LeishMANIAdb
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Aquaporin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aquaporin-like protein
Gene product:
aquaporin-like protein
Species:
Leishmania infantum
UniProt:
A4I858_LEIIN
TriTrypDb:
LINF_320030200
Length:
596

Annotations

Annotations by Jardim et al.

Transporters, Aquaporin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4I858
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I858

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 7
GO:0015267 channel activity 4 7
GO:0022803 passive transmembrane transporter activity 3 7
GO:0022857 transmembrane transporter activity 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 556 560 PF00656 0.718
CLV_C14_Caspase3-7 562 566 PF00656 0.675
CLV_NRD_NRD_1 164 166 PF00675 0.494
CLV_NRD_NRD_1 214 216 PF00675 0.483
CLV_NRD_NRD_1 463 465 PF00675 0.489
CLV_PCSK_KEX2_1 164 166 PF00082 0.494
CLV_PCSK_SKI1_1 155 159 PF00082 0.472
CLV_PCSK_SKI1_1 165 169 PF00082 0.418
CLV_PCSK_SKI1_1 215 219 PF00082 0.336
CLV_PCSK_SKI1_1 308 312 PF00082 0.370
CLV_PCSK_SKI1_1 340 344 PF00082 0.526
CLV_PCSK_SKI1_1 464 468 PF00082 0.469
CLV_PCSK_SKI1_1 531 535 PF00082 0.581
CLV_PCSK_SKI1_1 582 586 PF00082 0.498
DEG_Nend_UBRbox_2 1 3 PF02207 0.714
DEG_ODPH_VHL_1 436 449 PF01847 0.310
DEG_SPOP_SBC_1 143 147 PF00917 0.722
DEG_SPOP_SBC_1 506 510 PF00917 0.702
DEG_SPOP_SBC_1 583 587 PF00917 0.705
DOC_CYCLIN_yCln2_LP_2 197 203 PF00134 0.541
DOC_MAPK_gen_1 218 226 PF00069 0.581
DOC_MAPK_MEF2A_6 180 187 PF00069 0.593
DOC_PP2B_LxvP_1 224 227 PF13499 0.576
DOC_PP4_FxxP_1 32 35 PF00568 0.694
DOC_USP7_MATH_1 109 113 PF00917 0.617
DOC_USP7_MATH_1 129 133 PF00917 0.599
DOC_USP7_MATH_1 136 140 PF00917 0.739
DOC_USP7_MATH_1 254 258 PF00917 0.310
DOC_USP7_MATH_1 298 302 PF00917 0.481
DOC_USP7_MATH_1 345 349 PF00917 0.288
DOC_USP7_MATH_1 35 39 PF00917 0.696
DOC_USP7_MATH_1 410 414 PF00917 0.388
DOC_USP7_MATH_1 493 497 PF00917 0.667
DOC_USP7_MATH_1 506 510 PF00917 0.747
DOC_USP7_MATH_1 90 94 PF00917 0.722
DOC_WW_Pin1_4 113 118 PF00397 0.675
DOC_WW_Pin1_4 25 30 PF00397 0.666
DOC_WW_Pin1_4 49 54 PF00397 0.704
DOC_WW_Pin1_4 538 543 PF00397 0.723
DOC_WW_Pin1_4 86 91 PF00397 0.747
LIG_14-3-3_CanoR_1 101 109 PF00244 0.779
LIG_14-3-3_CanoR_1 515 519 PF00244 0.755
LIG_Actin_WH2_2 414 431 PF00022 0.274
LIG_AP2alpha_2 199 201 PF02296 0.641
LIG_BRCT_BRCA1_1 282 286 PF00533 0.305
LIG_BRCT_BRCA1_1 353 357 PF00533 0.310
LIG_BRCT_BRCA1_1 378 382 PF00533 0.474
LIG_FHA_1 166 172 PF00498 0.705
LIG_FHA_1 180 186 PF00498 0.583
LIG_FHA_1 250 256 PF00498 0.337
LIG_FHA_1 280 286 PF00498 0.319
LIG_FHA_1 322 328 PF00498 0.258
LIG_FHA_1 347 353 PF00498 0.266
LIG_FHA_1 456 462 PF00498 0.619
LIG_FHA_1 548 554 PF00498 0.714
LIG_FHA_2 149 155 PF00498 0.691
LIG_FHA_2 509 515 PF00498 0.714
LIG_FHA_2 542 548 PF00498 0.682
LIG_FHA_2 584 590 PF00498 0.757
LIG_GBD_Chelix_1 302 310 PF00786 0.262
LIG_GBD_Chelix_1 444 452 PF00786 0.373
LIG_Integrin_RGD_1 528 530 PF01839 0.464
LIG_LIR_Apic_2 31 35 PF02991 0.695
LIG_LIR_Apic_2 585 591 PF02991 0.664
LIG_LIR_Gen_1 219 227 PF02991 0.595
LIG_LIR_Gen_1 228 236 PF02991 0.570
LIG_LIR_Gen_1 238 247 PF02991 0.336
LIG_LIR_Gen_1 354 365 PF02991 0.310
LIG_LIR_Nem_3 219 224 PF02991 0.625
LIG_LIR_Nem_3 228 232 PF02991 0.595
LIG_LIR_Nem_3 238 243 PF02991 0.429
LIG_LIR_Nem_3 246 250 PF02991 0.308
LIG_LIR_Nem_3 287 291 PF02991 0.310
LIG_LIR_Nem_3 354 360 PF02991 0.310
LIG_MAD2 169 177 PF02301 0.687
LIG_NBox_RRM_1 296 306 PF00076 0.499
LIG_Pex14_2 32 36 PF04695 0.633
LIG_Pex14_2 382 386 PF04695 0.310
LIG_PTB_Apo_2 369 376 PF02174 0.310
LIG_PTB_Phospho_1 369 375 PF10480 0.310
LIG_SH2_CRK 221 225 PF00017 0.589
LIG_SH2_STAP1 181 185 PF00017 0.623
LIG_SH2_STAP1 221 225 PF00017 0.586
LIG_SH2_STAT3 375 378 PF00017 0.474
LIG_SH2_STAT5 181 184 PF00017 0.635
LIG_SH2_STAT5 239 242 PF00017 0.310
LIG_SH2_STAT5 290 293 PF00017 0.310
LIG_SH2_STAT5 318 321 PF00017 0.310
LIG_SH2_STAT5 351 354 PF00017 0.274
LIG_SH3_1 570 576 PF00018 0.690
LIG_SH3_2 573 578 PF14604 0.670
LIG_SH3_3 167 173 PF00018 0.663
LIG_SH3_3 37 43 PF00018 0.738
LIG_SH3_3 47 53 PF00018 0.625
LIG_SH3_3 570 576 PF00018 0.690
LIG_SUMO_SIM_anti_2 252 257 PF11976 0.294
LIG_SUMO_SIM_par_1 181 186 PF11976 0.618
LIG_SUMO_SIM_par_1 251 257 PF11976 0.310
LIG_SUMO_SIM_par_1 46 52 PF11976 0.641
LIG_TRAF2_1 544 547 PF00917 0.702
LIG_TRFH_1 434 438 PF08558 0.310
LIG_WRC_WIRS_1 244 249 PF05994 0.310
LIG_WRC_WIRS_1 285 290 PF05994 0.310
LIG_WRC_WIRS_1 361 366 PF05994 0.310
MOD_CDK_SPK_2 538 543 PF00069 0.721
MOD_CDK_SPxxK_3 538 545 PF00069 0.672
MOD_CK1_1 112 118 PF00069 0.685
MOD_CK1_1 141 147 PF00069 0.780
MOD_CK1_1 267 273 PF00069 0.287
MOD_CK1_1 346 352 PF00069 0.273
MOD_CK1_1 376 382 PF00069 0.472
MOD_CK1_1 393 399 PF00069 0.294
MOD_CK1_1 508 514 PF00069 0.728
MOD_CK1_1 51 57 PF00069 0.805
MOD_CK1_1 519 525 PF00069 0.830
MOD_CK1_1 566 572 PF00069 0.794
MOD_CK2_1 497 503 PF00069 0.704
MOD_CK2_1 508 514 PF00069 0.684
MOD_CK2_1 541 547 PF00069 0.683
MOD_CK2_1 574 580 PF00069 0.753
MOD_CK2_1 583 589 PF00069 0.671
MOD_CK2_1 72 78 PF00069 0.743
MOD_CMANNOS 432 435 PF00535 0.310
MOD_Cter_Amidation 162 165 PF01082 0.496
MOD_GlcNHglycan 140 143 PF01048 0.593
MOD_GlcNHglycan 146 149 PF01048 0.507
MOD_GlcNHglycan 23 26 PF01048 0.625
MOD_GlcNHglycan 291 294 PF01048 0.285
MOD_GlcNHglycan 353 356 PF01048 0.317
MOD_GlcNHglycan 37 40 PF01048 0.495
MOD_GlcNHglycan 378 381 PF01048 0.270
MOD_GlcNHglycan 392 395 PF01048 0.338
MOD_GlcNHglycan 397 400 PF01048 0.467
MOD_GlcNHglycan 402 405 PF01048 0.514
MOD_GlcNHglycan 412 415 PF01048 0.418
MOD_GlcNHglycan 499 502 PF01048 0.496
MOD_GlcNHglycan 565 568 PF01048 0.533
MOD_GlcNHglycan 74 77 PF01048 0.526
MOD_GlcNHglycan 92 95 PF01048 0.418
MOD_GlcNHglycan 96 99 PF01048 0.464
MOD_GSK3_1 109 116 PF00069 0.733
MOD_GSK3_1 138 145 PF00069 0.771
MOD_GSK3_1 179 186 PF00069 0.632
MOD_GSK3_1 21 28 PF00069 0.699
MOD_GSK3_1 280 287 PF00069 0.305
MOD_GSK3_1 343 350 PF00069 0.285
MOD_GSK3_1 351 358 PF00069 0.271
MOD_GSK3_1 48 55 PF00069 0.698
MOD_GSK3_1 485 492 PF00069 0.660
MOD_GSK3_1 493 500 PF00069 0.644
MOD_GSK3_1 501 508 PF00069 0.664
MOD_GSK3_1 510 517 PF00069 0.743
MOD_GSK3_1 518 525 PF00069 0.708
MOD_GSK3_1 86 93 PF00069 0.699
MOD_N-GLC_1 136 141 PF02516 0.519
MOD_N-GLC_1 259 264 PF02516 0.474
MOD_N-GLC_1 468 473 PF02516 0.401
MOD_N-GLC_1 78 83 PF02516 0.539
MOD_N-GLC_2 594 596 PF02516 0.454
MOD_NEK2_1 119 124 PF00069 0.747
MOD_NEK2_1 179 184 PF00069 0.623
MOD_NEK2_1 235 240 PF00069 0.474
MOD_NEK2_1 243 248 PF00069 0.310
MOD_NEK2_1 279 284 PF00069 0.319
MOD_NEK2_1 360 365 PF00069 0.340
MOD_NEK2_1 390 395 PF00069 0.310
MOD_NEK2_1 518 523 PF00069 0.671
MOD_NEK2_2 254 259 PF00069 0.310
MOD_PIKK_1 101 107 PF00454 0.716
MOD_PIKK_1 447 453 PF00454 0.406
MOD_PIKK_1 455 461 PF00454 0.617
MOD_PIKK_1 554 560 PF00454 0.737
MOD_PK_1 259 265 PF00069 0.274
MOD_PKA_2 100 106 PF00069 0.719
MOD_PKA_2 376 382 PF00069 0.474
MOD_PKA_2 400 406 PF00069 0.262
MOD_PKA_2 485 491 PF00069 0.662
MOD_PKA_2 504 510 PF00069 0.629
MOD_PKA_2 514 520 PF00069 0.687
MOD_PKA_2 547 553 PF00069 0.681
MOD_Plk_1 136 142 PF00069 0.725
MOD_Plk_1 259 265 PF00069 0.274
MOD_Plk_4 235 241 PF00069 0.474
MOD_Plk_4 259 265 PF00069 0.274
MOD_Plk_4 280 286 PF00069 0.310
MOD_Plk_4 347 353 PF00069 0.347
MOD_Plk_4 427 433 PF00069 0.274
MOD_ProDKin_1 113 119 PF00069 0.675
MOD_ProDKin_1 25 31 PF00069 0.666
MOD_ProDKin_1 49 55 PF00069 0.703
MOD_ProDKin_1 538 544 PF00069 0.724
MOD_ProDKin_1 86 92 PF00069 0.746
MOD_SUMO_for_1 157 160 PF00179 0.652
MOD_SUMO_rev_2 186 194 PF00179 0.576
MOD_SUMO_rev_2 426 431 PF00179 0.299
MOD_SUMO_rev_2 457 467 PF00179 0.620
MOD_SUMO_rev_2 577 584 PF00179 0.690
TRG_DiLeu_BaEn_1 193 198 PF01217 0.543
TRG_DiLeu_BaLyEn_6 231 236 PF01217 0.561
TRG_ENDOCYTIC_2 221 224 PF00928 0.614
TRG_ER_diArg_1 164 166 PF00400 0.650
TRG_ER_diArg_1 475 478 PF00400 0.645
TRG_ER_diArg_1 542 545 PF00400 0.708

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I348 Leptomonas seymouri 53% 98%
A0A3Q8IFK5 Leishmania donovani 99% 100%
A4HKM9 Leishmania braziliensis 76% 100%
E9B317 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q537 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS