Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I845_LEIIN

TriTrypDb:

LINF_320028500

Length:

1554

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 1469, 1470, 5

Expansion

Sequence features

A4I845

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I845

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0017076	purine nucleotide binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1076	1080	PF00656	0.600
CLV_C14_Caspase3-7	1139	1143	PF00656	0.640
CLV_NRD_NRD_1	1052	1054	PF00675	0.537
CLV_NRD_NRD_1	1105	1107	PF00675	0.627
CLV_NRD_NRD_1	1144	1146	PF00675	0.561
CLV_NRD_NRD_1	1455	1457	PF00675	0.715
CLV_NRD_NRD_1	1496	1498	PF00675	0.701
CLV_NRD_NRD_1	1512	1514	PF00675	0.836
CLV_NRD_NRD_1	1522	1524	PF00675	0.649
CLV_NRD_NRD_1	916	918	PF00675	0.655

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I394	Leptomonas seymouri	42%	77%
A0A3S7X5P9	Leishmania donovani	98%	94%
A4H7R4	Leishmania braziliensis	27%	72%
A4HKL2	Leishmania braziliensis	60%	97%
E9B303	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q553	Leishmania major	77%	100%

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