LeishMANIAdb
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Serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine protein kinase
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4I7Z6_LEIIN
TriTrypDb:
LINF_320023900
Length:
656

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 65
NetGPI no yes: 0, no: 65
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 40

Expansion

Sequence features

A4I7Z6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Z6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 66
GO:0006793 phosphorus metabolic process 3 66
GO:0006796 phosphate-containing compound metabolic process 4 66
GO:0006807 nitrogen compound metabolic process 2 66
GO:0008152 metabolic process 1 66
GO:0009987 cellular process 1 66
GO:0016310 phosphorylation 5 66
GO:0019538 protein metabolic process 3 66
GO:0036211 protein modification process 4 66
GO:0043170 macromolecule metabolic process 3 66
GO:0043412 macromolecule modification 4 66
GO:0044237 cellular metabolic process 2 66
GO:0044238 primary metabolic process 2 66
GO:0071704 organic substance metabolic process 2 66
GO:1901564 organonitrogen compound metabolic process 3 66
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 66
GO:0003824 catalytic activity 1 66
GO:0004672 protein kinase activity 3 66
GO:0005488 binding 1 66
GO:0005524 ATP binding 5 66
GO:0016301 kinase activity 4 66
GO:0016740 transferase activity 2 66
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 66
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 66
GO:0017076 purine nucleotide binding 4 66
GO:0030554 adenyl nucleotide binding 5 66
GO:0032553 ribonucleotide binding 3 66
GO:0032555 purine ribonucleotide binding 4 66
GO:0032559 adenyl ribonucleotide binding 5 66
GO:0035639 purine ribonucleoside triphosphate binding 4 66
GO:0036094 small molecule binding 2 66
GO:0043167 ion binding 2 66
GO:0043168 anion binding 3 66
GO:0097159 organic cyclic compound binding 2 66
GO:0097367 carbohydrate derivative binding 2 66
GO:0140096 catalytic activity, acting on a protein 2 66
GO:1901265 nucleoside phosphate binding 3 66
GO:1901363 heterocyclic compound binding 2 66
GO:0004674 protein serine/threonine kinase activity 4 39
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 46 50 PF00656 0.742
CLV_C14_Caspase3-7 93 97 PF00656 0.563
CLV_NRD_NRD_1 257 259 PF00675 0.365
CLV_NRD_NRD_1 313 315 PF00675 0.296
CLV_NRD_NRD_1 395 397 PF00675 0.289
CLV_NRD_NRD_1 76 78 PF00675 0.461
CLV_PCSK_FUR_1 582 586 PF00082 0.347
CLV_PCSK_KEX2_1 163 165 PF00082 0.417
CLV_PCSK_KEX2_1 257 259 PF00082 0.416
CLV_PCSK_KEX2_1 313 315 PF00082 0.300
CLV_PCSK_KEX2_1 372 374 PF00082 0.271
CLV_PCSK_KEX2_1 395 397 PF00082 0.272
CLV_PCSK_KEX2_1 457 459 PF00082 0.328
CLV_PCSK_KEX2_1 530 532 PF00082 0.507
CLV_PCSK_KEX2_1 584 586 PF00082 0.339
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.376
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.325
CLV_PCSK_PC1ET2_1 457 459 PF00082 0.305
CLV_PCSK_PC1ET2_1 530 532 PF00082 0.527
CLV_PCSK_PC1ET2_1 584 586 PF00082 0.347
CLV_PCSK_SKI1_1 144 148 PF00082 0.354
CLV_PCSK_SKI1_1 267 271 PF00082 0.346
CLV_PCSK_SKI1_1 288 292 PF00082 0.230
CLV_PCSK_SKI1_1 318 322 PF00082 0.293
CLV_PCSK_SKI1_1 330 334 PF00082 0.289
CLV_PCSK_SKI1_1 444 448 PF00082 0.279
CLV_PCSK_SKI1_1 54 58 PF00082 0.531
CLV_PCSK_SKI1_1 557 561 PF00082 0.288
CLV_PCSK_SKI1_1 584 588 PF00082 0.320
DEG_APCC_DBOX_1 443 451 PF00400 0.268
DEG_APCC_DBOX_1 584 592 PF00400 0.268
DOC_CKS1_1 358 363 PF01111 0.339
DOC_CYCLIN_RxL_1 554 565 PF00134 0.262
DOC_CYCLIN_yCln2_LP_2 358 364 PF00134 0.367
DOC_MAPK_gen_1 318 327 PF00069 0.299
DOC_MAPK_RevD_3 301 314 PF00069 0.315
DOC_PP4_FxxP_1 415 418 PF00568 0.341
DOC_PP4_FxxP_1 505 508 PF00568 0.504
DOC_USP7_MATH_1 204 208 PF00917 0.406
DOC_USP7_MATH_1 610 614 PF00917 0.291
DOC_USP7_MATH_1 625 629 PF00917 0.452
DOC_USP7_MATH_2 397 403 PF00917 0.282
DOC_USP7_UBL2_3 372 376 PF12436 0.251
DOC_USP7_UBL2_3 453 457 PF12436 0.174
DOC_WW_Pin1_4 113 118 PF00397 0.624
DOC_WW_Pin1_4 357 362 PF00397 0.309
DOC_WW_Pin1_4 592 597 PF00397 0.336
DOC_WW_Pin1_4 608 613 PF00397 0.341
LIG_14-3-3_CanoR_1 102 111 PF00244 0.553
LIG_14-3-3_CanoR_1 203 212 PF00244 0.373
LIG_14-3-3_CanoR_1 54 59 PF00244 0.582
LIG_14-3-3_CanoR_1 585 594 PF00244 0.370
LIG_Actin_RPEL_3 307 326 PF02755 0.398
LIG_APCC_ABBA_1 266 271 PF00400 0.174
LIG_APCC_ABBAyCdc20_2 313 319 PF00400 0.291
LIG_BRCT_BRCA1_1 328 332 PF00533 0.312
LIG_BRCT_BRCA1_1 537 541 PF00533 0.627
LIG_BRCT_BRCA1_1 630 634 PF00533 0.360
LIG_BRCT_BRCA1_2 328 334 PF00533 0.312
LIG_EH1_1 298 306 PF00400 0.268
LIG_EH1_1 643 651 PF00400 0.159
LIG_eIF4E_1 299 305 PF01652 0.302
LIG_EVH1_2 618 622 PF00568 0.398
LIG_FHA_1 106 112 PF00498 0.794
LIG_FHA_1 21 27 PF00498 0.465
LIG_FHA_1 241 247 PF00498 0.233
LIG_FHA_1 296 302 PF00498 0.390
LIG_FHA_1 40 46 PF00498 0.672
LIG_FHA_1 563 569 PF00498 0.278
LIG_FHA_2 16 22 PF00498 0.749
LIG_FHA_2 25 31 PF00498 0.454
LIG_FHA_2 290 296 PF00498 0.388
LIG_FHA_2 530 536 PF00498 0.472
LIG_LIR_Apic_2 360 366 PF02991 0.296
LIG_LIR_Apic_2 412 418 PF02991 0.350
LIG_LIR_Apic_2 613 619 PF02991 0.331
LIG_LIR_Gen_1 143 151 PF02991 0.483
LIG_LIR_Gen_1 223 232 PF02991 0.299
LIG_LIR_Gen_1 298 307 PF02991 0.292
LIG_LIR_Gen_1 329 340 PF02991 0.260
LIG_LIR_Gen_1 556 566 PF02991 0.297
LIG_LIR_Nem_3 143 148 PF02991 0.463
LIG_LIR_Nem_3 223 229 PF02991 0.275
LIG_LIR_Nem_3 298 303 PF02991 0.295
LIG_LIR_Nem_3 329 335 PF02991 0.259
LIG_LIR_Nem_3 538 544 PF02991 0.239
LIG_LIR_Nem_3 556 561 PF02991 0.182
LIG_Pex14_1 554 558 PF04695 0.294
LIG_PTB_Apo_2 162 169 PF02174 0.383
LIG_PTB_Phospho_1 162 168 PF10480 0.378
LIG_SH2_CRK 616 620 PF00017 0.398
LIG_SH2_NCK_1 168 172 PF00017 0.512
LIG_SH2_NCK_1 487 491 PF00017 0.486
LIG_SH2_PTP2 129 132 PF00017 0.484
LIG_SH2_PTP2 145 148 PF00017 0.519
LIG_SH2_SRC 473 476 PF00017 0.211
LIG_SH2_SRC 480 483 PF00017 0.198
LIG_SH2_STAP1 168 172 PF00017 0.311
LIG_SH2_STAP1 232 236 PF00017 0.303
LIG_SH2_STAP1 344 348 PF00017 0.287
LIG_SH2_STAP1 388 392 PF00017 0.298
LIG_SH2_STAP1 487 491 PF00017 0.443
LIG_SH2_STAP1 620 624 PF00017 0.347
LIG_SH2_STAT3 299 302 PF00017 0.294
LIG_SH2_STAT5 129 132 PF00017 0.452
LIG_SH2_STAT5 145 148 PF00017 0.377
LIG_SH2_STAT5 160 163 PF00017 0.341
LIG_SH2_STAT5 195 198 PF00017 0.443
LIG_SH2_STAT5 235 238 PF00017 0.343
LIG_SH2_STAT5 24 27 PF00017 0.718
LIG_SH2_STAT5 299 302 PF00017 0.270
LIG_SH2_STAT5 363 366 PF00017 0.299
LIG_SH2_STAT5 473 476 PF00017 0.359
LIG_SH2_STAT5 480 483 PF00017 0.370
LIG_SH2_STAT5 504 507 PF00017 0.419
LIG_SH2_STAT5 558 561 PF00017 0.310
LIG_SH3_3 185 191 PF00018 0.554
LIG_SH3_3 415 421 PF00018 0.212
LIG_SH3_4 467 474 PF00018 0.226
LIG_SUMO_SIM_anti_2 238 249 PF11976 0.267
LIG_SUMO_SIM_par_1 238 249 PF11976 0.284
LIG_SUMO_SIM_par_1 42 49 PF11976 0.689
LIG_SUMO_SIM_par_1 564 569 PF11976 0.377
LIG_TRAF2_1 460 463 PF00917 0.411
LIG_TRAF2_1 638 641 PF00917 0.233
LIG_TRFH_1 362 366 PF08558 0.280
LIG_TYR_ITIM 127 132 PF00017 0.529
LIG_TYR_ITIM 386 391 PF00017 0.327
LIG_UBA3_1 446 453 PF00899 0.270
LIG_UBA3_1 587 592 PF00899 0.289
MOD_CK1_1 106 112 PF00069 0.723
MOD_CK1_1 274 280 PF00069 0.433
MOD_CK1_1 346 352 PF00069 0.311
MOD_CK1_1 483 489 PF00069 0.437
MOD_CK1_1 590 596 PF00069 0.308
MOD_CK1_1 628 634 PF00069 0.392
MOD_CK2_1 15 21 PF00069 0.770
MOD_CK2_1 236 242 PF00069 0.398
MOD_CK2_1 289 295 PF00069 0.323
MOD_CK2_1 399 405 PF00069 0.331
MOD_CK2_1 457 463 PF00069 0.361
MOD_CK2_1 529 535 PF00069 0.465
MOD_CK2_1 592 598 PF00069 0.359
MOD_CK2_1 635 641 PF00069 0.268
MOD_Cter_Amidation 370 373 PF01082 0.265
MOD_Cter_Amidation 374 377 PF01082 0.241
MOD_Cter_Amidation 393 396 PF01082 0.295
MOD_GlcNHglycan 105 108 PF01048 0.592
MOD_GlcNHglycan 263 266 PF01048 0.391
MOD_GlcNHglycan 310 313 PF01048 0.356
MOD_GlcNHglycan 321 324 PF01048 0.320
MOD_GlcNHglycan 39 42 PF01048 0.696
MOD_GlcNHglycan 423 426 PF01048 0.292
MOD_GlcNHglycan 459 462 PF01048 0.248
MOD_GlcNHglycan 537 540 PF01048 0.461
MOD_GlcNHglycan 637 640 PF01048 0.284
MOD_GlcNHglycan 66 69 PF01048 0.710
MOD_GlcNHglycan 92 95 PF01048 0.692
MOD_GSK3_1 101 108 PF00069 0.719
MOD_GSK3_1 15 22 PF00069 0.749
MOD_GSK3_1 236 243 PF00069 0.456
MOD_GSK3_1 271 278 PF00069 0.374
MOD_GSK3_1 343 350 PF00069 0.301
MOD_GSK3_1 353 360 PF00069 0.298
MOD_GSK3_1 39 46 PF00069 0.645
MOD_GSK3_1 416 423 PF00069 0.434
MOD_GSK3_1 531 538 PF00069 0.551
MOD_GSK3_1 562 569 PF00069 0.314
MOD_GSK3_1 586 593 PF00069 0.304
MOD_N-GLC_1 113 118 PF02516 0.634
MOD_N-GLC_1 261 266 PF02516 0.426
MOD_N-GLC_1 284 289 PF02516 0.157
MOD_N-GLC_1 535 540 PF02516 0.571
MOD_N-GLC_1 54 59 PF02516 0.584
MOD_NEK2_1 220 225 PF00069 0.339
MOD_NEK2_1 326 331 PF00069 0.290
MOD_NEK2_1 338 343 PF00069 0.283
MOD_NEK2_1 5 10 PF00069 0.741
MOD_NEK2_1 566 571 PF00069 0.264
MOD_NEK2_1 587 592 PF00069 0.342
MOD_NEK2_1 626 631 PF00069 0.284
MOD_NMyristoyl 1 7 PF02799 0.588
MOD_PIKK_1 186 192 PF00454 0.535
MOD_PIKK_1 204 210 PF00454 0.188
MOD_PIKK_1 271 277 PF00454 0.380
MOD_PIKK_1 338 344 PF00454 0.290
MOD_PIKK_1 428 434 PF00454 0.425
MOD_PIKK_1 5 11 PF00454 0.708
MOD_PK_1 147 153 PF00069 0.513
MOD_PK_1 43 49 PF00069 0.454
MOD_PKA_1 457 463 PF00069 0.308
MOD_PKA_2 101 107 PF00069 0.549
MOD_PKA_2 457 463 PF00069 0.294
MOD_Plk_1 20 26 PF00069 0.680
MOD_Plk_1 240 246 PF00069 0.281
MOD_Plk_1 261 267 PF00069 0.409
MOD_Plk_1 284 290 PF00069 0.147
MOD_Plk_1 344 350 PF00069 0.256
MOD_Plk_2-3 399 405 PF00069 0.317
MOD_Plk_4 20 26 PF00069 0.680
MOD_Plk_4 240 246 PF00069 0.310
MOD_Plk_4 295 301 PF00069 0.366
MOD_Plk_4 353 359 PF00069 0.287
MOD_Plk_4 43 49 PF00069 0.454
MOD_Plk_4 480 486 PF00069 0.359
MOD_Plk_4 628 634 PF00069 0.305
MOD_ProDKin_1 113 119 PF00069 0.623
MOD_ProDKin_1 357 363 PF00069 0.309
MOD_ProDKin_1 592 598 PF00069 0.336
MOD_ProDKin_1 608 614 PF00069 0.341
TRG_DiLeu_BaEn_1 556 561 PF01217 0.324
TRG_DiLeu_BaEn_4 79 85 PF01217 0.469
TRG_ENDOCYTIC_2 129 132 PF00928 0.498
TRG_ENDOCYTIC_2 145 148 PF00928 0.474
TRG_ENDOCYTIC_2 388 391 PF00928 0.305
TRG_ENDOCYTIC_2 473 476 PF00928 0.347
TRG_ENDOCYTIC_2 558 561 PF00928 0.300
TRG_ER_diArg_1 256 258 PF00400 0.377
TRG_ER_diArg_1 313 315 PF00400 0.285
TRG_ER_diArg_1 395 397 PF00400 0.304
TRG_Pf-PMV_PEXEL_1 288 293 PF00026 0.360
TRG_Pf-PMV_PEXEL_1 531 535 PF00026 0.555
TRG_Pf-PMV_PEXEL_1 557 562 PF00026 0.353
TRG_Pf-PMV_PEXEL_1 651 656 PF00026 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P953 Leptomonas seymouri 30% 100%
A0A0N1I9A0 Leptomonas seymouri 68% 100%
A0A0N1PD05 Leptomonas seymouri 33% 100%
A0A0S4IMB7 Bodo saltans 34% 100%
A0A0S4IRZ7 Bodo saltans 40% 100%
A0A0S4J804 Bodo saltans 31% 100%
A0A0S4JPZ1 Bodo saltans 28% 100%
A0A1X0NIX2 Trypanosomatidae 28% 100%
A0A1X0NUB2 Trypanosomatidae 47% 100%
A0A1X0P527 Trypanosomatidae 31% 100%
A0A1X0P549 Trypanosomatidae 30% 100%
A0A1X0P863 Trypanosomatidae 30% 100%
A0A1X0P8W3 Trypanosomatidae 26% 89%
A0A1X0P994 Trypanosomatidae 30% 100%
A0A3Q8IFK8 Leishmania donovani 31% 100%
A0A3Q8IHH8 Leishmania donovani 31% 100%
A0A3Q8IIH5 Leishmania donovani 27% 100%
A0A3Q8IJM9 Leishmania donovani 30% 100%
A0A3R7MKG5 Trypanosoma rangeli 27% 100%
A0A3S7X5M4 Leishmania donovani 100% 100%
A0A3S7X6T8 Leishmania donovani 34% 100%
A0A3S7XAL3 Leishmania donovani 31% 100%
A0A3S7XAT9 Leishmania donovani 31% 100%
A0A422NCP0 Trypanosoma rangeli 32% 100%
A0A422NH41 Trypanosoma rangeli 45% 100%
A4HHQ5 Leishmania braziliensis 32% 100%
A4HJT5 Leishmania braziliensis 30% 100%
A4HKG9 Leishmania braziliensis 74% 100%
A4HLR0 Leishmania braziliensis 34% 100%
A4HNI1 Leishmania braziliensis 29% 100%
A4HP12 Leishmania braziliensis 30% 100%
A4HP13 Leishmania braziliensis 30% 100%
A4HW88 Leishmania infantum 27% 100%
A4I4X0 Leishmania infantum 31% 100%
A4I7A1 Leishmania infantum 31% 100%
A4I960 Leishmania infantum 34% 100%
A4IC37 Leishmania infantum 29% 100%
A4IDC1 Leishmania infantum 30% 100%
A4IDC2 Leishmania infantum 31% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AEB9 Leishmania major 32% 100%
E9AFZ2 Leishmania major 29% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
Q4Q1S3 Leishmania major 30% 100%
Q4Q1S4 Leishmania major 30% 100%
Q4Q3Y9 Leishmania major 32% 85%
Q4Q598 Leishmania major 93% 100%
Q4Q5W2 Leishmania major 31% 100%
Q4QFJ2 Leishmania major 27% 100%
Q8N5S9 Homo sapiens 25% 100%
Q8VBY2 Mus musculus 25% 100%
V5BC28 Trypanosoma cruzi 28% 100%
V5BPJ0 Trypanosoma cruzi 32% 100%
V5D7G4 Trypanosoma cruzi 30% 79%
V5DFW9 Trypanosoma cruzi 46% 100%
V5DKY9 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS