Putative sphingosine-1-phosphate phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine-1-phosphate phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I852_LEIIN

TriTrypDb:

LINF_320029300

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I852

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I852

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0030258	lipid modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.665
CLV_C14_Caspase3-7	567	571	PF00656	0.655
CLV_NRD_NRD_1	172	174	PF00675	0.328
CLV_PCSK_KEX2_1	172	174	PF00082	0.328
CLV_PCSK_KEX2_1	279	281	PF00082	0.464
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.507
CLV_PCSK_SKI1_1	261	265	PF00082	0.591
CLV_PCSK_SKI1_1	477	481	PF00082	0.301
DEG_COP1_1	16	27	PF00400	0.661
DEG_MDM2_SWIB_1	362	370	PF02201	0.307
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DOC_AGCK_PIF_1	215	220	PF00069	0.340
DOC_CKS1_1	147	152	PF01111	0.646
DOC_CYCLIN_yCln2_LP_2	624	630	PF00134	0.408
DOC_MAPK_DCC_7	202	212	PF00069	0.506
DOC_MAPK_gen_1	172	180	PF00069	0.558
DOC_MAPK_gen_1	490	500	PF00069	0.613
DOC_MAPK_gen_1	515	523	PF00069	0.640
DOC_MAPK_gen_1	95	103	PF00069	0.656
DOC_MAPK_JIP1_4	97	103	PF00069	0.656
DOC_MAPK_MEF2A_6	268	276	PF00069	0.240
DOC_MAPK_MEF2A_6	493	502	PF00069	0.548
DOC_MAPK_MEF2A_6	95	103	PF00069	0.656
DOC_PP1_RVXF_1	174	181	PF00149	0.597
DOC_PP2B_LxvP_1	210	213	PF13499	0.645
DOC_PP2B_LxvP_1	229	232	PF13499	0.269
DOC_PP2B_LxvP_1	237	240	PF13499	0.266
DOC_PP4_FxxP_1	12	15	PF00568	0.664
DOC_PP4_FxxP_1	264	267	PF00568	0.282
DOC_USP7_MATH_1	120	124	PF00917	0.666
DOC_USP7_MATH_1	13	17	PF00917	0.608
DOC_USP7_MATH_1	151	155	PF00917	0.701
DOC_USP7_MATH_1	240	244	PF00917	0.309
DOC_USP7_MATH_1	328	332	PF00917	0.367
DOC_USP7_MATH_1	525	529	PF00917	0.646
DOC_USP7_MATH_1	556	560	PF00917	0.791
DOC_USP7_UBL2_3	477	481	PF12436	0.555
DOC_WW_Pin1_4	146	151	PF00397	0.708
DOC_WW_Pin1_4	157	162	PF00397	0.738
DOC_WW_Pin1_4	23	28	PF00397	0.746
DOC_WW_Pin1_4	373	378	PF00397	0.339
DOC_WW_Pin1_4	394	399	PF00397	0.557
DOC_WW_Pin1_4	631	636	PF00397	0.534
LIG_14-3-3_CanoR_1	173	179	PF00244	0.518
LIG_14-3-3_CanoR_1	490	496	PF00244	0.522
LIG_14-3-3_CanoR_1	515	523	PF00244	0.638
LIG_14-3-3_CanoR_1	560	569	PF00244	0.659
LIG_14-3-3_CanoR_1	595	600	PF00244	0.442
LIG_14-3-3_CanoR_1	97	102	PF00244	0.689
LIG_Actin_WH2_2	463	479	PF00022	0.394
LIG_Actin_WH2_2	602	617	PF00022	0.332
LIG_AP2alpha_1	536	540	PF02296	0.599
LIG_APCC_ABBA_1	309	314	PF00400	0.228
LIG_BRCT_BRCA1_1	296	300	PF00533	0.240
LIG_BRCT_BRCA1_1	407	411	PF00533	0.440
LIG_BRCT_BRCA1_1	446	450	PF00533	0.273
LIG_BRCT_BRCA1_1	526	530	PF00533	0.636
LIG_BRCT_BRCA1_1	532	536	PF00533	0.768
LIG_CtBP_PxDLS_1	98	102	PF00389	0.655
LIG_deltaCOP1_diTrp_1	182	188	PF00928	0.497
LIG_EH1_1	339	347	PF00400	0.460
LIG_eIF4E_1	385	391	PF01652	0.385
LIG_FHA_1	134	140	PF00498	0.609
LIG_FHA_1	232	238	PF00498	0.315
LIG_FHA_1	29	35	PF00498	0.623
LIG_FHA_1	385	391	PF00498	0.433
LIG_FHA_1	410	416	PF00498	0.332
LIG_FHA_1	417	423	PF00498	0.270
LIG_FHA_1	561	567	PF00498	0.689
LIG_FHA_1	573	579	PF00498	0.580
LIG_FHA_1	615	621	PF00498	0.380
LIG_FHA_2	161	167	PF00498	0.627
LIG_FHA_2	33	39	PF00498	0.684
LIG_FHA_2	395	401	PF00498	0.555
LIG_FHA_2	563	569	PF00498	0.652
LIG_GSK3_LRP6_1	635	640	PF00069	0.445
LIG_LIR_Apic_2	10	15	PF02991	0.741
LIG_LIR_Apic_2	262	267	PF02991	0.282
LIG_LIR_Apic_2	284	290	PF02991	0.240
LIG_LIR_Gen_1	20	29	PF02991	0.620
LIG_LIR_Gen_1	225	235	PF02991	0.275
LIG_LIR_Gen_1	297	308	PF02991	0.254
LIG_LIR_Gen_1	331	339	PF02991	0.367
LIG_LIR_Gen_1	376	386	PF02991	0.310
LIG_LIR_Gen_1	596	606	PF02991	0.349
LIG_LIR_Nem_3	20	24	PF02991	0.702
LIG_LIR_Nem_3	223	229	PF02991	0.340
LIG_LIR_Nem_3	297	303	PF02991	0.254
LIG_LIR_Nem_3	331	335	PF02991	0.367
LIG_LIR_Nem_3	375	381	PF02991	0.303
LIG_MYND_1	209	213	PF01753	0.495
LIG_PCNA_PIPBox_1	296	305	PF02747	0.248
LIG_PCNA_yPIPBox_3	296	307	PF02747	0.207
LIG_Pex14_1	251	255	PF04695	0.287
LIG_Pex14_2	226	230	PF04695	0.250
LIG_Pex14_2	362	366	PF04695	0.290
LIG_Pex14_2	446	450	PF04695	0.274
LIG_Pex14_2	536	540	PF04695	0.640
LIG_Pex14_2	604	608	PF04695	0.316
LIG_RPA_C_Fungi	460	472	PF08784	0.336
LIG_SH2_CRK	287	291	PF00017	0.273
LIG_SH2_CRK	305	309	PF00017	0.273
LIG_SH2_CRK	429	433	PF00017	0.390
LIG_SH2_GRB2like	572	575	PF00017	0.525
LIG_SH2_PTP2	385	388	PF00017	0.322
LIG_SH2_SRC	405	408	PF00017	0.334
LIG_SH2_STAT5	184	187	PF00017	0.367
LIG_SH2_STAT5	214	217	PF00017	0.284
LIG_SH2_STAT5	255	258	PF00017	0.284
LIG_SH2_STAT5	305	308	PF00017	0.380
LIG_SH2_STAT5	326	329	PF00017	0.402
LIG_SH2_STAT5	336	339	PF00017	0.306
LIG_SH2_STAT5	381	384	PF00017	0.300
LIG_SH2_STAT5	385	388	PF00017	0.278
LIG_SH2_STAT5	405	408	PF00017	0.185
LIG_SH2_STAT5	499	502	PF00017	0.408
LIG_SH2_STAT5	572	575	PF00017	0.525
LIG_SH3_3	155	161	PF00018	0.585
LIG_SH3_3	203	209	PF00018	0.447
LIG_SH3_3	21	27	PF00018	0.778
LIG_SH3_3	264	270	PF00018	0.277
LIG_SH3_3	395	401	PF00018	0.435
LIG_SH3_3	563	569	PF00018	0.633
LIG_SH3_3	629	635	PF00018	0.638
LIG_SUMO_SIM_par_1	135	141	PF11976	0.508
LIG_SUMO_SIM_par_1	160	166	PF11976	0.502
LIG_SUMO_SIM_par_1	30	35	PF11976	0.528
LIG_SxIP_EBH_1	515	527	PF03271	0.539
LIG_TRAF2_1	565	568	PF00917	0.625
LIG_TYR_ITIM	212	217	PF00017	0.367
LIG_TYR_ITIM	383	388	PF00017	0.332
LIG_Vh1_VBS_1	460	478	PF01044	0.397
LIG_WRC_WIRS_1	217	222	PF05994	0.297
LIG_WRC_WIRS_1	299	304	PF05994	0.412
LIG_WRC_WIRS_1	605	610	PF05994	0.367
MOD_CK1_1	114	120	PF00069	0.742
MOD_CK1_1	160	166	PF00069	0.521
MOD_CK1_1	291	297	PF00069	0.275
MOD_CK1_1	580	586	PF00069	0.393
MOD_CK1_1	93	99	PF00069	0.623
MOD_CK2_1	160	166	PF00069	0.550
MOD_CK2_1	32	38	PF00069	0.561
MOD_CK2_1	558	564	PF00069	0.732
MOD_CMANNOS	587	590	PF00535	0.338
MOD_Cter_Amidation	277	280	PF01082	0.306
MOD_DYRK1A_RPxSP_1	23	27	PF00069	0.520
MOD_DYRK1A_RPxSP_1	373	377	PF00069	0.360
MOD_GlcNHglycan	153	156	PF01048	0.548
MOD_GlcNHglycan	16	19	PF01048	0.738
MOD_GlcNHglycan	296	299	PF01048	0.367
MOD_GlcNHglycan	46	49	PF01048	0.773
MOD_GlcNHglycan	483	486	PF01048	0.493
MOD_GlcNHglycan	73	76	PF01048	0.678
MOD_GlcNHglycan	92	95	PF01048	0.464
MOD_GSK3_1	19	26	PF00069	0.696
MOD_GSK3_1	28	35	PF00069	0.726
MOD_GSK3_1	294	301	PF00069	0.302
MOD_GSK3_1	3	10	PF00069	0.650
MOD_GSK3_1	405	412	PF00069	0.389
MOD_GSK3_1	44	51	PF00069	0.589
MOD_GSK3_1	461	468	PF00069	0.378
MOD_GSK3_1	521	528	PF00069	0.622
MOD_GSK3_1	554	561	PF00069	0.630
MOD_GSK3_1	631	638	PF00069	0.670
MOD_GSK3_1	93	100	PF00069	0.666
MOD_LATS_1	277	283	PF00433	0.297
MOD_LATS_1	593	599	PF00433	0.367
MOD_N-GLC_1	525	530	PF02516	0.539
MOD_N-GLC_1	55	60	PF02516	0.526
MOD_N-GLC_1	554	559	PF02516	0.535
MOD_N-GLC_1	71	76	PF02516	0.625
MOD_N-GLC_1	88	93	PF02516	0.554
MOD_NEK2_1	2	7	PF00069	0.669
MOD_NEK2_1	32	37	PF00069	0.755
MOD_NEK2_1	384	389	PF00069	0.297
MOD_NEK2_1	409	414	PF00069	0.351
MOD_NEK2_1	416	421	PF00069	0.262
MOD_NEK2_1	444	449	PF00069	0.332
MOD_NEK2_1	604	609	PF00069	0.347
MOD_NEK2_1	614	619	PF00069	0.388
MOD_NEK2_2	183	188	PF00069	0.395
MOD_NEK2_2	298	303	PF00069	0.273
MOD_NEK2_2	405	410	PF00069	0.303
MOD_NEK2_2	525	530	PF00069	0.527
MOD_PIKK_1	572	578	PF00454	0.614
MOD_PKA_1	279	285	PF00069	0.347
MOD_PKA_2	111	117	PF00069	0.625
MOD_PKA_2	279	285	PF00069	0.367
MOD_PKA_2	409	415	PF00069	0.367
MOD_PKA_2	514	520	PF00069	0.574
MOD_PKA_2	614	620	PF00069	0.365
MOD_Plk_1	19	25	PF00069	0.723
MOD_Plk_1	366	372	PF00069	0.395
MOD_Plk_1	465	471	PF00069	0.393
MOD_Plk_1	525	531	PF00069	0.543
MOD_Plk_4	143	149	PF00069	0.553
MOD_Plk_4	245	251	PF00069	0.314
MOD_Plk_4	352	358	PF00069	0.332
MOD_Plk_4	366	372	PF00069	0.313
MOD_Plk_4	446	452	PF00069	0.316
MOD_Plk_4	466	472	PF00069	0.330
MOD_Plk_4	525	531	PF00069	0.481
MOD_Plk_4	604	610	PF00069	0.323
MOD_ProDKin_1	146	152	PF00069	0.649
MOD_ProDKin_1	157	163	PF00069	0.681
MOD_ProDKin_1	23	29	PF00069	0.705
MOD_ProDKin_1	373	379	PF00069	0.412
MOD_ProDKin_1	394	400	PF00069	0.435
MOD_ProDKin_1	631	637	PF00069	0.662
MOD_SUMO_rev_2	109	117	PF00179	0.526
MOD_SUMO_rev_2	538	547	PF00179	0.543
TRG_DiLeu_BaEn_1	466	471	PF01217	0.351
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.392
TRG_ENDOCYTIC_2	214	217	PF00928	0.325
TRG_ENDOCYTIC_2	227	230	PF00928	0.325
TRG_ENDOCYTIC_2	305	308	PF00928	0.273
TRG_ENDOCYTIC_2	336	339	PF00928	0.367
TRG_ENDOCYTIC_2	381	384	PF00928	0.385
TRG_ENDOCYTIC_2	385	388	PF00928	0.347
TRG_ENDOCYTIC_2	429	432	PF00928	0.387
TRG_ENDOCYTIC_2	499	502	PF00928	0.434
TRG_ENDOCYTIC_2	599	602	PF00928	0.281
TRG_ER_diArg_1	171	173	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9L1	Leptomonas seymouri	53%	100%
A0A1X0NUR9	Trypanosomatidae	36%	100%
A0A3Q8IGA4	Leishmania donovani	99%	100%
A0A422MU49	Trypanosoma rangeli	38%	100%
A4HKM0	Leishmania braziliensis	66%	100%
Q4Q546	Leishmania major	89%	100%