Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I819_LEIIN

TriTrypDb:

LINF_320025800

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I819

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I819

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.624
CLV_NRD_NRD_1	103	105	PF00675	0.502
CLV_NRD_NRD_1	145	147	PF00675	0.556
CLV_NRD_NRD_1	30	32	PF00675	0.597
CLV_NRD_NRD_1	60	62	PF00675	0.615
CLV_PCSK_FUR_1	6	10	PF00082	0.513
CLV_PCSK_KEX2_1	102	104	PF00082	0.664
CLV_PCSK_KEX2_1	144	146	PF00082	0.612
CLV_PCSK_KEX2_1	29	31	PF00082	0.588
CLV_PCSK_KEX2_1	34	36	PF00082	0.590
CLV_PCSK_KEX2_1	59	61	PF00082	0.675
CLV_PCSK_KEX2_1	8	10	PF00082	0.512
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.664
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.609
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.536
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.590
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.675
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.512
CLV_PCSK_PC7_1	30	36	PF00082	0.566
CLV_PCSK_SKI1_1	141	145	PF00082	0.605
DEG_SPOP_SBC_1	134	138	PF00917	0.516
DOC_USP7_MATH_1	64	68	PF00917	0.802
DOC_USP7_UBL2_3	140	144	PF12436	0.612
DOC_USP7_UBL2_3	4	8	PF12436	0.523
LIG_14-3-3_CanoR_1	103	111	PF00244	0.634
LIG_BIR_III_2	126	130	PF00653	0.678
LIG_FHA_1	130	136	PF00498	0.626
LIG_FHA_2	37	43	PF00498	0.748
LIG_FHA_2	60	66	PF00498	0.659
LIG_LIR_Gen_1	108	117	PF02991	0.599
LIG_LIR_Nem_3	108	114	PF02991	0.542
LIG_SH2_STAT5	12	15	PF00017	0.490
LIG_SH2_STAT5	26	29	PF00017	0.351
MOD_CK1_1	105	111	PF00069	0.656
MOD_CK1_1	118	124	PF00069	0.579
MOD_CK1_1	133	139	PF00069	0.531
MOD_CK1_1	36	42	PF00069	0.685
MOD_CK1_1	85	91	PF00069	0.608
MOD_CK2_1	107	113	PF00069	0.605
MOD_CK2_1	36	42	PF00069	0.659
MOD_GlcNHglycan	131	135	PF01048	0.741
MOD_GlcNHglycan	70	73	PF01048	0.706
MOD_GlcNHglycan	88	91	PF01048	0.679
MOD_GSK3_1	118	125	PF00069	0.722
MOD_GSK3_1	129	136	PF00069	0.490
MOD_GSK3_1	64	71	PF00069	0.803
MOD_GSK3_1	82	89	PF00069	0.603
MOD_NEK2_1	84	89	PF00069	0.561
MOD_NEK2_2	139	144	PF00069	0.617
MOD_PKA_1	102	108	PF00069	0.622
MOD_PKA_1	59	65	PF00069	0.719
MOD_PKA_2	102	108	PF00069	0.622
MOD_PKA_2	129	135	PF00069	0.651
MOD_PKA_2	22	28	PF00069	0.558
MOD_PKA_2	36	42	PF00069	0.670
MOD_PKA_2	59	65	PF00069	0.719
MOD_Plk_1	130	136	PF00069	0.711
MOD_Plk_4	22	28	PF00069	0.558
TRG_NLS_MonoCore_2	57	62	PF00514	0.674
TRG_NLS_MonoExtC_3	57	63	PF00514	0.676
TRG_NLS_MonoExtN_4	100	106	PF00514	0.506
TRG_NLS_MonoExtN_4	141	148	PF00514	0.614
TRG_NLS_MonoExtN_4	2	7	PF00514	0.566
TRG_NLS_MonoExtN_4	57	62	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV1	Leptomonas seymouri	49%	100%
A0A3Q8IJB3	Leishmania donovani	100%	100%
A0A422NBB5	Trypanosoma rangeli	45%	100%
A4HKI7	Leishmania braziliensis	68%	100%
E9B2X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q579	Leishmania major	87%	100%