Vitamin B6 photo-protection and homoeostasis-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis - putative

Species:

Leishmania infantum

UniProt:

A4I813_LEIIN

TriTrypDb:

LINF_320025100

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I813

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I813

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.353
CLV_NRD_NRD_1	348	350	PF00675	0.454
CLV_NRD_NRD_1	355	357	PF00675	0.409
CLV_NRD_NRD_1	370	372	PF00675	0.313
CLV_NRD_NRD_1	407	409	PF00675	0.379
CLV_PCSK_KEX2_1	252	254	PF00082	0.374
CLV_PCSK_KEX2_1	354	356	PF00082	0.494
CLV_PCSK_KEX2_1	370	372	PF00082	0.310
CLV_PCSK_KEX2_1	407	409	PF00082	0.379
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.334
CLV_PCSK_SKI1_1	242	246	PF00082	0.336
CLV_PCSK_SKI1_1	253	257	PF00082	0.317
CLV_PCSK_SKI1_1	371	375	PF00082	0.321
DEG_APCC_DBOX_1	28	36	PF00400	0.427
DOC_CDC14_PxL_1	341	349	PF14671	0.565
DOC_CKS1_1	255	260	PF01111	0.517
DOC_CYCLIN_RxL_1	231	240	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.294
DOC_MAPK_DCC_7	324	332	PF00069	0.616
DOC_MAPK_gen_1	109	118	PF00069	0.443
DOC_MAPK_gen_1	276	284	PF00069	0.660
DOC_MAPK_gen_1	370	376	PF00069	0.483
DOC_MAPK_MEF2A_6	111	120	PF00069	0.454
DOC_MAPK_MEF2A_6	324	332	PF00069	0.600
DOC_MAPK_RevD_3	241	254	PF00069	0.565
DOC_PP1_RVXF_1	232	239	PF00149	0.445
DOC_PP2B_LxvP_1	453	456	PF13499	0.560
DOC_PP4_FxxP_1	33	36	PF00568	0.454
DOC_USP7_UBL2_3	379	383	PF12436	0.601
DOC_WW_Pin1_4	254	259	PF00397	0.485
DOC_WW_Pin1_4	289	294	PF00397	0.482
DOC_WW_Pin1_4	323	328	PF00397	0.524
DOC_WW_Pin1_4	78	83	PF00397	0.234
LIG_14-3-3_CanoR_1	161	168	PF00244	0.515
LIG_14-3-3_CanoR_1	349	354	PF00244	0.710
LIG_14-3-3_CanoR_1	355	363	PF00244	0.654
LIG_14-3-3_CanoR_1	449	457	PF00244	0.541
LIG_Actin_WH2_2	260	278	PF00022	0.625
LIG_BRCT_BRCA1_1	73	77	PF00533	0.370
LIG_Clathr_ClatBox_1	235	239	PF01394	0.489
LIG_CtBP_PxDLS_1	456	460	PF00389	0.544
LIG_deltaCOP1_diTrp_1	334	341	PF00928	0.558
LIG_deltaCOP1_diTrp_1	418	427	PF00928	0.598
LIG_EH1_1	447	455	PF00400	0.606
LIG_EVH1_1	341	345	PF00568	0.556
LIG_FHA_1	10	16	PF00498	0.584
LIG_FHA_1	144	150	PF00498	0.303
LIG_FHA_1	205	211	PF00498	0.264
LIG_FHA_1	230	236	PF00498	0.480
LIG_FHA_1	238	244	PF00498	0.450
LIG_FHA_1	284	290	PF00498	0.494
LIG_FHA_1	392	398	PF00498	0.501
LIG_FHA_2	255	261	PF00498	0.499
LIG_FHA_2	302	308	PF00498	0.612
LIG_FHA_2	329	335	PF00498	0.597
LIG_FHA_2	400	406	PF00498	0.519
LIG_LIR_Gen_1	178	189	PF02991	0.447
LIG_LIR_Gen_1	3	10	PF02991	0.649
LIG_LIR_Gen_1	66	77	PF02991	0.300
LIG_LIR_Nem_3	178	184	PF02991	0.443
LIG_LIR_Nem_3	232	236	PF02991	0.532
LIG_LIR_Nem_3	3	9	PF02991	0.598
LIG_LIR_Nem_3	334	339	PF02991	0.613
LIG_LIR_Nem_3	340	344	PF02991	0.640
LIG_LIR_Nem_3	66	72	PF02991	0.300
LIG_MAD2	102	110	PF02301	0.468
LIG_MLH1_MIPbox_1	73	77	PF16413	0.377
LIG_PCNA_PIPBox_1	70	79	PF02747	0.271
LIG_PCNA_yPIPBox_3	447	460	PF02747	0.609
LIG_Pex14_2	47	51	PF04695	0.443
LIG_Pex14_2	59	63	PF04695	0.271
LIG_SH2_CRK	393	397	PF00017	0.478
LIG_SH2_CRK	69	73	PF00017	0.319
LIG_SH2_GRB2like	311	314	PF00017	0.579
LIG_SH2_NCK_1	189	193	PF00017	0.423
LIG_SH2_SRC	311	314	PF00017	0.530
LIG_SH2_STAP1	393	397	PF00017	0.486
LIG_SH2_STAT5	157	160	PF00017	0.418
LIG_SH2_STAT5	189	192	PF00017	0.284
LIG_SH2_STAT5	199	202	PF00017	0.251
LIG_SH2_STAT5	311	314	PF00017	0.480
LIG_SH2_STAT5	389	392	PF00017	0.483
LIG_SH2_STAT5	393	396	PF00017	0.493
LIG_SH2_STAT5	52	55	PF00017	0.438
LIG_SH3_1	339	345	PF00018	0.650
LIG_SH3_3	12	18	PF00018	0.628
LIG_SH3_3	288	294	PF00018	0.485
LIG_SH3_3	339	345	PF00018	0.615
LIG_SH3_3	435	441	PF00018	0.565
LIG_SUMO_SIM_par_1	328	334	PF11976	0.556
LIG_TRAF2_1	257	260	PF00917	0.544
LIG_TRAF2_1	304	307	PF00917	0.554
LIG_TRAF2_1	402	405	PF00917	0.607
LIG_TYR_ITIM	391	396	PF00017	0.454
LIG_TYR_ITIM	67	72	PF00017	0.319
LIG_UBA3_1	269	277	PF00899	0.630
LIG_UBA3_1	317	324	PF00899	0.571
LIG_UBA3_1	32	37	PF00899	0.510
LIG_WRC_WIRS_1	181	186	PF05994	0.434
LIG_WRC_WIRS_1	203	208	PF05994	0.385
LIG_WW_2	342	345	PF00397	0.555
MOD_CK1_1	105	111	PF00069	0.586
MOD_CK1_1	224	230	PF00069	0.275
MOD_CK1_1	458	464	PF00069	0.593
MOD_CK1_1	54	60	PF00069	0.291
MOD_CK1_1	71	77	PF00069	0.211
MOD_CK2_1	254	260	PF00069	0.504
MOD_CK2_1	301	307	PF00069	0.587
MOD_CK2_1	328	334	PF00069	0.562
MOD_CK2_1	399	405	PF00069	0.515
MOD_Cter_Amidation	368	371	PF01082	0.353
MOD_GlcNHglycan	152	155	PF01048	0.275
MOD_GlcNHglycan	162	165	PF01048	0.239
MOD_GlcNHglycan	460	463	PF01048	0.395
MOD_GlcNHglycan	73	76	PF01048	0.447
MOD_GSK3_1	145	152	PF00069	0.389
MOD_GSK3_1	198	205	PF00069	0.273
MOD_GSK3_1	51	58	PF00069	0.440
MOD_N-GLC_1	121	126	PF02516	0.236
MOD_NEK2_1	114	119	PF00069	0.284
MOD_NEK2_1	198	203	PF00069	0.368
MOD_NEK2_1	221	226	PF00069	0.287
MOD_NEK2_1	409	414	PF00069	0.516
MOD_NEK2_1	51	56	PF00069	0.434
MOD_NEK2_1	63	68	PF00069	0.271
MOD_NEK2_1	77	82	PF00069	0.222
MOD_PIKK_1	354	360	PF00454	0.721
MOD_PKA_1	349	355	PF00069	0.711
MOD_PKA_2	160	166	PF00069	0.515
MOD_PKA_2	22	28	PF00069	0.507
MOD_PKA_2	354	360	PF00069	0.643
MOD_PKA_2	448	454	PF00069	0.509
MOD_Plk_1	121	127	PF00069	0.236
MOD_Plk_4	114	120	PF00069	0.297
MOD_Plk_4	121	127	PF00069	0.256
MOD_Plk_4	130	136	PF00069	0.212
MOD_Plk_4	198	204	PF00069	0.303
MOD_Plk_4	224	230	PF00069	0.365
MOD_Plk_4	55	61	PF00069	0.320
MOD_Plk_4	68	74	PF00069	0.212
MOD_ProDKin_1	254	260	PF00069	0.487
MOD_ProDKin_1	289	295	PF00069	0.487
MOD_ProDKin_1	323	329	PF00069	0.528
MOD_ProDKin_1	78	84	PF00069	0.234
MOD_SUMO_rev_2	359	367	PF00179	0.634
TRG_DiLeu_BaEn_1	260	265	PF01217	0.563
TRG_DiLeu_BaEn_3	404	410	PF01217	0.549
TRG_DiLeu_BaEn_3	425	431	PF01217	0.532
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.542
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.512
TRG_ENDOCYTIC_2	389	392	PF00928	0.481
TRG_ENDOCYTIC_2	393	396	PF00928	0.471
TRG_ENDOCYTIC_2	52	55	PF00928	0.459
TRG_ENDOCYTIC_2	69	72	PF00928	0.257
TRG_ER_diArg_1	253	255	PF00400	0.561
TRG_ER_diArg_1	29	32	PF00400	0.464
TRG_ER_diArg_1	353	356	PF00400	0.679
TRG_ER_diArg_1	370	372	PF00400	0.509
TRG_ER_diArg_1	406	408	PF00400	0.574
TRG_NES_CRM1_1	239	251	PF08389	0.489
TRG_NES_CRM1_1	260	273	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I637	Leptomonas seymouri	72%	77%
A0A0N1I7Q2	Leptomonas seymouri	60%	89%
A0A0S4JVE4	Bodo saltans	40%	81%
A0A1X0NUW8	Trypanosomatidae	53%	74%
A0A3Q8IFI0	Leishmania donovani	100%	100%
A0A422NB59	Trypanosoma rangeli	53%	80%
A4HKI1	Leishmania braziliensis	84%	100%
D0AA76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	79%
E9B2X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q586	Leishmania major	95%	100%
V5ALC0	Trypanosoma cruzi	51%	74%