Putative cysteine desulfhydrase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine desulfhydrase

Species:

Leishmania infantum

UniProt:

A4I885_LEIIN

TriTrypDb:

LINF_320033300

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I885

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I885

Function

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Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	8
GO:0000098	sulfur amino acid catabolic process	5	1
GO:0006082	organic acid metabolic process	3	8
GO:0006090	pyruvate metabolic process	7	1
GO:0006520	amino acid metabolic process	3	8
GO:0006534	cysteine metabolic process	5	8
GO:0006790	sulfur compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004121	cystathionine beta-lyase activity	4	8
GO:0004123	cystathionine gamma-lyase activity	4	5
GO:0005488	binding	1	8
GO:0016829	lyase activity	2	8
GO:0016846	carbon-sulfur lyase activity	3	8
GO:0019148	D-cysteine desulfhydrase activity	4	1
GO:0019842	vitamin binding	3	8
GO:0030170	pyridoxal phosphate binding	4	8
GO:0036094	small molecule binding	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.297
CLV_NRD_NRD_1	302	304	PF00675	0.301
CLV_NRD_NRD_1	50	52	PF00675	0.301
CLV_PCSK_KEX2_1	269	271	PF00082	0.267
CLV_PCSK_KEX2_1	302	304	PF00082	0.297
CLV_PCSK_KEX2_1	49	51	PF00082	0.299
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.390
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.259
CLV_PCSK_SKI1_1	125	129	PF00082	0.448
CLV_PCSK_SKI1_1	142	146	PF00082	0.200

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D2YG02	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	23%	92%
A0A0J6G7P5	Pseudomonas deceptionensis	28%	100%
A0A0N0P3U0	Leptomonas seymouri	29%	78%
A0A0N0P8H0	Leptomonas seymouri	67%	100%
A0A0N1HW05	Leptomonas seymouri	26%	97%
A0A0N1PG90	Leptomonas seymouri	68%	91%
A0A0S4IZX4	Bodo saltans	28%	97%
A0A1X0NP01	Trypanosomatidae	26%	82%
A0A1X0P5N4	Trypanosomatidae	26%	98%
A0A3Q8ILD8	Leishmania donovani	99%	100%

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