DUF4201 domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I814_LEIIN

TriTrypDb:

LINF_320025200

Length:

782

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 542
Promastigote/Amastigote: 154

Expansion

Sequence features

A4I814

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I814

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.668
CLV_C14_Caspase3-7	363	367	PF00656	0.652
CLV_C14_Caspase3-7	546	550	PF00656	0.757
CLV_C14_Caspase3-7	611	615	PF00656	0.575
CLV_C14_Caspase3-7	710	714	PF00656	0.757
CLV_NRD_NRD_1	121	123	PF00675	0.724
CLV_NRD_NRD_1	329	331	PF00675	0.477
CLV_NRD_NRD_1	392	394	PF00675	0.673
CLV_NRD_NRD_1	408	410	PF00675	0.417
CLV_NRD_NRD_1	43	45	PF00675	0.636
CLV_NRD_NRD_1	440	442	PF00675	0.588
CLV_NRD_NRD_1	470	472	PF00675	0.679
CLV_NRD_NRD_1	491	493	PF00675	0.733
CLV_NRD_NRD_1	526	528	PF00675	0.583
CLV_NRD_NRD_1	543	545	PF00675	0.526
CLV_PCSK_KEX2_1	121	123	PF00082	0.724
CLV_PCSK_KEX2_1	328	330	PF00082	0.489
CLV_PCSK_KEX2_1	392	394	PF00082	0.673
CLV_PCSK_KEX2_1	407	409	PF00082	0.444
CLV_PCSK_KEX2_1	428	430	PF00082	0.597
CLV_PCSK_KEX2_1	43	45	PF00082	0.636
CLV_PCSK_KEX2_1	439	441	PF00082	0.514
CLV_PCSK_KEX2_1	470	472	PF00082	0.648
CLV_PCSK_KEX2_1	520	522	PF00082	0.664
CLV_PCSK_KEX2_1	526	528	PF00082	0.591
CLV_PCSK_KEX2_1	543	545	PF00082	0.526
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.548
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.597
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.514
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.581
CLV_PCSK_PC7_1	324	330	PF00082	0.646
CLV_PCSK_SKI1_1	324	328	PF00082	0.565
CLV_PCSK_SKI1_1	341	345	PF00082	0.532
CLV_PCSK_SKI1_1	376	380	PF00082	0.592
CLV_PCSK_SKI1_1	392	396	PF00082	0.469
CLV_PCSK_SKI1_1	671	675	PF00082	0.647
DEG_APCC_DBOX_1	329	337	PF00400	0.647
DEG_APCC_DBOX_1	391	399	PF00400	0.667
DEG_APCC_DBOX_1	469	477	PF00400	0.693
DEG_APCC_DBOX_1	525	533	PF00400	0.605
DEG_SPOP_SBC_1	65	69	PF00917	0.759
DOC_MAPK_gen_1	178	186	PF00069	0.616
DOC_MAPK_gen_1	341	352	PF00069	0.595
DOC_MAPK_RevD_3	316	330	PF00069	0.501
DOC_PP2B_LxvP_1	117	120	PF13499	0.800
DOC_PP4_FxxP_1	155	158	PF00568	0.649
DOC_PP4_FxxP_1	494	497	PF00568	0.610
DOC_USP7_MATH_1	106	110	PF00917	0.670
DOC_USP7_MATH_1	120	124	PF00917	0.638
DOC_USP7_MATH_1	17	21	PF00917	0.601
DOC_USP7_MATH_1	202	206	PF00917	0.729
DOC_USP7_MATH_1	279	283	PF00917	0.822
DOC_USP7_MATH_1	290	294	PF00917	0.558
DOC_USP7_MATH_1	566	570	PF00917	0.743
DOC_USP7_MATH_1	624	628	PF00917	0.740
DOC_USP7_MATH_1	65	69	PF00917	0.793
DOC_USP7_MATH_1	711	715	PF00917	0.747
DOC_USP7_MATH_1	735	739	PF00917	0.773
DOC_USP7_UBL2_3	341	345	PF12436	0.597
DOC_USP7_UBL2_3	98	102	PF12436	0.617
DOC_WW_Pin1_4	102	107	PF00397	0.666
DOC_WW_Pin1_4	549	554	PF00397	0.743
DOC_WW_Pin1_4	560	565	PF00397	0.620
DOC_WW_Pin1_4	58	63	PF00397	0.803
DOC_WW_Pin1_4	760	765	PF00397	0.772
LIG_14-3-3_CanoR_1	183	187	PF00244	0.657
LIG_14-3-3_CanoR_1	521	529	PF00244	0.664
LIG_14-3-3_CanoR_1	593	598	PF00244	0.751
LIG_14-3-3_CanoR_1	82	87	PF00244	0.720
LIG_Actin_WH2_2	83	100	PF00022	0.618
LIG_AP2alpha_1	21	25	PF02296	0.800
LIG_APCC_ABBA_1	295	300	PF00400	0.474
LIG_BRCT_BRCA1_1	490	494	PF00533	0.629
LIG_deltaCOP1_diTrp_1	778	782	PF00928	0.790
LIG_FHA_1	286	292	PF00498	0.639
LIG_FHA_1	313	319	PF00498	0.526
LIG_FHA_1	614	620	PF00498	0.719
LIG_FHA_2	1	7	PF00498	0.742
LIG_FHA_2	135	141	PF00498	0.743
LIG_FHA_2	146	152	PF00498	0.587
LIG_FHA_2	228	234	PF00498	0.716
LIG_FHA_2	481	487	PF00498	0.596
LIG_FHA_2	506	512	PF00498	0.697
LIG_FHA_2	672	678	PF00498	0.686
LIG_FHA_2	695	701	PF00498	0.762
LIG_LIR_Apic_2	153	158	PF02991	0.649
LIG_LIR_Apic_2	491	497	PF02991	0.616
LIG_LIR_Gen_1	302	312	PF02991	0.471
LIG_LIR_Gen_1	348	357	PF02991	0.519
LIG_LIR_Gen_1	778	782	PF02991	0.790
LIG_LIR_Nem_3	302	308	PF02991	0.478
LIG_LIR_Nem_3	344	349	PF02991	0.631
LIG_LIR_Nem_3	778	782	PF02991	0.790
LIG_PDZ_Class_2	777	782	PF00595	0.789
LIG_Pex14_2	21	25	PF04695	0.800
LIG_SH2_NCK_1	507	511	PF00017	0.699
LIG_SH2_NCK_1	610	614	PF00017	0.610
LIG_SH2_NCK_1	759	763	PF00017	0.776
LIG_SH2_PTP2	349	352	PF00017	0.555
LIG_SH2_SRC	349	352	PF00017	0.555
LIG_SH2_SRC	610	613	PF00017	0.600
LIG_SH2_STAP1	707	711	PF00017	0.719
LIG_SH2_STAT3	163	166	PF00017	0.731
LIG_SH2_STAT5	209	212	PF00017	0.688
LIG_SH2_STAT5	349	352	PF00017	0.555
LIG_SH2_STAT5	507	510	PF00017	0.742
LIG_SH2_STAT5	517	520	PF00017	0.554
LIG_SH3_3	222	228	PF00018	0.761
LIG_SH3_3	653	659	PF00018	0.727
LIG_SH3_3	761	767	PF00018	0.773
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.489
LIG_SUMO_SIM_anti_2	375	382	PF11976	0.652
LIG_TRAF2_1	137	140	PF00917	0.741
LIG_TRAF2_1	230	233	PF00917	0.719
LIG_TRAF2_1	236	239	PF00917	0.604
LIG_TRAF2_1	577	580	PF00917	0.767
LIG_TRAF2_1	714	717	PF00917	0.755
LIG_TRAF2_1	720	723	PF00917	0.677
MOD_CDK_SPK_2	560	565	PF00069	0.775
MOD_CK1_1	109	115	PF00069	0.699
MOD_CK1_1	123	129	PF00069	0.607
MOD_CK1_1	261	267	PF00069	0.648
MOD_CK1_1	27	33	PF00069	0.734
MOD_CK1_1	282	288	PF00069	0.804
MOD_CK1_1	542	548	PF00069	0.801
MOD_CK1_1	583	589	PF00069	0.726
MOD_CK1_1	63	69	PF00069	0.740
MOD_CK1_1	635	641	PF00069	0.812
MOD_CK1_1	650	656	PF00069	0.572
MOD_CK1_1	77	83	PF00069	0.603
MOD_CK2_1	134	140	PF00069	0.777
MOD_CK2_1	227	233	PF00069	0.661
MOD_CK2_1	240	246	PF00069	0.478
MOD_CK2_1	480	486	PF00069	0.625
MOD_CK2_1	566	572	PF00069	0.800
MOD_CK2_1	620	626	PF00069	0.678
MOD_CK2_1	711	717	PF00069	0.756
MOD_GlcNHglycan	125	128	PF01048	0.789
MOD_GlcNHglycan	130	133	PF01048	0.701
MOD_GlcNHglycan	180	183	PF01048	0.830
MOD_GlcNHglycan	265	268	PF01048	0.676
MOD_GlcNHglycan	288	291	PF01048	0.543
MOD_GlcNHglycan	35	38	PF01048	0.803
MOD_GlcNHglycan	386	389	PF01048	0.541
MOD_GlcNHglycan	417	420	PF01048	0.655
MOD_GlcNHglycan	486	489	PF01048	0.653
MOD_GlcNHglycan	558	561	PF01048	0.794
MOD_GlcNHglycan	56	59	PF01048	0.792
MOD_GlcNHglycan	582	585	PF01048	0.717
MOD_GlcNHglycan	600	603	PF01048	0.535
MOD_GlcNHglycan	622	625	PF01048	0.724
MOD_GlcNHglycan	626	629	PF01048	0.694
MOD_GlcNHglycan	651	655	PF01048	0.741
MOD_GlcNHglycan	71	74	PF01048	0.677
MOD_GlcNHglycan	737	740	PF01048	0.772
MOD_GSK3_1	102	109	PF00069	0.496
MOD_GSK3_1	121	128	PF00069	0.524
MOD_GSK3_1	172	179	PF00069	0.751
MOD_GSK3_1	208	215	PF00069	0.807
MOD_GSK3_1	24	31	PF00069	0.828
MOD_GSK3_1	256	263	PF00069	0.643
MOD_GSK3_1	279	286	PF00069	0.656
MOD_GSK3_1	480	487	PF00069	0.697
MOD_GSK3_1	539	546	PF00069	0.709
MOD_GSK3_1	54	61	PF00069	0.732
MOD_GSK3_1	556	563	PF00069	0.620
MOD_GSK3_1	579	586	PF00069	0.804
MOD_GSK3_1	620	627	PF00069	0.769
MOD_GSK3_1	63	70	PF00069	0.759
MOD_GSK3_1	632	639	PF00069	0.667
MOD_GSK3_1	74	81	PF00069	0.638
MOD_GSK3_1	82	89	PF00069	0.797
MOD_N-GLC_1	212	217	PF02516	0.806
MOD_N-GLC_1	240	245	PF02516	0.614
MOD_N-GLC_1	272	277	PF02516	0.680
MOD_N-GLC_1	63	68	PF02516	0.740
MOD_N-GLC_1	82	87	PF02516	0.637
MOD_N-GLC_2	647	649	PF02516	0.729
MOD_NEK2_1	174	179	PF00069	0.731
MOD_NEK2_1	260	265	PF00069	0.670
MOD_NEK2_1	384	389	PF00069	0.643
MOD_NEK2_1	39	44	PF00069	0.754
MOD_PIKK_1	202	208	PF00454	0.731
MOD_PIKK_1	258	264	PF00454	0.731
MOD_PIKK_1	397	403	PF00454	0.550
MOD_PIKK_1	534	540	PF00454	0.655
MOD_PIKK_1	566	572	PF00454	0.777
MOD_PIKK_1	632	638	PF00454	0.775
MOD_PIKK_1	694	700	PF00454	0.760
MOD_PK_1	543	549	PF00069	0.749
MOD_PK_1	593	599	PF00069	0.749
MOD_PK_1	82	88	PF00069	0.743
MOD_PKA_1	121	127	PF00069	0.725
MOD_PKA_1	341	347	PF00069	0.635
MOD_PKA_1	520	526	PF00069	0.501
MOD_PKA_1	543	549	PF00069	0.749
MOD_PKA_2	120	126	PF00069	0.704
MOD_PKA_2	182	188	PF00069	0.781
MOD_PKA_2	298	304	PF00069	0.531
MOD_PKA_2	445	451	PF00069	0.491
MOD_PKA_2	480	486	PF00069	0.696
MOD_PKA_2	520	526	PF00069	0.660
MOD_PKA_2	542	548	PF00069	0.647
MOD_PKA_2	636	642	PF00069	0.807
MOD_PKA_2	78	84	PF00069	0.734
MOD_Plk_1	212	218	PF00069	0.802
MOD_Plk_1	240	246	PF00069	0.616
MOD_Plk_1	272	278	PF00069	0.680
MOD_Plk_1	291	297	PF00069	0.434
MOD_Plk_1	613	619	PF00069	0.761
MOD_Plk_1	630	636	PF00069	0.571
MOD_Plk_1	82	88	PF00069	0.840
MOD_Plk_2-3	135	141	PF00069	0.607
MOD_Plk_2-3	233	239	PF00069	0.615
MOD_Plk_2-3	240	246	PF00069	0.541
MOD_Plk_4	151	157	PF00069	0.773
MOD_Plk_4	306	312	PF00069	0.604
MOD_Plk_4	583	589	PF00069	0.651
MOD_Plk_4	82	88	PF00069	0.840
MOD_ProDKin_1	102	108	PF00069	0.667
MOD_ProDKin_1	549	555	PF00069	0.744
MOD_ProDKin_1	560	566	PF00069	0.619
MOD_ProDKin_1	58	64	PF00069	0.805
MOD_ProDKin_1	760	766	PF00069	0.775
MOD_SUMO_for_1	433	436	PF00179	0.565
MOD_SUMO_for_1	564	567	PF00179	0.775
TRG_DiLeu_BaEn_1	322	327	PF01217	0.647
TRG_DiLeu_BaEn_1	332	337	PF01217	0.555
TRG_DiLeu_BaEn_1	375	380	PF01217	0.575
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.660
TRG_ENDOCYTIC_2	349	352	PF00928	0.621
TRG_ENDOCYTIC_2	610	613	PF00928	0.718
TRG_ER_diArg_1	120	122	PF00400	0.720
TRG_ER_diArg_1	219	222	PF00400	0.699
TRG_ER_diArg_1	392	394	PF00400	0.673
TRG_ER_diArg_1	407	409	PF00400	0.444
TRG_ER_diArg_1	469	471	PF00400	0.585
TRG_ER_diArg_1	525	527	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5K7	Leishmania donovani	100%	100%
A4HKI2	Leishmania braziliensis	59%	100%
E9B2X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q585	Leishmania major	87%	100%