LeishMANIAdb
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PH domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PH domain-containing protein
Gene product:
kinteoplast poly(A) polymerase complex 1 subunit - putative
Species:
Leishmania infantum
UniProt:
A4I888_LEIIN
TriTrypDb:
LINF_320033700
Length:
790

Annotations

Annotations by Jardim et al.

Kinetoplastid proteins, kinteoplast poly(A) polymerase complex 1 subunit Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I888
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I888

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.543
CLV_C14_Caspase3-7 147 151 PF00656 0.506
CLV_C14_Caspase3-7 268 272 PF00656 0.730
CLV_C14_Caspase3-7 348 352 PF00656 0.502
CLV_C14_Caspase3-7 50 54 PF00656 0.509
CLV_C14_Caspase3-7 628 632 PF00656 0.675
CLV_C14_Caspase3-7 669 673 PF00656 0.534
CLV_C14_Caspase3-7 702 706 PF00656 0.554
CLV_NRD_NRD_1 170 172 PF00675 0.511
CLV_NRD_NRD_1 180 182 PF00675 0.468
CLV_NRD_NRD_1 216 218 PF00675 0.613
CLV_NRD_NRD_1 228 230 PF00675 0.544
CLV_NRD_NRD_1 27 29 PF00675 0.584
CLV_NRD_NRD_1 31 33 PF00675 0.551
CLV_NRD_NRD_1 358 360 PF00675 0.491
CLV_NRD_NRD_1 479 481 PF00675 0.584
CLV_NRD_NRD_1 515 517 PF00675 0.476
CLV_NRD_NRD_1 524 526 PF00675 0.395
CLV_NRD_NRD_1 607 609 PF00675 0.575
CLV_NRD_NRD_1 715 717 PF00675 0.522
CLV_NRD_NRD_1 763 765 PF00675 0.529
CLV_NRD_NRD_1 88 90 PF00675 0.473
CLV_PCSK_FUR_1 168 172 PF00082 0.544
CLV_PCSK_FUR_1 226 230 PF00082 0.618
CLV_PCSK_FUR_1 761 765 PF00082 0.516
CLV_PCSK_KEX2_1 170 172 PF00082 0.494
CLV_PCSK_KEX2_1 180 182 PF00082 0.473
CLV_PCSK_KEX2_1 218 220 PF00082 0.596
CLV_PCSK_KEX2_1 228 230 PF00082 0.565
CLV_PCSK_KEX2_1 293 295 PF00082 0.559
CLV_PCSK_KEX2_1 31 33 PF00082 0.594
CLV_PCSK_KEX2_1 358 360 PF00082 0.580
CLV_PCSK_KEX2_1 390 392 PF00082 0.388
CLV_PCSK_KEX2_1 408 410 PF00082 0.458
CLV_PCSK_KEX2_1 479 481 PF00082 0.463
CLV_PCSK_KEX2_1 606 608 PF00082 0.599
CLV_PCSK_KEX2_1 720 722 PF00082 0.557
CLV_PCSK_KEX2_1 761 763 PF00082 0.504
CLV_PCSK_KEX2_1 87 89 PF00082 0.481
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.670
CLV_PCSK_PC1ET2_1 293 295 PF00082 0.559
CLV_PCSK_PC1ET2_1 390 392 PF00082 0.388
CLV_PCSK_PC1ET2_1 408 410 PF00082 0.458
CLV_PCSK_PC1ET2_1 720 722 PF00082 0.526
CLV_PCSK_PC7_1 214 220 PF00082 0.648
CLV_PCSK_PC7_1 603 609 PF00082 0.600
CLV_PCSK_PC7_1 716 722 PF00082 0.541
CLV_PCSK_SKI1_1 160 164 PF00082 0.424
CLV_PCSK_SKI1_1 23 27 PF00082 0.700
CLV_PCSK_SKI1_1 294 298 PF00082 0.602
CLV_PCSK_SKI1_1 49 53 PF00082 0.488
CLV_PCSK_SKI1_1 64 68 PF00082 0.439
CLV_PCSK_SKI1_1 736 740 PF00082 0.452
CLV_PCSK_SKI1_1 782 786 PF00082 0.496
DEG_APCC_DBOX_1 179 187 PF00400 0.469
DEG_APCC_DBOX_1 678 686 PF00400 0.496
DEG_Nend_Nbox_1 1 3 PF02207 0.652
DEG_SPOP_SBC_1 17 21 PF00917 0.591
DEG_SPOP_SBC_1 540 544 PF00917 0.563
DOC_CYCLIN_RxL_1 299 310 PF00134 0.631
DOC_MAPK_gen_1 113 122 PF00069 0.541
DOC_MAPK_MEF2A_6 113 122 PF00069 0.541
DOC_MAPK_MEF2A_6 303 311 PF00069 0.608
DOC_MAPK_NFAT4_5 113 121 PF00069 0.540
DOC_MAPK_RevD_3 157 171 PF00069 0.505
DOC_PP1_RVXF_1 734 741 PF00149 0.451
DOC_PP2B_LxvP_1 683 686 PF13499 0.502
DOC_PP2B_LxvP_1 768 771 PF13499 0.516
DOC_PP4_FxxP_1 465 468 PF00568 0.488
DOC_USP7_MATH_1 125 129 PF00917 0.622
DOC_USP7_MATH_1 17 21 PF00917 0.661
DOC_USP7_MATH_1 248 252 PF00917 0.795
DOC_USP7_MATH_1 261 265 PF00917 0.728
DOC_USP7_MATH_1 557 561 PF00917 0.746
DOC_USP7_MATH_1 630 634 PF00917 0.686
DOC_USP7_UBL2_3 29 33 PF12436 0.636
DOC_USP7_UBL2_3 610 614 PF12436 0.678
DOC_USP7_UBL2_3 69 73 PF12436 0.389
DOC_WW_Pin1_4 12 17 PF00397 0.701
DOC_WW_Pin1_4 230 235 PF00397 0.679
DOC_WW_Pin1_4 237 242 PF00397 0.786
DOC_WW_Pin1_4 246 251 PF00397 0.790
DOC_WW_Pin1_4 279 284 PF00397 0.722
LIG_14-3-3_CanoR_1 196 204 PF00244 0.570
LIG_14-3-3_CanoR_1 219 227 PF00244 0.589
LIG_14-3-3_CanoR_1 228 234 PF00244 0.692
LIG_14-3-3_CanoR_1 236 241 PF00244 0.523
LIG_14-3-3_CanoR_1 334 338 PF00244 0.397
LIG_14-3-3_CanoR_1 358 364 PF00244 0.484
LIG_14-3-3_CanoR_1 47 52 PF00244 0.508
LIG_14-3-3_CanoR_1 472 477 PF00244 0.530
LIG_14-3-3_CanoR_1 592 598 PF00244 0.529
LIG_Actin_WH2_2 469 484 PF00022 0.563
LIG_ActinCP_TwfCPI_2 465 474 PF01115 0.553
LIG_AP2alpha_2 713 715 PF02296 0.597
LIG_BRCT_BRCA1_1 198 202 PF00533 0.598
LIG_BRCT_BRCA1_1 337 341 PF00533 0.573
LIG_deltaCOP1_diTrp_1 387 392 PF00928 0.382
LIG_deltaCOP1_diTrp_1 776 781 PF00928 0.480
LIG_FHA_1 162 168 PF00498 0.538
LIG_FHA_1 352 358 PF00498 0.508
LIG_FHA_1 368 374 PF00498 0.320
LIG_FHA_1 416 422 PF00498 0.533
LIG_FHA_1 592 598 PF00498 0.435
LIG_FHA_1 743 749 PF00498 0.555
LIG_FHA_2 104 110 PF00498 0.538
LIG_FHA_2 315 321 PF00498 0.559
LIG_FHA_2 50 56 PF00498 0.463
LIG_FHA_2 557 563 PF00498 0.736
LIG_FHA_2 626 632 PF00498 0.691
LIG_FHA_2 92 98 PF00498 0.507
LIG_GBD_Chelix_1 311 319 PF00786 0.577
LIG_GBD_Chelix_1 652 660 PF00786 0.549
LIG_LIR_Apic_2 462 468 PF02991 0.497
LIG_LIR_Gen_1 109 119 PF02991 0.532
LIG_LIR_Gen_1 323 333 PF02991 0.381
LIG_LIR_Gen_1 53 62 PF02991 0.481
LIG_LIR_Gen_1 616 625 PF02991 0.610
LIG_LIR_Nem_3 109 114 PF02991 0.523
LIG_LIR_Nem_3 323 328 PF02991 0.395
LIG_LIR_Nem_3 330 335 PF02991 0.367
LIG_LIR_Nem_3 404 410 PF02991 0.436
LIG_LIR_Nem_3 53 59 PF02991 0.480
LIG_LIR_Nem_3 616 621 PF02991 0.611
LIG_MYND_1 680 684 PF01753 0.498
LIG_NRBOX 640 646 PF00104 0.616
LIG_Pex14_2 328 332 PF04695 0.385
LIG_Pex14_2 727 731 PF04695 0.545
LIG_PTAP_UEV_1 244 249 PF05743 0.630
LIG_SH2_CRK 519 523 PF00017 0.411
LIG_SH2_STAP1 353 357 PF00017 0.462
LIG_SH2_STAP1 361 365 PF00017 0.490
LIG_SH2_STAP1 393 397 PF00017 0.393
LIG_SH2_STAP1 519 523 PF00017 0.533
LIG_SH2_STAT3 166 169 PF00017 0.543
LIG_SH2_STAT5 166 169 PF00017 0.431
LIG_SH2_STAT5 353 356 PF00017 0.417
LIG_SH2_STAT5 376 379 PF00017 0.548
LIG_SH2_STAT5 483 486 PF00017 0.420
LIG_SH2_STAT5 691 694 PF00017 0.432
LIG_SH2_STAT5 90 93 PF00017 0.527
LIG_SH3_1 764 770 PF00018 0.517
LIG_SH3_1 772 778 PF00018 0.459
LIG_SH3_3 228 234 PF00018 0.614
LIG_SH3_3 242 248 PF00018 0.759
LIG_SH3_3 394 400 PF00018 0.506
LIG_SH3_3 465 471 PF00018 0.595
LIG_SH3_3 678 684 PF00018 0.495
LIG_SH3_3 731 737 PF00018 0.438
LIG_SH3_3 764 770 PF00018 0.510
LIG_SH3_3 772 778 PF00018 0.470
LIG_SUMO_SIM_anti_2 308 314 PF11976 0.593
LIG_SUMO_SIM_anti_2 369 375 PF11976 0.437
LIG_TRAF2_1 213 216 PF00917 0.589
LIG_TRAF2_1 379 382 PF00917 0.535
LIG_TRAF2_2 119 124 PF00917 0.662
LIG_UBA3_1 315 324 PF00899 0.584
LIG_UBA3_1 656 665 PF00899 0.496
MOD_CDC14_SPxK_1 233 236 PF00782 0.670
MOD_CDK_SPxK_1 230 236 PF00069 0.639
MOD_CK1_1 175 181 PF00069 0.620
MOD_CK1_1 19 25 PF00069 0.759
MOD_CK1_1 232 238 PF00069 0.671
MOD_CK1_1 240 246 PF00069 0.705
MOD_CK1_1 314 320 PF00069 0.601
MOD_CK1_1 535 541 PF00069 0.666
MOD_CK1_1 602 608 PF00069 0.659
MOD_CK1_1 690 696 PF00069 0.443
MOD_CK2_1 252 258 PF00069 0.791
MOD_CK2_1 307 313 PF00069 0.614
MOD_CK2_1 314 320 PF00069 0.552
MOD_CK2_1 472 478 PF00069 0.453
MOD_CK2_1 49 55 PF00069 0.469
MOD_CK2_1 539 545 PF00069 0.644
MOD_CK2_1 663 669 PF00069 0.460
MOD_GlcNHglycan 244 248 PF01048 0.679
MOD_GlcNHglycan 267 270 PF01048 0.689
MOD_GlcNHglycan 435 438 PF01048 0.690
MOD_GlcNHglycan 538 541 PF01048 0.702
MOD_GlcNHglycan 554 557 PF01048 0.545
MOD_GlcNHglycan 559 562 PF01048 0.634
MOD_GlcNHglycan 692 695 PF01048 0.431
MOD_GlcNHglycan 710 713 PF01048 0.466
MOD_GSK3_1 125 132 PF00069 0.636
MOD_GSK3_1 17 24 PF00069 0.668
MOD_GSK3_1 232 239 PF00069 0.734
MOD_GSK3_1 248 255 PF00069 0.801
MOD_GSK3_1 261 268 PF00069 0.760
MOD_GSK3_1 277 284 PF00069 0.717
MOD_GSK3_1 307 314 PF00069 0.552
MOD_GSK3_1 532 539 PF00069 0.536
MOD_GSK3_1 548 555 PF00069 0.755
MOD_GSK3_1 593 600 PF00069 0.514
MOD_GSK3_1 602 609 PF00069 0.560
MOD_GSK3_1 65 72 PF00069 0.452
MOD_GSK3_1 8 15 PF00069 0.724
MOD_N-GLC_1 536 541 PF02516 0.650
MOD_NEK2_1 129 134 PF00069 0.583
MOD_NEK2_1 18 23 PF00069 0.795
MOD_NEK2_1 288 293 PF00069 0.659
MOD_NEK2_1 297 302 PF00069 0.592
MOD_NEK2_1 307 312 PF00069 0.523
MOD_NEK2_1 335 340 PF00069 0.477
MOD_NEK2_1 532 537 PF00069 0.578
MOD_NEK2_1 552 557 PF00069 0.492
MOD_NEK2_1 740 745 PF00069 0.493
MOD_NEK2_1 91 96 PF00069 0.503
MOD_NEK2_2 103 108 PF00069 0.561
MOD_NEK2_2 139 144 PF00069 0.495
MOD_NEK2_2 353 358 PF00069 0.530
MOD_OFUCOSY 262 267 PF10250 0.686
MOD_PIKK_1 129 135 PF00454 0.580
MOD_PIKK_1 191 197 PF00454 0.464
MOD_PIKK_1 335 341 PF00454 0.443
MOD_PIKK_1 451 457 PF00454 0.623
MOD_PIKK_1 591 597 PF00454 0.526
MOD_PK_1 359 365 PF00069 0.611
MOD_PKA_1 606 612 PF00069 0.671
MOD_PKA_2 333 339 PF00069 0.402
MOD_PKA_2 591 597 PF00069 0.561
MOD_PKA_2 602 608 PF00069 0.604
MOD_PKB_1 217 225 PF00069 0.596
MOD_Plk_1 139 145 PF00069 0.490
MOD_Plk_1 307 313 PF00069 0.556
MOD_Plk_1 91 97 PF00069 0.506
MOD_Plk_2-3 663 669 PF00069 0.460
MOD_Plk_4 139 145 PF00069 0.490
MOD_Plk_4 307 313 PF00069 0.504
MOD_Plk_4 593 599 PF00069 0.532
MOD_Plk_4 687 693 PF00069 0.460
MOD_ProDKin_1 12 18 PF00069 0.704
MOD_ProDKin_1 230 236 PF00069 0.691
MOD_ProDKin_1 237 243 PF00069 0.785
MOD_ProDKin_1 246 252 PF00069 0.792
MOD_ProDKin_1 279 285 PF00069 0.718
MOD_SUMO_for_1 379 382 PF00179 0.572
MOD_SUMO_for_1 613 616 PF00179 0.661
MOD_SUMO_rev_2 402 410 PF00179 0.538
MOD_SUMO_rev_2 661 666 PF00179 0.450
TRG_DiLeu_BaEn_1 640 645 PF01217 0.654
TRG_DiLeu_BaLyEn_6 652 657 PF01217 0.446
TRG_DiLeu_BaLyEn_6 734 739 PF01217 0.463
TRG_DiLeu_LyEn_5 640 645 PF01217 0.654
TRG_DiLeu_LyEn_5 678 683 PF01217 0.514
TRG_ENDOCYTIC_2 393 396 PF00928 0.464
TRG_ENDOCYTIC_2 407 410 PF00928 0.358
TRG_ENDOCYTIC_2 486 489 PF00928 0.489
TRG_ENDOCYTIC_2 519 522 PF00928 0.425
TRG_ER_diArg_1 167 170 PF00400 0.562
TRG_ER_diArg_1 226 229 PF00400 0.591
TRG_ER_diArg_1 357 359 PF00400 0.558
TRG_ER_diArg_1 479 482 PF00400 0.452
TRG_ER_diArg_1 606 608 PF00400 0.603
TRG_ER_diArg_1 761 764 PF00400 0.523
TRG_ER_diArg_1 87 89 PF00400 0.481
TRG_NLS_MonoExtC_3 27 32 PF00514 0.665
TRG_NLS_MonoExtC_3 715 720 PF00514 0.591
TRG_NLS_MonoExtN_4 26 32 PF00514 0.672
TRG_NLS_MonoExtN_4 290 296 PF00514 0.667
TRG_NLS_MonoExtN_4 714 720 PF00514 0.507
TRG_Pf-PMV_PEXEL_1 219 223 PF00026 0.585
TRG_Pf-PMV_PEXEL_1 474 478 PF00026 0.561
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 516 521 PF00026 0.461
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.525

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I355 Leptomonas seymouri 73% 93%
A0A0S4JPP8 Bodo saltans 43% 100%
A0A1X0NS88 Trypanosomatidae 49% 99%
A0A3R7LBC9 Trypanosoma rangeli 52% 100%
A0A3S7X5U8 Leishmania donovani 100% 100%
A4HKQ8 Leishmania braziliensis 85% 99%
E9B346 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q508 Leishmania major 96% 100%
V5AUT0 Trypanosoma cruzi 53% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS