Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I840_LEIIN

TriTrypDb:

LINF_320028000

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I840

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I840

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.515
CLV_MEL_PAP_1	338	344	PF00089	0.685
CLV_NRD_NRD_1	102	104	PF00675	0.659
CLV_NRD_NRD_1	218	220	PF00675	0.664
CLV_NRD_NRD_1	227	229	PF00675	0.378
CLV_NRD_NRD_1	326	328	PF00675	0.714
CLV_NRD_NRD_1	435	437	PF00675	0.599
CLV_PCSK_KEX2_1	218	220	PF00082	0.664
CLV_PCSK_KEX2_1	227	229	PF00082	0.378
CLV_PCSK_KEX2_1	435	437	PF00082	0.679
CLV_PCSK_SKI1_1	227	231	PF00082	0.484
CLV_PCSK_SKI1_1	436	440	PF00082	0.698
CLV_Separin_Metazoa	551	555	PF03568	0.530
DEG_APCC_DBOX_1	217	225	PF00400	0.619
DEG_APCC_DBOX_1	226	234	PF00400	0.385
DEG_COP1_1	105	113	PF00400	0.728
DEG_Nend_UBRbox_3	1	3	PF02207	0.830
DEG_SPOP_SBC_1	155	159	PF00917	0.739
DEG_SPOP_SBC_1	459	463	PF00917	0.679
DOC_CKS1_1	124	129	PF01111	0.842
DOC_CKS1_1	204	209	PF01111	0.681
DOC_CYCLIN_RxL_1	225	234	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	423	426	PF00134	0.598
DOC_MAPK_MEF2A_6	599	606	PF00069	0.510
DOC_PP1_RVXF_1	406	412	PF00149	0.480
DOC_PP2B_LxvP_1	423	426	PF13499	0.577
DOC_PP2B_LxvP_1	497	500	PF13499	0.582
DOC_USP7_MATH_1	130	134	PF00917	0.794
DOC_USP7_MATH_1	137	141	PF00917	0.818
DOC_USP7_MATH_1	156	160	PF00917	0.634
DOC_USP7_MATH_1	196	200	PF00917	0.772
DOC_USP7_MATH_1	239	243	PF00917	0.493
DOC_USP7_MATH_1	24	28	PF00917	0.495
DOC_USP7_MATH_1	298	302	PF00917	0.516
DOC_USP7_MATH_1	340	344	PF00917	0.649
DOC_USP7_MATH_1	441	445	PF00917	0.637
DOC_USP7_MATH_1	486	490	PF00917	0.620
DOC_USP7_MATH_1	544	548	PF00917	0.442
DOC_USP7_MATH_2	311	317	PF00917	0.735
DOC_USP7_UBL2_3	104	108	PF12436	0.831
DOC_WW_Pin1_4	123	128	PF00397	0.842
DOC_WW_Pin1_4	173	178	PF00397	0.717
DOC_WW_Pin1_4	188	193	PF00397	0.756
DOC_WW_Pin1_4	203	208	PF00397	0.575
DOC_WW_Pin1_4	416	421	PF00397	0.482
LIG_14-3-3_CanoR_1	23	31	PF00244	0.593
LIG_14-3-3_CanoR_1	255	263	PF00244	0.491
LIG_14-3-3_CanoR_1	34	42	PF00244	0.350
LIG_14-3-3_CanoR_1	341	349	PF00244	0.564
LIG_14-3-3_CanoR_1	403	408	PF00244	0.511
LIG_14-3-3_CanoR_1	435	439	PF00244	0.608
LIG_14-3-3_CanoR_1	443	447	PF00244	0.603
LIG_14-3-3_CanoR_1	570	575	PF00244	0.575
LIG_Actin_WH2_2	476	494	PF00022	0.461
LIG_Clathr_ClatBox_1	578	582	PF01394	0.487
LIG_CSL_BTD_1	410	413	PF09270	0.516
LIG_deltaCOP1_diTrp_1	10	18	PF00928	0.658
LIG_eIF4E_1	476	482	PF01652	0.451
LIG_FHA_1	24	30	PF00498	0.561
LIG_FHA_1	34	40	PF00498	0.488
LIG_FHA_1	492	498	PF00498	0.587
LIG_FHA_2	100	106	PF00498	0.647
LIG_FHA_2	332	338	PF00498	0.747
LIG_FHA_2	461	467	PF00498	0.732
LIG_FHA_2	571	577	PF00498	0.486
LIG_FHA_2	72	78	PF00498	0.695
LIG_LIR_Apic_2	66	71	PF02991	0.759
LIG_LIR_Gen_1	242	251	PF02991	0.556
LIG_LIR_Gen_1	252	260	PF02991	0.418
LIG_LIR_Gen_1	272	282	PF02991	0.446
LIG_LIR_Gen_1	382	389	PF02991	0.582
LIG_LIR_Gen_1	437	447	PF02991	0.527
LIG_LIR_Gen_1	467	476	PF02991	0.614
LIG_LIR_Gen_1	93	99	PF02991	0.697
LIG_LIR_Nem_3	10	14	PF02991	0.684
LIG_LIR_Nem_3	252	256	PF02991	0.501
LIG_LIR_Nem_3	257	263	PF02991	0.483
LIG_LIR_Nem_3	272	277	PF02991	0.452
LIG_LIR_Nem_3	382	387	PF02991	0.583
LIG_LIR_Nem_3	437	442	PF02991	0.554
LIG_LIR_Nem_3	467	473	PF02991	0.546
LIG_LIR_Nem_3	475	479	PF02991	0.422
LIG_LIR_Nem_3	93	97	PF02991	0.685
LIG_NRBOX	373	379	PF00104	0.561
LIG_PDZ_Class_3	606	611	PF00595	0.613
LIG_SH2_CRK	253	257	PF00017	0.490
LIG_SH2_CRK	68	72	PF00017	0.755
LIG_SH2_NCK_1	68	72	PF00017	0.755
LIG_SH2_NCK_1	94	98	PF00017	0.692
LIG_SH2_SRC	476	479	PF00017	0.551
LIG_SH2_STAP1	476	480	PF00017	0.553
LIG_SH2_STAT5	243	246	PF00017	0.384
LIG_SH2_STAT5	350	353	PF00017	0.546
LIG_SH2_STAT5	68	71	PF00017	0.722
LIG_SH3_1	108	114	PF00018	0.763
LIG_SH3_2	336	341	PF14604	0.650
LIG_SH3_3	108	114	PF00018	0.775
LIG_SH3_3	121	127	PF00018	0.631
LIG_SH3_3	172	178	PF00018	0.727
LIG_SH3_3	183	189	PF00018	0.721
LIG_SH3_3	330	336	PF00018	0.811
LIG_SH3_3	391	397	PF00018	0.514
LIG_SH3_3	520	526	PF00018	0.727
LIG_SH3_3	538	544	PF00018	0.537
LIG_SH3_3	588	594	PF00018	0.570
LIG_SH3_3	602	608	PF00018	0.364
LIG_SH3_5	90	94	PF00018	0.719
LIG_SUMO_SIM_anti_2	157	165	PF11976	0.654
LIG_SUMO_SIM_par_1	228	234	PF11976	0.508
LIG_SUMO_SIM_par_1	576	582	PF11976	0.448
LIG_TRAF2_1	74	77	PF00917	0.703
LIG_TRFH_1	470	474	PF08558	0.587
LIG_UBA3_1	286	294	PF00899	0.379
LIG_UBA3_1	42	48	PF00899	0.635
LIG_UBA3_1	423	428	PF00899	0.590
LIG_WRPW_2	589	592	PF00400	0.467
MOD_CDK_SPxK_1	203	209	PF00069	0.685
MOD_CK1_1	123	129	PF00069	0.789
MOD_CK1_1	147	153	PF00069	0.654
MOD_CK1_1	159	165	PF00069	0.659
MOD_CK1_1	169	175	PF00069	0.740
MOD_CK1_1	242	248	PF00069	0.404
MOD_CK1_1	254	260	PF00069	0.387
MOD_CK1_1	273	279	PF00069	0.548
MOD_CK1_1	32	38	PF00069	0.564
MOD_CK1_1	331	337	PF00069	0.761
MOD_CK1_1	54	60	PF00069	0.816
MOD_CK1_1	79	85	PF00069	0.770
MOD_CK2_1	132	138	PF00069	0.761
MOD_CK2_1	246	252	PF00069	0.467
MOD_CK2_1	442	448	PF00069	0.539
MOD_CK2_1	460	466	PF00069	0.630
MOD_CK2_1	570	576	PF00069	0.492
MOD_CK2_1	71	77	PF00069	0.692
MOD_Cter_Amidation	433	436	PF01082	0.500
MOD_GlcNHglycan	115	118	PF01048	0.697
MOD_GlcNHglycan	132	135	PF01048	0.744
MOD_GlcNHglycan	138	142	PF01048	0.668
MOD_GlcNHglycan	158	161	PF01048	0.556
MOD_GlcNHglycan	168	171	PF01048	0.726
MOD_GlcNHglycan	198	201	PF01048	0.645
MOD_GlcNHglycan	213	216	PF01048	0.438
MOD_GlcNHglycan	248	251	PF01048	0.584
MOD_GlcNHglycan	329	333	PF01048	0.802
MOD_GlcNHglycan	53	56	PF01048	0.793
MOD_GlcNHglycan	546	549	PF01048	0.613
MOD_GSK3_1	109	116	PF00069	0.702
MOD_GSK3_1	126	133	PF00069	0.661
MOD_GSK3_1	155	162	PF00069	0.833
MOD_GSK3_1	165	172	PF00069	0.725
MOD_GSK3_1	184	191	PF00069	0.612
MOD_GSK3_1	192	199	PF00069	0.807
MOD_GSK3_1	242	249	PF00069	0.415
MOD_GSK3_1	269	276	PF00069	0.563
MOD_GSK3_1	29	36	PF00069	0.529
MOD_GSK3_1	309	316	PF00069	0.695
MOD_GSK3_1	327	334	PF00069	0.579
MOD_GSK3_1	50	57	PF00069	0.693
MOD_LATS_1	21	27	PF00433	0.620
MOD_LATS_1	325	331	PF00433	0.615
MOD_N-GLC_1	24	29	PF02516	0.507
MOD_N-GLC_2	536	538	PF02516	0.725
MOD_NEK2_1	246	251	PF00069	0.573
MOD_NEK2_1	29	34	PF00069	0.472
MOD_NEK2_1	42	47	PF00069	0.457
MOD_NEK2_1	491	496	PF00069	0.544
MOD_NEK2_1	51	56	PF00069	0.670
MOD_NEK2_1	99	104	PF00069	0.784
MOD_NEK2_2	434	439	PF00069	0.561
MOD_PIKK_1	132	138	PF00454	0.783
MOD_PIKK_1	254	260	PF00454	0.485
MOD_PIKK_1	486	492	PF00454	0.509
MOD_PKA_1	327	333	PF00069	0.611
MOD_PKA_2	208	214	PF00069	0.741
MOD_PKA_2	254	260	PF00069	0.444
MOD_PKA_2	33	39	PF00069	0.601
MOD_PKA_2	340	346	PF00069	0.599
MOD_PKA_2	434	440	PF00069	0.593
MOD_PKA_2	442	448	PF00069	0.569
MOD_PKA_2	491	497	PF00069	0.474
MOD_PKA_2	544	550	PF00069	0.572
MOD_PKA_2	553	559	PF00069	0.478
MOD_PKA_2	569	575	PF00069	0.481
MOD_PKA_2	79	85	PF00069	0.852
MOD_Plk_1	120	126	PF00069	0.733
MOD_Plk_1	24	30	PF00069	0.552
MOD_Plk_1	251	257	PF00069	0.482
MOD_Plk_1	92	98	PF00069	0.673
MOD_Plk_4	144	150	PF00069	0.662
MOD_Plk_4	159	165	PF00069	0.786
MOD_Plk_4	239	245	PF00069	0.481
MOD_Plk_4	270	276	PF00069	0.556
MOD_Plk_4	419	425	PF00069	0.601
MOD_Plk_4	42	48	PF00069	0.518
MOD_Plk_4	560	566	PF00069	0.447
MOD_ProDKin_1	123	129	PF00069	0.843
MOD_ProDKin_1	173	179	PF00069	0.717
MOD_ProDKin_1	188	194	PF00069	0.753
MOD_ProDKin_1	203	209	PF00069	0.573
MOD_ProDKin_1	416	422	PF00069	0.480
MOD_SUMO_rev_2	100	110	PF00179	0.751
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.556
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.598
TRG_ENDOCYTIC_2	243	246	PF00928	0.425
TRG_ENDOCYTIC_2	253	256	PF00928	0.437
TRG_ENDOCYTIC_2	476	479	PF00928	0.444
TRG_ENDOCYTIC_2	589	592	PF00928	0.467
TRG_ENDOCYTIC_2	94	97	PF00928	0.681
TRG_ER_diArg_1	217	219	PF00400	0.671
TRG_ER_diArg_1	227	229	PF00400	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W3	Leptomonas seymouri	31%	100%
A0A3S7X5P2	Leishmania donovani	100%	100%
A4HKK7	Leishmania braziliensis	71%	100%
E9B2Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q558	Leishmania major	90%	100%