Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I878_LEIIN

TriTrypDb:

LINF_320032600

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I878

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I878

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.614
CLV_C14_Caspase3-7	550	554	PF00656	0.636
CLV_C14_Caspase3-7	82	86	PF00656	0.603
CLV_C14_Caspase3-7	877	881	PF00656	0.581
CLV_NRD_NRD_1	161	163	PF00675	0.481
CLV_NRD_NRD_1	262	264	PF00675	0.533
CLV_NRD_NRD_1	265	267	PF00675	0.542
CLV_NRD_NRD_1	297	299	PF00675	0.739
CLV_NRD_NRD_1	302	304	PF00675	0.698
CLV_NRD_NRD_1	31	33	PF00675	0.588
CLV_NRD_NRD_1	365	367	PF00675	0.610
CLV_NRD_NRD_1	620	622	PF00675	0.607
CLV_NRD_NRD_1	654	656	PF00675	0.723
CLV_NRD_NRD_1	670	672	PF00675	0.507
CLV_NRD_NRD_1	706	708	PF00675	0.608
CLV_NRD_NRD_1	89	91	PF00675	0.598
CLV_PCSK_FUR_1	263	267	PF00082	0.538
CLV_PCSK_FUR_1	652	656	PF00082	0.711
CLV_PCSK_FUR_1	668	672	PF00082	0.554
CLV_PCSK_FUR_1	703	707	PF00082	0.593
CLV_PCSK_KEX2_1	161	163	PF00082	0.484
CLV_PCSK_KEX2_1	262	264	PF00082	0.571
CLV_PCSK_KEX2_1	265	267	PF00082	0.575
CLV_PCSK_KEX2_1	302	304	PF00082	0.719
CLV_PCSK_KEX2_1	31	33	PF00082	0.593
CLV_PCSK_KEX2_1	365	367	PF00082	0.549
CLV_PCSK_KEX2_1	620	622	PF00082	0.606
CLV_PCSK_KEX2_1	654	656	PF00082	0.723
CLV_PCSK_KEX2_1	670	672	PF00082	0.507
CLV_PCSK_KEX2_1	705	707	PF00082	0.627
CLV_PCSK_KEX2_1	743	745	PF00082	0.783
CLV_PCSK_KEX2_1	787	789	PF00082	0.835
CLV_PCSK_KEX2_1	89	91	PF00082	0.598
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.733
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.738
CLV_PCSK_PC7_1	298	304	PF00082	0.765
CLV_PCSK_SKI1_1	254	258	PF00082	0.599
CLV_PCSK_SKI1_1	328	332	PF00082	0.655
CLV_PCSK_SKI1_1	437	441	PF00082	0.612
CLV_PCSK_SKI1_1	681	685	PF00082	0.487
CLV_PCSK_SKI1_1	737	741	PF00082	0.635
CLV_PCSK_SKI1_1	900	904	PF00082	0.692
CLV_Separin_Metazoa	523	527	PF03568	0.569
CLV_Separin_Metazoa	826	830	PF03568	0.597
DEG_APCC_DBOX_1	33	41	PF00400	0.539
DEG_APCC_DBOX_1	743	751	PF00400	0.715
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SPOP_SBC_1	335	339	PF00917	0.732
DEG_SPOP_SBC_1	915	919	PF00917	0.490
DOC_ANK_TNKS_1	560	567	PF00023	0.715
DOC_CKS1_1	342	347	PF01111	0.813
DOC_CKS1_1	442	447	PF01111	0.752
DOC_CKS1_1	471	476	PF01111	0.844
DOC_MAPK_DCC_7	31	40	PF00069	0.544
DOC_MAPK_gen_1	31	40	PF00069	0.544
DOC_MAPK_gen_1	620	628	PF00069	0.591
DOC_MAPK_gen_1	743	749	PF00069	0.798
DOC_MAPK_gen_1	787	797	PF00069	0.791
DOC_MAPK_MEF2A_6	118	126	PF00069	0.537
DOC_MAPK_MEF2A_6	31	40	PF00069	0.585
DOC_PP4_FxxP_1	471	474	PF00568	0.718
DOC_PP4_FxxP_1	691	694	PF00568	0.713
DOC_PP4_FxxP_1	696	699	PF00568	0.712
DOC_USP7_MATH_1	108	112	PF00917	0.561
DOC_USP7_MATH_1	198	202	PF00917	0.693
DOC_USP7_MATH_1	206	210	PF00917	0.714
DOC_USP7_MATH_1	22	26	PF00917	0.605
DOC_USP7_MATH_1	222	226	PF00917	0.682
DOC_USP7_MATH_1	335	339	PF00917	0.680
DOC_USP7_MATH_1	345	349	PF00917	0.614
DOC_USP7_MATH_1	479	483	PF00917	0.855
DOC_USP7_MATH_1	61	65	PF00917	0.681
DOC_USP7_MATH_1	730	734	PF00917	0.610
DOC_USP7_MATH_1	735	739	PF00917	0.584
DOC_USP7_MATH_1	762	766	PF00917	0.603
DOC_USP7_MATH_1	888	892	PF00917	0.755
DOC_USP7_MATH_1	915	919	PF00917	0.601
DOC_USP7_UBL2_3	166	170	PF12436	0.494
DOC_WW_Pin1_4	113	118	PF00397	0.607
DOC_WW_Pin1_4	14	19	PF00397	0.648
DOC_WW_Pin1_4	171	176	PF00397	0.665
DOC_WW_Pin1_4	191	196	PF00397	0.702
DOC_WW_Pin1_4	217	222	PF00397	0.845
DOC_WW_Pin1_4	341	346	PF00397	0.817
DOC_WW_Pin1_4	441	446	PF00397	0.775
DOC_WW_Pin1_4	470	475	PF00397	0.831
DOC_WW_Pin1_4	48	53	PF00397	0.559
DOC_WW_Pin1_4	586	591	PF00397	0.766
DOC_WW_Pin1_4	68	73	PF00397	0.635
DOC_WW_Pin1_4	777	782	PF00397	0.808
DOC_WW_Pin1_4	786	791	PF00397	0.751
DOC_WW_Pin1_4	829	834	PF00397	0.791
DOC_WW_Pin1_4	854	859	PF00397	0.793
LIG_14-3-3_CanoR_1	223	227	PF00244	0.731
LIG_14-3-3_CanoR_1	305	314	PF00244	0.787
LIG_14-3-3_CanoR_1	350	359	PF00244	0.619
LIG_14-3-3_CanoR_1	379	383	PF00244	0.715
LIG_14-3-3_CanoR_1	388	394	PF00244	0.622
LIG_14-3-3_CanoR_1	423	433	PF00244	0.619
LIG_14-3-3_CanoR_1	455	463	PF00244	0.674
LIG_14-3-3_CanoR_1	557	565	PF00244	0.764
LIG_14-3-3_CanoR_1	654	662	PF00244	0.626
LIG_14-3-3_CanoR_1	729	739	PF00244	0.630
LIG_14-3-3_CanoR_1	763	767	PF00244	0.794
LIG_14-3-3_CanoR_1	89	94	PF00244	0.559
LIG_APCC_ABBA_1	637	642	PF00400	0.694
LIG_BIR_III_2	805	809	PF00653	0.731
LIG_BIR_III_4	880	884	PF00653	0.718
LIG_BRCT_BRCA1_1	115	119	PF00533	0.512
LIG_BRCT_BRCA1_1	140	144	PF00533	0.466
LIG_BRCT_BRCA1_1	348	352	PF00533	0.600
LIG_BRCT_BRCA1_1	412	416	PF00533	0.760
LIG_BRCT_BRCA1_1	467	471	PF00533	0.643
LIG_CSL_BTD_1	795	798	PF09270	0.709
LIG_CtBP_PxDLS_1	847	853	PF00389	0.529
LIG_EVH1_2	501	505	PF00568	0.681
LIG_FHA_1	102	108	PF00498	0.548
LIG_FHA_1	426	432	PF00498	0.679
LIG_FHA_1	442	448	PF00498	0.830
LIG_FHA_1	572	578	PF00498	0.568
LIG_FHA_1	777	783	PF00498	0.684
LIG_FHA_1	907	913	PF00498	0.595
LIG_FHA_2	241	247	PF00498	0.650
LIG_FHA_2	353	359	PF00498	0.510
LIG_FHA_2	372	378	PF00498	0.520
LIG_FHA_2	395	401	PF00498	0.702
LIG_FHA_2	489	495	PF00498	0.697
LIG_FHA_2	548	554	PF00498	0.795
LIG_FHA_2	603	609	PF00498	0.733
LIG_FHA_2	664	670	PF00498	0.652
LIG_FHA_2	71	77	PF00498	0.604
LIG_FHA_2	800	806	PF00498	0.735
LIG_FHA_2	928	934	PF00498	0.530
LIG_LIR_Apic_2	468	474	PF02991	0.713
LIG_LIR_Apic_2	693	699	PF02991	0.672
LIG_LIR_Apic_2	802	807	PF02991	0.595
LIG_LIR_Gen_1	138	147	PF02991	0.499
LIG_LIR_Gen_1	605	612	PF02991	0.597
LIG_LIR_Gen_1	823	833	PF02991	0.763
LIG_LIR_Gen_1	91	101	PF02991	0.552
LIG_LIR_Nem_3	116	122	PF02991	0.507
LIG_LIR_Nem_3	138	143	PF02991	0.507
LIG_LIR_Nem_3	413	419	PF02991	0.670
LIG_LIR_Nem_3	605	610	PF02991	0.598
LIG_LIR_Nem_3	634	640	PF02991	0.707
LIG_LIR_Nem_3	823	828	PF02991	0.770
LIG_Pex14_2	505	509	PF04695	0.693
LIG_SH2_CRK	140	144	PF00017	0.422
LIG_SH2_STAP1	140	144	PF00017	0.466
LIG_SH2_STAT5	398	401	PF00017	0.692
LIG_SH2_STAT5	419	422	PF00017	0.765
LIG_SH2_STAT5	604	607	PF00017	0.586
LIG_SH2_STAT5	920	923	PF00017	0.573
LIG_SH3_3	114	120	PF00018	0.590
LIG_SH3_3	192	198	PF00018	0.690
LIG_SH3_3	30	36	PF00018	0.690
LIG_SH3_3	439	445	PF00018	0.825
LIG_SH3_3	496	502	PF00018	0.733
LIG_SH3_3	534	540	PF00018	0.634
LIG_SH3_3	778	784	PF00018	0.833
LIG_SH3_3	828	834	PF00018	0.782
LIG_SH3_4	166	173	PF00018	0.501
LIG_SUMO_SIM_par_1	43	48	PF11976	0.584
LIG_TRAF2_1	354	357	PF00917	0.550
LIG_TRAF2_1	374	377	PF00917	0.473
LIG_UBA3_1	711	718	PF00899	0.606
LIG_WW_3	589	593	PF00397	0.716
MOD_CDC14_SPxK_1	220	223	PF00782	0.846
MOD_CDC14_SPxK_1	589	592	PF00782	0.737
MOD_CDC14_SPxK_1	857	860	PF00782	0.583
MOD_CDK_SPK_2	113	118	PF00069	0.520
MOD_CDK_SPK_2	171	176	PF00069	0.559
MOD_CDK_SPK_2	441	446	PF00069	0.701
MOD_CDK_SPK_2	786	791	PF00069	0.832
MOD_CDK_SPxK_1	217	223	PF00069	0.847
MOD_CDK_SPxK_1	341	347	PF00069	0.697
MOD_CDK_SPxK_1	475	481	PF00069	0.738
MOD_CDK_SPxK_1	586	592	PF00069	0.738
MOD_CDK_SPxK_1	854	860	PF00069	0.573
MOD_CDK_SPxxK_3	780	787	PF00069	0.776
MOD_CK1_1	111	117	PF00069	0.563
MOD_CK1_1	235	241	PF00069	0.707
MOD_CK1_1	306	312	PF00069	0.627
MOD_CK1_1	346	352	PF00069	0.657
MOD_CK1_1	381	387	PF00069	0.749
MOD_CK1_1	389	395	PF00069	0.654
MOD_CK1_1	427	433	PF00069	0.772
MOD_CK1_1	461	467	PF00069	0.848
MOD_CK1_1	64	70	PF00069	0.672
MOD_CK1_1	733	739	PF00069	0.672
MOD_CK1_1	832	838	PF00069	0.653
MOD_CK1_1	864	870	PF00069	0.750
MOD_CK2_1	179	185	PF00069	0.596
MOD_CK2_1	286	292	PF00069	0.631
MOD_CK2_1	352	358	PF00069	0.664
MOD_CK2_1	371	377	PF00069	0.514
MOD_CK2_1	394	400	PF00069	0.702
MOD_CK2_1	456	462	PF00069	0.743
MOD_CK2_1	663	669	PF00069	0.671
MOD_CK2_1	735	741	PF00069	0.653
MOD_CK2_1	88	94	PF00069	0.578
MOD_CK2_1	927	933	PF00069	0.528
MOD_Cter_Amidation	741	744	PF01082	0.732
MOD_DYRK1A_RPxSP_1	829	833	PF00069	0.717
MOD_GlcNHglycan	110	113	PF01048	0.668
MOD_GlcNHglycan	191	194	PF01048	0.771
MOD_GlcNHglycan	200	203	PF01048	0.637
MOD_GlcNHglycan	209	212	PF01048	0.592
MOD_GlcNHglycan	224	227	PF01048	0.655
MOD_GlcNHglycan	24	27	PF01048	0.663
MOD_GlcNHglycan	308	311	PF01048	0.833
MOD_GlcNHglycan	338	341	PF01048	0.693
MOD_GlcNHglycan	352	355	PF01048	0.552
MOD_GlcNHglycan	448	451	PF01048	0.683
MOD_GlcNHglycan	464	467	PF01048	0.731
MOD_GlcNHglycan	544	547	PF01048	0.769
MOD_GlcNHglycan	558	561	PF01048	0.826
MOD_GlcNHglycan	719	722	PF01048	0.662
MOD_GlcNHglycan	784	787	PF01048	0.792
MOD_GlcNHglycan	81	84	PF01048	0.737
MOD_GlcNHglycan	890	893	PF01048	0.649
MOD_GlcNHglycan	97	100	PF01048	0.599
MOD_GSK3_1	107	114	PF00069	0.729
MOD_GSK3_1	22	29	PF00069	0.586
MOD_GSK3_1	228	235	PF00069	0.749
MOD_GSK3_1	280	287	PF00069	0.713
MOD_GSK3_1	341	348	PF00069	0.712
MOD_GSK3_1	371	378	PF00069	0.678
MOD_GSK3_1	422	429	PF00069	0.795
MOD_GSK3_1	446	453	PF00069	0.811
MOD_GSK3_1	458	465	PF00069	0.753
MOD_GSK3_1	475	482	PF00069	0.740
MOD_GSK3_1	48	55	PF00069	0.683
MOD_GSK3_1	485	492	PF00069	0.735
MOD_GSK3_1	538	545	PF00069	0.802
MOD_GSK3_1	61	68	PF00069	0.507
MOD_GSK3_1	650	657	PF00069	0.648
MOD_GSK3_1	694	701	PF00069	0.706
MOD_GSK3_1	733	740	PF00069	0.795
MOD_GSK3_1	776	783	PF00069	0.785
MOD_GSK3_1	796	803	PF00069	0.657
MOD_GSK3_1	911	918	PF00069	0.609
MOD_GSK3_1	923	930	PF00069	0.489
MOD_N-GLC_1	254	259	PF02516	0.606
MOD_N-GLC_1	280	285	PF02516	0.713
MOD_N-GLC_1	768	773	PF02516	0.693
MOD_NEK2_1	107	112	PF00069	0.549
MOD_NEK2_1	228	233	PF00069	0.761
MOD_NEK2_1	336	341	PF00069	0.754
MOD_NEK2_1	440	445	PF00069	0.789
MOD_NEK2_1	814	819	PF00069	0.689
MOD_NEK2_2	135	140	PF00069	0.490
MOD_NEK2_2	280	285	PF00069	0.752
MOD_NEK2_2	663	668	PF00069	0.706
MOD_PIKK_1	286	292	PF00454	0.773
MOD_PIKK_1	352	358	PF00454	0.508
MOD_PIKK_1	694	700	PF00454	0.688
MOD_PIKK_1	730	736	PF00454	0.657
MOD_PIKK_1	861	867	PF00454	0.725
MOD_PKA_1	298	304	PF00069	0.742
MOD_PKA_1	654	660	PF00069	0.708
MOD_PKA_1	89	95	PF00069	0.598
MOD_PKA_2	222	228	PF00069	0.728
MOD_PKA_2	346	352	PF00069	0.685
MOD_PKA_2	378	384	PF00069	0.730
MOD_PKA_2	422	428	PF00069	0.615
MOD_PKA_2	509	515	PF00069	0.663
MOD_PKA_2	556	562	PF00069	0.849
MOD_PKA_2	654	660	PF00069	0.747
MOD_PKA_2	669	675	PF00069	0.458
MOD_PKA_2	762	768	PF00069	0.703
MOD_PKA_2	78	84	PF00069	0.588
MOD_PKA_2	88	94	PF00069	0.567
MOD_PKB_1	296	304	PF00069	0.744
MOD_PKB_1	483	491	PF00069	0.667
MOD_PKB_1	652	660	PF00069	0.627
MOD_Plk_1	228	234	PF00069	0.743
MOD_Plk_1	280	286	PF00069	0.619
MOD_Plk_1	768	774	PF00069	0.633
MOD_Plk_2-3	448	454	PF00069	0.663
MOD_Plk_4	135	141	PF00069	0.461
MOD_Plk_4	394	400	PF00069	0.624
MOD_Plk_4	602	608	PF00069	0.635
MOD_Plk_4	916	922	PF00069	0.550
MOD_ProDKin_1	113	119	PF00069	0.606
MOD_ProDKin_1	14	20	PF00069	0.648
MOD_ProDKin_1	171	177	PF00069	0.667
MOD_ProDKin_1	191	197	PF00069	0.704
MOD_ProDKin_1	217	223	PF00069	0.847
MOD_ProDKin_1	341	347	PF00069	0.813
MOD_ProDKin_1	441	447	PF00069	0.776
MOD_ProDKin_1	470	476	PF00069	0.831
MOD_ProDKin_1	48	54	PF00069	0.563
MOD_ProDKin_1	586	592	PF00069	0.768
MOD_ProDKin_1	68	74	PF00069	0.635
MOD_ProDKin_1	777	783	PF00069	0.808
MOD_ProDKin_1	786	792	PF00069	0.749
MOD_ProDKin_1	829	835	PF00069	0.784
MOD_ProDKin_1	854	860	PF00069	0.797
MOD_SUMO_rev_2	292	301	PF00179	0.669
MOD_SUMO_rev_2	738	745	PF00179	0.630
MOD_SUMO_rev_2	751	756	PF00179	0.451
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.604
TRG_ENDOCYTIC_2	140	143	PF00928	0.486
TRG_ENDOCYTIC_2	604	607	PF00928	0.526
TRG_ENDOCYTIC_2	825	828	PF00928	0.775
TRG_ER_diArg_1	155	158	PF00400	0.483
TRG_ER_diArg_1	265	267	PF00400	0.570
TRG_ER_diArg_1	302	305	PF00400	0.769
TRG_ER_diArg_1	31	34	PF00400	0.637
TRG_ER_diArg_1	364	366	PF00400	0.667
TRG_ER_diArg_1	481	484	PF00400	0.642
TRG_ER_diArg_1	561	564	PF00400	0.744
TRG_ER_diArg_1	619	621	PF00400	0.583
TRG_ER_diArg_1	644	647	PF00400	0.702
TRG_ER_diArg_1	652	655	PF00400	0.699
TRG_ER_diArg_1	670	673	PF00400	0.500
TRG_ER_diArg_1	703	706	PF00400	0.619
TRG_ER_diArg_1	790	793	PF00400	0.811
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	922	927	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGB2	Leptomonas seymouri	33%	100%
A0A3S7X5S6	Leishmania donovani	99%	100%
A4HKP7	Leishmania braziliensis	54%	99%
E9B336	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q518	Leishmania major	83%	99%