LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
HD domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I875_LEIIN
TriTrypDb:
LINF_320032300
Length:
673

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Promastigote/Amastigote: 422

Expansion

Sequence features

A4I875
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I875

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006163 purine nucleotide metabolic process 5 2
GO:0006195 purine nucleotide catabolic process 6 2
GO:0006203 dGTP catabolic process 7 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006753 nucleoside phosphate metabolic process 4 2
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009117 nucleotide metabolic process 5 2
GO:0009141 nucleoside triphosphate metabolic process 5 2
GO:0009143 nucleoside triphosphate catabolic process 6 2
GO:0009144 purine nucleoside triphosphate metabolic process 6 2
GO:0009146 purine nucleoside triphosphate catabolic process 7 2
GO:0009151 purine deoxyribonucleotide metabolic process 6 2
GO:0009155 purine deoxyribonucleotide catabolic process 6 2
GO:0009166 nucleotide catabolic process 6 2
GO:0009200 deoxyribonucleoside triphosphate metabolic process 6 2
GO:0009204 deoxyribonucleoside triphosphate catabolic process 7 2
GO:0009215 purine deoxyribonucleoside triphosphate metabolic process 7 2
GO:0009217 purine deoxyribonucleoside triphosphate catabolic process 8 2
GO:0009262 deoxyribonucleotide metabolic process 4 2
GO:0009264 deoxyribonucleotide catabolic process 5 2
GO:0009394 2'-deoxyribonucleotide metabolic process 5 2
GO:0009987 cellular process 1 2
GO:0019439 aromatic compound catabolic process 4 2
GO:0019637 organophosphate metabolic process 3 2
GO:0019692 deoxyribose phosphate metabolic process 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034655 nucleobase-containing compound catabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0044270 cellular nitrogen compound catabolic process 4 2
GO:0044281 small molecule metabolic process 2 2
GO:0046070 dGTP metabolic process 7 2
GO:0046386 deoxyribose phosphate catabolic process 5 2
GO:0046434 organophosphate catabolic process 4 2
GO:0046483 heterocycle metabolic process 3 2
GO:0046700 heterocycle catabolic process 4 2
GO:0055086 nucleobase-containing small molecule metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:0072521 purine-containing compound metabolic process 4 2
GO:0072523 purine-containing compound catabolic process 5 2
GO:1901135 carbohydrate derivative metabolic process 3 2
GO:1901136 carbohydrate derivative catabolic process 4 2
GO:1901292 nucleoside phosphate catabolic process 5 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901361 organic cyclic compound catabolic process 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901565 organonitrogen compound catabolic process 4 2
GO:1901575 organic substance catabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008832 dGTPase activity 6 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016793 triphosphoric monoester hydrolase activity 5 2
GO:0042578 phosphoric ester hydrolase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.412
CLV_C14_Caspase3-7 92 96 PF00656 0.330
CLV_NRD_NRD_1 13 15 PF00675 0.714
CLV_NRD_NRD_1 158 160 PF00675 0.332
CLV_NRD_NRD_1 170 172 PF00675 0.327
CLV_NRD_NRD_1 376 378 PF00675 0.379
CLV_NRD_NRD_1 384 386 PF00675 0.323
CLV_NRD_NRD_1 620 622 PF00675 0.543
CLV_PCSK_KEX2_1 13 15 PF00082 0.661
CLV_PCSK_KEX2_1 158 160 PF00082 0.311
CLV_PCSK_KEX2_1 227 229 PF00082 0.400
CLV_PCSK_KEX2_1 24 26 PF00082 0.473
CLV_PCSK_KEX2_1 376 378 PF00082 0.403
CLV_PCSK_KEX2_1 384 386 PF00082 0.323
CLV_PCSK_KEX2_1 426 428 PF00082 0.405
CLV_PCSK_KEX2_1 608 610 PF00082 0.591
CLV_PCSK_KEX2_1 620 622 PF00082 0.537
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.400
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.489
CLV_PCSK_PC1ET2_1 426 428 PF00082 0.405
CLV_PCSK_PC1ET2_1 608 610 PF00082 0.591
CLV_PCSK_SKI1_1 384 388 PF00082 0.338
CLV_PCSK_SKI1_1 44 48 PF00082 0.469
CLV_PCSK_SKI1_1 56 60 PF00082 0.292
CLV_PCSK_SKI1_1 608 612 PF00082 0.626
DEG_APCC_DBOX_1 290 298 PF00400 0.390
DEG_APCC_DBOX_1 383 391 PF00400 0.373
DEG_COP1_1 99 109 PF00400 0.275
DEG_SPOP_SBC_1 638 642 PF00917 0.791
DOC_ANK_TNKS_1 90 97 PF00023 0.275
DOC_CKS1_1 247 252 PF01111 0.422
DOC_CKS1_1 528 533 PF01111 0.434
DOC_CKS1_1 645 650 PF01111 0.530
DOC_CYCLIN_RxL_1 605 616 PF00134 0.567
DOC_CYCLIN_yCln2_LP_2 645 651 PF00134 0.533
DOC_MAPK_gen_1 227 233 PF00069 0.386
DOC_MAPK_gen_1 302 312 PF00069 0.373
DOC_MAPK_gen_1 608 614 PF00069 0.568
DOC_MAPK_MEF2A_6 534 541 PF00069 0.394
DOC_PP1_RVXF_1 536 542 PF00149 0.392
DOC_PP2B_PxIxI_1 40 46 PF00149 0.324
DOC_PP4_FxxP_1 104 107 PF00568 0.330
DOC_PP4_FxxP_1 488 491 PF00568 0.432
DOC_PP4_MxPP_1 1 4 PF00568 0.568
DOC_USP7_MATH_1 23 27 PF00917 0.451
DOC_USP7_MATH_1 333 337 PF00917 0.368
DOC_USP7_MATH_1 366 370 PF00917 0.520
DOC_USP7_MATH_1 4 8 PF00917 0.607
DOC_USP7_MATH_1 491 495 PF00917 0.505
DOC_USP7_MATH_1 517 521 PF00917 0.440
DOC_USP7_MATH_1 567 571 PF00917 0.781
DOC_USP7_MATH_1 586 590 PF00917 0.502
DOC_USP7_MATH_1 638 642 PF00917 0.776
DOC_USP7_MATH_1 71 75 PF00917 0.374
DOC_USP7_MATH_2 531 537 PF00917 0.397
DOC_WW_Pin1_4 246 251 PF00397 0.419
DOC_WW_Pin1_4 46 51 PF00397 0.353
DOC_WW_Pin1_4 527 532 PF00397 0.452
DOC_WW_Pin1_4 556 561 PF00397 0.546
DOC_WW_Pin1_4 582 587 PF00397 0.761
DOC_WW_Pin1_4 644 649 PF00397 0.532
LIG_14-3-3_CanoR_1 147 155 PF00244 0.325
LIG_14-3-3_CanoR_1 158 167 PF00244 0.318
LIG_14-3-3_CanoR_1 218 224 PF00244 0.393
LIG_14-3-3_CanoR_1 25 30 PF00244 0.434
LIG_14-3-3_CanoR_1 393 402 PF00244 0.451
LIG_14-3-3_CanoR_1 403 410 PF00244 0.427
LIG_14-3-3_CanoR_1 414 419 PF00244 0.462
LIG_14-3-3_CanoR_1 44 52 PF00244 0.502
LIG_14-3-3_CanoR_1 492 501 PF00244 0.469
LIG_14-3-3_CanoR_1 538 548 PF00244 0.491
LIG_14-3-3_CanoR_1 595 601 PF00244 0.649
LIG_Actin_WH2_2 177 194 PF00022 0.363
LIG_Actin_WH2_2 300 318 PF00022 0.373
LIG_BRCT_BRCA1_1 138 142 PF00533 0.295
LIG_BRCT_BRCA1_1 255 259 PF00533 0.333
LIG_Clathr_ClatBox_1 309 313 PF01394 0.356
LIG_FHA_1 218 224 PF00498 0.365
LIG_FHA_1 302 308 PF00498 0.440
LIG_FHA_1 506 512 PF00498 0.522
LIG_FHA_1 595 601 PF00498 0.650
LIG_FHA_1 665 671 PF00498 0.591
LIG_FHA_2 185 191 PF00498 0.437
LIG_FHA_2 360 366 PF00498 0.440
LIG_FHA_2 439 445 PF00498 0.372
LIG_FHA_2 470 476 PF00498 0.446
LIG_FHA_2 528 534 PF00498 0.453
LIG_FHA_2 589 595 PF00498 0.524
LIG_LIR_Apic_2 103 107 PF02991 0.275
LIG_LIR_Apic_2 486 491 PF02991 0.428
LIG_LIR_Apic_2 64 69 PF02991 0.370
LIG_LIR_Gen_1 139 150 PF02991 0.295
LIG_LIR_Gen_1 190 201 PF02991 0.266
LIG_LIR_Gen_1 249 259 PF02991 0.451
LIG_LIR_Gen_1 348 356 PF02991 0.342
LIG_LIR_Gen_1 509 518 PF02991 0.665
LIG_LIR_Gen_1 540 548 PF02991 0.457
LIG_LIR_LC3C_4 519 523 PF02991 0.361
LIG_LIR_Nem_3 139 145 PF02991 0.295
LIG_LIR_Nem_3 190 196 PF02991 0.261
LIG_LIR_Nem_3 31 37 PF02991 0.418
LIG_LIR_Nem_3 348 353 PF02991 0.333
LIG_LIR_Nem_3 38 42 PF02991 0.352
LIG_LIR_Nem_3 540 544 PF02991 0.447
LIG_LIR_Nem_3 64 68 PF02991 0.394
LIG_LIR_Nem_3 88 93 PF02991 0.330
LIG_PCNA_yPIPBox_3 296 307 PF02747 0.403
LIG_PTB_Apo_2 60 67 PF02174 0.383
LIG_PTB_Phospho_1 60 66 PF10480 0.380
LIG_SH2_CRK 396 400 PF00017 0.392
LIG_SH2_CRK 651 655 PF00017 0.583
LIG_SH2_CRK 90 94 PF00017 0.330
LIG_SH2_NCK_1 396 400 PF00017 0.353
LIG_SH2_PTP2 193 196 PF00017 0.353
LIG_SH2_PTP2 66 69 PF00017 0.412
LIG_SH2_SRC 344 347 PF00017 0.302
LIG_SH2_SRC 66 69 PF00017 0.353
LIG_SH2_STAT5 193 196 PF00017 0.353
LIG_SH2_STAT5 238 241 PF00017 0.363
LIG_SH2_STAT5 344 347 PF00017 0.358
LIG_SH2_STAT5 396 399 PF00017 0.445
LIG_SH2_STAT5 487 490 PF00017 0.417
LIG_SH2_STAT5 66 69 PF00017 0.392
LIG_SH2_STAT5 84 87 PF00017 0.352
LIG_SH3_3 208 214 PF00018 0.374
LIG_SH3_3 335 341 PF00018 0.405
LIG_SH3_3 525 531 PF00018 0.408
LIG_SUMO_SIM_anti_2 166 171 PF11976 0.342
LIG_SUMO_SIM_anti_2 461 466 PF11976 0.431
LIG_SUMO_SIM_anti_2 519 525 PF11976 0.330
LIG_SUMO_SIM_anti_2 639 647 PF11976 0.549
LIG_SUMO_SIM_par_1 304 311 PF11976 0.307
LIG_TRAF2_1 421 424 PF00917 0.566
LIG_TRAF2_1 530 533 PF00917 0.399
LIG_TYR_ITIM 191 196 PF00017 0.357
LIG_UBA3_1 167 172 PF00899 0.275
LIG_UBA3_1 197 205 PF00899 0.336
LIG_WRC_WIRS_1 142 147 PF05994 0.330
MOD_CDK_SPxxK_3 527 534 PF00069 0.448
MOD_CK1_1 359 365 PF00069 0.439
MOD_CK1_1 369 375 PF00069 0.411
MOD_CK1_1 405 411 PF00069 0.423
MOD_CK1_1 540 546 PF00069 0.450
MOD_CK1_1 554 560 PF00069 0.662
MOD_CK1_1 582 588 PF00069 0.677
MOD_CK1_1 598 604 PF00069 0.632
MOD_CK2_1 359 365 PF00069 0.511
MOD_CK2_1 4 10 PF00069 0.615
MOD_CK2_1 418 424 PF00069 0.587
MOD_CK2_1 433 439 PF00069 0.261
MOD_CK2_1 527 533 PF00069 0.470
MOD_CK2_1 588 594 PF00069 0.550
MOD_CK2_1 616 622 PF00069 0.547
MOD_CK2_1 638 644 PF00069 0.563
MOD_CK2_1 71 77 PF00069 0.338
MOD_GlcNHglycan 148 151 PF01048 0.284
MOD_GlcNHglycan 228 231 PF01048 0.383
MOD_GlcNHglycan 368 371 PF01048 0.569
MOD_GlcNHglycan 483 486 PF01048 0.488
MOD_GlcNHglycan 575 578 PF01048 0.590
MOD_GlcNHglycan 580 584 PF01048 0.628
MOD_GlcNHglycan 600 603 PF01048 0.528
MOD_GSK3_1 141 148 PF00069 0.346
MOD_GSK3_1 25 32 PF00069 0.541
MOD_GSK3_1 394 401 PF00069 0.381
MOD_GSK3_1 4 11 PF00069 0.628
MOD_GSK3_1 414 421 PF00069 0.485
MOD_GSK3_1 439 446 PF00069 0.300
MOD_GSK3_1 501 508 PF00069 0.450
MOD_GSK3_1 533 540 PF00069 0.392
MOD_GSK3_1 548 555 PF00069 0.592
MOD_GSK3_1 582 589 PF00069 0.652
MOD_GSK3_1 594 601 PF00069 0.561
MOD_GSK3_1 664 671 PF00069 0.591
MOD_N-GLC_1 110 115 PF02516 0.349
MOD_N-GLC_1 176 181 PF02516 0.349
MOD_N-GLC_1 359 364 PF02516 0.414
MOD_N-GLC_1 505 510 PF02516 0.529
MOD_NEK2_1 141 146 PF00069 0.326
MOD_NEK2_1 289 294 PF00069 0.335
MOD_NEK2_1 322 327 PF00069 0.398
MOD_NEK2_1 356 361 PF00069 0.388
MOD_NEK2_1 395 400 PF00069 0.419
MOD_NEK2_1 443 448 PF00069 0.368
MOD_NEK2_1 537 542 PF00069 0.482
MOD_NEK2_1 596 601 PF00069 0.630
MOD_NEK2_1 61 66 PF00069 0.359
MOD_NEK2_1 76 81 PF00069 0.299
MOD_NEK2_1 89 94 PF00069 0.295
MOD_PIKK_1 419 425 PF00454 0.509
MOD_PIKK_1 467 473 PF00454 0.459
MOD_PIKK_1 559 565 PF00454 0.625
MOD_PIKK_1 568 574 PF00454 0.589
MOD_PK_1 25 31 PF00069 0.439
MOD_PK_1 414 420 PF00069 0.468
MOD_PK_1 8 14 PF00069 0.632
MOD_PKA_1 158 164 PF00069 0.275
MOD_PKA_2 146 152 PF00069 0.256
MOD_PKA_2 158 164 PF00069 0.215
MOD_PKA_2 217 223 PF00069 0.391
MOD_PKA_2 240 246 PF00069 0.342
MOD_PKA_2 29 35 PF00069 0.556
MOD_PKA_2 301 307 PF00069 0.385
MOD_PKA_2 402 408 PF00069 0.547
MOD_PKA_2 491 497 PF00069 0.481
MOD_PKA_2 537 543 PF00069 0.489
MOD_PKA_2 594 600 PF00069 0.674
MOD_Plk_1 269 275 PF00069 0.412
MOD_Plk_1 359 365 PF00069 0.511
MOD_Plk_1 405 411 PF00069 0.535
MOD_Plk_1 438 444 PF00069 0.411
MOD_Plk_1 551 557 PF00069 0.544
MOD_Plk_1 76 82 PF00069 0.295
MOD_Plk_2-3 308 314 PF00069 0.304
MOD_Plk_2-3 433 439 PF00069 0.355
MOD_Plk_4 141 147 PF00069 0.330
MOD_Plk_4 163 169 PF00069 0.330
MOD_Plk_4 248 254 PF00069 0.439
MOD_Plk_4 29 35 PF00069 0.541
MOD_Plk_4 405 411 PF00069 0.453
MOD_Plk_4 483 489 PF00069 0.406
MOD_Plk_4 507 513 PF00069 0.535
MOD_Plk_4 517 523 PF00069 0.355
MOD_Plk_4 61 67 PF00069 0.349
MOD_ProDKin_1 246 252 PF00069 0.415
MOD_ProDKin_1 46 52 PF00069 0.349
MOD_ProDKin_1 527 533 PF00069 0.446
MOD_ProDKin_1 556 562 PF00069 0.545
MOD_ProDKin_1 582 588 PF00069 0.760
MOD_ProDKin_1 644 650 PF00069 0.531
MOD_SUMO_for_1 425 428 PF00179 0.402
MOD_SUMO_rev_2 16 26 PF00179 0.571
MOD_SUMO_rev_2 613 619 PF00179 0.489
TRG_DiLeu_BaEn_3 15 21 PF01217 0.515
TRG_DiLeu_BaEn_4 665 671 PF01217 0.591
TRG_ENDOCYTIC_2 193 196 PF00928 0.353
TRG_ENDOCYTIC_2 34 37 PF00928 0.386
TRG_ENDOCYTIC_2 396 399 PF00928 0.351
TRG_ENDOCYTIC_2 651 654 PF00928 0.585
TRG_ENDOCYTIC_2 84 87 PF00928 0.356
TRG_ENDOCYTIC_2 90 93 PF00928 0.350
TRG_ER_diArg_1 12 14 PF00400 0.532
TRG_ER_diArg_1 157 159 PF00400 0.361
TRG_ER_diArg_1 384 386 PF00400 0.411
TRG_NLS_MonoExtC_3 607 613 PF00514 0.626
TRG_NLS_MonoExtN_4 605 612 PF00514 0.585
TRG_Pf-PMV_PEXEL_1 384 388 PF00026 0.381
TRG_Pf-PMV_PEXEL_1 44 48 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 91 95 PF00026 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD02 Leptomonas seymouri 68% 100%
A0A0S4J2F4 Bodo saltans 31% 100%
A0A0S4J714 Bodo saltans 34% 95%
A0A3Q8IGB9 Leishmania donovani 100% 100%
A0A3R7LQB8 Trypanosoma rangeli 34% 89%
A0A3S7WPC5 Leishmania donovani 35% 100%
A4H4I2 Leishmania braziliensis 36% 100%
A4HKP4 Leishmania braziliensis 89% 100%
A4HSQ7 Leishmania infantum 35% 100%
C9ZTA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AKP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B333 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q09374 Caenorhabditis elegans 28% 100%
Q4Q521 Leishmania major 96% 100%
Q4QJ63 Leishmania major 35% 100%
Q6INN8 Xenopus laevis 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS