LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
NOL1/NOP2/sun family - putative
Species:
Leishmania infantum
UniProt:
A4I865_LEIIN
TriTrypDb:
LINF_320031000
Length:
414

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000315 organellar large ribosomal subunit 5 1
GO:0005762 mitochondrial large ribosomal subunit 3 1
GO:0015934 large ribosomal subunit 4 1
GO:0032991 protein-containing complex 1 1
GO:0044391 ribosomal subunit 3 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4I865
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I865

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0032259 methylation 2 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043414 macromolecule methylation 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000154 rRNA modification 6 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0016072 rRNA metabolic process 7 1
GO:0031167 rRNA methylation 5 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008168 methyltransferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 229 233 PF00656 0.453
CLV_C14_Caspase3-7 346 350 PF00656 0.692
CLV_C14_Caspase3-7 351 355 PF00656 0.666
CLV_MEL_PAP_1 65 71 PF00089 0.457
CLV_NRD_NRD_1 212 214 PF00675 0.254
CLV_NRD_NRD_1 60 62 PF00675 0.454
CLV_NRD_NRD_1 96 98 PF00675 0.398
CLV_PCSK_FUR_1 210 214 PF00082 0.221
CLV_PCSK_KEX2_1 212 214 PF00082 0.240
CLV_PCSK_KEX2_1 47 49 PF00082 0.449
CLV_PCSK_PC1ET2_1 47 49 PF00082 0.387
CLV_PCSK_SKI1_1 255 259 PF00082 0.221
CLV_PCSK_SKI1_1 284 288 PF00082 0.253
CLV_PCSK_SKI1_1 328 332 PF00082 0.347
CLV_PCSK_SKI1_1 345 349 PF00082 0.565
CLV_PCSK_SKI1_1 377 381 PF00082 0.432
CLV_PCSK_SKI1_1 62 66 PF00082 0.349
DEG_SPOP_SBC_1 104 108 PF00917 0.486
DEG_SPOP_SBC_1 404 408 PF00917 0.720
DOC_CKS1_1 363 368 PF01111 0.438
DOC_CYCLIN_RxL_1 374 383 PF00134 0.452
DOC_MAPK_gen_1 322 329 PF00069 0.416
DOC_PP2B_LxvP_1 340 343 PF13499 0.578
DOC_PP2B_LxvP_1 378 381 PF13499 0.427
DOC_PP4_FxxP_1 191 194 PF00568 0.477
DOC_USP7_MATH_1 250 254 PF00917 0.477
DOC_USP7_MATH_1 28 32 PF00917 0.637
DOC_USP7_MATH_1 350 354 PF00917 0.589
DOC_USP7_MATH_1 405 409 PF00917 0.528
DOC_USP7_UBL2_3 23 27 PF12436 0.687
DOC_USP7_UBL2_3 29 33 PF12436 0.634
DOC_WW_Pin1_4 190 195 PF00397 0.477
DOC_WW_Pin1_4 261 266 PF00397 0.446
DOC_WW_Pin1_4 305 310 PF00397 0.447
DOC_WW_Pin1_4 362 367 PF00397 0.504
LIG_14-3-3_CanoR_1 299 309 PF00244 0.448
LIG_14-3-3_CanoR_1 68 74 PF00244 0.503
LIG_BIR_III_4 145 149 PF00653 0.462
LIG_BIR_III_4 354 358 PF00653 0.582
LIG_CtBP_PxDLS_1 265 269 PF00389 0.500
LIG_FHA_1 105 111 PF00498 0.471
LIG_FHA_1 274 280 PF00498 0.472
LIG_FHA_1 291 297 PF00498 0.400
LIG_FHA_1 302 308 PF00498 0.383
LIG_FHA_1 363 369 PF00498 0.618
LIG_FHA_1 76 82 PF00498 0.497
LIG_FHA_2 171 177 PF00498 0.533
LIG_FHA_2 197 203 PF00498 0.426
LIG_FHA_2 227 233 PF00498 0.441
LIG_FHA_2 321 327 PF00498 0.484
LIG_FHA_2 34 40 PF00498 0.433
LIG_FHA_2 344 350 PF00498 0.743
LIG_LIR_Apic_2 235 239 PF02991 0.413
LIG_LIR_Gen_1 38 45 PF02991 0.306
LIG_LIR_Nem_3 36 40 PF02991 0.370
LIG_LIR_Nem_3 373 378 PF02991 0.332
LIG_Pex14_1 387 391 PF04695 0.418
LIG_Rb_LxCxE_1 193 206 PF01857 0.512
LIG_SH2_CRK 375 379 PF00017 0.446
LIG_SH2_NCK_1 41 45 PF00017 0.430
LIG_SH2_SRC 237 240 PF00017 0.436
LIG_SH2_STAP1 41 45 PF00017 0.430
LIG_SH2_STAT5 153 156 PF00017 0.309
LIG_SH2_STAT5 223 226 PF00017 0.443
LIG_SH3_3 244 250 PF00018 0.410
LIG_SH3_3 338 344 PF00018 0.718
LIG_SH3_3 360 366 PF00018 0.594
LIG_SUMO_SIM_par_1 264 270 PF11976 0.500
LIG_TRAF2_1 73 76 PF00917 0.444
MOD_CK1_1 261 267 PF00069 0.536
MOD_CK1_1 272 278 PF00069 0.480
MOD_CK1_1 303 309 PF00069 0.441
MOD_CK1_1 353 359 PF00069 0.594
MOD_CK1_1 406 412 PF00069 0.621
MOD_CK2_1 196 202 PF00069 0.435
MOD_CK2_1 264 270 PF00069 0.457
MOD_CK2_1 305 311 PF00069 0.431
MOD_CK2_1 320 326 PF00069 0.394
MOD_CK2_1 33 39 PF00069 0.497
MOD_CK2_1 353 359 PF00069 0.728
MOD_CK2_1 404 410 PF00069 0.556
MOD_CK2_1 79 85 PF00069 0.509
MOD_Cter_Amidation 45 48 PF01082 0.274
MOD_GlcNHglycan 112 115 PF01048 0.679
MOD_GlcNHglycan 158 161 PF01048 0.396
MOD_GlcNHglycan 260 263 PF01048 0.274
MOD_GlcNHglycan 30 33 PF01048 0.568
MOD_GlcNHglycan 333 336 PF01048 0.463
MOD_GlcNHglycan 354 358 PF01048 0.620
MOD_GSK3_1 269 276 PF00069 0.483
MOD_GSK3_1 301 308 PF00069 0.420
MOD_GSK3_1 75 82 PF00069 0.504
MOD_GSK3_1 99 106 PF00069 0.692
MOD_N-GLC_1 99 104 PF02516 0.649
MOD_NEK2_1 258 263 PF00069 0.477
MOD_NEK2_1 320 325 PF00069 0.410
MOD_NEK2_1 4 9 PF00069 0.527
MOD_NEK2_2 290 295 PF00069 0.461
MOD_PIKK_1 226 232 PF00454 0.421
MOD_PIKK_1 67 73 PF00454 0.468
MOD_PKA_2 226 232 PF00069 0.521
MOD_PKA_2 4 10 PF00069 0.565
MOD_PKA_2 67 73 PF00069 0.411
MOD_Plk_1 370 376 PF00069 0.397
MOD_Plk_2-3 232 238 PF00069 0.512
MOD_Plk_4 170 176 PF00069 0.403
MOD_Plk_4 232 238 PF00069 0.439
MOD_Plk_4 364 370 PF00069 0.456
MOD_Plk_4 85 91 PF00069 0.416
MOD_ProDKin_1 190 196 PF00069 0.477
MOD_ProDKin_1 261 267 PF00069 0.446
MOD_ProDKin_1 305 311 PF00069 0.447
MOD_ProDKin_1 362 368 PF00069 0.495
MOD_SUMO_rev_2 396 404 PF00179 0.451
TRG_DiLeu_BaEn_1 85 90 PF01217 0.541
TRG_DiLeu_BaLyEn_6 374 379 PF01217 0.454
TRG_ENDOCYTIC_2 152 155 PF00928 0.317
TRG_ENDOCYTIC_2 375 378 PF00928 0.343
TRG_ENDOCYTIC_2 41 44 PF00928 0.366
TRG_ER_diArg_1 210 213 PF00400 0.457
TRG_Pf-PMV_PEXEL_1 213 217 PF00026 0.213
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.210
TRG_Pf-PMV_PEXEL_1 255 259 PF00026 0.210
TRG_Pf-PMV_PEXEL_1 284 288 PF00026 0.264
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK00 Leptomonas seymouri 67% 100%
A0A0S4J448 Bodo saltans 41% 100%
A0A1X0NJV9 Trypanosomatidae 29% 73%
A0A1X0NRJ9 Trypanosomatidae 40% 100%
A0A3Q8ID92 Leishmania donovani 100% 100%
A0A3R7K4S3 Trypanosoma rangeli 47% 100%
A4HKN4 Leishmania braziliensis 80% 100%
D0AAD3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9B323 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q0P5D8 Bos taurus 30% 100%
Q0V8R7 Bos taurus 28% 100%
Q4KMK0 Danio rerio 32% 100%
Q4Q532 Leishmania major 92% 100%
Q5M7E3 Xenopus laevis 30% 100%
Q66KI9 Xenopus tropicalis 30% 100%
Q8CCT7 Mus musculus 30% 100%
Q96CB9 Homo sapiens 27% 100%
Q9CZ57 Mus musculus 29% 100%
V5B8C1 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS