Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease - putative

Species:

Leishmania infantum

UniProt:

A4I804_LEIIN

TriTrypDb:

LINF_320024700

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I804

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I804

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0005488	binding	1	5
GO:0008408	3'-5' exonuclease activity	6	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.704
CLV_C14_Caspase3-7	479	483	PF00656	0.730
CLV_NRD_NRD_1	138	140	PF00675	0.750
CLV_NRD_NRD_1	527	529	PF00675	0.581
CLV_PCSK_KEX2_1	137	139	PF00082	0.749
CLV_PCSK_KEX2_1	527	529	PF00082	0.581
CLV_PCSK_KEX2_1	66	68	PF00082	0.707
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.728
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.707
CLV_PCSK_PC7_1	523	529	PF00082	0.603
CLV_PCSK_SKI1_1	510	514	PF00082	0.546
CLV_PCSK_SKI1_1	606	610	PF00082	0.381
CLV_PCSK_SKI1_1	651	655	PF00082	0.391
CLV_PCSK_SKI1_1	672	676	PF00082	0.391
CLV_PCSK_SKI1_1	689	693	PF00082	0.228
CLV_PCSK_SKI1_1	704	708	PF00082	0.247
CLV_Separin_Metazoa	517	521	PF03568	0.463
DEG_ODPH_VHL_1	448	459	PF01847	0.754
DEG_SPOP_SBC_1	130	134	PF00917	0.589
DOC_CKS1_1	244	249	PF01111	0.739
DOC_CKS1_1	421	426	PF01111	0.769
DOC_CKS1_1	86	91	PF01111	0.718
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.623
DOC_MAPK_DCC_7	138	148	PF00069	0.730
DOC_MAPK_MEF2A_6	602	609	PF00069	0.591
DOC_MAPK_MEF2A_6	651	659	PF00069	0.591
DOC_MAPK_NFAT4_5	602	610	PF00069	0.591
DOC_MAPK_RevD_3	123	139	PF00069	0.632
DOC_PP1_RVXF_1	482	489	PF00149	0.645
DOC_PP1_RVXF_1	604	610	PF00149	0.591
DOC_PP2B_LxvP_1	140	143	PF13499	0.723
DOC_PP2B_LxvP_1	84	87	PF13499	0.730
DOC_PP2B_PxIxI_1	3	9	PF00149	0.732
DOC_PP4_FxxP_1	244	247	PF00568	0.737
DOC_PP4_MxPP_1	1	4	PF00568	0.742
DOC_USP7_MATH_1	167	171	PF00917	0.582
DOC_USP7_MATH_1	196	200	PF00917	0.620
DOC_USP7_MATH_1	226	230	PF00917	0.743
DOC_USP7_MATH_1	239	243	PF00917	0.591
DOC_USP7_MATH_1	267	271	PF00917	0.684
DOC_USP7_MATH_1	279	283	PF00917	0.553
DOC_USP7_MATH_1	304	308	PF00917	0.729
DOC_USP7_MATH_1	388	392	PF00917	0.769
DOC_USP7_MATH_1	394	398	PF00917	0.673
DOC_USP7_MATH_1	415	419	PF00917	0.784
DOC_USP7_MATH_1	433	437	PF00917	0.504
DOC_USP7_MATH_1	439	443	PF00917	0.701
DOC_USP7_MATH_1	588	592	PF00917	0.514
DOC_WW_Pin1_4	123	128	PF00397	0.733
DOC_WW_Pin1_4	243	248	PF00397	0.740
DOC_WW_Pin1_4	250	255	PF00397	0.612
DOC_WW_Pin1_4	290	295	PF00397	0.757
DOC_WW_Pin1_4	329	334	PF00397	0.722
DOC_WW_Pin1_4	343	348	PF00397	0.582
DOC_WW_Pin1_4	417	422	PF00397	0.778
DOC_WW_Pin1_4	59	64	PF00397	0.736
DOC_WW_Pin1_4	590	595	PF00397	0.591
DOC_WW_Pin1_4	641	646	PF00397	0.591
DOC_WW_Pin1_4	85	90	PF00397	0.723
LIG_14-3-3_CanoR_1	179	184	PF00244	0.688
LIG_14-3-3_CanoR_1	339	347	PF00244	0.600
LIG_14-3-3_CanoR_1	410	415	PF00244	0.626
LIG_14-3-3_CanoR_1	530	535	PF00244	0.744
LIG_14-3-3_CanoR_1	689	698	PF00244	0.591
LIG_14-3-3_CanoR_1	727	732	PF00244	0.473
LIG_Actin_WH2_2	574	592	PF00022	0.517
LIG_APCC_ABBA_1	657	662	PF00400	0.591
LIG_BIR_III_4	42	46	PF00653	0.704
LIG_BRCT_BRCA1_1	240	244	PF00533	0.726
LIG_BRCT_BRCA1_1	430	434	PF00533	0.603
LIG_BRCT_BRCA1_1	634	638	PF00533	0.591
LIG_BRCT_BRCA1_1	741	745	PF00533	0.564
LIG_CtBP_PxDLS_1	294	298	PF00389	0.629
LIG_FHA_1	102	108	PF00498	0.712
LIG_FHA_1	150	156	PF00498	0.737
LIG_FHA_1	543	549	PF00498	0.614
LIG_FHA_1	573	579	PF00498	0.591
LIG_FHA_1	690	696	PF00498	0.591
LIG_FHA_2	368	374	PF00498	0.750
LIG_FHA_2	474	480	PF00498	0.689
LIG_FHA_2	659	665	PF00498	0.591
LIG_FHA_2	89	95	PF00498	0.730
LIG_FXI_DFP_1	745	749	PF00024	0.554
LIG_IRF3_LxIS_1	629	635	PF10401	0.591
LIG_LIR_Apic_2	241	247	PF02991	0.735
LIG_LIR_Apic_2	250	254	PF02991	0.595
LIG_LIR_Gen_1	431	441	PF02991	0.598
LIG_LIR_Gen_1	572	581	PF02991	0.591
LIG_LIR_Gen_1	635	645	PF02991	0.591
LIG_LIR_Gen_1	652	660	PF02991	0.591
LIG_LIR_Nem_3	256	260	PF02991	0.608
LIG_LIR_Nem_3	431	437	PF02991	0.601
LIG_LIR_Nem_3	572	576	PF02991	0.591
LIG_LIR_Nem_3	616	622	PF02991	0.633
LIG_LIR_Nem_3	635	641	PF02991	0.413
LIG_LIR_Nem_3	652	657	PF02991	0.591
LIG_LIR_Nem_3	742	748	PF02991	0.550
LIG_MLH1_MIPbox_1	240	244	PF16413	0.582
LIG_MYND_1	213	217	PF01753	0.759
LIG_PCNA_yPIPBox_3	231	244	PF02747	0.733
LIG_PTAP_UEV_1	429	434	PF05743	0.646
LIG_PTB_Apo_2	730	737	PF02174	0.545
LIG_Rb_pABgroove_1	603	611	PF01858	0.591
LIG_SH2_CRK	251	255	PF00017	0.696
LIG_SH2_CRK	573	577	PF00017	0.591
LIG_SH2_NCK_1	257	261	PF00017	0.578
LIG_SH2_NCK_1	573	577	PF00017	0.591
LIG_SH2_SRC	257	260	PF00017	0.717
LIG_SH2_SRC	464	467	PF00017	0.707
LIG_SH2_STAP1	544	548	PF00017	0.539
LIG_SH2_STAP1	573	577	PF00017	0.591
LIG_SH2_STAT5	273	276	PF00017	0.614
LIG_SH2_STAT5	544	547	PF00017	0.451
LIG_SH2_STAT5	577	580	PF00017	0.591
LIG_SH2_STAT5	622	625	PF00017	0.561
LIG_SH2_STAT5	698	701	PF00017	0.591
LIG_SH2_STAT5	705	708	PF00017	0.524
LIG_SH3_1	139	145	PF00018	0.729
LIG_SH3_1	419	425	PF00018	0.669
LIG_SH3_2	421	426	PF14604	0.769
LIG_SH3_3	124	130	PF00018	0.700
LIG_SH3_3	139	145	PF00018	0.559
LIG_SH3_3	210	216	PF00018	0.709
LIG_SH3_3	418	424	PF00018	0.774
LIG_SH3_3	427	433	PF00018	0.632
LIG_SH3_3	639	645	PF00018	0.591
LIG_SH3_3	84	90	PF00018	0.724
LIG_SUMO_SIM_par_1	293	299	PF11976	0.627
LIG_SUMO_SIM_par_1	545	553	PF11976	0.523
LIG_SUMO_SIM_par_1	566	572	PF11976	0.577
LIG_TRAF2_1	14	17	PF00917	0.642
LIG_TRFH_1	638	642	PF08558	0.591
LIG_TYR_ITIM	696	701	PF00017	0.591
LIG_WRC_WIRS_1	180	185	PF05994	0.582
LIG_WRC_WIRS_1	203	208	PF05994	0.643
LIG_WRC_WIRS_1	240	245	PF05994	0.586
LIG_WW_2	213	216	PF00397	0.713
LIG_WW_3	332	336	PF00397	0.706
LIG_WW_3	423	427	PF00397	0.766
MOD_CDC14_SPxK_1	332	335	PF00782	0.707
MOD_CDK_SPxK_1	329	335	PF00069	0.712
MOD_CDK_SPxK_1	420	426	PF00069	0.771
MOD_CDK_SPxxK_3	59	66	PF00069	0.737
MOD_CDK_SPxxK_3	590	597	PF00069	0.561
MOD_CK1_1	100	106	PF00069	0.714
MOD_CK1_1	11	17	PF00069	0.743
MOD_CK1_1	129	135	PF00069	0.629
MOD_CK1_1	189	195	PF00069	0.725
MOD_CK1_1	199	205	PF00069	0.596
MOD_CK1_1	242	248	PF00069	0.732
MOD_CK1_1	293	299	PF00069	0.771
MOD_CK1_1	33	39	PF00069	0.751
MOD_CK1_1	341	347	PF00069	0.740
MOD_CK1_1	367	373	PF00069	0.748
MOD_CK1_1	397	403	PF00069	0.763
MOD_CK1_1	420	426	PF00069	0.771
MOD_CK1_1	71	77	PF00069	0.728
MOD_CK1_1	739	745	PF00069	0.566
MOD_CK2_1	11	17	PF00069	0.738
MOD_CK2_1	367	373	PF00069	0.748
MOD_CK2_1	389	395	PF00069	0.763
MOD_CK2_1	473	479	PF00069	0.690
MOD_CK2_1	88	94	PF00069	0.726
MOD_DYRK1A_RPxSP_1	59	63	PF00069	0.736
MOD_DYRK1A_RPxSP_1	590	594	PF00069	0.517
MOD_GlcNHglycan	10	13	PF01048	0.746
MOD_GlcNHglycan	119	122	PF01048	0.707
MOD_GlcNHglycan	152	155	PF01048	0.643
MOD_GlcNHglycan	169	172	PF01048	0.491
MOD_GlcNHglycan	187	191	PF01048	0.614
MOD_GlcNHglycan	198	201	PF01048	0.567
MOD_GlcNHglycan	206	209	PF01048	0.495
MOD_GlcNHglycan	277	280	PF01048	0.688
MOD_GlcNHglycan	281	284	PF01048	0.650
MOD_GlcNHglycan	298	301	PF01048	0.549
MOD_GlcNHglycan	318	321	PF01048	0.527
MOD_GlcNHglycan	358	361	PF01048	0.713
MOD_GlcNHglycan	386	389	PF01048	0.777
MOD_GlcNHglycan	391	394	PF01048	0.694
MOD_GlcNHglycan	395	399	PF01048	0.637
MOD_GlcNHglycan	430	433	PF01048	0.715
MOD_GlcNHglycan	441	444	PF01048	0.630
MOD_GlcNHglycan	590	593	PF01048	0.288
MOD_GlcNHglycan	73	76	PF01048	0.698
MOD_GSK3_1	126	133	PF00069	0.728
MOD_GSK3_1	169	176	PF00069	0.682
MOD_GSK3_1	204	211	PF00069	0.723
MOD_GSK3_1	215	222	PF00069	0.604
MOD_GSK3_1	238	245	PF00069	0.728
MOD_GSK3_1	262	269	PF00069	0.729
MOD_GSK3_1	275	282	PF00069	0.552
MOD_GSK3_1	30	37	PF00069	0.752
MOD_GSK3_1	339	346	PF00069	0.741
MOD_GSK3_1	384	391	PF00069	0.774
MOD_GSK3_1	406	413	PF00069	0.718
MOD_GSK3_1	44	51	PF00069	0.567
MOD_GSK3_1	464	471	PF00069	0.746
MOD_GSK3_1	542	549	PF00069	0.582
MOD_GSK3_1	658	665	PF00069	0.517
MOD_GSK3_1	66	73	PF00069	0.740
MOD_GSK3_1	737	744	PF00069	0.566
MOD_GSK3_1	97	104	PF00069	0.725
MOD_LATS_1	337	343	PF00433	0.606
MOD_N-GLC_1	208	213	PF02516	0.742
MOD_N-GLC_1	373	378	PF02516	0.677
MOD_N-GLC_1	383	388	PF02516	0.715
MOD_N-GLC_2	628	630	PF02516	0.391
MOD_N-GLC_2	77	79	PF02516	0.738
MOD_NEK2_1	101	106	PF00069	0.671
MOD_NEK2_1	131	136	PF00069	0.700
MOD_NEK2_1	174	179	PF00069	0.699
MOD_NEK2_1	266	271	PF00069	0.728
MOD_NEK2_1	316	321	PF00069	0.617
MOD_NEK2_1	34	39	PF00069	0.751
MOD_NEK2_1	632	637	PF00069	0.591
MOD_NEK2_1	736	741	PF00069	0.567
MOD_NEK2_2	239	244	PF00069	0.684
MOD_NEK2_2	267	272	PF00069	0.706
MOD_NEK2_2	52	57	PF00069	0.611
MOD_NEK2_2	649	654	PF00069	0.591
MOD_OFUCOSY	630	637	PF10250	0.391
MOD_PIKK_1	169	175	PF00454	0.573
MOD_PIKK_1	219	225	PF00454	0.682
MOD_PK_1	410	416	PF00069	0.731
MOD_PK_1	530	536	PF00069	0.695
MOD_PK_1	561	567	PF00069	0.591
MOD_PK_1	727	733	PF00069	0.482
MOD_PKA_1	66	72	PF00069	0.702
MOD_PKA_2	178	184	PF00069	0.690
MOD_PKA_2	262	268	PF00069	0.730
MOD_PKA_2	338	344	PF00069	0.603
MOD_PKA_2	415	421	PF00069	0.637
MOD_PKA_2	66	72	PF00069	0.702
MOD_PKA_2	736	742	PF00069	0.548
MOD_PKB_1	528	536	PF00069	0.639
MOD_Plk_1	186	192	PF00069	0.619
MOD_Plk_1	373	379	PF00069	0.749
MOD_Plk_1	97	103	PF00069	0.727
MOD_Plk_2-3	373	379	PF00069	0.749
MOD_Plk_4	239	245	PF00069	0.682
MOD_Plk_4	572	578	PF00069	0.591
MOD_Plk_4	649	655	PF00069	0.591
MOD_ProDKin_1	123	129	PF00069	0.732
MOD_ProDKin_1	243	249	PF00069	0.738
MOD_ProDKin_1	250	256	PF00069	0.609
MOD_ProDKin_1	290	296	PF00069	0.758
MOD_ProDKin_1	329	335	PF00069	0.724
MOD_ProDKin_1	343	349	PF00069	0.582
MOD_ProDKin_1	417	423	PF00069	0.777
MOD_ProDKin_1	59	65	PF00069	0.737
MOD_ProDKin_1	590	596	PF00069	0.591
MOD_ProDKin_1	641	647	PF00069	0.591
MOD_ProDKin_1	85	91	PF00069	0.723
TRG_ENDOCYTIC_2	257	260	PF00928	0.614
TRG_ENDOCYTIC_2	573	576	PF00928	0.591
TRG_ENDOCYTIC_2	698	701	PF00928	0.591
TRG_ER_diArg_1	138	140	PF00400	0.749
TRG_ER_KDEL_1	751	754	PF00810	0.447
TRG_NES_CRM1_1	616	627	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5Q4	Leishmania donovani	99%	100%
E9B2W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q590	Leishmania major	86%	100%