LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF4200) - putative
Species:
Leishmania infantum
UniProt:
A4I820_LEIIN
TriTrypDb:
LINF_320025900
Length:
731

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4I820
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I820

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 718 722 PF00656 0.648
CLV_NRD_NRD_1 111 113 PF00675 0.337
CLV_NRD_NRD_1 155 157 PF00675 0.245
CLV_NRD_NRD_1 185 187 PF00675 0.245
CLV_NRD_NRD_1 269 271 PF00675 0.668
CLV_NRD_NRD_1 280 282 PF00675 0.662
CLV_NRD_NRD_1 34 36 PF00675 0.553
CLV_NRD_NRD_1 518 520 PF00675 0.685
CLV_NRD_NRD_1 534 536 PF00675 0.668
CLV_NRD_NRD_1 577 579 PF00675 0.703
CLV_NRD_NRD_1 650 652 PF00675 0.459
CLV_NRD_NRD_1 670 672 PF00675 0.457
CLV_NRD_NRD_1 703 705 PF00675 0.561
CLV_PCSK_FUR_1 668 672 PF00082 0.510
CLV_PCSK_KEX2_1 123 125 PF00082 0.259
CLV_PCSK_KEX2_1 155 157 PF00082 0.258
CLV_PCSK_KEX2_1 269 271 PF00082 0.696
CLV_PCSK_KEX2_1 34 36 PF00082 0.510
CLV_PCSK_KEX2_1 352 354 PF00082 0.425
CLV_PCSK_KEX2_1 458 460 PF00082 0.727
CLV_PCSK_KEX2_1 534 536 PF00082 0.727
CLV_PCSK_KEX2_1 577 579 PF00082 0.708
CLV_PCSK_KEX2_1 649 651 PF00082 0.460
CLV_PCSK_KEX2_1 670 672 PF00082 0.508
CLV_PCSK_KEX2_1 703 705 PF00082 0.602
CLV_PCSK_KEX2_1 94 96 PF00082 0.245
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.268
CLV_PCSK_PC1ET2_1 269 271 PF00082 0.668
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.425
CLV_PCSK_PC1ET2_1 458 460 PF00082 0.654
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.245
CLV_PCSK_SKI1_1 164 168 PF00082 0.338
CLV_PCSK_SKI1_1 199 203 PF00082 0.338
CLV_PCSK_SKI1_1 226 230 PF00082 0.475
CLV_PCSK_SKI1_1 27 31 PF00082 0.600
CLV_PCSK_SKI1_1 559 563 PF00082 0.730
CLV_PCSK_SKI1_1 670 674 PF00082 0.503
DEG_Nend_UBRbox_2 1 3 PF02207 0.611
DEG_SPOP_SBC_1 416 420 PF00917 0.416
DOC_ANK_TNKS_1 518 525 PF00023 0.607
DOC_CYCLIN_RxL_1 223 233 PF00134 0.470
DOC_CYCLIN_RxL_1 24 32 PF00134 0.613
DOC_CYCLIN_yCln2_LP_2 626 632 PF00134 0.523
DOC_MAPK_gen_1 136 145 PF00069 0.503
DOC_MAPK_gen_1 162 171 PF00069 0.445
DOC_MAPK_gen_1 186 192 PF00069 0.445
DOC_MAPK_gen_1 352 358 PF00069 0.417
DOC_MAPK_gen_1 649 658 PF00069 0.458
DOC_MAPK_MEF2A_6 299 307 PF00069 0.370
DOC_PIKK_1 36 44 PF02985 0.524
DOC_PP4_FxxP_1 10 13 PF00568 0.621
DOC_USP7_MATH_1 20 24 PF00917 0.620
DOC_USP7_MATH_1 325 329 PF00917 0.410
DOC_USP7_MATH_1 416 420 PF00917 0.443
DOC_USP7_MATH_1 449 453 PF00917 0.672
DOC_USP7_MATH_1 454 458 PF00917 0.689
DOC_USP7_MATH_1 462 466 PF00917 0.757
DOC_USP7_MATH_1 547 551 PF00917 0.756
DOC_USP7_MATH_1 57 61 PF00917 0.658
DOC_USP7_MATH_1 576 580 PF00917 0.692
DOC_USP7_MATH_1 64 68 PF00917 0.675
DOC_USP7_UBL2_3 113 117 PF12436 0.493
DOC_USP7_UBL2_3 348 352 PF12436 0.385
DOC_USP7_UBL2_3 639 643 PF12436 0.481
DOC_USP7_UBL2_3 701 705 PF12436 0.591
DOC_WW_Pin1_4 287 292 PF00397 0.587
DOC_WW_Pin1_4 512 517 PF00397 0.575
LIG_14-3-3_CanoR_1 101 111 PF00244 0.538
LIG_14-3-3_CanoR_1 238 243 PF00244 0.420
LIG_14-3-3_CanoR_1 461 471 PF00244 0.682
LIG_14-3-3_CanoR_1 519 523 PF00244 0.745
LIG_14-3-3_CanoR_1 537 542 PF00244 0.739
LIG_14-3-3_CanoR_1 624 629 PF00244 0.557
LIG_14-3-3_CanoR_1 689 694 PF00244 0.622
LIG_Actin_WH2_2 488 505 PF00022 0.624
LIG_EH_1 7 11 PF12763 0.560
LIG_FHA_1 166 172 PF00498 0.538
LIG_FHA_1 222 228 PF00498 0.463
LIG_FHA_1 288 294 PF00498 0.584
LIG_FHA_1 324 330 PF00498 0.461
LIG_FHA_1 409 415 PF00498 0.503
LIG_FHA_1 416 422 PF00498 0.515
LIG_FHA_1 471 477 PF00498 0.570
LIG_FHA_2 241 247 PF00498 0.432
LIG_FHA_2 335 341 PF00498 0.514
LIG_FHA_2 357 363 PF00498 0.450
LIG_FHA_2 487 493 PF00498 0.499
LIG_FHA_2 611 617 PF00498 0.450
LIG_FHA_2 84 90 PF00498 0.582
LIG_HCF-1_HBM_1 308 311 PF13415 0.477
LIG_LIR_Gen_1 137 145 PF02991 0.447
LIG_LIR_Gen_1 200 208 PF02991 0.465
LIG_LIR_Gen_1 308 318 PF02991 0.463
LIG_LIR_Gen_1 366 376 PF02991 0.396
LIG_LIR_Gen_1 496 506 PF02991 0.570
LIG_LIR_Nem_3 137 142 PF02991 0.447
LIG_LIR_Nem_3 200 204 PF02991 0.451
LIG_LIR_Nem_3 308 314 PF02991 0.411
LIG_LIR_Nem_3 366 371 PF02991 0.377
LIG_LIR_Nem_3 496 502 PF02991 0.450
LIG_LIR_Nem_3 620 625 PF02991 0.447
LIG_RPA_C_Fungi 233 245 PF08784 0.452
LIG_SH2_CRK 212 216 PF00017 0.370
LIG_SH2_NCK_1 311 315 PF00017 0.402
LIG_SH2_SRC 19 22 PF00017 0.568
LIG_SH2_STAP1 77 81 PF00017 0.659
LIG_SH2_STAT5 625 628 PF00017 0.459
LIG_SH3_3 684 690 PF00018 0.611
LIG_SH3_3 691 697 PF00018 0.663
LIG_SUMO_SIM_anti_2 200 206 PF11976 0.311
LIG_SUMO_SIM_anti_2 610 616 PF11976 0.440
LIG_SUMO_SIM_anti_2 634 639 PF11976 0.546
LIG_SUMO_SIM_par_1 610 616 PF11976 0.437
LIG_TRAF2_1 243 246 PF00917 0.527
LIG_TRAF2_1 313 316 PF00917 0.383
LIG_TRAF2_1 483 486 PF00917 0.604
LIG_TRAF2_1 659 662 PF00917 0.575
LIG_UBA3_1 611 618 PF00899 0.432
LIG_UBA3_1 680 686 PF00899 0.512
LIG_WRC_WIRS_1 139 144 PF05994 0.284
MOD_CDK_SPxxK_3 512 519 PF00069 0.656
MOD_CK1_1 103 109 PF00069 0.404
MOD_CK1_1 23 29 PF00069 0.528
MOD_CK1_1 452 458 PF00069 0.726
MOD_CK1_1 566 572 PF00069 0.735
MOD_CK1_1 579 585 PF00069 0.750
MOD_CK1_1 60 66 PF00069 0.686
MOD_CK1_1 692 698 PF00069 0.717
MOD_CK2_1 143 149 PF00069 0.339
MOD_CK2_1 176 182 PF00069 0.362
MOD_CK2_1 240 246 PF00069 0.522
MOD_CK2_1 310 316 PF00069 0.445
MOD_CK2_1 417 423 PF00069 0.567
MOD_CK2_1 486 492 PF00069 0.571
MOD_CK2_1 610 616 PF00069 0.474
MOD_CK2_1 83 89 PF00069 0.456
MOD_GlcNHglycan 174 177 PF01048 0.283
MOD_GlcNHglycan 238 241 PF01048 0.474
MOD_GlcNHglycan 275 278 PF01048 0.682
MOD_GlcNHglycan 477 480 PF01048 0.673
MOD_GlcNHglycan 550 553 PF01048 0.749
MOD_GlcNHglycan 573 576 PF01048 0.715
MOD_GlcNHglycan 578 581 PF01048 0.647
MOD_GlcNHglycan 62 65 PF01048 0.724
MOD_GlcNHglycan 67 70 PF01048 0.554
MOD_GlcNHglycan 73 76 PF01048 0.517
MOD_GSK3_1 172 179 PF00069 0.362
MOD_GSK3_1 19 26 PF00069 0.636
MOD_GSK3_1 236 243 PF00069 0.423
MOD_GSK3_1 271 278 PF00069 0.516
MOD_GSK3_1 449 456 PF00069 0.664
MOD_GSK3_1 514 521 PF00069 0.751
MOD_GSK3_1 529 536 PF00069 0.676
MOD_GSK3_1 548 555 PF00069 0.722
MOD_GSK3_1 559 566 PF00069 0.734
MOD_GSK3_1 576 583 PF00069 0.636
MOD_GSK3_1 60 67 PF00069 0.609
MOD_GSK3_1 81 88 PF00069 0.600
MOD_N-GLC_1 287 292 PF02516 0.673
MOD_N-GLC_1 529 534 PF02516 0.700
MOD_N-GLC_1 713 718 PF02516 0.609
MOD_NEK2_1 102 107 PF00069 0.487
MOD_NEK2_1 143 148 PF00069 0.283
MOD_NEK2_1 185 190 PF00069 0.431
MOD_NEK2_1 211 216 PF00069 0.439
MOD_NEK2_1 356 361 PF00069 0.568
MOD_NEK2_1 417 422 PF00069 0.465
MOD_NEK2_1 548 553 PF00069 0.635
MOD_NEK2_1 673 678 PF00069 0.456
MOD_NEK2_2 325 330 PF00069 0.397
MOD_PIKK_1 566 572 PF00454 0.755
MOD_PIKK_1 594 600 PF00454 0.697
MOD_PIKK_1 673 679 PF00454 0.487
MOD_PK_1 271 277 PF00069 0.649
MOD_PKA_1 172 178 PF00069 0.283
MOD_PKA_1 271 277 PF00069 0.683
MOD_PKA_2 100 106 PF00069 0.395
MOD_PKA_2 185 191 PF00069 0.260
MOD_PKA_2 271 277 PF00069 0.683
MOD_PKA_2 518 524 PF00069 0.729
MOD_PKA_2 533 539 PF00069 0.465
MOD_PKA_2 570 576 PF00069 0.770
MOD_PKB_1 535 543 PF00069 0.619
MOD_Plk_1 20 26 PF00069 0.601
MOD_Plk_1 491 497 PF00069 0.507
MOD_Plk_1 602 608 PF00069 0.736
MOD_Plk_2-3 610 616 PF00069 0.454
MOD_Plk_4 138 144 PF00069 0.284
MOD_Plk_4 610 616 PF00069 0.440
MOD_ProDKin_1 287 293 PF00069 0.585
MOD_ProDKin_1 512 518 PF00069 0.577
MOD_SUMO_rev_2 110 118 PF00179 0.375
MOD_SUMO_rev_2 294 301 PF00179 0.550
MOD_SUMO_rev_2 344 354 PF00179 0.419
MOD_SUMO_rev_2 485 489 PF00179 0.538
MOD_SUMO_rev_2 610 619 PF00179 0.435
MOD_SUMO_rev_2 695 702 PF00179 0.630
TRG_DiLeu_BaEn_3 372 378 PF01217 0.386
TRG_DiLeu_BaEn_3 401 407 PF01217 0.414
TRG_ENDOCYTIC_2 198 201 PF00928 0.283
TRG_ENDOCYTIC_2 212 215 PF00928 0.355
TRG_ENDOCYTIC_2 311 314 PF00928 0.455
TRG_ER_diArg_1 154 156 PF00400 0.301
TRG_ER_diArg_1 270 273 PF00400 0.669
TRG_ER_diArg_1 33 35 PF00400 0.570
TRG_ER_diArg_1 534 537 PF00400 0.549
TRG_ER_diArg_1 649 651 PF00400 0.479
TRG_ER_diArg_1 668 671 PF00400 0.489
TRG_ER_diArg_1 688 691 PF00400 0.363
TRG_NES_CRM1_1 384 398 PF08389 0.419
TRG_NLS_Bipartite_1 172 190 PF00514 0.413
TRG_NLS_Bipartite_1 269 285 PF00514 0.588
TRG_NLS_MonoExtN_4 269 274 PF00514 0.598
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.283
TRG_Pf-PMV_PEXEL_1 624 628 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEP4 Leptomonas seymouri 54% 95%
A0A1X0NUV9 Trypanosomatidae 39% 100%
A0A3Q8IG83 Leishmania donovani 100% 100%
A0A422NB67 Trypanosoma rangeli 40% 100%
A4HKI8 Leishmania braziliensis 74% 100%
D0AA86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9B2X8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q578 Leishmania major 93% 100%
V5DCC5 Trypanosoma cruzi 38% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS