LeishMANIAdb
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Membrane associated protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane associated protein-like protein
Gene product:
hypothetical protein
Species:
Leishmania infantum
UniProt:
A4I850_LEIIN
TriTrypDb:
LINF_320029000 * , LINF_320029100 *
Length:
1183

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I850
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I850

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1028 1030 PF00675 0.588
CLV_NRD_NRD_1 1063 1065 PF00675 0.564
CLV_NRD_NRD_1 1092 1094 PF00675 0.581
CLV_NRD_NRD_1 1099 1101 PF00675 0.581
CLV_NRD_NRD_1 157 159 PF00675 0.356
CLV_NRD_NRD_1 194 196 PF00675 0.390
CLV_NRD_NRD_1 59 61 PF00675 0.498
CLV_PCSK_KEX2_1 1028 1030 PF00082 0.588
CLV_PCSK_KEX2_1 1092 1094 PF00082 0.562
CLV_PCSK_KEX2_1 1168 1170 PF00082 0.596
CLV_PCSK_KEX2_1 157 159 PF00082 0.356
CLV_PCSK_KEX2_1 194 196 PF00082 0.390
CLV_PCSK_PC1ET2_1 1168 1170 PF00082 0.596
CLV_PCSK_PC7_1 153 159 PF00082 0.355
CLV_PCSK_SKI1_1 1107 1111 PF00082 0.526
CLV_PCSK_SKI1_1 283 287 PF00082 0.565
CLV_PCSK_SKI1_1 71 75 PF00082 0.524
DEG_Nend_Nbox_1 1 3 PF02207 0.525
DEG_SCF_FBW7_1 992 998 PF00400 0.533
DEG_SPOP_SBC_1 171 175 PF00917 0.429
DEG_SPOP_SBC_1 25 29 PF00917 0.607
DOC_CKS1_1 1070 1075 PF01111 0.554
DOC_CKS1_1 1085 1090 PF01111 0.518
DOC_CKS1_1 992 997 PF01111 0.533
DOC_CYCLIN_yCln2_LP_2 1067 1073 PF00134 0.554
DOC_MAPK_gen_1 1092 1099 PF00069 0.708
DOC_MAPK_gen_1 1100 1108 PF00069 0.650
DOC_MAPK_gen_1 1165 1173 PF00069 0.626
DOC_MAPK_gen_1 936 944 PF00069 0.485
DOC_MAPK_MEF2A_6 1100 1108 PF00069 0.588
DOC_PP2B_LxvP_1 1067 1070 PF13499 0.545
DOC_PP4_FxxP_1 1157 1160 PF00568 0.573
DOC_PP4_FxxP_1 239 242 PF00568 0.538
DOC_USP7_MATH_1 1035 1039 PF00917 0.551
DOC_USP7_MATH_1 1121 1125 PF00917 0.566
DOC_USP7_MATH_1 1152 1156 PF00917 0.550
DOC_USP7_MATH_1 171 175 PF00917 0.458
DOC_USP7_MATH_1 20 24 PF00917 0.603
DOC_USP7_MATH_1 235 239 PF00917 0.549
DOC_USP7_MATH_1 25 29 PF00917 0.594
DOC_USP7_MATH_1 274 278 PF00917 0.525
DOC_USP7_MATH_1 307 311 PF00917 0.560
DOC_USP7_MATH_1 322 326 PF00917 0.576
DOC_USP7_MATH_1 95 99 PF00917 0.408
DOC_USP7_MATH_1 954 958 PF00917 0.448
DOC_WW_Pin1_4 1039 1044 PF00397 0.542
DOC_WW_Pin1_4 1049 1054 PF00397 0.524
DOC_WW_Pin1_4 1065 1070 PF00397 0.523
DOC_WW_Pin1_4 1084 1089 PF00397 0.515
DOC_WW_Pin1_4 1100 1105 PF00397 0.576
DOC_WW_Pin1_4 1111 1116 PF00397 0.534
DOC_WW_Pin1_4 1130 1135 PF00397 0.505
DOC_WW_Pin1_4 1156 1161 PF00397 0.573
DOC_WW_Pin1_4 173 178 PF00397 0.442
DOC_WW_Pin1_4 245 250 PF00397 0.669
DOC_WW_Pin1_4 260 265 PF00397 0.582
DOC_WW_Pin1_4 320 325 PF00397 0.580
DOC_WW_Pin1_4 991 996 PF00397 0.564
LIG_14-3-3_CanoR_1 1028 1033 PF00244 0.623
LIG_14-3-3_CanoR_1 1107 1116 PF00244 0.527
LIG_14-3-3_CanoR_1 1153 1157 PF00244 0.617
LIG_14-3-3_CanoR_1 194 200 PF00244 0.381
LIG_14-3-3_CanoR_1 96 105 PF00244 0.369
LIG_14-3-3_CanoR_1 985 993 PF00244 0.560
LIG_Actin_WH2_2 55 73 PF00022 0.469
LIG_CtBP_PxDLS_1 1096 1101 PF00389 0.563
LIG_deltaCOP1_diTrp_1 1001 1011 PF00928 0.565
LIG_deltaCOP1_diTrp_1 1174 1183 PF00928 0.576
LIG_FHA_1 1018 1024 PF00498 0.584
LIG_FHA_1 1081 1087 PF00498 0.553
LIG_FHA_1 1103 1109 PF00498 0.525
LIG_FHA_1 196 202 PF00498 0.377
LIG_FHA_1 261 267 PF00498 0.608
LIG_FHA_1 300 306 PF00498 0.594
LIG_FHA_1 50 56 PF00498 0.471
LIG_FHA_1 65 71 PF00498 0.424
LIG_FHA_2 309 315 PF00498 0.569
LIG_FHA_2 996 1002 PF00498 0.594
LIG_LIR_Apic_2 1155 1160 PF02991 0.574
LIG_LIR_Apic_2 238 242 PF02991 0.534
LIG_LIR_Gen_1 1008 1019 PF02991 0.736
LIG_LIR_Gen_1 213 224 PF02991 0.451
LIG_LIR_Nem_3 1008 1014 PF02991 0.714
LIG_LIR_Nem_3 213 219 PF02991 0.427
LIG_LIR_Nem_3 57 62 PF02991 0.434
LIG_NRBOX 103 109 PF00104 0.349
LIG_PCNA_yPIPBox_3 1079 1093 PF02747 0.525
LIG_SH2_CRK 216 220 PF00017 0.433
LIG_SH2_NCK_1 1051 1055 PF00017 0.510
LIG_SH2_STAT3 278 281 PF00017 0.523
LIG_SH2_STAT5 1022 1025 PF00017 0.579
LIG_SH2_STAT5 1051 1054 PF00017 0.510
LIG_SH2_STAT5 262 265 PF00017 0.587
LIG_SH2_STAT5 278 281 PF00017 0.465
LIG_SH3_3 1067 1073 PF00018 0.550
LIG_SH3_3 1082 1088 PF00018 0.521
LIG_SH3_3 12 18 PF00018 0.549
LIG_SH3_3 246 252 PF00018 0.574
LIG_SUMO_SIM_anti_2 100 110 PF11976 0.380
LIG_TRAF2_1 330 333 PF00917 0.579
LIG_UBA3_1 55 61 PF00899 0.496
LIG_WRC_WIRS_1 1 6 PF05994 0.480
LIG_WRPW_2 282 285 PF00400 0.562
LIG_WW_3 18 22 PF00397 0.536
MOD_CDK_SPxxK_3 1100 1107 PF00069 0.588
MOD_CK1_1 1038 1044 PF00069 0.551
MOD_CK1_1 1124 1130 PF00069 0.575
MOD_CK1_1 113 119 PF00069 0.362
MOD_CK1_1 1161 1167 PF00069 0.541
MOD_CK1_1 24 30 PF00069 0.602
MOD_CK1_1 258 264 PF00069 0.595
MOD_CK1_1 288 294 PF00069 0.527
MOD_CK1_1 301 307 PF00069 0.508
MOD_CK2_1 308 314 PF00069 0.569
MOD_CK2_1 327 333 PF00069 0.545
MOD_CK2_1 76 82 PF00069 0.546
MOD_CK2_1 95 101 PF00069 0.307
MOD_Cter_Amidation 1090 1093 PF01082 0.555
MOD_GlcNHglycan 1044 1047 PF01048 0.552
MOD_GlcNHglycan 1074 1077 PF01048 0.528
MOD_GlcNHglycan 1116 1119 PF01048 0.572
MOD_GlcNHglycan 1142 1145 PF01048 0.630
MOD_GlcNHglycan 1160 1163 PF01048 0.514
MOD_GlcNHglycan 23 26 PF01048 0.578
MOD_GlcNHglycan 288 291 PF01048 0.538
MOD_GlcNHglycan 948 952 PF01048 0.483
MOD_GlcNHglycan 962 966 PF01048 0.427
MOD_GSK3_1 1035 1042 PF00069 0.674
MOD_GSK3_1 1065 1072 PF00069 0.554
MOD_GSK3_1 1080 1087 PF00069 0.590
MOD_GSK3_1 1091 1098 PF00069 0.661
MOD_GSK3_1 1107 1114 PF00069 0.564
MOD_GSK3_1 1121 1128 PF00069 0.587
MOD_GSK3_1 1152 1159 PF00069 0.573
MOD_GSK3_1 20 27 PF00069 0.603
MOD_GSK3_1 251 258 PF00069 0.620
MOD_GSK3_1 295 302 PF00069 0.560
MOD_GSK3_1 320 327 PF00069 0.603
MOD_GSK3_1 50 57 PF00069 0.432
MOD_GSK3_1 981 988 PF00069 0.650
MOD_GSK3_1 991 998 PF00069 0.709
MOD_LATS_1 983 989 PF00433 0.523
MOD_NEK2_1 128 133 PF00069 0.433
MOD_NEK2_1 170 175 PF00069 0.439
MOD_NEK2_1 218 223 PF00069 0.453
MOD_NEK2_1 285 290 PF00069 0.590
MOD_NEK2_1 297 302 PF00069 0.534
MOD_NEK2_1 308 313 PF00069 0.537
MOD_NEK2_2 1095 1100 PF00069 0.559
MOD_NEK2_2 1152 1157 PF00069 0.544
MOD_NEK2_2 76 81 PF00069 0.516
MOD_PIKK_1 110 116 PF00454 0.465
MOD_PIKK_1 195 201 PF00454 0.394
MOD_PIKK_1 322 328 PF00454 0.586
MOD_PIKK_1 972 978 PF00454 0.499
MOD_PKA_1 1028 1034 PF00069 0.570
MOD_PKA_1 194 200 PF00069 0.381
MOD_PKA_2 1027 1033 PF00069 0.623
MOD_PKA_2 1091 1097 PF00069 0.559
MOD_PKA_2 1121 1127 PF00069 0.627
MOD_PKA_2 1152 1158 PF00069 0.551
MOD_PKA_2 194 200 PF00069 0.381
MOD_PKA_2 20 26 PF00069 0.546
MOD_PKA_2 274 280 PF00069 0.539
MOD_PKA_2 8 14 PF00069 0.512
MOD_PKA_2 95 101 PF00069 0.375
MOD_Plk_1 151 157 PF00069 0.357
MOD_Plk_1 258 264 PF00069 0.599
MOD_Plk_4 1152 1158 PF00069 0.574
MOD_Plk_4 179 185 PF00069 0.405
MOD_Plk_4 265 271 PF00069 0.555
MOD_Plk_4 274 280 PF00069 0.520
MOD_Plk_4 54 60 PF00069 0.435
MOD_Plk_4 995 1001 PF00069 0.628
MOD_ProDKin_1 1039 1045 PF00069 0.544
MOD_ProDKin_1 1049 1055 PF00069 0.524
MOD_ProDKin_1 1065 1071 PF00069 0.525
MOD_ProDKin_1 1084 1090 PF00069 0.513
MOD_ProDKin_1 1100 1106 PF00069 0.576
MOD_ProDKin_1 1111 1117 PF00069 0.534
MOD_ProDKin_1 1130 1136 PF00069 0.507
MOD_ProDKin_1 1156 1162 PF00069 0.574
MOD_ProDKin_1 173 179 PF00069 0.430
MOD_ProDKin_1 245 251 PF00069 0.671
MOD_ProDKin_1 260 266 PF00069 0.580
MOD_ProDKin_1 320 326 PF00069 0.581
MOD_ProDKin_1 991 997 PF00069 0.563
TRG_DiLeu_BaEn_1 103 108 PF01217 0.346
TRG_DiLeu_BaEn_1 125 130 PF01217 0.388
TRG_DiLeu_BaEn_1 214 219 PF01217 0.427
TRG_DiLeu_BaEn_4 332 338 PF01217 0.546
TRG_DiLeu_BaEn_4 342 348 PF01217 0.473
TRG_DiLeu_BaEn_4 352 358 PF01217 0.408
TRG_DiLeu_BaEn_4 362 368 PF01217 0.397
TRG_DiLeu_BaEn_4 372 378 PF01217 0.424
TRG_DiLeu_BaEn_4 382 388 PF01217 0.424
TRG_DiLeu_BaEn_4 392 398 PF01217 0.416
TRG_DiLeu_BaEn_4 402 408 PF01217 0.396
TRG_DiLeu_BaEn_4 412 418 PF01217 0.428
TRG_DiLeu_BaEn_4 422 428 PF01217 0.447
TRG_DiLeu_BaEn_4 432 438 PF01217 0.459
TRG_DiLeu_BaEn_4 442 448 PF01217 0.416
TRG_DiLeu_BaEn_4 452 458 PF01217 0.425
TRG_DiLeu_BaEn_4 462 468 PF01217 0.416
TRG_DiLeu_BaEn_4 472 478 PF01217 0.433
TRG_DiLeu_BaEn_4 482 488 PF01217 0.492
TRG_DiLeu_BaEn_4 492 498 PF01217 0.421
TRG_DiLeu_BaEn_4 502 508 PF01217 0.414
TRG_DiLeu_BaEn_4 512 518 PF01217 0.448
TRG_DiLeu_BaEn_4 522 528 PF01217 0.413
TRG_DiLeu_BaEn_4 532 538 PF01217 0.456
TRG_DiLeu_BaEn_4 542 548 PF01217 0.494
TRG_DiLeu_BaEn_4 552 558 PF01217 0.469
TRG_DiLeu_BaEn_4 562 568 PF01217 0.416
TRG_DiLeu_BaEn_4 572 578 PF01217 0.430
TRG_DiLeu_BaEn_4 582 588 PF01217 0.443
TRG_DiLeu_BaEn_4 592 598 PF01217 0.421
TRG_DiLeu_BaEn_4 602 608 PF01217 0.416
TRG_DiLeu_BaEn_4 612 618 PF01217 0.439
TRG_DiLeu_BaEn_4 622 628 PF01217 0.420
TRG_DiLeu_BaEn_4 632 638 PF01217 0.455
TRG_DiLeu_BaEn_4 642 648 PF01217 0.462
TRG_DiLeu_BaEn_4 652 658 PF01217 0.449
TRG_DiLeu_BaEn_4 662 668 PF01217 0.469
TRG_DiLeu_BaEn_4 672 678 PF01217 0.432
TRG_DiLeu_BaEn_4 682 688 PF01217 0.461
TRG_DiLeu_BaEn_4 692 698 PF01217 0.471
TRG_DiLeu_BaEn_4 702 708 PF01217 0.411
TRG_DiLeu_BaEn_4 712 718 PF01217 0.412
TRG_DiLeu_BaEn_4 722 728 PF01217 0.447
TRG_DiLeu_BaEn_4 732 738 PF01217 0.436
TRG_DiLeu_BaEn_4 742 748 PF01217 0.474
TRG_DiLeu_BaEn_4 752 758 PF01217 0.426
TRG_DiLeu_BaEn_4 762 768 PF01217 0.435
TRG_DiLeu_BaEn_4 772 778 PF01217 0.409
TRG_DiLeu_BaEn_4 782 788 PF01217 0.406
TRG_DiLeu_BaEn_4 792 798 PF01217 0.426
TRG_DiLeu_BaEn_4 802 808 PF01217 0.404
TRG_DiLeu_BaEn_4 812 818 PF01217 0.407
TRG_DiLeu_BaEn_4 822 828 PF01217 0.386
TRG_DiLeu_BaEn_4 832 838 PF01217 0.380
TRG_DiLeu_BaEn_4 842 848 PF01217 0.408
TRG_DiLeu_BaEn_4 852 858 PF01217 0.426
TRG_DiLeu_BaEn_4 862 868 PF01217 0.413
TRG_DiLeu_BaEn_4 872 878 PF01217 0.396
TRG_DiLeu_BaEn_4 882 888 PF01217 0.412
TRG_DiLeu_BaEn_4 892 898 PF01217 0.407
TRG_DiLeu_BaEn_4 902 908 PF01217 0.389
TRG_DiLeu_BaEn_4 912 918 PF01217 0.393
TRG_DiLeu_BaEn_4 922 928 PF01217 0.421
TRG_DiLeu_BaEn_4 932 938 PF01217 0.452
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.356
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.393
TRG_ENDOCYTIC_2 216 219 PF00928 0.420
TRG_ENDOCYTIC_2 968 971 PF00928 0.530
TRG_ER_diArg_1 157 159 PF00400 0.356
TRG_ER_diArg_1 193 195 PF00400 0.375
TRG_ER_diArg_1 207 210 PF00400 0.346
TRG_NLS_MonoExtC_3 1099 1104 PF00514 0.589
TRG_NLS_MonoExtN_4 1061 1068 PF00514 0.530
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IJE1 Leishmania donovani 100% 100%
A4HFE2 Leishmania braziliensis 53% 100%
A4HKL8 Leishmania braziliensis 52% 80%
Q4Q548 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS