Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I853_LEIIN

TriTrypDb:

LINF_320029400

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I853

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I853

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.759
CLV_C14_Caspase3-7	65	69	PF00656	0.467
CLV_NRD_NRD_1	118	120	PF00675	0.741
CLV_NRD_NRD_1	152	154	PF00675	0.768
CLV_NRD_NRD_1	272	274	PF00675	0.746
CLV_NRD_NRD_1	34	36	PF00675	0.663
CLV_NRD_NRD_1	414	416	PF00675	0.774
CLV_NRD_NRD_1	423	425	PF00675	0.661
CLV_NRD_NRD_1	56	58	PF00675	0.502
CLV_NRD_NRD_1	71	73	PF00675	0.506
CLV_NRD_NRD_1	96	98	PF00675	0.653
CLV_PCSK_FUR_1	54	58	PF00082	0.468
CLV_PCSK_KEX2_1	118	120	PF00082	0.737
CLV_PCSK_KEX2_1	152	154	PF00082	0.768
CLV_PCSK_KEX2_1	247	249	PF00082	0.792
CLV_PCSK_KEX2_1	34	36	PF00082	0.663
CLV_PCSK_KEX2_1	346	348	PF00082	0.771
CLV_PCSK_KEX2_1	414	416	PF00082	0.774
CLV_PCSK_KEX2_1	423	425	PF00082	0.661
CLV_PCSK_KEX2_1	56	58	PF00082	0.604
CLV_PCSK_KEX2_1	71	73	PF00082	0.532
CLV_PCSK_KEX2_1	96	98	PF00082	0.653
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.792
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.771
CLV_PCSK_PC7_1	30	36	PF00082	0.662
CLV_PCSK_SKI1_1	153	157	PF00082	0.668
CLV_PCSK_SKI1_1	205	209	PF00082	0.764
CLV_PCSK_SKI1_1	226	230	PF00082	0.763
CLV_PCSK_SKI1_1	332	336	PF00082	0.761
CLV_PCSK_SKI1_1	96	100	PF00082	0.643
DEG_SIAH_1	119	127	PF03145	0.630
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.756
DOC_MAPK_DCC_7	396	405	PF00069	0.751
DOC_MAPK_gen_1	171	180	PF00069	0.685
DOC_MAPK_gen_1	244	251	PF00069	0.736
DOC_MAPK_gen_1	396	405	PF00069	0.813
DOC_PP1_RVXF_1	245	252	PF00149	0.792
DOC_PP2B_LxvP_1	399	402	PF13499	0.755
DOC_USP7_MATH_1	131	135	PF00917	0.676
DOC_USP7_MATH_1	136	140	PF00917	0.602
DOC_USP7_MATH_1	206	210	PF00917	0.628
DOC_USP7_MATH_1	224	228	PF00917	0.629
DOC_USP7_MATH_1	284	288	PF00917	0.635
DOC_USP7_MATH_1	330	334	PF00917	0.767
DOC_USP7_MATH_1	356	360	PF00917	0.742
DOC_WW_Pin1_4	127	132	PF00397	0.762
DOC_WW_Pin1_4	209	214	PF00397	0.722
DOC_WW_Pin1_4	216	221	PF00397	0.648
DOC_WW_Pin1_4	239	244	PF00397	0.816
DOC_WW_Pin1_4	357	362	PF00397	0.832
DOC_WW_Pin1_4	386	391	PF00397	0.628
DOC_WW_Pin1_4	404	409	PF00397	0.657
LIG_14-3-3_CanoR_1	273	277	PF00244	0.679
LIG_14-3-3_CanoR_1	332	337	PF00244	0.759
LIG_14-3-3_CanoR_1	423	427	PF00244	0.732
LIG_BRCT_BRCA1_1	321	325	PF00533	0.727
LIG_CSL_BTD_1	221	224	PF09270	0.615
LIG_FHA_1	173	179	PF00498	0.574
LIG_FHA_1	324	330	PF00498	0.820
LIG_FHA_1	34	40	PF00498	0.656
LIG_FHA_2	23	29	PF00498	0.658
LIG_FHA_2	431	437	PF00498	0.725
LIG_FHA_2	63	69	PF00498	0.580
LIG_LIR_Gen_1	254	265	PF02991	0.606
LIG_LIR_Nem_3	254	260	PF02991	0.738
LIG_LIR_Nem_3	9	15	PF02991	0.666
LIG_Rb_LxCxE_1	38	59	PF01857	0.454
LIG_SH2_CRK	12	16	PF00017	0.551
LIG_SH2_GRB2like	392	395	PF00017	0.699
LIG_SH3_1	218	224	PF00018	0.618
LIG_SH3_2	114	119	PF14604	0.720
LIG_SH3_2	221	226	PF14604	0.615
LIG_SH3_3	111	117	PF00018	0.611
LIG_SH3_3	120	126	PF00018	0.643
LIG_SH3_3	207	213	PF00018	0.794
LIG_SH3_3	217	223	PF00018	0.694
LIG_SH3_3	287	293	PF00018	0.701
LIG_SUMO_SIM_par_1	401	407	PF11976	0.758
LIG_TRAF2_1	7	10	PF00917	0.670
LIG_TRAF2_1	88	91	PF00917	0.648
LIG_UBA3_1	166	173	PF00899	0.659
MOD_CDC14_SPxK_1	360	363	PF00782	0.842
MOD_CDK_SPK_2	239	244	PF00069	0.656
MOD_CDK_SPK_2	404	409	PF00069	0.810
MOD_CDK_SPxK_1	357	363	PF00069	0.837
MOD_CDK_SPxxK_3	239	246	PF00069	0.716
MOD_CK1_1	209	215	PF00069	0.762
MOD_CK1_1	407	413	PF00069	0.823
MOD_CK1_1	418	424	PF00069	0.554
MOD_CK2_1	183	189	PF00069	0.687
MOD_CK2_1	239	245	PF00069	0.718
MOD_CK2_1	4	10	PF00069	0.686
MOD_CK2_1	430	436	PF00069	0.723
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.618
MOD_GlcNHglycan	133	136	PF01048	0.679
MOD_GlcNHglycan	140	143	PF01048	0.726
MOD_GlcNHglycan	144	147	PF01048	0.586
MOD_GlcNHglycan	286	289	PF01048	0.663
MOD_GlcNHglycan	293	296	PF01048	0.711
MOD_GlcNHglycan	321	324	PF01048	0.741
MOD_GlcNHglycan	332	335	PF01048	0.638
MOD_GlcNHglycan	382	385	PF01048	0.707
MOD_GlcNHglycan	409	412	PF01048	0.843
MOD_GlcNHglycan	418	421	PF01048	0.583
MOD_GlcNHglycan	6	9	PF01048	0.682
MOD_GSK3_1	127	134	PF00069	0.819
MOD_GSK3_1	136	143	PF00069	0.661
MOD_GSK3_1	180	187	PF00069	0.612
MOD_GSK3_1	205	212	PF00069	0.807
MOD_GSK3_1	222	229	PF00069	0.524
MOD_GSK3_1	291	298	PF00069	0.649
MOD_GSK3_1	311	318	PF00069	0.707
MOD_GSK3_1	319	326	PF00069	0.718
MOD_GSK3_1	328	335	PF00069	0.513
MOD_GSK3_1	348	355	PF00069	0.455
MOD_GSK3_1	386	393	PF00069	0.612
MOD_GSK3_1	415	422	PF00069	0.657
MOD_GSK3_1	427	434	PF00069	0.628
MOD_N-GLC_1	295	300	PF02516	0.738
MOD_N-GLC_1	311	316	PF02516	0.609
MOD_N-GLC_1	415	420	PF02516	0.779
MOD_N-GLC_2	307	309	PF02516	0.748
MOD_NEK2_2	323	328	PF00069	0.831
MOD_PIKK_1	22	28	PF00454	0.591
MOD_PIKK_1	315	321	PF00454	0.794
MOD_PIKK_1	354	360	PF00454	0.715
MOD_PIKK_1	62	68	PF00454	0.590
MOD_PKA_2	194	200	PF00069	0.837
MOD_PKA_2	258	264	PF00069	0.785
MOD_PKA_2	269	275	PF00069	0.826
MOD_PKA_2	319	325	PF00069	0.688
MOD_PKA_2	33	39	PF00069	0.656
MOD_PKA_2	348	354	PF00069	0.781
MOD_PKA_2	422	428	PF00069	0.729
MOD_PKA_2	430	436	PF00069	0.628
MOD_PKA_2	82	88	PF00069	0.670
MOD_Plk_1	153	159	PF00069	0.713
MOD_Plk_1	295	301	PF00069	0.729
MOD_Plk_4	153	159	PF00069	0.788
MOD_Plk_4	206	212	PF00069	0.812
MOD_Plk_4	272	278	PF00069	0.727
MOD_Plk_4	332	338	PF00069	0.758
MOD_ProDKin_1	127	133	PF00069	0.762
MOD_ProDKin_1	209	215	PF00069	0.722
MOD_ProDKin_1	216	222	PF00069	0.649
MOD_ProDKin_1	239	245	PF00069	0.816
MOD_ProDKin_1	357	363	PF00069	0.837
MOD_ProDKin_1	386	392	PF00069	0.628
MOD_ProDKin_1	404	410	PF00069	0.656
MOD_SUMO_rev_2	241	249	PF00179	0.792
TRG_DiLeu_BaEn_1	10	15	PF01217	0.662
TRG_ENDOCYTIC_2	12	15	PF00928	0.661
TRG_ER_diArg_1	117	119	PF00400	0.789
TRG_ER_diArg_1	151	153	PF00400	0.764
TRG_ER_diArg_1	347	350	PF00400	0.570
TRG_ER_diArg_1	396	399	PF00400	0.561
TRG_ER_diArg_1	54	57	PF00400	0.478
TRG_ER_diArg_1	71	73	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITE5	Leishmania donovani	99%	100%
A4HKM1	Leishmania braziliensis	62%	100%
E9B310	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q545	Leishmania major	85%	100%