WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I879_LEIIN

TriTrypDb:

LINF_320032700

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I879

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I879

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.609
CLV_NRD_NRD_1	24	26	PF00675	0.449
CLV_NRD_NRD_1	36	38	PF00675	0.412
CLV_PCSK_KEX2_1	24	26	PF00082	0.449
CLV_PCSK_KEX2_1	36	38	PF00082	0.407
CLV_PCSK_SKI1_1	25	29	PF00082	0.434
CLV_PCSK_SKI1_1	367	371	PF00082	0.384
DEG_Nend_UBRbox_3	1	3	PF02207	0.438
DEG_SPOP_SBC_1	178	182	PF00917	0.272
DOC_CKS1_1	138	143	PF01111	0.473
DOC_MAPK_gen_1	24	31	PF00069	0.432
DOC_MAPK_gen_1	301	311	PF00069	0.415
DOC_MAPK_gen_1	352	362	PF00069	0.470
DOC_MAPK_HePTP_8	266	278	PF00069	0.462
DOC_MAPK_MEF2A_6	24	31	PF00069	0.592
DOC_MAPK_MEF2A_6	269	278	PF00069	0.467
DOC_MAPK_MEF2A_6	355	364	PF00069	0.421
DOC_MAPK_NFAT4_5	24	32	PF00069	0.423
DOC_PP1_RVXF_1	163	170	PF00149	0.453
DOC_PP1_RVXF_1	222	228	PF00149	0.327
DOC_PP2B_LxvP_1	27	30	PF13499	0.419
DOC_USP7_MATH_1	142	146	PF00917	0.417
DOC_USP7_MATH_1	178	182	PF00917	0.424
DOC_USP7_MATH_1	71	75	PF00917	0.418
DOC_WW_Pin1_4	11	16	PF00397	0.495
DOC_WW_Pin1_4	137	142	PF00397	0.461
DOC_WW_Pin1_4	183	188	PF00397	0.357
DOC_WW_Pin1_4	67	72	PF00397	0.702
LIG_14-3-3_CanoR_1	206	212	PF00244	0.383
LIG_14-3-3_CanoR_1	24	30	PF00244	0.479
LIG_BIR_III_2	333	337	PF00653	0.521
LIG_FHA_1	108	114	PF00498	0.485
LIG_FHA_1	12	18	PF00498	0.592
LIG_FHA_1	129	135	PF00498	0.388
LIG_FHA_1	26	32	PF00498	0.413
LIG_FHA_1	345	351	PF00498	0.440
LIG_FHA_1	73	79	PF00498	0.461
LIG_FHA_2	368	374	PF00498	0.332
LIG_FHA_2	82	88	PF00498	0.446
LIG_LIR_Apic_2	286	292	PF02991	0.361
LIG_LIR_Gen_1	205	214	PF02991	0.494
LIG_LIR_Gen_1	313	321	PF02991	0.465
LIG_LIR_Nem_3	205	211	PF02991	0.519
LIG_LIR_Nem_3	271	276	PF02991	0.431
LIG_LIR_Nem_3	306	310	PF02991	0.494
LIG_LIR_Nem_3	313	317	PF02991	0.440
LIG_PTAP_UEV_1	186	191	PF05743	0.449
LIG_SH2_PTP2	289	292	PF00017	0.411
LIG_SH2_SRC	86	89	PF00017	0.569
LIG_SH2_STAP1	116	120	PF00017	0.451
LIG_SH2_STAT3	116	119	PF00017	0.433
LIG_SH2_STAT3	148	151	PF00017	0.344
LIG_SH2_STAT5	289	292	PF00017	0.355
LIG_SH2_STAT5	310	313	PF00017	0.347
LIG_SH2_STAT5	51	54	PF00017	0.591
LIG_SH2_STAT5	91	94	PF00017	0.352
LIG_SH3_3	135	141	PF00018	0.412
LIG_SH3_3	184	190	PF00018	0.442
LIG_TRAF2_1	246	249	PF00917	0.468
MOD_CK1_1	107	113	PF00069	0.379
MOD_CK1_1	18	24	PF00069	0.496
MOD_CK1_1	409	415	PF00069	0.679
MOD_CK2_1	232	238	PF00069	0.319
MOD_CK2_1	243	249	PF00069	0.348
MOD_CK2_1	367	373	PF00069	0.330
MOD_CK2_1	81	87	PF00069	0.410
MOD_GlcNHglycan	17	20	PF01048	0.497
MOD_GlcNHglycan	175	178	PF01048	0.477
MOD_GlcNHglycan	187	190	PF01048	0.449
MOD_GlcNHglycan	234	237	PF01048	0.317
MOD_GlcNHglycan	317	320	PF01048	0.496
MOD_GlcNHglycan	324	327	PF01048	0.484
MOD_GlcNHglycan	329	333	PF01048	0.536
MOD_GlcNHglycan	396	399	PF01048	0.675
MOD_GlcNHglycan	417	420	PF01048	0.727
MOD_GlcNHglycan	430	433	PF01048	0.739
MOD_GlcNHglycan	47	50	PF01048	0.415
MOD_GlcNHglycan	63	66	PF01048	0.632
MOD_GSK3_1	100	107	PF00069	0.348
MOD_GSK3_1	11	18	PF00069	0.494
MOD_GSK3_1	115	122	PF00069	0.389
MOD_GSK3_1	142	149	PF00069	0.378
MOD_GSK3_1	173	180	PF00069	0.395
MOD_GSK3_1	277	284	PF00069	0.396
MOD_GSK3_1	385	392	PF00069	0.538
MOD_GSK3_1	394	401	PF00069	0.568
MOD_GSK3_1	63	70	PF00069	0.532
MOD_N-GLC_1	98	103	PF02516	0.470
MOD_NEK2_1	104	109	PF00069	0.351
MOD_NEK2_1	115	120	PF00069	0.453
MOD_NEK2_1	146	151	PF00069	0.404
MOD_NEK2_1	173	178	PF00069	0.431
MOD_NEK2_1	202	207	PF00069	0.388
MOD_NEK2_1	407	412	PF00069	0.735
MOD_NEK2_1	81	86	PF00069	0.373
MOD_PIKK_1	107	113	PF00454	0.476
MOD_PIKK_1	115	121	PF00454	0.479
MOD_PIKK_1	128	134	PF00454	0.448
MOD_PIKK_1	344	350	PF00454	0.502
MOD_PKA_2	23	29	PF00069	0.476
MOD_PKA_2	297	303	PF00069	0.494
MOD_PKA_2	428	434	PF00069	0.666
MOD_Plk_1	220	226	PF00069	0.318
MOD_Plk_4	119	125	PF00069	0.468
MOD_Plk_4	142	148	PF00069	0.358
MOD_Plk_4	277	283	PF00069	0.382
MOD_ProDKin_1	11	17	PF00069	0.495
MOD_ProDKin_1	137	143	PF00069	0.460
MOD_ProDKin_1	183	189	PF00069	0.355
MOD_ProDKin_1	67	73	PF00069	0.695
MOD_SUMO_rev_2	223	233	PF00179	0.372
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.448
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.453
TRG_ER_diArg_1	224	227	PF00400	0.316
TRG_ER_diArg_1	23	25	PF00400	0.460
TRG_ER_diArg_1	35	37	PF00400	0.403
TRG_ER_diArg_1	5	8	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A3	Leptomonas seymouri	77%	100%
A0A0S4J2R9	Bodo saltans	44%	100%
A0A1X0NRV1	Trypanosomatidae	44%	100%
A0A3Q8IDA1	Leishmania donovani	100%	100%
A0A3R7L0G4	Trypanosoma rangeli	53%	100%
A4HKP8	Leishmania braziliensis	84%	100%
D0AAE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B337	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q517	Leishmania major	95%	100%
V5BET5	Trypanosoma cruzi	51%	100%