LeishMANIAdb
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Cop-coated vesicle membrane protein p24

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cop-coated vesicle membrane protein p24
Gene product:
cop-coated vesicle membrane protein p24 precursor - putative
Species:
Leishmania infantum
UniProt:
A4I824_LEIIN
TriTrypDb:
LINF_320026300
Length:
160

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic GOLD domain proteins, involved in sorting of GPI-achored proteins. Kinetoplastids contain several paralogous GOLD domain protein families, not all closely related to each others.. Localization: ER (by homology)

Annotations by Jardim et al.

Intracellular protein trafficking, Cop-coated vesicle membrane p24

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 6, no: 5
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005783 endoplasmic reticulum 5 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0005794 Golgi apparatus 5 1
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 1
GO:0030135 coated vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I824
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I824

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 157 159 PF00082 0.364
CLV_PCSK_PC1ET2_1 157 159 PF00082 0.367
CLV_PCSK_SKI1_1 151 155 PF00082 0.226
CLV_PCSK_SKI1_1 37 41 PF00082 0.417
DEG_Nend_Nbox_1 1 3 PF02207 0.373
DOC_PP1_RVXF_1 125 132 PF00149 0.238
DOC_PP1_RVXF_1 22 29 PF00149 0.305
DOC_PP1_RVXF_1 35 41 PF00149 0.226
DOC_PP1_RVXF_1 60 67 PF00149 0.226
LIG_14-3-3_CanoR_1 55 60 PF00244 0.325
LIG_Actin_WH2_2 86 103 PF00022 0.251
LIG_BRCT_BRCA1_1 46 50 PF00533 0.328
LIG_CaM_IQ_9 93 109 PF13499 0.251
LIG_FHA_1 118 124 PF00498 0.241
LIG_FHA_1 58 64 PF00498 0.250
LIG_LIR_Gen_1 65 70 PF02991 0.313
LIG_MAD2 37 45 PF02301 0.251
LIG_SH2_STAP1 48 52 PF00017 0.328
LIG_SH2_STAT3 149 152 PF00017 0.421
LIG_SH2_STAT5 149 152 PF00017 0.278
LIG_SH3_3 75 81 PF00018 0.298
LIG_SxIP_EBH_1 37 50 PF03271 0.275
LIG_WRC_WIRS_1 63 68 PF05994 0.313
MOD_CK1_1 57 63 PF00069 0.235
MOD_GSK3_1 5 12 PF00069 0.235
MOD_GSK3_1 50 57 PF00069 0.220
MOD_GSK3_1 58 65 PF00069 0.217
MOD_GSK3_1 85 92 PF00069 0.292
MOD_NEK2_1 153 158 PF00069 0.560
MOD_NEK2_1 39 44 PF00069 0.220
MOD_NEK2_1 50 55 PF00069 0.224
MOD_NEK2_1 89 94 PF00069 0.251
MOD_PKA_2 117 123 PF00069 0.238
MOD_PKA_2 31 37 PF00069 0.253
MOD_PKA_2 54 60 PF00069 0.313
MOD_Plk_1 15 21 PF00069 0.233
MOD_Plk_1 22 28 PF00069 0.243
MOD_Plk_4 133 139 PF00069 0.421
MOD_Plk_4 143 149 PF00069 0.364
MOD_Plk_4 15 21 PF00069 0.266
MOD_Plk_4 22 28 PF00069 0.269
TRG_ER_diArg_1 110 113 PF00400 0.236
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZG2 Leptomonas seymouri 73% 73%
A0A0N1I2E2 Leptomonas seymouri 31% 75%
A0A0S4JG68 Bodo saltans 31% 72%
A0A0S4JHA6 Bodo saltans 31% 79%
A0A0S4JYK0 Bodo saltans 50% 79%
A0A1X0NPX7 Trypanosomatidae 30% 73%
A0A1X0NVX2 Trypanosomatidae 55% 70%
A0A3Q8ITC4 Leishmania donovani 100% 100%
A0A422NB76 Trypanosoma rangeli 55% 73%
A0A422NFM3 Trypanosoma rangeli 26% 71%
A0AQ71 Drosophila simulans 24% 78%
A4HJ92 Leishmania braziliensis 32% 100%
A4HKJ2 Leishmania braziliensis 84% 100%
A4I6N6 Leishmania infantum 32% 77%
A7SXK3 Nematostella vectensis 35% 79%
B3LVB0 Drosophila ananassae 25% 78%
B3MTS8 Drosophila ananassae 25% 74%
B3NZM5 Drosophila erecta 24% 74%
B3P6T8 Drosophila erecta 24% 78%
B4GE47 Drosophila persimilis 24% 78%
B4GMC3 Drosophila persimilis 25% 74%
B4HJV5 Drosophila sechellia 24% 74%
B4JG34 Drosophila grimshawi 25% 74%
B4JYU5 Drosophila grimshawi 25% 78%
B4K4G5 Drosophila mojavensis 25% 78%
B4KB41 Drosophila mojavensis 25% 74%
B4LYB8 Drosophila virilis 25% 74%
B4MGF8 Drosophila virilis 25% 78%
B4NIY1 Drosophila willistoni 24% 78%
B4NKL0 Drosophila willistoni 25% 74%
B4PUZ3 Drosophila yakuba 24% 78%
B4PVC6 Drosophila yakuba 24% 74%
B4QWH9 Drosophila simulans 25% 74%
D0AA90 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 70%
D3ZTX0 Rattus norvegicus 28% 71%
E9B2Y2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O13770 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 76%
O17528 Caenorhabditis elegans 32% 79%
P32803 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 79%
P38819 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 75%
P39704 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 74%
P49020 Cricetulus griseus 33% 82%
Q12450 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 77%
Q15363 Homo sapiens 33% 80%
Q28BQ6 Xenopus tropicalis 22% 73%
Q295B2 Drosophila pseudoobscura pseudoobscura 24% 74%
Q3T133 Bos taurus 26% 68%
Q4Q574 Leishmania major 97% 100%
Q4Q6F1 Leishmania major 31% 100%
Q54BN0 Dictyostelium discoideum 34% 77%
Q5I0E7 Rattus norvegicus 28% 68%
Q63524 Rattus norvegicus 33% 80%
Q6AY25 Rattus norvegicus 28% 72%
Q6BTC2 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 30% 75%
Q6IDL4 Arabidopsis thaliana 27% 74%
Q769F9 Dictyostelium discoideum 37% 78%
Q78IS1 Mus musculus 29% 72%
Q7Z7H5 Homo sapiens 28% 70%
Q8R1V4 Mus musculus 28% 70%
Q8SXY6 Drosophila melanogaster 24% 78%
Q99KF1 Mus musculus 26% 68%
Q9BVK6 Homo sapiens 26% 68%
Q9FVU0 Arabidopsis thaliana 26% 75%
Q9I7K5 Drosophila melanogaster 25% 74%
Q9LIL4 Arabidopsis thaliana 29% 75%
Q9P7I9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 80%
Q9R0Q3 Mus musculus 33% 80%
Q9Y3B3 Homo sapiens 28% 71%
Q9Y3Q3 Homo sapiens 27% 74%
V5BG96 Trypanosoma cruzi 55% 73%
V5BK13 Trypanosoma cruzi 25% 72%
V5BKG3 Trypanosoma cruzi 26% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS