LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I812_LEIIN
TriTrypDb:
LINF_320025000
Length:
440

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I812
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I812

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 417 421 PF00656 0.701
CLV_NRD_NRD_1 132 134 PF00675 0.526
CLV_NRD_NRD_1 31 33 PF00675 0.474
CLV_NRD_NRD_1 315 317 PF00675 0.626
CLV_NRD_NRD_1 36 38 PF00675 0.432
CLV_NRD_NRD_1 94 96 PF00675 0.563
CLV_PCSK_KEX2_1 132 134 PF00082 0.516
CLV_PCSK_KEX2_1 31 33 PF00082 0.469
CLV_PCSK_KEX2_1 315 317 PF00082 0.626
CLV_PCSK_KEX2_1 406 408 PF00082 0.676
CLV_PCSK_PC1ET2_1 406 408 PF00082 0.676
CLV_PCSK_SKI1_1 221 225 PF00082 0.554
CLV_PCSK_SKI1_1 253 257 PF00082 0.640
CLV_PCSK_SKI1_1 266 270 PF00082 0.534
CLV_PCSK_SKI1_1 37 41 PF00082 0.516
CLV_PCSK_SKI1_1 62 66 PF00082 0.600
CLV_PCSK_SKI1_1 67 71 PF00082 0.543
CLV_PCSK_SKI1_1 73 77 PF00082 0.433
DEG_APCC_DBOX_1 265 273 PF00400 0.547
DEG_COP1_1 394 403 PF00400 0.670
DOC_CDC14_PxL_1 285 293 PF14671 0.545
DOC_CYCLIN_RxL_1 67 77 PF00134 0.431
DOC_MAPK_DCC_7 266 274 PF00069 0.490
DOC_MAPK_gen_1 82 89 PF00069 0.479
DOC_MAPK_gen_1 95 101 PF00069 0.491
DOC_MAPK_RevD_3 25 38 PF00069 0.512
DOC_PP2B_LxvP_1 373 376 PF13499 0.672
DOC_USP7_MATH_1 155 159 PF00917 0.389
DOC_USP7_MATH_1 2 6 PF00917 0.488
DOC_USP7_MATH_1 319 323 PF00917 0.621
DOC_WW_Pin1_4 412 417 PF00397 0.708
LIG_14-3-3_CanoR_1 197 205 PF00244 0.462
LIG_14-3-3_CanoR_1 321 327 PF00244 0.631
LIG_BIR_II_1 1 5 PF00653 0.587
LIG_BRCT_BRCA1_1 4 8 PF00533 0.452
LIG_EH1_1 329 337 PF00400 0.482
LIG_FHA_1 100 106 PF00498 0.556
LIG_FHA_1 200 206 PF00498 0.541
LIG_FHA_1 21 27 PF00498 0.496
LIG_FHA_2 19 25 PF00498 0.490
LIG_FHA_2 403 409 PF00498 0.725
LIG_FHA_2 424 430 PF00498 0.792
LIG_FHA_2 432 438 PF00498 0.678
LIG_LIR_Gen_1 10 20 PF02991 0.500
LIG_LIR_Gen_1 171 182 PF02991 0.501
LIG_LIR_Gen_1 21 29 PF02991 0.490
LIG_LIR_Gen_1 234 243 PF02991 0.534
LIG_LIR_Gen_1 322 332 PF02991 0.556
LIG_LIR_Nem_3 10 15 PF02991 0.468
LIG_LIR_Nem_3 171 177 PF02991 0.568
LIG_LIR_Nem_3 188 193 PF02991 0.334
LIG_LIR_Nem_3 21 25 PF02991 0.498
LIG_LIR_Nem_3 234 239 PF02991 0.523
LIG_LIR_Nem_3 279 284 PF02991 0.518
LIG_LIR_Nem_3 322 327 PF02991 0.584
LIG_Pex14_1 232 236 PF04695 0.473
LIG_Pex14_1 326 330 PF04695 0.563
LIG_Pex14_2 281 285 PF04695 0.557
LIG_Rb_pABgroove_1 237 245 PF01858 0.454
LIG_REV1ctd_RIR_1 179 185 PF16727 0.504
LIG_SH2_CRK 190 194 PF00017 0.454
LIG_SH2_CRK 236 240 PF00017 0.472
LIG_SH2_CRK 286 290 PF00017 0.516
LIG_SH2_STAP1 12 16 PF00017 0.504
LIG_SH2_STAP1 22 26 PF00017 0.496
LIG_SH2_STAP1 243 247 PF00017 0.563
LIG_SH2_STAT3 243 246 PF00017 0.564
LIG_SH2_STAT3 81 84 PF00017 0.464
LIG_SH2_STAT5 22 25 PF00017 0.441
LIG_SH2_STAT5 238 241 PF00017 0.524
LIG_SH3_3 387 393 PF00018 0.808
LIG_SH3_3 397 403 PF00018 0.584
LIG_SH3_3 94 100 PF00018 0.605
LIG_TRAF2_1 212 215 PF00917 0.534
LIG_TRAF2_1 39 42 PF00917 0.513
LIG_TRAF2_1 426 429 PF00917 0.750
LIG_WW_3 92 96 PF00397 0.539
MOD_CK1_1 231 237 PF00069 0.578
MOD_CK1_1 322 328 PF00069 0.686
MOD_CK1_1 430 436 PF00069 0.662
MOD_CK2_1 18 24 PF00069 0.473
MOD_CK2_1 4 10 PF00069 0.450
MOD_CK2_1 402 408 PF00069 0.818
MOD_CK2_1 423 429 PF00069 0.709
MOD_CK2_1 431 437 PF00069 0.662
MOD_GlcNHglycan 233 236 PF01048 0.469
MOD_GlcNHglycan 350 353 PF01048 0.806
MOD_GlcNHglycan 416 419 PF01048 0.735
MOD_GSK3_1 155 162 PF00069 0.458
MOD_GSK3_1 407 414 PF00069 0.771
MOD_GSK3_1 423 430 PF00069 0.790
MOD_N-GLC_1 295 300 PF02516 0.515
MOD_NEK2_1 295 300 PF00069 0.538
MOD_PIKK_1 2 8 PF00454 0.509
MOD_PIKK_1 295 301 PF00454 0.600
MOD_PKA_1 82 88 PF00069 0.534
MOD_PKA_2 314 320 PF00069 0.572
MOD_PKA_2 322 328 PF00069 0.545
MOD_Plk_1 172 178 PF00069 0.446
MOD_Plk_1 228 234 PF00069 0.642
MOD_Plk_1 427 433 PF00069 0.669
MOD_Plk_2-3 353 359 PF00069 0.619
MOD_Plk_4 385 391 PF00069 0.711
MOD_ProDKin_1 412 418 PF00069 0.707
MOD_SUMO_rev_2 214 220 PF00179 0.591
MOD_SUMO_rev_2 33 40 PF00179 0.510
MOD_SUMO_rev_2 60 65 PF00179 0.396
TRG_DiLeu_BaEn_3 263 269 PF01217 0.429
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.496
TRG_ENDOCYTIC_2 12 15 PF00928 0.445
TRG_ENDOCYTIC_2 190 193 PF00928 0.505
TRG_ENDOCYTIC_2 22 25 PF00928 0.437
TRG_ENDOCYTIC_2 236 239 PF00928 0.473
TRG_ER_diArg_1 132 135 PF00400 0.524
TRG_ER_diArg_1 163 166 PF00400 0.499
TRG_ER_diArg_1 314 316 PF00400 0.629
TRG_ER_diArg_1 321 324 PF00400 0.556
TRG_NES_CRM1_1 240 254 PF08389 0.435
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.508
TRG_Pf-PMV_PEXEL_1 132 136 PF00026 0.413
TRG_Pf-PMV_PEXEL_1 38 42 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.426

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NU98 Trypanosomatidae 42% 73%
A0A3S7X5P1 Leishmania donovani 100% 100%
A0A422NBA5 Trypanosoma rangeli 36% 100%
A4HKI0 Leishmania braziliensis 63% 100%
Q4Q587 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS