD_GSK3_1 20 27 PF00069 0.641
MOD_GSK3_1 202 209 PF00069 0.632
MOD_GSK3_1 288 295 PF00069 0.573
MOD_GSK3_1 315 322 PF00069 0.584
MOD_GSK3_1 446 453 PF00069 0.677
MOD_GSK3_1 48 55 PF00069 0.601
MOD_GSK3_1 537 544 PF00069 0.724
MOD_GSK3_1 575 582 PF00069 0.779
MOD_GSK3_1 58 65 PF00069 0.562
MOD_GSK3_1 589 596 PF00069 0.760
MOD_GSK3_1 607 614 PF00069 0.658
MOD_GSK3_1 622 629 PF00069 0.669
MOD_GSK3_1 633 640 PF00069 0.637
MOD_GSK3_1 673 680 PF00069 0.732
MOD_GSK3_1 681 688 PF00069 0.714
MOD_GSK3_1 709 716 PF00069 0.702
MOD_GSK3_1 741 748 PF00069 0.751
MOD_GSK3_1 777 784 PF00069 0.740
MOD_GSK3_1 798 805 PF00069 0.634
MOD_GSK3_1 80 87 PF00069 0.720
MOD_GSK3_1 811 818 PF00069 0.756
MOD_GSK3_1 824 831 PF00069 0.556
MOD_N-GLC_1 588 593 PF02516 0.577
MOD_N-GLC_1 827 832 PF02516 0.706
MOD_NEK2_1 163 168 PF00069 0.657
MOD_NEK2_1 328 333 PF00069 0.502
MOD_NEK2_1 440 445 PF00069 0.512
MOD_NEK2_1 499 504 PF00069 0.475
MOD_NEK2_1 566 571 PF00069 0.619
MOD_NEK2_1 588 593 PF00069 0.709
MOD_NEK2_1 709 714 PF00069 0.587
MOD_NEK2_1 816 821 PF00069 0.609
MOD_PIKK_1 212 218 PF00454 0.779
MOD_PIKK_1 383 389 PF00454 0.467
MOD_PIKK_1 476 482 PF00454 0.612
MOD_PIKK_1 607 613 PF00454 0.726
MOD_PIKK_1 677 683 PF00454 0.731
MOD_PK_1 775 781 PF00069 0.629
MOD_PKA_1 147 153 PF00069 0.656
MOD_PKA_2 11 17 PF00069 0.602
MOD_PKA_2 147 153 PF00069 0.643
MOD_PKA_2 254 260 PF00069 0.449
MOD_PKA_2 29 35 PF00069 0.516
MOD_PKA_2 305 311 PF00069 0.658
MOD_PKA_2 440 446 PF00069 0.576
MOD_PKA_2 45 51 PF00069 0.565
MOD_PKA_2 509 515 PF00069 0.535
MOD_PKA_2 537 543 PF00069 0.775
MOD_PKA_2 616 622 PF00069 0.729
MOD_PKA_2 741 747 PF00069 0.659
MOD_PKA_2 814 820 PF00069 0.629
MOD_PKB_1 146 154 PF00069 0.595
MOD_PKB_1 755 763 PF00069 0.603
MOD_PKB_1 773 781 PF00069 0.609
MOD_Plk_1 328 334 PF00069 0.500
MOD_Plk_1 775 781 PF00069 0.629
MOD_Plk_2-3 178 184 PF00069 0.607
MOD_Plk_4 113 119 PF00069 0.634
MOD_Plk_4 178 184 PF00069 0.583
MOD_Plk_4 357 363 PF00069 0.444
MOD_Plk_4 596 602 PF00069 0.535
MOD_Plk_4 777 783 PF00069 0.625
MOD_Plk_4 795 801 PF00069 0.601
MOD_ProDKin_1 110 116 PF00069 0.671
MOD_ProDKin_1 122 128 PF00069 0.592
MOD_ProDKin_1 138 144 PF00069 0.651
MOD_ProDKin_1 184 190 PF00069 0.717
MOD_ProDKin_1 20 26 PF00069 0.634
MOD_ProDKin_1 206 212 PF00069 0.628
MOD_ProDKin_1 307 313 PF00069 0.653
MOD_ProDKin_1 31 37 PF00069 0.643
MOD_ProDKin_1 336 342 PF00069 0.422
MOD_ProDKin_1 468 474 PF00069 0.594
MOD_ProDKin_1 52 58 PF00069 0.533
MOD_ProDKin_1 582 588 PF00069 0.672
MOD_ProDKin_1 593 599 PF00069 0.611
MOD_ProDKin_1 604 610 PF00069 0.720
MOD_ProDKin_1 633 639 PF00069 0.657
MOD_ProDKin_1 674 680 PF00069 0.805
MOD_ProDKin_1 800 806 PF00069 0.611
TRG_DiLeu_BaEn_1 178 183 PF01217 0.581
TRG_DiLeu_BaEn_4 435 441 PF01217 0.465
TRG_DiLeu_BaLyEn_6 16 21 PF01217 0.607
TRG_DiLeu_BaLyEn_6 487 492 PF01217 0.471
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.502
TRG_DiLeu_BaLyEn_6 55 60 PF01217 0.502
TRG_DiLeu_BaLyEn_6 619 624 PF01217 0.670
TRG_ENDOCYTIC_2 370 373 PF00928 0.424
TRG_ENDOCYTIC_2 6 9 PF00928 0.523
TRG_ER_diArg_1 145 148 PF00400 0.684
TRG_ER_diArg_1 225 227 PF00400 0.535
TRG_ER_diArg_1 35 38 PF00400 0.698
TRG_ER_diArg_1 440 442 PF00400 0.483
TRG_ER_diArg_1 444 447 PF00400 0.530
TRG_ER_diArg_1 509 511 PF00400 0.459
TRG_ER_diArg_1 524 527 PF00400 0.550
TRG_ER_diArg_1 56 58 PF00400 0.553
TRG_ER_diArg_1 632 634 PF00400 0.658
TRG_ER_diArg_1 772 775 PF00400 0.686
TRG_ER_diArg_1 865 867 PF00400 0.556
TRG_Pf-PMV_PEXEL_1 490 494 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 511 515 PF00026 0.433

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1L2 Leptomonas seymouri 35% 100%
A0A3S5H7S7 Leishmania donovani 99% 100%
A4HKR7 Leishmania braziliensis 66% 100%
E9B355 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q4Z9 Leishmania major 87% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS