Putative cytochrome-b5 reductase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome-b5 reductase - putative

Species:

Leishmania infantum

UniProt:

A4I862_LEIIN

TriTrypDb:

LINF_320029800

Length:

338

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, cytochrome-b5 reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 22
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I862

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I862

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	17
GO:0016491	oxidoreductase activity	2	27
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	17
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	17
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	5	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.376
CLV_C14_Caspase3-7	246	250	PF00656	0.305
CLV_NRD_NRD_1	250	252	PF00675	0.303
CLV_PCSK_SKI1_1	182	186	PF00082	0.216
CLV_PCSK_SKI1_1	192	196	PF00082	0.234
CLV_PCSK_SKI1_1	3	7	PF00082	0.445
CLV_PCSK_SKI1_1	34	38	PF00082	0.434
CLV_PCSK_SKI1_1	60	64	PF00082	0.215
DEG_SCF_FBW7_1	98	104	PF00400	0.301
DOC_CDC14_PxL_1	260	268	PF14671	0.425
DOC_CKS1_1	95	100	PF01111	0.241
DOC_CYCLIN_RxL_1	179	189	PF00134	0.259
DOC_CYCLIN_RxL_1	192	201	PF00134	0.202
DOC_CYCLIN_RxL_1	57	67	PF00134	0.233
DOC_MAPK_gen_1	204	212	PF00069	0.307
DOC_MAPK_gen_1	231	238	PF00069	0.480
DOC_MAPK_MEF2A_6	231	240	PF00069	0.487
DOC_MAPK_MEF2A_6	258	265	PF00069	0.418
DOC_PP4_FxxP_1	219	222	PF00568	0.442
DOC_PP4_FxxP_1	95	98	PF00568	0.221
DOC_USP7_MATH_1	186	190	PF00917	0.247
DOC_USP7_MATH_1	273	277	PF00917	0.393
DOC_USP7_MATH_1	319	323	PF00917	0.496
DOC_USP7_UBL2_3	141	145	PF12436	0.304
DOC_USP7_UBL2_3	192	196	PF12436	0.252
DOC_WD40_RPTOR_TOS_1	125	131	PF00400	0.315
DOC_WW_Pin1_4	231	236	PF00397	0.516
DOC_WW_Pin1_4	244	249	PF00397	0.438
DOC_WW_Pin1_4	271	276	PF00397	0.478
DOC_WW_Pin1_4	94	99	PF00397	0.240
LIG_14-3-3_CanoR_1	119	127	PF00244	0.209
LIG_14-3-3_CanoR_1	148	155	PF00244	0.328
LIG_BRCT_BRCA1_1	131	135	PF00533	0.303
LIG_BRCT_BRCA1_1	66	70	PF00533	0.187
LIG_Clathr_ClatBox_1	124	128	PF01394	0.281
LIG_FHA_1	119	125	PF00498	0.215
LIG_FHA_1	235	241	PF00498	0.494
LIG_FHA_1	275	281	PF00498	0.419
LIG_FHA_2	172	178	PF00498	0.260
LIG_FHA_2	244	250	PF00498	0.312
LIG_LIR_Apic_2	217	222	PF02991	0.441
LIG_LIR_Gen_1	67	78	PF02991	0.237
LIG_LIR_Nem_3	104	110	PF02991	0.222
LIG_LIR_Nem_3	132	138	PF02991	0.289
LIG_LIR_Nem_3	38	44	PF02991	0.304
LIG_LIR_Nem_3	67	73	PF02991	0.309
LIG_NRBOX	194	200	PF00104	0.363
LIG_PDZ_Class_2	333	338	PF00595	0.260
LIG_Pex14_2	37	41	PF04695	0.291
LIG_PTB_Apo_2	224	231	PF02174	0.453
LIG_PTB_Phospho_1	224	230	PF10480	0.270
LIG_SH2_CRK	96	100	PF00017	0.240
LIG_SH2_NCK_1	96	100	PF00017	0.218
LIG_SH2_PTP2	260	263	PF00017	0.341
LIG_SH2_SRC	260	263	PF00017	0.454
LIG_SH2_SRC	308	311	PF00017	0.504
LIG_SH2_STAT5	107	110	PF00017	0.240
LIG_SH2_STAT5	214	217	PF00017	0.242
LIG_SH2_STAT5	253	256	PF00017	0.303
LIG_SH2_STAT5	260	263	PF00017	0.303
LIG_SH2_STAT5	96	99	PF00017	0.228
LIG_SH3_3	278	284	PF00018	0.331
LIG_SH3_3	86	92	PF00018	0.258
LIG_SH3_3	95	101	PF00018	0.270
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.429
LIG_SUMO_SIM_par_1	234	239	PF11976	0.494
LIG_TRFH_1	70	74	PF08558	0.221
LIG_UBA3_1	134	141	PF00899	0.230
LIG_UBA3_1	194	202	PF00899	0.260
LIG_ULM_U2AF65_1	145	150	PF00076	0.389
LIG_WRPW_2	41	44	PF00400	0.341
MOD_CDK_SPxxK_3	244	251	PF00069	0.486
MOD_CK1_1	171	177	PF00069	0.260
MOD_CK1_1	242	248	PF00069	0.462
MOD_CK1_1	274	280	PF00069	0.441
MOD_Cter_Amidation	249	252	PF01082	0.481
MOD_GlcNHglycan	302	305	PF01048	0.343
MOD_GlcNHglycan	310	313	PF01048	0.376
MOD_GlcNHglycan	320	324	PF01048	0.378
MOD_GSK3_1	16	23	PF00069	0.420
MOD_GSK3_1	171	178	PF00069	0.225
MOD_GSK3_1	239	246	PF00069	0.310
MOD_GSK3_1	97	104	PF00069	0.237
MOD_N-GLC_1	101	106	PF02516	0.240
MOD_N-GLC_1	168	173	PF02516	0.247
MOD_N-GLC_1	186	191	PF02516	0.258
MOD_NEK2_1	266	271	PF00069	0.386
MOD_NEK2_1	324	329	PF00069	0.455
MOD_PIKK_1	20	26	PF00454	0.465
MOD_PIKK_1	239	245	PF00454	0.496
MOD_PKA_2	118	124	PF00069	0.212
MOD_PKA_2	147	153	PF00069	0.368
MOD_Plk_1	168	174	PF00069	0.242
MOD_Plk_4	129	135	PF00069	0.289
MOD_Plk_4	274	280	PF00069	0.413
MOD_ProDKin_1	231	237	PF00069	0.522
MOD_ProDKin_1	244	250	PF00069	0.439
MOD_ProDKin_1	271	277	PF00069	0.472
MOD_ProDKin_1	94	100	PF00069	0.240
MOD_SUMO_for_1	32	35	PF00179	0.523
MOD_SUMO_rev_2	189	194	PF00179	0.259
TRG_DiLeu_BaEn_1	190	195	PF01217	0.214
TRG_ENDOCYTIC_2	107	110	PF00928	0.240
TRG_ENDOCYTIC_2	260	263	PF00928	0.381
TRG_ENDOCYTIC_2	96	99	PF00928	0.240
TRG_NLS_MonoExtC_3	112	117	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L4	Leptomonas seymouri	28%	100%
A0A0N0P705	Leptomonas seymouri	26%	100%
A0A0N1I0P2	Leptomonas seymouri	26%	79%
A0A0N1I279	Leptomonas seymouri	86%	100%
A0A0N1IAZ4	Leptomonas seymouri	28%	100%
A0A0N1ILC4	Leptomonas seymouri	40%	100%
A0A0N1PBS9	Leptomonas seymouri	33%	100%
A0A0S4IMP5	Bodo saltans	52%	93%
A0A0S4ITW4	Bodo saltans	25%	82%
A0A0S4JV75	Bodo saltans	43%	95%
A0A0S4KHI4	Bodo saltans	29%	100%
A0A1X0NRH2	Trypanosomatidae	64%	100%
A0A1X0NT99	Trypanosomatidae	26%	100%
A0A1X0NTX4	Trypanosomatidae	26%	100%
A0A1X0NV22	Trypanosomatidae	29%	100%
A0A1X0NWV9	Trypanosomatidae	24%	86%
A0A1X0P541	Trypanosomatidae	42%	100%
A0A3Q8I8J2	Leishmania donovani	26%	100%
A0A3Q8I905	Leishmania donovani	24%	98%
A0A3Q8IBE7	Leishmania donovani	28%	100%
A0A3Q8ILI9	Leishmania donovani	27%	100%
A0A3R7JSY9	Trypanosoma rangeli	29%	100%
A0A3R7JUA9	Trypanosoma rangeli	26%	100%
A0A3R7JZZ7	Trypanosoma rangeli	61%	100%
A0A3R7MD20	Trypanosoma rangeli	28%	100%
A0A3S5H6T5	Leishmania donovani	33%	100%
A0A3S5H7H5	Leishmania donovani	39%	100%
A0A3S7X5Q8	Leishmania donovani	99%	100%
A0A422NMZ5	Trypanosoma rangeli	41%	100%
A1C7E9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	31%	100%
A1CRK9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	100%
A1D4H0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	27%	100%
A1DHW1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	31%	100%
A2Q898	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A2QCV4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A3GF86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	30%	100%
A3LT66	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	100%
A4H794	Leishmania braziliensis	30%	100%
A4H7X5	Leishmania braziliensis	32%	86%
A4HCD2	Leishmania braziliensis	28%	95%
A4HCD3	Leishmania braziliensis	27%	83%
A4HKM5	Leishmania braziliensis	93%	100%
A4HUT9	Leishmania infantum	24%	100%
A4HVN4	Leishmania infantum	25%	100%
A4HWA2	Leishmania infantum	33%	86%
A4HZV4	Leishmania infantum	27%	90%
A4HZV5	Leishmania infantum	29%	92%
A4QR21	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	100%
A4R935	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	100%
A5DQ25	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	100%
A5DQE4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	28%	100%
A5E5C5	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	25%	100%
A5E7U2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	31%	100%
A6R1T7	Ajellomyces capsulatus (strain NAm1 / WU24)	27%	100%
A6R2K7	Ajellomyces capsulatus (strain NAm1 / WU24)	31%	100%
A6SI59	Botryotinia fuckeliana (strain B05.10)	30%	98%
A6ZVM6	Saccharomyces cerevisiae (strain YJM789)	28%	100%
A6ZZH2	Saccharomyces cerevisiae (strain YJM789)	25%	100%
A7EKT5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	30%	98%
A7THS1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	26%	100%
A7TM72	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	100%
A7TNL7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	100%
B0CQN7	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	27%	100%
C9ZNT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZSH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZSH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A5S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A6L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	87%
D0AAC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AD50	Leishmania major	41%	100%
E9AHE4	Leishmania infantum	39%	100%
E9ANH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AQ02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	86%
E9AVR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	91%
E9AVR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
E9AYX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B313	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O74557	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P00387	Homo sapiens	28%	100%
P07514	Bos taurus	28%	100%
P0CP14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	100%
P0CP15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	100%
P20070	Rattus norvegicus	30%	100%
P36060	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P38626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P83291	Arabidopsis thaliana	32%	100%
P83686	Sus scrofa	29%	100%
Q0CRD8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	29%	100%
Q0CY37	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	100%
Q0P487	Danio rerio	28%	100%
Q0U9W5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	26%	100%
Q0UEY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	30%	100%
Q0X0E5	Canis lupus familiaris	29%	100%
Q12746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q1DWN4	Coccidioides immitis (strain RS)	30%	100%
Q1DXN1	Coccidioides immitis (strain RS)	27%	100%
Q2HG02	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	97%
Q2UFN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q2UKB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q3KNK3	Mus musculus	28%	100%
Q4P7Y8	Ustilago maydis (strain 521 / FGSC 9021)	30%	97%
Q4PGW7	Ustilago maydis (strain 521 / FGSC 9021)	29%	100%
Q4Q541	Leishmania major	97%	100%
Q4QBR9	Leishmania major	27%	90%
Q4QBS0	Leishmania major	28%	95%
Q4QFH9	Leishmania major	32%	86%
Q4QG48	Leishmania major	26%	100%
Q4QH53	Leishmania major	24%	100%
Q4WJW8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q4X0B5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
Q54NC1	Dictyostelium discoideum	27%	100%
Q59M70	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q59P03	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q5AZB4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	100%
Q5BG98	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5BJ68	Xenopus tropicalis	28%	100%
Q5PQA4	Xenopus laevis	29%	100%
Q5ZHX7	Gallus gallus	29%	100%
Q60HG4	Macaca fascicularis	28%	100%
Q6AY12	Rattus norvegicus	28%	100%
Q6BCY4	Homo sapiens	30%	100%
Q6BQ54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6BUX2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6C9G8	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6CA86	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	100%
Q6CID0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6CS27	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6FLT3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
Q6FUX5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q75AL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q75C62	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q7RXL1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q7SFY2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	99%
Q9DCN2	Mus musculus	29%	100%
Q9UR35	Mortierella alpina	26%	100%
Q9ZNT1	Arabidopsis thaliana	28%	100%
V5AQN7	Trypanosoma cruzi	25%	100%
V5AU35	Trypanosoma cruzi	41%	100%
V5B8B1	Trypanosoma cruzi	63%	100%
V5BVT5	Trypanosoma cruzi	30%	100%
V5DSW9	Trypanosoma cruzi	23%	90%