LeishMANIAdb
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EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EamA domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I856_LEIIN
TriTrypDb:
LINF_320029700
Length:
139

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I856
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I856

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 59 63 PF00082 0.336
DEG_APCC_DBOX_1 74 82 PF00400 0.511
DEG_COP1_1 25 32 PF00400 0.405
DEG_Nend_Nbox_1 1 3 PF02207 0.413
DOC_MAPK_MEF2A_6 34 42 PF00069 0.442
DOC_PP1_RVXF_1 57 63 PF00149 0.328
DOC_USP7_MATH_1 135 139 PF00917 0.649
DOC_USP7_MATH_1 23 27 PF00917 0.406
DOC_WW_Pin1_4 111 116 PF00397 0.426
DOC_WW_Pin1_4 83 88 PF00397 0.510
LIG_Clathr_ClatBox_1 106 110 PF01394 0.473
LIG_EH1_1 62 70 PF00400 0.373
LIG_FHA_1 94 100 PF00498 0.404
LIG_LIR_Nem_3 72 77 PF02991 0.597
LIG_PDZ_Class_2 134 139 PF00595 0.642
LIG_SH2_STAT5 39 42 PF00017 0.456
LIG_SH2_STAT5 77 80 PF00017 0.522
LIG_SH3_3 129 135 PF00018 0.491
MOD_GlcNHglycan 100 103 PF01048 0.312
MOD_GlcNHglycan 15 18 PF01048 0.504
MOD_GlcNHglycan 25 28 PF01048 0.527
MOD_GlcNHglycan 34 37 PF01048 0.539
MOD_GSK3_1 28 35 PF00069 0.335
MOD_GSK3_1 79 86 PF00069 0.506
MOD_N-GLC_1 4 9 PF02516 0.564
MOD_NEK2_1 32 37 PF00069 0.394
MOD_NEK2_1 69 74 PF00069 0.453
MOD_NEK2_1 98 103 PF00069 0.309
MOD_PIKK_1 79 85 PF00454 0.600
MOD_Plk_1 4 10 PF00069 0.361
MOD_Plk_2-3 43 49 PF00069 0.433
MOD_Plk_4 28 34 PF00069 0.354
MOD_Plk_4 69 75 PF00069 0.469
MOD_ProDKin_1 111 117 PF00069 0.345
MOD_ProDKin_1 83 89 PF00069 0.505
TRG_ENDOCYTIC_2 39 42 PF00928 0.456
TRG_PTS2 1 42 PF00400 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II38 Leptomonas seymouri 83% 73%
A0A0S4IRV5 Bodo saltans 45% 78%
A0A1X0NRG8 Trypanosomatidae 48% 73%
A0A1X0NUK8 Trypanosomatidae 47% 73%
A0A3Q8IH44 Leishmania donovani 99% 100%
A0A3R7KNK3 Trypanosoma rangeli 54% 78%
A4HKM4 Leishmania braziliensis 91% 100%
D0AAC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 87%
Q4Q542 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS