Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I817_LEIIN

TriTrypDb:

LINF_320025600

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I817

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I817

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.563
CLV_C14_Caspase3-7	355	359	PF00656	0.623
CLV_NRD_NRD_1	384	386	PF00675	0.651
CLV_NRD_NRD_1	419	421	PF00675	0.644
CLV_PCSK_FUR_1	417	421	PF00082	0.641
CLV_PCSK_KEX2_1	384	386	PF00082	0.667
CLV_PCSK_KEX2_1	390	392	PF00082	0.642
CLV_PCSK_KEX2_1	419	421	PF00082	0.644
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.593
CLV_PCSK_SKI1_1	15	19	PF00082	0.555
CLV_PCSK_SKI1_1	269	273	PF00082	0.566
CLV_PCSK_SKI1_1	391	395	PF00082	0.568
CLV_PCSK_SKI1_1	453	457	PF00082	0.584
DEG_COP1_1	170	179	PF00400	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.623
DEG_SCF_TRCP1_1	468	474	PF00400	0.588
DEG_SIAH_1	402	410	PF03145	0.561
DEG_SPOP_SBC_1	297	301	PF00917	0.553
DOC_CKS1_1	87	92	PF01111	0.687
DOC_CYCLIN_RxL_1	385	397	PF00134	0.559
DOC_MAPK_gen_1	262	270	PF00069	0.692
DOC_MAPK_RevD_3	405	420	PF00069	0.611
DOC_PP4_FxxP_1	275	278	PF00568	0.584
DOC_USP7_MATH_1	138	142	PF00917	0.644
DOC_USP7_MATH_1	167	171	PF00917	0.695
DOC_USP7_MATH_1	218	222	PF00917	0.597
DOC_USP7_MATH_1	297	301	PF00917	0.658
DOC_USP7_MATH_1	303	307	PF00917	0.688
DOC_USP7_MATH_1	310	314	PF00917	0.666
DOC_USP7_MATH_1	340	344	PF00917	0.645
DOC_USP7_MATH_1	409	413	PF00917	0.625
DOC_USP7_MATH_1	5	9	PF00917	0.611
DOC_WW_Pin1_4	124	129	PF00397	0.628
DOC_WW_Pin1_4	169	174	PF00397	0.626
DOC_WW_Pin1_4	191	196	PF00397	0.628
DOC_WW_Pin1_4	252	257	PF00397	0.621
DOC_WW_Pin1_4	26	31	PF00397	0.628
DOC_WW_Pin1_4	274	279	PF00397	0.640
DOC_WW_Pin1_4	336	341	PF00397	0.600
DOC_WW_Pin1_4	35	40	PF00397	0.666
DOC_WW_Pin1_4	86	91	PF00397	0.691
LIG_14-3-3_CanoR_1	233	238	PF00244	0.604
LIG_14-3-3_CanoR_1	262	270	PF00244	0.692
LIG_14-3-3_CanoR_1	309	315	PF00244	0.667
LIG_14-3-3_CanoR_1	338	348	PF00244	0.659
LIG_14-3-3_CanoR_1	391	401	PF00244	0.610
LIG_14-3-3_CanoR_1	413	417	PF00244	0.565
LIG_BRCT_BRCA1_1	135	139	PF00533	0.732
LIG_BRCT_BRCA1_1	331	335	PF00533	0.634
LIG_BRCT_BRCA1_1	358	362	PF00533	0.627
LIG_CaM_IQ_9	439	455	PF13499	0.589
LIG_eIF4E_1	42	48	PF01652	0.609
LIG_FHA_1	169	175	PF00498	0.644
LIG_FHA_1	309	315	PF00498	0.699
LIG_FHA_1	54	60	PF00498	0.516
LIG_FHA_2	29	35	PF00498	0.682
LIG_FHA_2	344	350	PF00498	0.594
LIG_FHA_2	77	83	PF00498	0.673
LIG_GBD_Chelix_1	344	352	PF00786	0.560
LIG_IRF3_LxIS_1	348	355	PF10401	0.583
LIG_LIR_Apic_2	272	278	PF02991	0.585
LIG_LIR_Gen_1	136	147	PF02991	0.544
LIG_LIR_Nem_3	129	135	PF02991	0.622
LIG_LIR_Nem_3	136	142	PF02991	0.562
LIG_LIR_Nem_3	197	202	PF02991	0.627
LIG_LIR_Nem_3	99	104	PF02991	0.752
LIG_LYPXL_yS_3	132	135	PF13949	0.598
LIG_MYND_1	173	177	PF01753	0.629
LIG_PCNA_yPIPBox_3	338	348	PF02747	0.512
LIG_PDZ_Class_1	471	476	PF00595	0.591
LIG_SH2_STAP1	438	442	PF00017	0.588
LIG_SH2_STAT5	392	395	PF00017	0.643
LIG_SH2_STAT5	78	81	PF00017	0.658
LIG_SH3_3	145	151	PF00018	0.632
LIG_SH3_3	257	263	PF00018	0.772
LIG_SUMO_SIM_par_1	170	178	PF11976	0.605
LIG_TRAF2_1	151	154	PF00917	0.674
LIG_TRAF2_1	255	258	PF00917	0.670
LIG_TRAF2_1	318	321	PF00917	0.544
LIG_TYR_ITIM	130	135	PF00017	0.603
LIG_UBA3_1	17	23	PF00899	0.537
LIG_WRC_WIRS_1	207	212	PF05994	0.582
LIG_WRC_WIRS_1	344	349	PF05994	0.660
MOD_CK1_1	182	188	PF00069	0.661
MOD_CK1_1	209	215	PF00069	0.680
MOD_CK1_1	217	223	PF00069	0.702
MOD_CK1_1	3	9	PF00069	0.602
MOD_CK1_1	336	342	PF00069	0.673
MOD_CK1_1	343	349	PF00069	0.583
MOD_CK1_1	412	418	PF00069	0.619
MOD_CK1_1	85	91	PF00069	0.635
MOD_CK2_1	251	257	PF00069	0.717
MOD_CK2_1	314	320	PF00069	0.693
MOD_CK2_1	369	375	PF00069	0.643
MOD_CK2_1	5	11	PF00069	0.568
MOD_CK2_1	76	82	PF00069	0.695
MOD_Cter_Amidation	382	385	PF01082	0.654
MOD_GlcNHglycan	216	219	PF01048	0.654
MOD_GlcNHglycan	235	238	PF01048	0.447
MOD_GlcNHglycan	264	267	PF01048	0.672
MOD_GlcNHglycan	287	290	PF01048	0.685
MOD_GlcNHglycan	300	303	PF01048	0.677
MOD_GlcNHglycan	314	317	PF01048	0.678
MOD_GlcNHglycan	358	361	PF01048	0.658
MOD_GlcNHglycan	386	389	PF01048	0.658
MOD_GlcNHglycan	430	433	PF01048	0.528
MOD_GlcNHglycan	468	471	PF01048	0.584
MOD_GlcNHglycan	5	8	PF01048	0.608
MOD_GSK3_1	120	127	PF00069	0.758
MOD_GSK3_1	133	140	PF00069	0.628
MOD_GSK3_1	142	149	PF00069	0.576
MOD_GSK3_1	175	182	PF00069	0.656
MOD_GSK3_1	191	198	PF00069	0.521
MOD_GSK3_1	206	213	PF00069	0.607
MOD_GSK3_1	214	221	PF00069	0.689
MOD_GSK3_1	28	35	PF00069	0.661
MOD_GSK3_1	308	315	PF00069	0.640
MOD_GSK3_1	329	336	PF00069	0.600
MOD_GSK3_1	339	346	PF00069	0.500
MOD_GSK3_1	352	359	PF00069	0.656
MOD_GSK3_1	369	376	PF00069	0.549
MOD_GSK3_1	392	399	PF00069	0.672
MOD_GSK3_1	424	431	PF00069	0.563
MOD_GSK3_1	53	60	PF00069	0.609
MOD_GSK3_1	82	89	PF00069	0.653
MOD_N-GLC_1	340	345	PF02516	0.523
MOD_NEK2_1	208	213	PF00069	0.633
MOD_NEK2_1	308	313	PF00069	0.737
MOD_NEK2_1	352	357	PF00069	0.615
MOD_NEK2_1	394	399	PF00069	0.659
MOD_NEK2_1	411	416	PF00069	0.525
MOD_NEK2_2	96	101	PF00069	0.547
MOD_PIKK_1	158	164	PF00454	0.652
MOD_PIKK_1	218	224	PF00454	0.581
MOD_PIKK_1	28	34	PF00454	0.634
MOD_PIKK_1	76	82	PF00454	0.651
MOD_PKA_1	384	390	PF00069	0.654
MOD_PKA_2	303	309	PF00069	0.701
MOD_PKA_2	384	390	PF00069	0.661
MOD_PKA_2	397	403	PF00069	0.568
MOD_PKA_2	412	418	PF00069	0.532
MOD_PKA_2	466	472	PF00069	0.620
MOD_Plk_1	121	127	PF00069	0.607
MOD_Plk_1	283	289	PF00069	0.687
MOD_Plk_1	333	339	PF00069	0.632
MOD_Plk_1	340	346	PF00069	0.550
MOD_Plk_1	68	74	PF00069	0.669
MOD_Plk_1	82	88	PF00069	0.575
MOD_Plk_2-3	373	379	PF00069	0.634
MOD_Plk_4	142	148	PF00069	0.611
MOD_Plk_4	211	217	PF00069	0.627
MOD_Plk_4	340	346	PF00069	0.615
MOD_Plk_4	373	379	PF00069	0.654
MOD_Plk_4	397	403	PF00069	0.609
MOD_Plk_4	82	88	PF00069	0.766
MOD_Plk_4	96	102	PF00069	0.613
MOD_ProDKin_1	124	130	PF00069	0.627
MOD_ProDKin_1	169	175	PF00069	0.628
MOD_ProDKin_1	191	197	PF00069	0.633
MOD_ProDKin_1	252	258	PF00069	0.620
MOD_ProDKin_1	26	32	PF00069	0.630
MOD_ProDKin_1	274	280	PF00069	0.639
MOD_ProDKin_1	336	342	PF00069	0.602
MOD_ProDKin_1	35	41	PF00069	0.668
MOD_ProDKin_1	86	92	PF00069	0.689
MOD_SUMO_rev_2	153	159	PF00179	0.617
MOD_SUMO_rev_2	29	38	PF00179	0.525
TRG_DiLeu_BaEn_1	373	378	PF01217	0.644
TRG_DiLeu_BaEn_1	43	48	PF01217	0.606
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.603
TRG_ENDOCYTIC_2	132	135	PF00928	0.620
TRG_ENDOCYTIC_2	42	45	PF00928	0.562
TRG_ER_diArg_1	416	419	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5L4	Leishmania donovani	98%	100%
A4HKI6	Leishmania braziliensis	50%	100%
E9B2X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q581	Leishmania major	83%	100%