Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I848_LEIIN

TriTrypDb:

LINF_320028800

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I848

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I848

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.552
CLV_C14_Caspase3-7	170	174	PF00656	0.538
CLV_C14_Caspase3-7	203	207	PF00656	0.627
CLV_NRD_NRD_1	243	245	PF00675	0.445
CLV_NRD_NRD_1	332	334	PF00675	0.460
CLV_PCSK_KEX2_1	242	244	PF00082	0.457
CLV_PCSK_KEX2_1	277	279	PF00082	0.467
CLV_PCSK_KEX2_1	319	321	PF00082	0.534
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.467
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.382
CLV_PCSK_PC7_1	238	244	PF00082	0.482
CLV_PCSK_SKI1_1	110	114	PF00082	0.376
CLV_PCSK_SKI1_1	319	323	PF00082	0.540
DEG_SPOP_SBC_1	194	198	PF00917	0.590
DOC_CYCLIN_RxL_1	313	324	PF00134	0.417
DOC_MAPK_gen_1	242	251	PF00069	0.438
DOC_MAPK_MEF2A_6	242	250	PF00069	0.367
DOC_WW_Pin1_4	171	176	PF00397	0.551
DOC_WW_Pin1_4	185	190	PF00397	0.555
DOC_WW_Pin1_4	293	298	PF00397	0.721
DOC_WW_Pin1_4	59	64	PF00397	0.609
LIG_14-3-3_CanoR_1	149	157	PF00244	0.474
LIG_14-3-3_CanoR_1	177	187	PF00244	0.601
LIG_14-3-3_CanoR_1	216	220	PF00244	0.663
LIG_14-3-3_CanoR_1	223	232	PF00244	0.610
LIG_AP2alpha_1	232	236	PF02296	0.422
LIG_BRCT_BRCA1_1	232	236	PF00533	0.482
LIG_FHA_1	10	16	PF00498	0.637
LIG_FHA_1	135	141	PF00498	0.397
LIG_FHA_1	179	185	PF00498	0.652
LIG_FHA_1	200	206	PF00498	0.602
LIG_FHA_1	261	267	PF00498	0.401
LIG_FHA_1	28	34	PF00498	0.528
LIG_FHA_1	326	332	PF00498	0.489
LIG_FHA_2	115	121	PF00498	0.384
LIG_FHA_2	196	202	PF00498	0.691
LIG_FHA_2	210	216	PF00498	0.673
LIG_LIR_Gen_1	229	236	PF02991	0.461
LIG_LIR_Nem_3	229	235	PF02991	0.541
LIG_LIR_Nem_3	341	347	PF02991	0.366
LIG_Pex14_2	232	236	PF04695	0.422
LIG_PTAP_UEV_1	288	293	PF05743	0.578
LIG_SH2_GRB2like	129	132	PF00017	0.448
LIG_SH2_STAP1	142	146	PF00017	0.467
LIG_SH2_STAT5	129	132	PF00017	0.421
LIG_SH2_STAT5	180	183	PF00017	0.611
LIG_SH3_1	299	305	PF00018	0.538
LIG_SH3_3	169	175	PF00018	0.694
LIG_SH3_3	214	220	PF00018	0.557
LIG_SH3_3	286	292	PF00018	0.617
LIG_SH3_3	299	305	PF00018	0.647
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.434
LIG_TRAF2_1	279	282	PF00917	0.501
LIG_UBA3_1	248	254	PF00899	0.415
LIG_WW_3	305	309	PF00397	0.491
MOD_CDC14_SPxK_1	174	177	PF00782	0.545
MOD_CDK_SPxK_1	171	177	PF00069	0.541
MOD_CDK_SPxK_1	293	299	PF00069	0.550
MOD_CK1_1	10	16	PF00069	0.563
MOD_CK1_1	179	185	PF00069	0.606
MOD_CK1_1	196	202	PF00069	0.534
MOD_CK1_1	226	232	PF00069	0.782
MOD_CK1_1	3	9	PF00069	0.618
MOD_CK1_1	31	37	PF00069	0.682
MOD_CK1_1	40	46	PF00069	0.582
MOD_CK2_1	114	120	PF00069	0.469
MOD_CK2_1	26	32	PF00069	0.668
MOD_CK2_1	276	282	PF00069	0.483
MOD_GlcNHglycan	168	172	PF01048	0.703
MOD_GlcNHglycan	181	184	PF01048	0.612
MOD_GlcNHglycan	2	5	PF01048	0.682
MOD_GlcNHglycan	42	45	PF01048	0.676
MOD_GlcNHglycan	94	97	PF01048	0.489
MOD_GSK3_1	130	137	PF00069	0.316
MOD_GSK3_1	149	156	PF00069	0.517
MOD_GSK3_1	167	174	PF00069	0.539
MOD_GSK3_1	179	186	PF00069	0.736
MOD_GSK3_1	189	196	PF00069	0.636
MOD_GSK3_1	226	233	PF00069	0.611
MOD_GSK3_1	27	34	PF00069	0.628
MOD_GSK3_1	3	10	PF00069	0.654
MOD_GSK3_1	36	43	PF00069	0.661
MOD_GSK3_1	55	62	PF00069	0.493
MOD_GSK3_1	73	80	PF00069	0.668
MOD_N-GLC_1	130	135	PF02516	0.339
MOD_N-GLC_1	230	235	PF02516	0.529
MOD_N-GLC_1	40	45	PF02516	0.663
MOD_N-GLC_1	7	12	PF02516	0.629
MOD_NEK2_1	112	117	PF00069	0.401
MOD_NEK2_1	325	330	PF00069	0.410
MOD_NEK2_2	77	82	PF00069	0.551
MOD_PKA_2	148	154	PF00069	0.434
MOD_PKA_2	176	182	PF00069	0.604
MOD_PKA_2	215	221	PF00069	0.707
MOD_PKA_2	224	230	PF00069	0.526
MOD_PKB_1	223	231	PF00069	0.545
MOD_Plk_1	130	136	PF00069	0.341
MOD_Plk_1	167	173	PF00069	0.570
MOD_Plk_1	200	206	PF00069	0.628
MOD_Plk_1	209	215	PF00069	0.582
MOD_Plk_1	40	46	PF00069	0.784
MOD_Plk_2-3	209	215	PF00069	0.642
MOD_Plk_2-3	276	282	PF00069	0.481
MOD_Plk_4	130	136	PF00069	0.341
MOD_Plk_4	325	331	PF00069	0.405
MOD_ProDKin_1	171	177	PF00069	0.553
MOD_ProDKin_1	185	191	PF00069	0.557
MOD_ProDKin_1	293	299	PF00069	0.725
MOD_ProDKin_1	59	65	PF00069	0.609
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.528
TRG_ER_diArg_1	242	244	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y8	Leptomonas seymouri	46%	99%
A0A3S7X5S5	Leishmania donovani	100%	100%
A4HKL6	Leishmania braziliensis	67%	98%
E9B306	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q550	Leishmania major	93%	100%