Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit - putative

Species:

Leishmania infantum

UniProt:

A4I844_LEIIN

TriTrypDb:

LINF_320028400

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4I844

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I844

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.423
CLV_NRD_NRD_1	15	17	PF00675	0.475
CLV_NRD_NRD_1	42	44	PF00675	0.460
CLV_NRD_NRD_1	92	94	PF00675	0.631
CLV_PCSK_KEX2_1	130	132	PF00082	0.466
CLV_PCSK_KEX2_1	15	17	PF00082	0.475
CLV_PCSK_KEX2_1	42	44	PF00082	0.460
CLV_PCSK_KEX2_1	92	94	PF00082	0.628
CLV_PCSK_PC7_1	126	132	PF00082	0.467
CLV_PCSK_PC7_1	38	44	PF00082	0.460
CLV_PCSK_SKI1_1	16	20	PF00082	0.471
CLV_PCSK_SKI1_1	30	34	PF00082	0.471
CLV_PCSK_SKI1_1	45	49	PF00082	0.409
DEG_SCF_FBW7_1	186	192	PF00400	0.690
DOC_CKS1_1	186	191	PF01111	0.691
DOC_MAPK_DCC_7	19	29	PF00069	0.282
DOC_MAPK_MEF2A_6	23	31	PF00069	0.296
DOC_MAPK_RevD_3	117	131	PF00069	0.503
DOC_USP7_MATH_1	189	193	PF00917	0.704
DOC_USP7_MATH_1	196	200	PF00917	0.695
DOC_WW_Pin1_4	146	151	PF00397	0.628
DOC_WW_Pin1_4	185	190	PF00397	0.730
LIG_14-3-3_CanoR_1	162	166	PF00244	0.627
LIG_14-3-3_CanoR_1	177	183	PF00244	0.551
LIG_14-3-3_CanoR_1	71	77	PF00244	0.358
LIG_14-3-3_CanoR_1	92	100	PF00244	0.421
LIG_14-3-3_CterR_2	204	206	PF00244	0.770
LIG_Actin_WH2_2	138	156	PF00022	0.660
LIG_Actin_WH2_2	6	21	PF00022	0.282
LIG_BIR_II_1	1	5	PF00653	0.424
LIG_eIF4E_1	105	111	PF01652	0.447
LIG_FHA_1	122	128	PF00498	0.651
LIG_FHA_1	19	25	PF00498	0.339
LIG_FHA_1	73	79	PF00498	0.353
LIG_LIR_Apic_2	181	186	PF02991	0.678
LIG_LIR_Gen_1	102	111	PF02991	0.321
LIG_LIR_Nem_3	102	108	PF02991	0.304
LIG_NRBOX	105	111	PF00104	0.424
LIG_PCNA_PIPBox_1	176	185	PF02747	0.662
LIG_SH2_CRK	183	187	PF00017	0.747
LIG_SH2_GRB2like	77	80	PF00017	0.371
LIG_SH2_NCK_1	183	187	PF00017	0.689
LIG_SH2_STAT5	105	108	PF00017	0.381
LIG_SH2_STAT5	17	20	PF00017	0.282
LIG_SH2_STAT5	77	80	PF00017	0.371
LIG_SH3_1	183	189	PF00018	0.688
LIG_SH3_3	183	189	PF00018	0.697
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.424
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.439
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.391
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.298
LIG_WRC_WIRS_1	179	184	PF05994	0.532
MOD_GlcNHglycan	1	4	PF01048	0.545
MOD_GlcNHglycan	48	51	PF01048	0.417
MOD_GSK3_1	185	192	PF00069	0.698
MOD_N-GLC_1	25	30	PF02516	0.335
MOD_NEK2_1	18	23	PF00069	0.447
MOD_NEK2_1	72	77	PF00069	0.424
MOD_NEK2_2	196	201	PF00069	0.686
MOD_NEK2_2	25	30	PF00069	0.335
MOD_PIKK_1	99	105	PF00454	0.493
MOD_PKA_2	161	167	PF00069	0.555
MOD_PKA_2	70	76	PF00069	0.440
MOD_PKA_2	91	97	PF00069	0.529
MOD_Plk_1	25	31	PF00069	0.335
MOD_Plk_4	101	107	PF00069	0.382
MOD_Plk_4	178	184	PF00069	0.594
MOD_ProDKin_1	146	152	PF00069	0.537
MOD_ProDKin_1	185	191	PF00069	0.682
TRG_ENDOCYTIC_2	105	108	PF00928	0.401
TRG_ER_diArg_1	129	131	PF00400	0.536
TRG_ER_diArg_1	14	16	PF00400	0.325
TRG_ER_diArg_1	41	43	PF00400	0.305
TRG_ER_diArg_1	91	93	PF00400	0.514
TRG_NES_CRM1_1	133	146	PF08389	0.505
TRG_NES_CRM1_1	55	70	PF08389	0.266
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J0	Leptomonas seymouri	80%	100%
A0A0S4JR38	Bodo saltans	54%	100%
A0A1X0NU58	Trypanosomatidae	69%	100%
A0A3Q8IL84	Leishmania donovani	100%	100%
A4HKL1	Leishmania braziliensis	87%	100%
D0AAB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B302	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q554	Leishmania major	95%	100%
V5BKR8	Trypanosoma cruzi	69%	100%