LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Importin N-terminal domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Importin N-terminal domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I837_LEIIN
TriTrypDb:
LINF_320027600
Length:
1082

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I837
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I837

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0034504 protein localization to nucleus 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051169 nuclear transport 4 12
GO:0051170 import into nucleus 6 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
Molecular functions
Term Name Level Count
GO:0005048 signal sequence binding 4 1
GO:0005488 binding 1 1
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0061608 nuclear import signal receptor activity 3 1
GO:0140104 molecular carrier activity 1 1
GO:0140142 nucleocytoplasmic carrier activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 466 470 PF00656 0.473
CLV_C14_Caspase3-7 659 663 PF00656 0.632
CLV_C14_Caspase3-7 832 836 PF00656 0.508
CLV_NRD_NRD_1 1032 1034 PF00675 0.446
CLV_NRD_NRD_1 20 22 PF00675 0.443
CLV_NRD_NRD_1 290 292 PF00675 0.235
CLV_NRD_NRD_1 351 353 PF00675 0.247
CLV_NRD_NRD_1 63 65 PF00675 0.406
CLV_NRD_NRD_1 817 819 PF00675 0.281
CLV_PCSK_KEX2_1 1032 1034 PF00082 0.446
CLV_PCSK_KEX2_1 816 818 PF00082 0.282
CLV_PCSK_PC1ET2_1 816 818 PF00082 0.340
CLV_PCSK_SKI1_1 188 192 PF00082 0.384
CLV_PCSK_SKI1_1 389 393 PF00082 0.446
CLV_PCSK_SKI1_1 455 459 PF00082 0.451
CLV_PCSK_SKI1_1 488 492 PF00082 0.495
CLV_PCSK_SKI1_1 530 534 PF00082 0.352
CLV_PCSK_SKI1_1 576 580 PF00082 0.403
CLV_PCSK_SKI1_1 64 68 PF00082 0.344
CLV_PCSK_SKI1_1 677 681 PF00082 0.414
CLV_PCSK_SKI1_1 824 828 PF00082 0.340
CLV_PCSK_SKI1_1 863 867 PF00082 0.321
DEG_Nend_UBRbox_2 1 3 PF02207 0.434
DEG_SPOP_SBC_1 924 928 PF00917 0.524
DOC_CKS1_1 551 556 PF01111 0.472
DOC_CYCLIN_RxL_1 61 70 PF00134 0.388
DOC_CYCLIN_yCln2_LP_2 101 107 PF00134 0.495
DOC_MAPK_gen_1 1032 1039 PF00069 0.470
DOC_MAPK_gen_1 560 569 PF00069 0.431
DOC_MAPK_HePTP_8 803 815 PF00069 0.521
DOC_MAPK_MEF2A_6 272 280 PF00069 0.500
DOC_MAPK_MEF2A_6 488 497 PF00069 0.493
DOC_MAPK_MEF2A_6 806 815 PF00069 0.521
DOC_PP2B_PxIxI_1 492 498 PF00149 0.411
DOC_PP4_FxxP_1 669 672 PF00568 0.567
DOC_PP4_FxxP_1 866 869 PF00568 0.521
DOC_SPAK_OSR1_1 668 672 PF12202 0.565
DOC_USP7_MATH_1 1066 1070 PF00917 0.509
DOC_USP7_MATH_1 107 111 PF00917 0.328
DOC_USP7_MATH_1 44 48 PF00917 0.501
DOC_USP7_MATH_1 924 928 PF00917 0.519
DOC_USP7_UBL2_3 288 292 PF12436 0.447
DOC_USP7_UBL2_3 408 412 PF12436 0.491
DOC_USP7_UBL2_3 558 562 PF12436 0.451
DOC_WW_Pin1_4 100 105 PF00397 0.514
DOC_WW_Pin1_4 1064 1069 PF00397 0.482
DOC_WW_Pin1_4 32 37 PF00397 0.411
DOC_WW_Pin1_4 365 370 PF00397 0.412
DOC_WW_Pin1_4 550 555 PF00397 0.382
DOC_WW_Pin1_4 67 72 PF00397 0.470
DOC_WW_Pin1_4 793 798 PF00397 0.464
LIG_14-3-3_CanoR_1 21 28 PF00244 0.484
LIG_14-3-3_CanoR_1 389 399 PF00244 0.441
LIG_14-3-3_CanoR_1 415 420 PF00244 0.324
LIG_14-3-3_CanoR_1 455 464 PF00244 0.379
LIG_14-3-3_CanoR_1 610 619 PF00244 0.321
LIG_14-3-3_CanoR_1 786 791 PF00244 0.532
LIG_APCC_ABBA_1 114 119 PF00400 0.503
LIG_APCC_ABBA_1 491 496 PF00400 0.463
LIG_APCC_ABBA_1 533 538 PF00400 0.420
LIG_APCC_ABBA_1 541 546 PF00400 0.321
LIG_BIR_III_4 136 140 PF00653 0.325
LIG_BRCT_BRCA1_1 297 301 PF00533 0.463
LIG_BRCT_BRCA1_1 425 429 PF00533 0.334
LIG_deltaCOP1_diTrp_1 121 127 PF00928 0.363
LIG_EH1_1 937 945 PF00400 0.323
LIG_eIF4E_1 973 979 PF01652 0.486
LIG_FHA_1 1002 1008 PF00498 0.364
LIG_FHA_1 1010 1016 PF00498 0.375
LIG_FHA_1 192 198 PF00498 0.409
LIG_FHA_1 55 61 PF00498 0.488
LIG_FHA_1 603 609 PF00498 0.391
LIG_FHA_1 611 617 PF00498 0.287
LIG_FHA_1 681 687 PF00498 0.451
LIG_FHA_1 798 804 PF00498 0.479
LIG_FHA_1 916 922 PF00498 0.402
LIG_FHA_1 986 992 PF00498 0.371
LIG_FHA_2 169 175 PF00498 0.421
LIG_FHA_2 279 285 PF00498 0.447
LIG_FHA_2 318 324 PF00498 0.470
LIG_FHA_2 47 53 PF00498 0.475
LIG_FHA_2 470 476 PF00498 0.624
LIG_FHA_2 597 603 PF00498 0.497
LIG_FHA_2 825 831 PF00498 0.521
LIG_IRF3_LxIS_1 844 849 PF10401 0.485
LIG_LIR_Apic_2 864 869 PF02991 0.521
LIG_LIR_Gen_1 121 131 PF02991 0.365
LIG_LIR_Gen_1 225 233 PF02991 0.493
LIG_LIR_Gen_1 298 309 PF02991 0.440
LIG_LIR_Gen_1 993 1002 PF02991 0.365
LIG_LIR_Nem_3 121 126 PF02991 0.369
LIG_LIR_Nem_3 225 229 PF02991 0.499
LIG_LIR_Nem_3 298 304 PF02991 0.450
LIG_LIR_Nem_3 485 490 PF02991 0.474
LIG_LIR_Nem_3 577 582 PF02991 0.354
LIG_LIR_Nem_3 872 878 PF02991 0.387
LIG_LIR_Nem_3 993 998 PF02991 0.333
LIG_MLH1_MIPbox_1 297 301 PF16413 0.540
LIG_NRBOX 5 11 PF00104 0.441
LIG_Pex14_2 296 300 PF04695 0.447
LIG_Pex14_2 301 305 PF04695 0.447
LIG_Pex14_2 866 870 PF04695 0.435
LIG_PTB_Apo_2 307 314 PF02174 0.521
LIG_PTB_Phospho_1 307 313 PF10480 0.521
LIG_Rb_LxCxE_1 739 758 PF01857 0.489
LIG_REV1ctd_RIR_1 510 519 PF16727 0.394
LIG_SH2_GRB2like 220 223 PF00017 0.492
LIG_SH2_PTP2 494 497 PF00017 0.456
LIG_SH2_PTP2 995 998 PF00017 0.418
LIG_SH2_SRC 494 497 PF00017 0.328
LIG_SH2_SRC 536 539 PF00017 0.413
LIG_SH2_SRC 544 547 PF00017 0.404
LIG_SH2_STAP1 582 586 PF00017 0.333
LIG_SH2_STAP1 962 966 PF00017 0.484
LIG_SH2_STAT3 220 223 PF00017 0.492
LIG_SH2_STAT3 589 592 PF00017 0.486
LIG_SH2_STAT5 1078 1081 PF00017 0.502
LIG_SH2_STAT5 161 164 PF00017 0.380
LIG_SH2_STAT5 220 223 PF00017 0.492
LIG_SH2_STAT5 282 285 PF00017 0.435
LIG_SH2_STAT5 307 310 PF00017 0.447
LIG_SH2_STAT5 413 416 PF00017 0.346
LIG_SH2_STAT5 494 497 PF00017 0.341
LIG_SH2_STAT5 536 539 PF00017 0.361
LIG_SH2_STAT5 589 592 PF00017 0.339
LIG_SH2_STAT5 626 629 PF00017 0.445
LIG_SH2_STAT5 710 713 PF00017 0.347
LIG_SH2_STAT5 938 941 PF00017 0.347
LIG_SH2_STAT5 973 976 PF00017 0.415
LIG_SH2_STAT5 984 987 PF00017 0.369
LIG_SH2_STAT5 995 998 PF00017 0.359
LIG_SH3_1 205 211 PF00018 0.498
LIG_SH3_3 205 211 PF00018 0.451
LIG_SH3_3 548 554 PF00018 0.407
LIG_SH3_3 908 914 PF00018 0.477
LIG_Sin3_3 377 384 PF02671 0.437
LIG_SUMO_SIM_anti_2 565 571 PF11976 0.427
LIG_SUMO_SIM_anti_2 59 64 PF11976 0.414
LIG_SUMO_SIM_par_1 212 218 PF11976 0.411
LIG_SUMO_SIM_par_1 676 684 PF11976 0.500
LIG_TRAF2_1 23 26 PF00917 0.516
LIG_TRFH_1 307 311 PF08558 0.447
LIG_UBA3_1 737 743 PF00899 0.441
LIG_UBA3_1 854 863 PF00899 0.520
LIG_WRC_WIRS_1 464 469 PF05994 0.353
MOD_CK1_1 1069 1075 PF00069 0.455
MOD_CK1_1 129 135 PF00069 0.425
MOD_CK1_1 228 234 PF00069 0.455
MOD_CK1_1 242 248 PF00069 0.455
MOD_CK1_1 47 53 PF00069 0.519
MOD_CK1_1 523 529 PF00069 0.335
MOD_CK1_1 733 739 PF00069 0.378
MOD_CK1_1 772 778 PF00069 0.400
MOD_CK1_1 919 925 PF00069 0.502
MOD_CK1_1 949 955 PF00069 0.572
MOD_CK2_1 168 174 PF00069 0.460
MOD_CK2_1 20 26 PF00069 0.539
MOD_CK2_1 212 218 PF00069 0.495
MOD_CK2_1 228 234 PF00069 0.480
MOD_CK2_1 278 284 PF00069 0.447
MOD_CK2_1 296 302 PF00069 0.447
MOD_CK2_1 469 475 PF00069 0.518
MOD_CK2_1 681 687 PF00069 0.462
MOD_CK2_1 733 739 PF00069 0.334
MOD_CK2_1 772 778 PF00069 0.446
MOD_Cter_Amidation 350 353 PF01082 0.247
MOD_GlcNHglycan 109 112 PF01048 0.253
MOD_GlcNHglycan 14 17 PF01048 0.446
MOD_GlcNHglycan 22 25 PF01048 0.436
MOD_GlcNHglycan 339 342 PF01048 0.247
MOD_GlcNHglycan 45 49 PF01048 0.465
MOD_GlcNHglycan 732 735 PF01048 0.403
MOD_GlcNHglycan 94 97 PF01048 0.464
MOD_GSK3_1 1009 1016 PF00069 0.365
MOD_GSK3_1 125 132 PF00069 0.495
MOD_GSK3_1 138 145 PF00069 0.373
MOD_GSK3_1 161 168 PF00069 0.427
MOD_GSK3_1 191 198 PF00069 0.425
MOD_GSK3_1 238 245 PF00069 0.448
MOD_GSK3_1 387 394 PF00069 0.489
MOD_GSK3_1 43 50 PF00069 0.397
MOD_GSK3_1 463 470 PF00069 0.476
MOD_GSK3_1 520 527 PF00069 0.326
MOD_GSK3_1 546 553 PF00069 0.469
MOD_GSK3_1 677 684 PF00069 0.474
MOD_GSK3_1 793 800 PF00069 0.497
MOD_GSK3_1 896 903 PF00069 0.423
MOD_GSK3_1 905 912 PF00069 0.360
MOD_GSK3_1 915 922 PF00069 0.265
MOD_GSK3_1 946 953 PF00069 0.467
MOD_GSK3_1 990 997 PF00069 0.315
MOD_LATS_1 406 412 PF00433 0.480
MOD_N-GLC_1 67 72 PF02516 0.480
MOD_N-GLC_2 819 821 PF02516 0.340
MOD_NEK2_1 1 6 PF00069 0.534
MOD_NEK2_1 1001 1006 PF00069 0.364
MOD_NEK2_1 126 131 PF00069 0.363
MOD_NEK2_1 191 196 PF00069 0.411
MOD_NEK2_1 240 245 PF00069 0.530
MOD_NEK2_1 278 283 PF00069 0.513
MOD_NEK2_1 296 301 PF00069 0.338
MOD_NEK2_1 305 310 PF00069 0.422
MOD_NEK2_1 31 36 PF00069 0.519
MOD_NEK2_1 354 359 PF00069 0.464
MOD_NEK2_1 43 48 PF00069 0.410
MOD_NEK2_1 467 472 PF00069 0.529
MOD_NEK2_1 846 851 PF00069 0.531
MOD_NEK2_1 854 859 PF00069 0.494
MOD_NEK2_1 889 894 PF00069 0.421
MOD_NEK2_1 946 951 PF00069 0.448
MOD_NEK2_1 994 999 PF00069 0.330
MOD_NEK2_2 172 177 PF00069 0.456
MOD_NEK2_2 387 392 PF00069 0.455
MOD_PIKK_1 391 397 PF00454 0.489
MOD_PIKK_1 423 429 PF00454 0.347
MOD_PIKK_1 47 53 PF00454 0.541
MOD_PIKK_1 506 512 PF00454 0.470
MOD_PIKK_1 94 100 PF00454 0.527
MOD_PK_1 212 218 PF00069 0.411
MOD_PK_1 786 792 PF00069 0.540
MOD_PKA_1 824 830 PF00069 0.521
MOD_PKA_2 195 201 PF00069 0.401
MOD_PKA_2 20 26 PF00069 0.493
MOD_PKA_2 343 349 PF00069 0.496
MOD_PKA_2 506 512 PF00069 0.514
MOD_PKA_2 730 736 PF00069 0.329
MOD_Plk_1 1 7 PF00069 0.539
MOD_Plk_1 191 197 PF00069 0.415
MOD_Plk_1 233 239 PF00069 0.503
MOD_Plk_1 772 778 PF00069 0.474
MOD_Plk_2-3 225 231 PF00069 0.496
MOD_Plk_2-3 546 552 PF00069 0.503
MOD_Plk_4 1013 1019 PF00069 0.243
MOD_Plk_4 126 132 PF00069 0.409
MOD_Plk_4 212 218 PF00069 0.450
MOD_Plk_4 228 234 PF00069 0.416
MOD_Plk_4 296 302 PF00069 0.451
MOD_Plk_4 357 363 PF00069 0.443
MOD_Plk_4 395 401 PF00069 0.425
MOD_Plk_4 463 469 PF00069 0.348
MOD_Plk_4 56 62 PF00069 0.393
MOD_Plk_4 565 571 PF00069 0.356
MOD_Plk_4 626 632 PF00069 0.429
MOD_Plk_4 681 687 PF00069 0.412
MOD_Plk_4 720 726 PF00069 0.486
MOD_Plk_4 733 739 PF00069 0.327
MOD_Plk_4 772 778 PF00069 0.429
MOD_Plk_4 854 860 PF00069 0.493
MOD_Plk_4 905 911 PF00069 0.429
MOD_Plk_4 994 1000 PF00069 0.322
MOD_ProDKin_1 100 106 PF00069 0.508
MOD_ProDKin_1 1064 1070 PF00069 0.474
MOD_ProDKin_1 32 38 PF00069 0.409
MOD_ProDKin_1 365 371 PF00069 0.407
MOD_ProDKin_1 550 556 PF00069 0.372
MOD_ProDKin_1 67 73 PF00069 0.463
MOD_ProDKin_1 793 799 PF00069 0.464
MOD_SUMO_for_1 407 410 PF00179 0.493
MOD_SUMO_rev_2 15 24 PF00179 0.555
MOD_SUMO_rev_2 180 189 PF00179 0.480
MOD_SUMO_rev_2 409 414 PF00179 0.367
MOD_SUMO_rev_2 684 691 PF00179 0.440
MOD_SUMO_rev_2 746 751 PF00179 0.546
TRG_DiLeu_BaEn_1 331 336 PF01217 0.521
TRG_DiLeu_BaEn_1 565 570 PF01217 0.308
TRG_DiLeu_BaEn_2 664 670 PF01217 0.558
TRG_ENDOCYTIC_2 28 31 PF00928 0.409
TRG_ENDOCYTIC_2 494 497 PF00928 0.494
TRG_ENDOCYTIC_2 544 547 PF00928 0.484
TRG_ENDOCYTIC_2 745 748 PF00928 0.475
TRG_ENDOCYTIC_2 995 998 PF00928 0.373
TRG_ER_diArg_1 1032 1034 PF00400 0.446
TRG_ER_diArg_1 205 208 PF00400 0.512
TRG_ER_diArg_1 603 606 PF00400 0.366
TRG_Pf-PMV_PEXEL_1 1032 1036 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZF6 Leptomonas seymouri 77% 100%
A0A0S4JKP1 Bodo saltans 38% 100%
A0A1X0NU68 Trypanosomatidae 41% 100%
A0A3Q8ID72 Leishmania donovani 100% 100%
A0A3R7MFW4 Trypanosoma rangeli 43% 100%
A4HKK5 Leishmania braziliensis 91% 100%
D0AAA4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B2Z5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O00410 Homo sapiens 22% 99%
O60518 Homo sapiens 21% 98%
O74476 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 99%
P32337 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 99%
Q4Q561 Leishmania major 99% 100%
Q8BIV3 Mus musculus 21% 98%
Q8BKC5 Mus musculus 22% 99%
V5BG77 Trypanosoma cruzi 42% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS