LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I872_LEIIN
TriTrypDb:
LINF_320032000
Length:
665

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I872
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I872

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 1
GO:0005198 structural molecule activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 160 164 PF00656 0.540
CLV_C14_Caspase3-7 272 276 PF00656 0.625
CLV_C14_Caspase3-7 387 391 PF00656 0.447
CLV_C14_Caspase3-7 75 79 PF00656 0.581
CLV_NRD_NRD_1 138 140 PF00675 0.574
CLV_NRD_NRD_1 16 18 PF00675 0.619
CLV_NRD_NRD_1 184 186 PF00675 0.586
CLV_NRD_NRD_1 255 257 PF00675 0.557
CLV_NRD_NRD_1 304 306 PF00675 0.424
CLV_NRD_NRD_1 426 428 PF00675 0.457
CLV_NRD_NRD_1 618 620 PF00675 0.444
CLV_NRD_NRD_1 642 644 PF00675 0.487
CLV_PCSK_FUR_1 302 306 PF00082 0.424
CLV_PCSK_KEX2_1 137 139 PF00082 0.722
CLV_PCSK_KEX2_1 16 18 PF00082 0.619
CLV_PCSK_KEX2_1 184 186 PF00082 0.586
CLV_PCSK_KEX2_1 254 256 PF00082 0.554
CLV_PCSK_KEX2_1 267 269 PF00082 0.596
CLV_PCSK_KEX2_1 302 304 PF00082 0.456
CLV_PCSK_KEX2_1 348 350 PF00082 0.437
CLV_PCSK_KEX2_1 426 428 PF00082 0.456
CLV_PCSK_KEX2_1 618 620 PF00082 0.449
CLV_PCSK_KEX2_1 642 644 PF00082 0.466
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.657
CLV_PCSK_PC1ET2_1 348 350 PF00082 0.393
CLV_PCSK_PC7_1 134 140 PF00082 0.566
CLV_PCSK_PC7_1 344 350 PF00082 0.447
CLV_PCSK_SKI1_1 125 129 PF00082 0.575
CLV_PCSK_SKI1_1 26 30 PF00082 0.494
CLV_PCSK_SKI1_1 312 316 PF00082 0.493
CLV_PCSK_SKI1_1 34 38 PF00082 0.438
CLV_PCSK_SKI1_1 344 348 PF00082 0.466
CLV_PCSK_SKI1_1 374 378 PF00082 0.483
CLV_PCSK_SKI1_1 511 515 PF00082 0.449
CLV_PCSK_SKI1_1 519 523 PF00082 0.367
CLV_PCSK_SKI1_1 618 622 PF00082 0.514
CLV_PCSK_SKI1_1 94 98 PF00082 0.732
DEG_APCC_DBOX_1 114 122 PF00400 0.555
DEG_COP1_1 582 591 PF00400 0.433
DOC_CYCLIN_RxL_1 120 132 PF00134 0.505
DOC_MAPK_gen_1 618 624 PF00069 0.610
DOC_MAPK_gen_1 642 648 PF00069 0.514
DOC_MAPK_MEF2A_6 174 183 PF00069 0.471
DOC_MAPK_RevD_3 605 619 PF00069 0.387
DOC_PP1_RVXF_1 222 228 PF00149 0.480
DOC_PP1_RVXF_1 517 523 PF00149 0.407
DOC_PP2B_LxvP_1 455 458 PF13499 0.553
DOC_PP2B_LxvP_1 581 584 PF13499 0.398
DOC_PP2B_LxvP_1 586 589 PF13499 0.478
DOC_PP4_FxxP_1 227 230 PF00568 0.649
DOC_PP4_FxxP_1 231 234 PF00568 0.662
DOC_USP7_MATH_1 217 221 PF00917 0.778
DOC_USP7_MATH_1 273 277 PF00917 0.674
DOC_USP7_MATH_1 444 448 PF00917 0.440
DOC_USP7_MATH_1 661 665 PF00917 0.372
DOC_USP7_MATH_1 80 84 PF00917 0.626
DOC_WW_Pin1_4 459 464 PF00397 0.768
DOC_WW_Pin1_4 489 494 PF00397 0.620
DOC_WW_Pin1_4 496 501 PF00397 0.433
LIG_14-3-3_CanoR_1 167 173 PF00244 0.544
LIG_14-3-3_CanoR_1 26 36 PF00244 0.434
LIG_14-3-3_CanoR_1 303 309 PF00244 0.470
LIG_14-3-3_CanoR_1 427 433 PF00244 0.366
LIG_14-3-3_CanoR_1 618 623 PF00244 0.446
LIG_14-3-3_CanoR_1 642 647 PF00244 0.567
LIG_Actin_WH2_2 363 380 PF00022 0.383
LIG_APCC_ABBAyCdc20_2 137 143 PF00400 0.530
LIG_BIR_II_1 1 5 PF00653 0.747
LIG_BIR_III_4 51 55 PF00653 0.532
LIG_Clathr_ClatBox_1 566 570 PF01394 0.428
LIG_Clathr_ClatBox_1 69 73 PF01394 0.527
LIG_FHA_1 145 151 PF00498 0.636
LIG_FHA_1 220 226 PF00498 0.655
LIG_FHA_1 27 33 PF00498 0.574
LIG_FHA_1 420 426 PF00498 0.445
LIG_FHA_1 470 476 PF00498 0.644
LIG_FHA_1 51 57 PF00498 0.612
LIG_FHA_1 602 608 PF00498 0.418
LIG_FHA_1 615 621 PF00498 0.470
LIG_FHA_1 624 630 PF00498 0.476
LIG_FHA_1 632 638 PF00498 0.496
LIG_FHA_2 105 111 PF00498 0.550
LIG_FHA_2 645 651 PF00498 0.549
LIG_FHA_2 95 101 PF00498 0.754
LIG_LIR_Gen_1 395 402 PF02991 0.455
LIG_LIR_Gen_1 502 508 PF02991 0.517
LIG_LIR_Nem_3 395 401 PF02991 0.390
LIG_LIR_Nem_3 502 506 PF02991 0.533
LIG_MYND_1 230 234 PF01753 0.602
LIG_Pex14_2 227 231 PF04695 0.478
LIG_Pex14_2 58 62 PF04695 0.583
LIG_PTAP_UEV_1 462 467 PF05743 0.532
LIG_PTAP_UEV_1 588 593 PF05743 0.429
LIG_SH2_PTP2 327 330 PF00017 0.526
LIG_SH2_STAP1 309 313 PF00017 0.626
LIG_SH2_STAP1 39 43 PF00017 0.396
LIG_SH2_STAP1 398 402 PF00017 0.448
LIG_SH2_STAT3 39 42 PF00017 0.421
LIG_SH2_STAT5 309 312 PF00017 0.435
LIG_SH2_STAT5 327 330 PF00017 0.526
LIG_SH3_3 319 325 PF00018 0.497
LIG_SH3_3 460 466 PF00018 0.618
LIG_SH3_3 492 498 PF00018 0.626
LIG_SH3_3 586 592 PF00018 0.568
LIG_SH3_3 6 12 PF00018 0.591
LIG_SH3_3 617 623 PF00018 0.460
LIG_SUMO_SIM_par_1 603 608 PF11976 0.386
LIG_TRAF2_1 331 334 PF00917 0.456
LIG_WRC_WIRS_1 576 581 PF05994 0.431
MOD_CK1_1 152 158 PF00069 0.629
MOD_CK1_1 169 175 PF00069 0.486
MOD_CK1_1 243 249 PF00069 0.526
MOD_CK1_1 276 282 PF00069 0.670
MOD_CK1_1 307 313 PF00069 0.572
MOD_CK1_1 447 453 PF00069 0.583
MOD_CK1_1 556 562 PF00069 0.578
MOD_CK1_1 644 650 PF00069 0.540
MOD_CK2_1 151 157 PF00069 0.632
MOD_CK2_1 215 221 PF00069 0.606
MOD_CK2_1 337 343 PF00069 0.585
MOD_CK2_1 579 585 PF00069 0.469
MOD_CK2_1 80 86 PF00069 0.593
MOD_Cter_Amidation 265 268 PF01082 0.664
MOD_GlcNHglycan 131 134 PF01048 0.576
MOD_GlcNHglycan 151 154 PF01048 0.438
MOD_GlcNHglycan 20 23 PF01048 0.406
MOD_GlcNHglycan 242 245 PF01048 0.524
MOD_GlcNHglycan 275 278 PF01048 0.568
MOD_GlcNHglycan 442 445 PF01048 0.490
MOD_GlcNHglycan 452 455 PF01048 0.548
MOD_GlcNHglycan 463 466 PF01048 0.614
MOD_GlcNHglycan 488 492 PF01048 0.690
MOD_GlcNHglycan 527 530 PF01048 0.344
MOD_GlcNHglycan 589 592 PF01048 0.504
MOD_GlcNHglycan 6 9 PF01048 0.539
MOD_GlcNHglycan 631 634 PF01048 0.697
MOD_GlcNHglycan 661 664 PF01048 0.506
MOD_GlcNHglycan 78 81 PF01048 0.566
MOD_GlcNHglycan 82 85 PF01048 0.596
MOD_GSK3_1 104 111 PF00069 0.386
MOD_GSK3_1 145 152 PF00069 0.629
MOD_GSK3_1 215 222 PF00069 0.698
MOD_GSK3_1 273 280 PF00069 0.566
MOD_GSK3_1 440 447 PF00069 0.448
MOD_GSK3_1 46 53 PF00069 0.560
MOD_GSK3_1 545 552 PF00069 0.386
MOD_GSK3_1 575 582 PF00069 0.399
MOD_GSK3_1 610 617 PF00069 0.449
MOD_GSK3_1 625 632 PF00069 0.432
MOD_GSK3_1 638 645 PF00069 0.577
MOD_GSK3_1 76 83 PF00069 0.618
MOD_GSK3_1 84 91 PF00069 0.775
MOD_NEK2_1 149 154 PF00069 0.657
MOD_NEK2_1 193 198 PF00069 0.631
MOD_NEK2_1 296 301 PF00069 0.350
MOD_NEK2_1 326 331 PF00069 0.438
MOD_NEK2_1 384 389 PF00069 0.539
MOD_NEK2_1 440 445 PF00069 0.471
MOD_NEK2_1 448 453 PF00069 0.522
MOD_NEK2_1 553 558 PF00069 0.470
MOD_NEK2_1 579 584 PF00069 0.443
MOD_NEK2_1 624 629 PF00069 0.587
MOD_NEK2_2 54 59 PF00069 0.597
MOD_PIKK_1 296 302 PF00454 0.472
MOD_PIKK_1 384 390 PF00454 0.510
MOD_PIKK_1 448 454 PF00454 0.449
MOD_PIKK_1 545 551 PF00454 0.325
MOD_PKA_1 16 22 PF00069 0.579
MOD_PKA_1 255 261 PF00069 0.581
MOD_PKA_1 304 310 PF00069 0.593
MOD_PKA_1 618 624 PF00069 0.422
MOD_PKA_1 642 648 PF00069 0.412
MOD_PKA_2 16 22 PF00069 0.622
MOD_PKA_2 166 172 PF00069 0.569
MOD_PKA_2 255 261 PF00069 0.664
MOD_PKA_2 304 310 PF00069 0.439
MOD_PKA_2 610 616 PF00069 0.444
MOD_PKA_2 618 624 PF00069 0.462
MOD_PKA_2 641 647 PF00069 0.576
MOD_PKB_1 302 310 PF00069 0.351
MOD_Plk_1 419 425 PF00069 0.313
MOD_Plk_4 145 151 PF00069 0.652
MOD_Plk_4 444 450 PF00069 0.492
MOD_Plk_4 499 505 PF00069 0.510
MOD_Plk_4 553 559 PF00069 0.460
MOD_Plk_4 572 578 PF00069 0.319
MOD_Plk_4 601 607 PF00069 0.374
MOD_Plk_4 625 631 PF00069 0.622
MOD_Plk_4 644 650 PF00069 0.291
MOD_ProDKin_1 459 465 PF00069 0.770
MOD_ProDKin_1 489 495 PF00069 0.617
MOD_ProDKin_1 496 502 PF00069 0.425
MOD_SUMO_for_1 70 73 PF00179 0.629
TRG_DiLeu_BaEn_1 65 70 PF01217 0.515
TRG_DiLeu_BaEn_2 340 346 PF01217 0.366
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.481
TRG_DiLeu_BaLyEn_6 474 479 PF01217 0.541
TRG_ENDOCYTIC_2 293 296 PF00928 0.522
TRG_ENDOCYTIC_2 327 330 PF00928 0.353
TRG_ENDOCYTIC_2 398 401 PF00928 0.459
TRG_ER_diArg_1 115 118 PF00400 0.557
TRG_ER_diArg_1 137 139 PF00400 0.574
TRG_ER_diArg_1 183 185 PF00400 0.588
TRG_ER_diArg_1 253 256 PF00400 0.546
TRG_ER_diArg_1 302 305 PF00400 0.418
TRG_ER_diArg_1 425 427 PF00400 0.556
TRG_ER_diArg_1 618 620 PF00400 0.487
TRG_Pf-PMV_PEXEL_1 34 38 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A1 Leptomonas seymouri 46% 100%
A0A1X0NRK2 Trypanosomatidae 31% 100%
A0A3Q8IG27 Leishmania donovani 100% 100%
A4HKP1 Leishmania braziliensis 73% 100%
D0AAE1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B330 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q524 Leishmania major 90% 100%
V5AUP9 Trypanosoma cruzi 32% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS