Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I808_LEIIN

TriTrypDb:

LINF_320020700

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I808

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I808

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.614
CLV_C14_Caspase3-7	181	185	PF00656	0.626
CLV_C14_Caspase3-7	264	268	PF00656	0.471
CLV_C14_Caspase3-7	57	61	PF00656	0.459
CLV_NRD_NRD_1	149	151	PF00675	0.624
CLV_NRD_NRD_1	230	232	PF00675	0.563
CLV_NRD_NRD_1	257	259	PF00675	0.525
CLV_NRD_NRD_1	351	353	PF00675	0.487
CLV_NRD_NRD_1	75	77	PF00675	0.750
CLV_PCSK_KEX2_1	148	150	PF00082	0.729
CLV_PCSK_KEX2_1	230	232	PF00082	0.563
CLV_PCSK_KEX2_1	257	259	PF00082	0.525
CLV_PCSK_KEX2_1	75	77	PF00082	0.748
CLV_PCSK_SKI1_1	137	141	PF00082	0.572
CLV_PCSK_SKI1_1	150	154	PF00082	0.613
DEG_APCC_DBOX_1	136	144	PF00400	0.526
DEG_APCC_DBOX_1	20	28	PF00400	0.519
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DOC_CKS1_1	236	241	PF01111	0.503
DOC_CKS1_1	322	327	PF01111	0.447
DOC_CYCLIN_RxL_1	48	57	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.551
DOC_MAPK_gen_1	146	154	PF00069	0.538
DOC_MAPK_gen_1	230	236	PF00069	0.552
DOC_MAPK_gen_1	286	295	PF00069	0.470
DOC_MAPK_gen_1	88	97	PF00069	0.565
DOC_PP1_RVXF_1	255	262	PF00149	0.540
DOC_PP2B_LxvP_1	164	167	PF13499	0.612
DOC_PP4_FxxP_1	322	325	PF00568	0.440
DOC_USP7_MATH_1	155	159	PF00917	0.800
DOC_USP7_MATH_1	265	269	PF00917	0.464
DOC_USP7_MATH_1	82	86	PF00917	0.659
DOC_WW_Pin1_4	157	162	PF00397	0.644
DOC_WW_Pin1_4	200	205	PF00397	0.631
DOC_WW_Pin1_4	235	240	PF00397	0.631
DOC_WW_Pin1_4	321	326	PF00397	0.444
DOC_WW_Pin1_4	65	70	PF00397	0.599
DOC_WW_Pin1_4	78	83	PF00397	0.650
LIG_14-3-3_CanoR_1	127	131	PF00244	0.564
LIG_14-3-3_CanoR_1	352	357	PF00244	0.460
LIG_Actin_WH2_2	5	23	PF00022	0.595
LIG_APCC_ABBA_1	130	135	PF00400	0.536
LIG_BRCT_BRCA1_1	116	120	PF00533	0.558
LIG_BRCT_BRCA1_1	267	271	PF00533	0.436
LIG_BRCT_BRCA1_1	318	322	PF00533	0.474
LIG_FHA_1	126	132	PF00498	0.608
LIG_FHA_1	188	194	PF00498	0.629
LIG_FHA_1	236	242	PF00498	0.498
LIG_FHA_1	289	295	PF00498	0.471
LIG_FHA_1	356	362	PF00498	0.446
LIG_FHA_1	90	96	PF00498	0.622
LIG_FHA_2	117	123	PF00498	0.650
LIG_HCF-1_HBM_1	339	342	PF13415	0.395
LIG_LIR_Apic_2	319	325	PF02991	0.454
LIG_LIR_Gen_1	244	253	PF02991	0.461
LIG_LIR_Gen_1	270	279	PF02991	0.447
LIG_LIR_Gen_1	339	350	PF02991	0.455
LIG_LIR_Nem_3	270	275	PF02991	0.442
LIG_LIR_Nem_3	339	345	PF02991	0.424
LIG_NRBOX	359	365	PF00104	0.434
LIG_RPA_C_Fungi	240	252	PF08784	0.471
LIG_SH2_STAT3	351	354	PF00017	0.477
LIG_SH2_STAT5	301	304	PF00017	0.444
LIG_SH2_STAT5	323	326	PF00017	0.450
LIG_SH2_STAT5	342	345	PF00017	0.236
LIG_SH2_STAT5	365	368	PF00017	0.440
LIG_SH3_3	10	16	PF00018	0.607
LIG_SH3_3	128	134	PF00018	0.583
LIG_SH3_3	149	155	PF00018	0.647
LIG_SH3_3	164	170	PF00018	0.547
LIG_SH3_3	233	239	PF00018	0.531
LIG_SUMO_SIM_par_1	206	213	PF11976	0.595
LIG_SUMO_SIM_par_1	51	57	PF11976	0.482
LIG_TRFH_1	130	134	PF08558	0.489
LIG_TRFH_1	342	346	PF08558	0.421
LIG_UBA3_1	139	146	PF00899	0.523
LIG_ULM_U2AF65_1	257	262	PF00076	0.545
MOD_CK1_1	156	162	PF00069	0.623
MOD_CK1_1	263	269	PF00069	0.563
MOD_CK1_1	282	288	PF00069	0.427
MOD_CK1_1	34	40	PF00069	0.582
MOD_CK1_1	355	361	PF00069	0.407
MOD_CK1_1	68	74	PF00069	0.613
MOD_CK1_1	81	87	PF00069	0.656
MOD_CK1_1	98	104	PF00069	0.610
MOD_CK2_1	116	122	PF00069	0.563
MOD_CK2_1	206	212	PF00069	0.570
MOD_CK2_1	34	40	PF00069	0.590
MOD_GlcNHglycan	115	119	PF01048	0.591
MOD_GlcNHglycan	2	6	PF01048	0.630
MOD_GlcNHglycan	249	252	PF01048	0.575
MOD_GlcNHglycan	281	284	PF01048	0.538
MOD_GlcNHglycan	33	36	PF01048	0.559
MOD_GSK3_1	153	160	PF00069	0.712
MOD_GSK3_1	263	270	PF00069	0.514
MOD_GSK3_1	71	78	PF00069	0.644
MOD_GSK3_1	95	102	PF00069	0.594
MOD_N-GLC_1	156	161	PF02516	0.553
MOD_N-GLC_1	182	187	PF02516	0.633
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	116	121	PF00069	0.615
MOD_NEK2_1	144	149	PF00069	0.540
MOD_NEK2_1	241	246	PF00069	0.480
MOD_NEK2_1	95	100	PF00069	0.673
MOD_PK_1	352	358	PF00069	0.429
MOD_PKA_1	352	358	PF00069	0.464
MOD_PKA_1	75	81	PF00069	0.639
MOD_PKA_2	126	132	PF00069	0.647
MOD_PKA_2	20	26	PF00069	0.547
MOD_PKA_2	75	81	PF00069	0.655
MOD_PKB_1	148	156	PF00069	0.550
MOD_PKB_1	258	266	PF00069	0.554
MOD_PKB_1	286	294	PF00069	0.479
MOD_Plk_1	150	156	PF00069	0.551
MOD_Plk_1	182	188	PF00069	0.612
MOD_Plk_4	126	132	PF00069	0.538
MOD_Plk_4	75	81	PF00069	0.711
MOD_ProDKin_1	157	163	PF00069	0.643
MOD_ProDKin_1	200	206	PF00069	0.630
MOD_ProDKin_1	235	241	PF00069	0.628
MOD_ProDKin_1	321	327	PF00069	0.446
MOD_ProDKin_1	65	71	PF00069	0.600
MOD_ProDKin_1	78	84	PF00069	0.651
TRG_DiLeu_BaEn_1	339	344	PF01217	0.425
TRG_DiLeu_BaEn_4	40	46	PF01217	0.562
TRG_ENDOCYTIC_2	299	302	PF00928	0.480
TRG_ENDOCYTIC_2	342	345	PF00928	0.413
TRG_ER_diArg_1	148	150	PF00400	0.599
TRG_ER_diArg_1	229	231	PF00400	0.608
TRG_ER_diArg_1	257	260	PF00400	0.537
TRG_ER_diArg_1	295	298	PF00400	0.476
TRG_ER_diArg_1	49	52	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J3	Leishmania donovani	99%	100%
A4HKD7	Leishmania braziliensis	61%	100%
E9B2S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5D2	Leishmania major	84%	100%